Contemporary Status and Frontiers of Cervical Cancer Screening in the United States.

Cervical cancer screening and its implementation have evolved tremendously since the first method, cytology using Papanicolaou stain, was introduced in the 1950s. New screening methods, such as human papillomavirus (HPV) testing, have been discovered and evidence-based changes have been made to official screening guidelines set forth by various U.S. organizations. With the advent of an HPV vaccine in 2006, and with more recent research into populations carrying disparate burdens of cervical disease, effectiveness of current cervical cancer screening programs is being called into question since the disease incidence has not decreased as expected in the last 20 years. This review highlights where cervical cancer screening in the U.S. started, the current clinical methods, and promising developments on the frontiers of screening research to introduce new screening options or improve current screening programs and outcomes. We also highlight certain population factors that hinder effective screening in high-risk groups, based on research aimed at ensuring that population-wide screening continues to be an effective strategy for reducing cervical cancer incidence and mortality.