Zsombor Tóth, Márton Márialigeti, Zoltán Lajos, Noémi Tarpataki
{"title":"Report of a feline Cryptococcus neoformans infection in Hungary.","authors":"Zsombor Tóth, Márton Márialigeti, Zoltán Lajos, Noémi Tarpataki","doi":"10.1556/004.2025.01187","DOIUrl":null,"url":null,"abstract":"<p><p>Cryptococcosis is a globally occurring fungal disease that affects both humans and animals. It is the most common systemic mycosis in cats, primarily documented through case reports and retrospective studies. In feline cases, clinical symptoms typically begin with skin lesions appearing in the nasal and frontal regions, as observed in the case presented here. This case report details a 13-year-old European shorthair cat that presented with a 3-month history of progressive naso-ocular lesions and weight loss. The cat was likely infected through cat scratches, leading to contamination with encapsulated yeast cells, which resulted in localized skin lesions. Skin scrape cytology of the lesions showed many macrophages with numerous extra and intracytoplasmic organisms compatible with Cryptococcus species. Histopathological examination revealed pyogranulomatous inflammation with encapsulated yeasts. Latex cryptococcal antigen agglutination test on serum was positive. Fungal culture identified Cryptococcus neoformans. Unfortunately, shortly after the initiation of targeted treatment, the cat passed away. The authors provide a comprehensive overview of this cryptococcosis case. Cryptococcosis is an underdiagnosed disease and its early detection can be challenging due to nonspecific symptoms. Early initiation of targeted antifungal therapy significantly increases the chances of recovery.</p>","PeriodicalId":7247,"journal":{"name":"Acta veterinaria Hungarica","volume":" ","pages":""},"PeriodicalIF":0.8000,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta veterinaria Hungarica","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1556/004.2025.01187","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Cryptococcosis is a globally occurring fungal disease that affects both humans and animals. It is the most common systemic mycosis in cats, primarily documented through case reports and retrospective studies. In feline cases, clinical symptoms typically begin with skin lesions appearing in the nasal and frontal regions, as observed in the case presented here. This case report details a 13-year-old European shorthair cat that presented with a 3-month history of progressive naso-ocular lesions and weight loss. The cat was likely infected through cat scratches, leading to contamination with encapsulated yeast cells, which resulted in localized skin lesions. Skin scrape cytology of the lesions showed many macrophages with numerous extra and intracytoplasmic organisms compatible with Cryptococcus species. Histopathological examination revealed pyogranulomatous inflammation with encapsulated yeasts. Latex cryptococcal antigen agglutination test on serum was positive. Fungal culture identified Cryptococcus neoformans. Unfortunately, shortly after the initiation of targeted treatment, the cat passed away. The authors provide a comprehensive overview of this cryptococcosis case. Cryptococcosis is an underdiagnosed disease and its early detection can be challenging due to nonspecific symptoms. Early initiation of targeted antifungal therapy significantly increases the chances of recovery.
期刊介绍:
Acta Veterinaria Hungarica publishes original research papers presenting new scientific results of international interest, and to a limited extent also review articles and clinical case reports, on veterinary physiology (physiological chemistry and metabolism), veterinary microbiology (bacteriology, virology, immunology, molecular biology), on the infectious diseases of domestic animals, on veterinary parasitology, pathology, clinical veterinary science and reproduction.