Report of a feline Cryptococcus neoformans infection in Hungary.

IF 0.8 4区 农林科学 Q3 VETERINARY SCIENCES
Zsombor Tóth, Márton Márialigeti, Zoltán Lajos, Noémi Tarpataki
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引用次数: 0

Abstract

Cryptococcosis is a globally occurring fungal disease that affects both humans and animals. It is the most common systemic mycosis in cats, primarily documented through case reports and retrospective studies. In feline cases, clinical symptoms typically begin with skin lesions appearing in the nasal and frontal regions, as observed in the case presented here. This case report details a 13-year-old European shorthair cat that presented with a 3-month history of progressive naso-ocular lesions and weight loss. The cat was likely infected through cat scratches, leading to contamination with encapsulated yeast cells, which resulted in localized skin lesions. Skin scrape cytology of the lesions showed many macrophages with numerous extra and intracytoplasmic organisms compatible with Cryptococcus species. Histopathological examination revealed pyogranulomatous inflammation with encapsulated yeasts. Latex cryptococcal antigen agglutination test on serum was positive. Fungal culture identified Cryptococcus neoformans. Unfortunately, shortly after the initiation of targeted treatment, the cat passed away. The authors provide a comprehensive overview of this cryptococcosis case. Cryptococcosis is an underdiagnosed disease and its early detection can be challenging due to nonspecific symptoms. Early initiation of targeted antifungal therapy significantly increases the chances of recovery.

匈牙利一猫新型隐球菌感染报告。
隐球菌病是一种影响人类和动物的全球性真菌疾病。这是猫中最常见的系统性真菌病,主要通过病例报告和回顾性研究记录。在猫的病例中,临床症状通常开始于出现在鼻腔和额叶区域的皮肤损伤,如本病例所示。本病例报告详细介绍了一只13岁的欧洲短毛猫,出现了3个月的进行性鼻眼病变和体重减轻的历史。这只猫可能是通过猫抓伤感染的,导致被包裹的酵母细胞污染,导致局部皮肤损伤。皮损的皮肤刮擦细胞学显示大量巨噬细胞和大量与隐球菌相容的胞浆内和胞外生物。组织病理学检查显示脓肉芽肿性炎症伴囊化酵母菌。血清乳胶隐球菌抗原凝集试验阳性。真菌培养鉴定为新型隐球菌。不幸的是,在开始靶向治疗后不久,这只猫就去世了。作者提供了一个全面的概述这个隐球菌病的情况。隐球菌病是一种未被诊断的疾病,由于其非特异性症状,其早期检测可能具有挑战性。早期开始靶向抗真菌治疗可显著增加恢复的机会。
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来源期刊
Acta veterinaria Hungarica
Acta veterinaria Hungarica 农林科学-兽医学
CiteScore
1.80
自引率
0.00%
发文量
39
审稿时长
>36 weeks
期刊介绍: Acta Veterinaria Hungarica publishes original research papers presenting new scientific results of international interest, and to a limited extent also review articles and clinical case reports, on veterinary physiology (physiological chemistry and metabolism), veterinary microbiology (bacteriology, virology, immunology, molecular biology), on the infectious diseases of domestic animals, on veterinary parasitology, pathology, clinical veterinary science and reproduction.
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