Tertiary hyperparathyroidism in a dog - Case report.

IF 0.8 4区 农林科学 Q3 VETERINARY SCIENCES
Diego Ribeiro, Reiner Silveira de Moraes, Josiane Aparecida Martiniano de Pádua, Laura Soares Magalhães, Ana Karla de Lima Silva, Priscylla Tatiana Chalfun Guimarães Okamoto, Rodrigo Bernardes Nogueira
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引用次数: 0

Abstract

Tertiary hyperparathyroidism (THPT) is rarely discussed in animals. This study aimed to report a case of tertiary renal hyperparathyroidism in a dog. A 16-year-old spayed female, Shih Tzu, previously diagnosed with stage 2 chronic kidney disease, presented increased levels of serum urea, creatinine, total calcium, ionized calcium, phosphorus and PTH, indicating THPT. Clinical treatment for the renal condition was initiated and cinacalcet hydrochloride (0.5 mg*kg-1, orally, once daily for 7 days, followed by 1 mg*kg-1, orally, once daily for 7 days) was administered to correct the hormonal disorders. PTH, total calcium and ionized concentrations decreased by 56%, 76% and 15%, respectively, in 14 days. However, exacerbation of the uremic crisis was observed, leading to death 26 days after the initiation of the medication. This report appears to be the first to comprehensively discuss THPT in veterinary medicine. The shorter life expectancy of these animals compared to that of humans may be a determining factor for the low prevalence of THPT in dogs. The tendency toward a reduction in PTH, total calcium and ionized calcium achieved after the initiation of cinacalcet hydrochloride use encourages the development of further clinical studies to investigate its application in animals.

犬三期甲状旁腺功能亢进1例报告。
三期甲状旁腺功能亢进(THPT)在动物中很少被讨论。本研究的目的是报告一个病例的第三期肾甲状旁腺功能亢进的狗。16岁雌性施犬,先前诊断为慢性肾病2期,血清尿素、肌酐、总钙、离子钙、磷和甲状旁腺激素水平升高,提示THPT。开始临床治疗肾脏疾病,给予盐酸昔那卡塞(0.5 mg*kg-1,口服,每日1次,连用7天,随后给予盐酸昔那卡塞1 mg*kg-1,口服,每日1次,连用7天)纠正激素紊乱。PTH、总钙和离子浓度在14 d内分别下降56%、76%和15%。然而,观察到尿毒症危象加剧,在开始用药26天后导致死亡。该报告似乎是第一个全面讨论THPT在兽医学中的应用。与人类相比,这些动物的预期寿命较短,这可能是狗中THPT患病率较低的决定因素。在开始使用盐酸西那卡塞后,甲状旁腺激素、总钙和电离钙的减少趋势鼓励了进一步临床研究的发展,以调查其在动物中的应用。
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来源期刊
Acta veterinaria Hungarica
Acta veterinaria Hungarica 农林科学-兽医学
CiteScore
1.80
自引率
0.00%
发文量
39
审稿时长
>36 weeks
期刊介绍: Acta Veterinaria Hungarica publishes original research papers presenting new scientific results of international interest, and to a limited extent also review articles and clinical case reports, on veterinary physiology (physiological chemistry and metabolism), veterinary microbiology (bacteriology, virology, immunology, molecular biology), on the infectious diseases of domestic animals, on veterinary parasitology, pathology, clinical veterinary science and reproduction.
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