Cancer prevention research (Philadelphia, Pa.)最新文献

{"title":"Availability, Reading Level, Quality, and Accessibility of Cancer Center Smoking Cessation Materials.","authors":"Dalia Littman, Abhishek Bhattacharya, Fumiko Chino","doi":"10.1158/1940-6207.CAPR-24-0534","DOIUrl":"https://doi.org/10.1158/1940-6207.CAPR-24-0534","url":null,"abstract":"<p><p>Smoking cessation following a cancer diagnosis is associated with improved outcomes, including reduced overall mortality. We searched the websites of 64 NCI-designated cancer centers that provide clinical cancer care to adults for webpages about smoking cessation and assessed the quality of the available content. Thirty-five of 64 (55%) websites hosted smoking cessation-focused webpages. Of those 35 webpages, 20 (57%) explicitly stated that smoking cessation decreases overall mortality, 8 (23%) included information about smoking cessation medications, 9 (26%) offered behavioral counseling tips such as setting a quit date or advising on habit replacement, and 11 (31%) described the risks and benefits of e-cigarette use. Links to other established smoking cessation organizations were evaluated; 15 (43%) webpages linked to smokefree.gov, 20 (57%) listed the phone numbers for state or national quitlines, and 5 (14%) described the Cancer Center Cessation Initiative. The average estimated reading level of the webpages was 10.5. These findings suggest that cancer center websites, which patients may access for trustworthy online medical information, often lack actionable and/or comprehensible information to help patients with cancer quit smoking. There is an opportunity to strengthen online communication to patients about effective smoking cessation strategies, which may help patients live longer and healthier lives.</p><p><strong>Prevention relevance: </strong>Smoking cessation is paramount to preventing the onset of cancer, and in those who have a cancer diagnosis, quitting smoking will improve outcomes and also help reduce the risk of developing a second cancer.</p>","PeriodicalId":72514,"journal":{"name":"Cancer prevention research (Philadelphia, Pa.)","volume":" ","pages":"OF1-OF4"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contemporary Status and Frontiers of Cervical Cancer Screening in the United States.","authors":"Abbigael V Eli, Benjamin B Kasten, Christopher M Mayer, Rishab Samant, Yolanda E Hartman, Isha Chaudhary, Noorullah Imran, Valeria L Dal Zotto, Andrea G Kahn, Rebecca C Arend, Jason M Warram","doi":"10.1158/1940-6207.CAPR-25-0118","DOIUrl":"10.1158/1940-6207.CAPR-25-0118","url":null,"abstract":"<p><p>Cervical cancer screening and its implementation have evolved tremendously since the first method, cytology using Papanicolaou stain, was introduced in the 1950s. New screening methods, such as human papillomavirus (HPV) testing, have been discovered and evidence-based changes have been made to official screening guidelines set forth by various U.S. organizations. With the advent of an HPV vaccine in 2006, and with more recent research into populations carrying disparate burdens of cervical disease, effectiveness of current cervical cancer screening programs is being called into question since the disease incidence has not decreased as expected in the last 20 years. This review highlights where cervical cancer screening in the U.S. started, the current clinical methods, and promising developments on the frontiers of screening research to introduce new screening options or improve current screening programs and outcomes. We also highlight certain population factors that hinder effective screening in high-risk groups, based on research aimed at ensuring that population-wide screening continues to be an effective strategy for reducing cervical cancer incidence and mortality.</p>","PeriodicalId":72514,"journal":{"name":"Cancer prevention research (Philadelphia, Pa.)","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of health education on cervical cancer screening uptake and knowledge among target women in Addis Ababa: A randomized controlled trial.","authors":"Ebrahim Mohammed, Girma Taye, Mathewos Assefa, Adamu Addissie, Ahmedin Jemal","doi":"10.1158/1940-6207.CAPR-25-0188","DOIUrl":"https://doi.org/10.1158/1940-6207.CAPR-25-0188","url":null,"abstract":"<p><p>Health education can improve cervical cancer screening uptake, however evidence from randomized controlled trials in the general population of Addis Ababa is limited. The aim of this study is to assess the effect of health education on screening uptake and knowledge among women aged 30-49 years in Addis Ababa, Ethiopia. A randomized controlled trial was conducted involving 1,300 women who had never been screened before. The intervention group received home-based health education about cervical cancer, supplemented by brochures. Chi-square test, independent sample t-test and Paired t-tests were used to assess pre- and post-intervention differences. The impact of the intervention was measured using the differences in differences (DID) approach. Three months after intervention, 1,154 (88.8%) were interviewed. Screening uptake was significantly higher in the intervention group, 241(41.8%) of women screened compared to 93 (16.1%) in the control group. Post-intervention, awareness increased by 42.2%, knowledge of symptoms rose by 23.1%, knowledge of risk factors increased by 15.2%, positive attitudes improved by 26.7% and overall knowledge increased by 19.5%, among the intervention group indicating the change is statistically significant. The difference in differences analysis indicated 51% of change in overall knowledge due to intervention. Age, occupation and income were significantly associated with uptake of screening while lack of time was a common barrier. Structured home-based education significantly increases cervical cancer knowledge and screening uptake. Scaling up home-based health education can significantly improve screening uptake.</p>","PeriodicalId":72514,"journal":{"name":"Cancer prevention research (Philadelphia, Pa.)","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colorectal Cancer Screening Modalities in the US: Regional and Rural Variance, the Resilience of Colonoscopy, and the Rise of mt-sDNA Testing.","authors":"Nicholas Edwardson, Vernon S Pankratz, Samir Gupta, David van der Goes, Prajakta Adsul, Gulshan Parasher, Kevin English, Shiraz I Mishra","doi":"10.1158/1940-6207.CAPR-25-0185","DOIUrl":"https://doi.org/10.1158/1940-6207.CAPR-25-0185","url":null,"abstract":"<p><p>This study examined trends in colorectal cancer (CRC) screening modality utilization across the United States from 2016 to 2022, leveraging a large national claims database. The purpose was to identify national, regional, and demographic patterns in screening behavior during a period that encompassed the introduction of multitarget stool DNA testing (mt-sDNA) and the COVID-19 pandemic. Among 6.9 million CRC screenings analyzed, overall utilization rose through 2019, dipped in 2020 due to pandemic disruptions, and rebounded by 2022. Colonoscopy remained the dominant modality, with its utilization increasing in both relative and absolute terms. Mt-sDNA testing experienced rapid adoption, increasing from under 1% to 17% of all screenings, while fecal occult blood testing and fecal immunochemical testing (FOBFIT) declined. Multinomial logistic regression revealed that utilization patterns varied significantly by region, rurality, sex, age, and year. The Midwest and rural patients exhibited higher uptake of both colonoscopy and mt-sDNA compared to other groups, while the West maintained the highest reliance on FOBFIT. Findings highlight the nonuniform adoption of screening modalities across regions, urban and rural patients, categories of sex, and age cohorts. Understanding these patterns can inform and improve future resource allocation with the goal of increasing CRC screening uptake and adherence.</p>","PeriodicalId":72514,"journal":{"name":"Cancer prevention research (Philadelphia, Pa.)","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Availability, Reading Level, Quality, and Accessibility of Cancer Center Smoking Cessation Materials.","authors":"Dalia Littman, Abhishek Bhattacharya, Fumiko Chino","doi":"10.1158/1940-6207.CAPR-24-0534","DOIUrl":"https://doi.org/10.1158/1940-6207.CAPR-24-0534","url":null,"abstract":"<p><p>Smoking cessation following a cancer diagnosis is associated with improved outcomes, including reduced overall mortality. We searched the websites of 64 National Cancer Institute designated cancer centers that provide clinical cancer care to adults for webpages about smoking cessation and assessed the quality of the available content. 35 of 64 (55%) websites hosted smoking cessation-focused webpages. Of those 35 webpages, 20 (57%) explicitly stated that smoking cessation decreases overall mortality, 8 (23%) included information about smoking cessation medications, 9 (26%) offered behavioral counseling tips such as setting a quit date or advising on habit replacement and 11 (31%) described the risks and benefits of e-cigarette use. Links to other established smoking cessation organizations were evaluated; 15 (43%) webpages linked to smokefree.gov, 20 (57%) listed the phone numbers for state or national quitlines, and 5 (14%) described the Cancer Center Cessation Initiative. The average estimated reading level of the webpages was 10.5. These findings suggest that cancer center websites, which patients may access for trustworthy online medical information, often lack actionable and/or comprehensible information to help patients with cancer quit smoking. There is an opportunity to strengthen online communication to patients about effective smoking cessation strategies, which may help patients live longer and healthier lives.</p>","PeriodicalId":72514,"journal":{"name":"Cancer prevention research (Philadelphia, Pa.)","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Elevated Serum Triglycerides with Colorectal Cancer Risk: Findings from a Large-scale Prospective Cohort of Korean Adults.","authors":"Sukhong Min, Hyobin Lee, Sinyoung Cho, Seung-Yong Jeong, Aesun Shin, Daehee Kang","doi":"10.1158/1940-6207.CAPR-25-0058","DOIUrl":"https://doi.org/10.1158/1940-6207.CAPR-25-0058","url":null,"abstract":"<p><p>Colorectal cancer incidence is increasing in Korea, emphasizing the need to identify its risk factors. Serum lipids may influence colorectal cancer risk, but evidence is conflicting. We examined the associations between serum lipids and colorectal cancer risk in Koreans. Using data from the Korean Genome and Epidemiology Study's Health Examinees cohort, we assessed serum low-density lipoproteins, high-density lipoproteins, triglycerides (TG), and total cholesterol among those who did not use lipid-lowering drugs. Dyslipidemia and its subcategories were defined using established clinical thresholds. Cancer cases were identified via the national cancer registry. Associations between lipids and cancers were evaluated using Cox regression. Subgroup analyses were conducted by sex, age, diabetes, and prior screening experience, along with sensitivity analyses based on follow-up duration. During a median follow-up of 9.1 years, 821 new colorectal cancer cases occurred among 111,330 participants of 40 to 69 years of age (38,455 men and 72,875 women). For colorectal cancer, elevated TG [Q4 vs. Q1: HR = 1.32; 95% confidence interval (CI), 1.07-1.62; P-trend = 0.02] and total cholesterol (Q4 vs. Q1: HR = 1.22; 95% CI, 1.00-1.51) increased the risk. For colon cancer, high TG increased the risk (Q4 vs. Q1: HR = 1.42; 95% CI, 1.08-1.86; P-trend = 0.01). Those with hypertriglyceridemia, compared with those without, showed increased risk (HR = 1.42; 95% CI, 1.07-1.87) for rectal cancer, whereas other lipids showed no significant associations. Similar but attenuated results were found in the subgroup analyses among participants ≥50 years of age. TG was associated with colorectal, colon, and rectal cancers in Koreans. Findings suggest that lipid levels may be relevant to colorectal cancer prevention strategies.</p><p><strong>Prevention relevance: </strong>Our findings highlight serum lipids as potential modifiable risk factors for colorectal cancer in Koreans. These results support lipid management as a preventive strategy, informing public health efforts. Targeted lipid control programs may reduce colorectal cancer risk, particularly among high-risk individuals, warranting further evaluation of lipid-lowering therapies for prevention.</p>","PeriodicalId":72514,"journal":{"name":"Cancer prevention research (Philadelphia, Pa.)","volume":" ","pages":"OF1-OF11"},"PeriodicalIF":2.6,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stage at Diagnosis for Common Cancers according to Rurality, Area Deprivation, and Insurance, 2017 to 2021.","authors":"Kathleen M Fairfield, Kimberly Murray, Lise M Cloutier, John L Daggett, Benjamin R Felix, Christina A Kapala, Renee M Fay-Leblanc, Adriana E Nadeau, Bridget K Rauscher, Kathryn Rensenbrink, Debra A Rothenberg, Kevin D Stein","doi":"10.1158/1940-6207.CAPR-24-0587","DOIUrl":"10.1158/1940-6207.CAPR-24-0587","url":null,"abstract":"<p><p>Poor access to care among rural and vulnerable populations may result in later-stage cancer diagnoses. Using Maine Cancer Registry data (2017-2021), we examined relationships between rurality, insurance, area deprivation index, and stage for breast, colorectal, lung/bronchus, and prostate cancers. Among 21,208 cancers, regional/distant spread at diagnosis was present among 24% of breast, 60% of colorectal, 69% of lung/bronchus, and 25% of prostate cancers. In the multivariable model, we modeled the odds of being diagnosed with regional/distant (vs. in situ/local spread) according to insurance, rurality, and area deprivation index. Compared with commercial insurance, we observed higher odds of diagnosis at the regional/distant stage (vs. in situ/localized) associated with having Medicaid insurance for breast [adjusted OR (AOR), 1.65; 95% confidence interval (CI), 1.33-2.04], colorectal (AOR, 1.46; 95% CI, 1.09-1.98), and prostate (AOR, 1.88; 95% CI, 1.30-2.70) cancers but no association for lung cancer. People living in isolated rural areas had higher odds of being diagnosed with later-stage colorectal (AOR, 1.24; 95% CI, 1.01-1.53), lung/bronchus (AOR, 1.22; 95% CI, 1.04-1.43), and prostate cancers (AOR, 1.24; 95% CI, 1.04-1.47) compared with urban dwellers. Living in isolated rural areas or being insured by Medicaid was associated with later-stage cancer diagnoses compared with those in more urban areas and with commercial insurance. This suggests an opportunity to improve early detection among these vulnerable populations.</p><p><strong>Prevention relevance: </strong>Rural areas and populations with lower socioeconomic status have an increased incidence of cancer. Screening is an important tool for cancer control, and in the case of colorectal cancer polyp removal and treatment of in situ breast cancers, may be considered prevention. Early detection prevents poor cancer outcomes across these malignancies.</p>","PeriodicalId":72514,"journal":{"name":"Cancer prevention research (Philadelphia, Pa.)","volume":" ","pages":"465-474"},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Evaluation of Cancer Signal Origin Prediction and Diagnostic Resolution following Multicancer Early Detection Testing in the PATHFINDER Study.","authors":"Catherine R Marinac, Charles H McDonnell, Lincoln D Nadauld, Christina A Dilaveri, Robert Reid, Karen C Chung, Margarita Lopatin, Eric T Fung, Deborah Schrag, Rita Shaknovich, Eric A Klein","doi":"10.1158/1940-6207.CAPR-24-0468","DOIUrl":"10.1158/1940-6207.CAPR-24-0468","url":null,"abstract":"<p><p>Blood-based multicancer early detection (MCED) tests represent a new approach for cancer detection. To gain insights into the utility of various approaches of evaluating a cancer signal detected (CSD) test result, we evaluated diagnostic journeys of a subset of 6,662 participants in PATHFINDER who had a CSD on both an initial and refined version of an MCED test that also provided a prediction of cancer signal origin (CSO). We sought to determine whether CSO prediction-guided diagnostic evaluations led to diagnostic resolution; whether participants with known risk factors for cancer beyond age alone and a negative initial diagnostic evaluation had a cancer diagnosis during study follow-up; the utility of whole-body imaging in reaching diagnostic resolution; and differences in the diagnostic journeys needed to reach diagnostic resolution for both true- and false-positive results. Of the 39 participants in this analysis, 82% (32/39) achieved diagnostic resolution after the initial evaluation, including 78% (25/32) who reached resolution specifically with a CSO prediction-directed workup. Eighteen percent (7/39) required additional evaluation for persistent clinical suspicion of cancer, all of whom achieved resolution (3 with and 4 without cancer). Whole-body imaging contributed to diagnostic resolution in only 49% of CSD cases. Approximately 90% of true- and false-positive cases had imaging tests; more true positives versus false positives (81.0% vs. 38.9%) had nonsurgical and/or surgical procedures. In conclusion, CSO prediction-directed evaluations enabled diagnostic resolution for most participants, although some with negative initial evaluations but persistent suspicion of cancer required additional testing.</p><p><strong>Prevention relevance: </strong>MCED testing has the potential to increase detection of cancer at earlier stages. As MCED testing is a new technology, there are few data on the diagnostic journeys patients undergo following testing. We observed that for most patients, CSO prediction-directed workups were efficient, leading to diagnostic resolution after initial evaluation.</p>","PeriodicalId":72514,"journal":{"name":"Cancer prevention research (Philadelphia, Pa.)","volume":" ","pages":"475-483"},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12314506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weight Loss Is Protective in Preclinical Breast Cancer Models: Interactions with the Anticancer Immune Response.","authors":"Rachel R Sassoon, Rachel J Perry","doi":"10.1158/1940-6207.CAPR-25-0168","DOIUrl":"10.1158/1940-6207.CAPR-25-0168","url":null,"abstract":"<p><p>Growing research suggests that advanced aging and obesity are correlated with an increased risk and poorer prognosis in triple-negative breast cancer. In this issue of Cancer Prevention Research, Smith and colleagues fed young and old mice a control/low-fat diet, a high-fat diet, or an intermittent calorie restriction (ICR) diet prior to injection of E0771 breast cancer cells. The ICR mice exhibited lower rates of tumor growth across all interventions, with tumor size in ICR mice matched to that of young, lean controls. Most notably, the authors found that ICR mice also exhibited the highest antitumor immunity. These data provide encouraging preclinical evidence that immune dysfunction induced by obesogenic diets is reversible. See related article by Smith et al., p. 453.</p>","PeriodicalId":72514,"journal":{"name":"Cancer prevention research (Philadelphia, Pa.)","volume":" ","pages":"437-438"},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and Acceptability of Pay-it-forward in Increasing Uptake of HPV Vaccination among 15- to 18-Year-Old Girls in China: Pilot RCT Results.","authors":"Yifan Li, Chuanyu Qin, Katherine T Li, Yu He, Shengyue Qiu, Dan Wu, Jing Li","doi":"10.1158/1940-6207.CAPR-24-0549","DOIUrl":"10.1158/1940-6207.CAPR-24-0549","url":null,"abstract":"<p><p>China has a low human papillomavirus (HPV) vaccination rate due to limited public funding and mistrust in domestic vaccines. This pilot study aimed to evaluate the feasibility, acceptability, and preliminary effectiveness of an innovative pay-it-forward strategy to improve HPV vaccine uptake among adolescent girls. Conducted at a community health center in Western China (January 4-February 18, 2022), the study recruited 100 adolescent girls (ages 15-18 years) with no prior HPV vaccination. Participants were randomly assigned to either the standard-of-care arm (self-paid vaccines, n = 50) or the pay-it-forward arm (subsidized vaccines, handwritten postcards, and the opportunity to donate and/or write postcards, n = 50). Feasibility was assessed through recruitment, retention, and questionnaire completion rates. Acceptability and feasibility were measured using a standard scale. Preliminary effectiveness was evaluated by first-dose vaccination rate. Of 109 screened participants, 100 were eligible to participate (91.7%). The retention rate was 100% in both arms. The questionnaire completion rate was 98% (49/50) in the pay-it-forward arm and 82% (41/50) in the standard-of-care arm. Most participants self-reported that the strategy was feasible (97.6%, 41/42) and acceptable (90.5%, 38/42). Ninety-seven percent (97/100) of participants made vaccination appointments. The first-dose HPV vaccine uptake rate was 98% (49/50) in the pay-it-forward arm and 82% (41/50) in the standard-of-care arm (P < 0.05). No serious adverse events were identified. The pay-it-forward strategy was feasible and acceptable and showed preliminary effectiveness in increasing HPV vaccination uptake. Further refinement and population-based recruitment are needed to better reflect local contexts and enhance the generalizability of the formal trial.</p><p><strong>Prevention relevance: </strong>The results of this pilot study demonstrate that the pay-it-forward strategy is both feasible and acceptable in increasing HPV vaccine uptake among 15- to 18-year-old girls. The future use of this strategy holds promise as an effective approach to enhance HPV vaccination rates that will eventually lead to a reduction in cervical cancer incidence.</p>","PeriodicalId":72514,"journal":{"name":"Cancer prevention research (Philadelphia, Pa.)","volume":" ","pages":"485-492"},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12314514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}