Acta veterinaria Hungarica最新文献_第6页

Effect of hydroxylated and methylated flavonoids on cytochrome P450 activity in porcine intestinal epithelial cells. 羟基化和甲基化黄酮对猪肠上皮细胞色素P450活性的影响。

IF 0.9 4区农林科学

Acta veterinaria Hungarica Pub Date : 2023-06-20 DOI: 10.1556/004.2023.00746

Zita Karancsi, Dóra Kovács, György Csikó, Orsolya Palócz, Ákos Jerzsele, Péter Gálfi, Orsolya Farkas

{"title":"Effect of hydroxylated and methylated flavonoids on cytochrome P450 activity in porcine intestinal epithelial cells.","authors":"Zita Karancsi, Dóra Kovács, György Csikó, Orsolya Palócz, Ákos Jerzsele, Péter Gálfi, Orsolya Farkas","doi":"10.1556/004.2023.00746","DOIUrl":"https://doi.org/10.1556/004.2023.00746","url":null,"abstract":"Cytochrome P450 (CYP) oxidases are among the main metabolizing enzymes that are responsible for the transformation of xenobiotics, including clinically important drugs. Their activity can be influenced by several compounds leading to decreased efficacy or increased toxicity of co-administered medicines. Flavonoids exert various beneficial effects on human and animal health; therefore they are used as food and feed supplements. However, they are also well-known for their CYP modulating potential. Since the amount of CYP enzymes is highest in the liver, interaction studies are mainly conducted in hepatocytes, however, CYP activity in the gastrointestinal tract is also remarkable. In this study, effects of apigenin (API), quercetin (QUE) and their methylated derivatives trimethylapigenin (TM-API), 3-O-methylquercetin (3M-QUE) and 3',7-di-O-methylquercetin (3'7DM-QUE) on the CYP enzyme activity was examined in IPEC-J2 porcine intestinal epithelial cells. Potential food-drug interactions were studied using flavonoid treatment in combination with inducer and inhibitor compounds. API, TM-API, QUE and 3M-QUE significantly inhibited the CYP3A29 enzyme, while 3'7DM-QUE did not alter its activity. Enzyme inhibition has also been observed in case of some food-drug combinations. Our results support previous findings about CYP modulating effects of flavonoids and highlights the possibility of interactions when flavonoid-containing supplements are consumed during drug treatments.","PeriodicalId":7247,"journal":{"name":"Acta veterinaria Hungarica","volume":"71 1","pages":"16-24"},"PeriodicalIF":0.9,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9695332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of blaCTX-M genes in ESBL-producing Klebsiella isolates from animals in Croatia. 克罗地亚产esbl克雷伯菌分离株中blaCTX-M基因的检测

IF 0.9 4区农林科学

Acta veterinaria Hungarica Pub Date : 2023-06-20 DOI: 10.1556/004.2023.00845

Selma Pintarić, Zrinka Štritof, Vesna Mojčec Perko, Andrea Tumpa, Marija Cvetnić, Lana Hadžić

引用次数: 0

Effect of postpartum drenching on rumination time and reticuloruminal pH at a Hungarian dairy farm. 产后浇水对匈牙利奶牛场反刍时间和网状胃pH值的影响。

IF 0.9 4区农林科学

Acta veterinaria Hungarica Pub Date : 2023-06-20 DOI: 10.1556/004.2023.00835

Lea Lénárt, András Horváth, Tamás Kis, Dávid Buják, Ottó Szenci

{"title":"Effect of postpartum drenching on rumination time and reticuloruminal pH at a Hungarian dairy farm.","authors":"Lea Lénárt, András Horváth, Tamás Kis, Dávid Buják, Ottó Szenci","doi":"10.1556/004.2023.00835","DOIUrl":"https://doi.org/10.1556/004.2023.00835","url":null,"abstract":"The aim of this research was to investigate the effect of drenching with a feed additive on rumination time (RT) and reticuloruminal pH post-partum at a Hungarian large-scale dairy farm. One hundred and sixty-one cows were fitted with a Ruminact© HR-Tag and from these 20 also received SmaXtec© ruminal boli approximately 5 days before calving. Drenching and control groups were established based on calving dates. Animals in the drenching group were dosed three times (Day 0/day of calving/, Day 1, and Day 2 after calving) using a feed additive containing calcium propionate, magnesium sulphate, yeast, potassium chloride and sodium chloride mixed in approximately 25 L of lukewarm water. RT before calving and sensitivity to subacute ruminal acidosis (SARA) were considered in the final analysis. There was a significant decrease in RT in the drenched groups compared to the controls after drenching. Reticuloruminal pH was significantly higher and time below reticuloruminal pH 5.8 remained significantly lower in SARA-tolerant drenched animals on the days of the first and the second drenchings. Drenching temporarily decreased RT in both drenched groups compared to controls. The feed additive had a positive effect on reticuloruminal pH and time below reticuloruminal pH 5.8 in tolerant drenched animals.","PeriodicalId":7247,"journal":{"name":"Acta veterinaria Hungarica","volume":"71 1","pages":"46-53"},"PeriodicalIF":0.9,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9751175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Assessment of the microbiological status of two Hungarian ostrich farms. 两个匈牙利鸵鸟养殖场微生物状况评估。

IF 0.9 4区农林科学

Acta veterinaria Hungarica Pub Date : 2023-06-20 DOI: 10.1556/004.2023.00765

Dóra Lili Brassó, Renáta Knop, Zsófia Várszegi, Péter Bársony, István Komlósi, Árpád Bacsadi, Andrea Bistyák

{"title":"Assessment of the microbiological status of two Hungarian ostrich farms.","authors":"Dóra Lili Brassó, Renáta Knop, Zsófia Várszegi, Péter Bársony, István Komlósi, Árpád Bacsadi, Andrea Bistyák","doi":"10.1556/004.2023.00765","DOIUrl":"https://doi.org/10.1556/004.2023.00765","url":null,"abstract":"The aim of this study was to estimate the occurrence of bacterial infection and contamination in two ostrich-producing farms. Compared to other poultry species, the hatchability of ostrich eggs is especially low. In a quest to identify factors that may affect hatchability, we collected faecal samples from adult birds, as well as eggs with dead-in-shell embryos, dead chicks and swab samples from the surface of the eggs and from the environment. The samples were screened for the presence of bacteria by routine bacteriological culture methods. The most prevalent bacteria, detected in the samples, were Escherichia coli, Bacillus spp. and coliform bacteria, whereas Pseudomonas spp. were less frequently found. The intensity and species compositon of the bacterial contamination was comparable in the two farms. Our results revealed that the bacteria, present in the environment, may likely be transmitted to the surface of the eggs. If they are able to penetrate the shell then the embryos and chicks become infected easily. These findings draw the attention to the special importance of enforcing efficient decontamination and disinfection measures to keep the environment and egg surface free from germs. Besides the appropriate egg treatment procedure, the incubation and hatching technology should also be kept under control.","PeriodicalId":7247,"journal":{"name":"Acta veterinaria Hungarica","volume":"71 1","pages":"3-11"},"PeriodicalIF":0.9,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9697334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Memoriam Professor Ferenc Kutas (1930-2023). 纪念费伦茨·库塔斯教授(1930-2023)。

IF 0.9 4区农林科学

Acta veterinaria Hungarica Pub Date : 2023-06-20 DOI: 10.1556/004.2023.00010

Mária Benkő, Tibor Kassai

引用次数: 0

Autologous platelet-rich plasma treatment in a dog with vincristine extravasation injury. 自体富血小板血浆治疗长春新碱外渗伤1例。

IF 0.9 4区农林科学

Acta veterinaria Hungarica Pub Date : 2023-06-20 DOI: 10.1556/004.2023.00730

Basak Boztok Ozgermen

{"title":"Autologous platelet-rich plasma treatment in a dog with vincristine extravasation injury.","authors":"Basak Boztok Ozgermen","doi":"10.1556/004.2023.00730","DOIUrl":"https://doi.org/10.1556/004.2023.00730","url":null,"abstract":"Extravasation of vincristine sulfate (VS) is a common complication encountered during canine transmissible venereal tumor treatment and other hematopoietic neoplasms, such as lymphoma and leukemias. The leakage of the chemotherapeutic agent may result in soft tissue damage leading to ulceration and necrosis. Studies have shown that platelet-rich plasma consists of growth factors and cytokines, thus plays a crucial role in wound healing. This study aimed to evaluate the effects of autologous platelet-rich plasma and antimicrobial wound dressing for the treatment of VS extravasation-related acute full-thickness skin wounds. A male Aksaray Malakli shepherd dog (3 years old) was brought to our clinic with a wound on the left forelimb which appeared two days after intravenous injection of VS. Extravasation was suspected. A total of 3.5 mL autologous platelet-rich plasma was injected into the wound margins and an antimicrobial dressing containing chlorhexidine acetate was used weekly to close the wound. The wound healed without any complications in 6 weeks. It was concluded that autologous platelet-rich plasma treatment is a simple and cost-effective method for the treatment of VS extravasation-related acute full-thickness skin wounds.","PeriodicalId":7247,"journal":{"name":"Acta veterinaria Hungarica","volume":"71 1","pages":"25-29"},"PeriodicalIF":0.9,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9751183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myofibroblastic tumour in the liver of a cat - A case report. 猫肝脏肌成纤维细胞瘤1例报告。

IF 0.9 4区农林科学

Acta veterinaria Hungarica Pub Date : 2023-06-20 DOI: 10.1556/004.2023.00840

Katarzyna Paździor-Czapula, Joanna Fiedorowicz, Iwona Otrocka-Domagała

引用次数: 0

Pathological and molecular investigation of canine distemper virus: Phylogenetic analysis of co-circulating genetic lineages in Türkiye. 犬瘟热病毒的病理和分子研究:犬瘟热病毒共循环遗传谱系的系统发育分析。

IF 0.9 4区农林科学

Acta veterinaria Hungarica Pub Date : 2023-06-20 DOI: 10.1556/004.2023.00809

Zeynep Karapınar, Fatma İlhan, Mustafa Usta, Mehmet Özkan Timurkan

{"title":"Pathological and molecular investigation of canine distemper virus: Phylogenetic analysis of co-circulating genetic lineages in Türkiye.","authors":"Zeynep Karapınar, Fatma İlhan, Mustafa Usta, Mehmet Özkan Timurkan","doi":"10.1556/004.2023.00809","DOIUrl":"https://doi.org/10.1556/004.2023.00809","url":null,"abstract":"Canine distemper virus (CDV) is a highly contagious virus that infects a wide variety of animals of carnivore species and may cause manifestations from subclinical infection to fatal disease. In this study, dogs clinically suspected having distemper were examined by reverse transcriptase-polymerase chain reaction (RT-PCR), histopathology and immuno-histochemistry. By histopathological examination, characteristic intracytoplasmic and/or intranuclear inclusion bodies were observed in the lung, stomach, small intestine, liver, kidney, spleen and central nervous system. Interstitial and broncho-interstitial pneumonia, gastroenteritis and encephalitis were revealed. CDV antigens were detected in all tissues with characteristic histopathological findings. The antigens were more abundant in the bronchial and bronchiolar epithelium and in the syntitial cells. Phylogenetic analyses were performed using the PCR-amplified partial sequences of the genes encoding the viral heamagglutinin and fusion proteins. The phylogenetic trees showed that the newly determined sequences were diverse and clustered within different lineages of the European or the Arctic strains.","PeriodicalId":7247,"journal":{"name":"Acta veterinaria Hungarica","volume":"71 1","pages":"54-64"},"PeriodicalIF":0.9,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9698579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metastatic exocrine pancreatic adenocarcinoma in a giant otter (Pteronura brasiliensis). 巨型水獭（Pteronura brasiliensis）的转移性胰腺外分泌腺癌。

IF 0.9 4区农林科学

Acta veterinaria Hungarica Pub Date : 2023-05-05 Print Date: 2023-06-20 DOI: 10.1556/004.2023.00888

Maria Helena Barros Pinto, Thiago Rodrigues Cardoso Braga, Guilherme Reis Blume, Letícia Batelli de Oliveira, Nicolas Thomas Costa das Chagas, Fernanda Rezende Souza, Geovanni Dantas Cassali, Fabiano José Ferreira de Sant'Ana

{"title":"Metastatic exocrine pancreatic adenocarcinoma in a giant otter (Pteronura brasiliensis).","authors":"Maria Helena Barros Pinto, Thiago Rodrigues Cardoso Braga, Guilherme Reis Blume, Letícia Batelli de Oliveira, Nicolas Thomas Costa das Chagas, Fernanda Rezende Souza, Geovanni Dantas Cassali, Fabiano José Ferreira de Sant'Ana","doi":"10.1556/004.2023.00888","DOIUrl":"10.1556/004.2023.00888","url":null,"abstract":"Neoplasms of the exocrine pancreas are uncommon in domestic animals and rarely occur in wildlife. This article describes the clinical and pathological findings of one case of metastatic exocrine pancreatic adenocarcinoma in an 18-year-old giant otter (Pteronura brasiliensis) in captivity with a history of inappetence and apathy. Abdominal ultrasonography was inconclusive, and tomography revealed a neoplasm affecting the urinary bladder and hydroureter. During the anaesthesia recovery, the animal presented a cardiorespiratory arrest and died. Grossly, there were neoplastic nodules in the pancreas, urinary bladder, spleen, adrenal glands, and mediastinal lymph node. Microscopically, all nodules were composed of a malignant hypercellular proliferation of epithelial cells with acinar or solid disposition, supported by a sparse fibrovascular stroma. Neoplastic cells were immunolabeled with antibodies to Pan-CK, CK7, CK20, PPP and chromogranin A. Approximately 25% of the cells were positive for the presence of Ki-67 too. Pathological and immunohistochemical findings confirmed the diagnosis of metastatic exocrine pancreatic adenocarcinoma.","PeriodicalId":7247,"journal":{"name":"Acta veterinaria Hungarica","volume":"71 1","pages":"41-45"},"PeriodicalIF":0.9,"publicationDate":"2023-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9751174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasonography of the paralumbar muscles as a new aid during melarsomine treatment in canine heartworm disease. Description and illustration of the method - A preliminary study. 犬心丝虫病的超声检查作为一种新的辅助手段。方法的描述和说明-初步研究。

IF 0.9 4区农林科学

Acta veterinaria Hungarica Pub Date : 2022-12-15 DOI: 10.1556/004.2022.00034

Károly Vörös, Zsolt Becker, Zoltán Dudás Györki, Bernd Schulze Gronover, Ferenc Szalay

{"title":"Ultrasonography of the paralumbar muscles as a new aid during melarsomine treatment in canine heartworm disease. Description and illustration of the method - A preliminary study.","authors":"Károly Vörös, Zsolt Becker, Zoltán Dudás Györki, Bernd Schulze Gronover, Ferenc Szalay","doi":"10.1556/004.2022.00034","DOIUrl":"https://doi.org/10.1556/004.2022.00034","url":null,"abstract":"Melarsomine is used intramuscularly to destroy adult heartworms when treating canine heartworm disease (HWD). This drug is highly irritative and can elicit local complications. Therefore, melarsomine should be injected into the paralumbar muscles by strictly adhering to the manufacturers' prescriptions. However, it is not known how to determine the optimal location of the needle during the injection process. Ultrasonography (US) of the epaxial (paralumbar) musculature was used as a new method to measure the cross-sectional diameter of the paralumbar musculature, to determine the required location of the injection needle, and to study the local side effects in two dogs with HWD. The macroscopic appearance of the melarsomine solution during injection was demonstrated by video imaging. Melarsomine was not fully gravitating, but its majority was spreading along the thickest fascia of the musculature. Three minutes thereafter, no ultrasound signs of the melarsomine solution were seen, suggesting a full absorption at least ultrasonographically. This procedure was simulated in vitro with methylene blue solution having the same appearance. Removing the injection needle only after 5 min post-injection could prevent undesirable leakage of the drug through the injection channel into the subcutaneous tissue. Ultrasonography can be a useful aid during the treatment of HWD with melarsomine according to this preliminary study.","PeriodicalId":7247,"journal":{"name":"Acta veterinaria Hungarica","volume":"70 4","pages":"263-268"},"PeriodicalIF":0.9,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9181077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0