Michael Doughlaus Krindges, Amanda Tavares da Mata, Tony Edgley Catão Tenório, Yuri Duarte Porto, Vinicius Silva Castro, Adelino da Cunha, Ricardo César Tavares Carvalho
{"title":"Analysis of the main causes of chicken carcass condemnation in slaughterhouses in Mato Grosso, Brazil.","authors":"Michael Doughlaus Krindges, Amanda Tavares da Mata, Tony Edgley Catão Tenório, Yuri Duarte Porto, Vinicius Silva Castro, Adelino da Cunha, Ricardo César Tavares Carvalho","doi":"10.29374/2527-2179.bjvm007526","DOIUrl":"10.29374/2527-2179.bjvm007526","url":null,"abstract":"<p><p>Pre-slaughter inspection activities encompass clinical, documentary, and sanitary checks; post-mortem inspection identifies abnormalities in chicken carcasses, such as lesions caused by disease or inadequate handling and processing, leading to partial or total condemnation. The objectives were to determine the causes of condemnation for poultry carcasses slaughtered in Mato Grosso, identify the triggering factors, and evaluate the economic impact on the chicken production chain between January 2017 and December 2024. This was a retrospective, exploratory study using data from the Federal Inspection Service's Management Information System (SIGSIF) and reports from inspected establishments. Of the 1,251,623,202 chickens slaughtered, 9.5% (118,990,903) of the carcasses were condemned: 2.69% (33,759,843) totally and 6.8% (85,231,060) partially. Gastrointestinal contamination showed the highest percentages for both totally and partially condemned carcasses (57.16% and 37.55%, respectively), followed by cellulitis, accounting for 18% of both types of condemnation. Repugnant appearance (7.94%) and bruising/fractures (11.29%) ranked third among total and partial condemnations. Factors influencing condemnations included environmental conditions (temperature and relative humidity) as well as handling practices during rearing, transport, and processing. Economic losses associated with the 118,990,903 condemned birds during this period totaled R$ 1,365,420,611.93. We concluded that the partial and total condemnation of poultry involves a complex set of factors, ranging from on-farm management to processing. Understanding the situation in the state enables the formulation of measures to prevent and mitigate condemnations and the resulting economic losses associated with the disposal of these birds.</p>","PeriodicalId":72458,"journal":{"name":"Brazilian journal of veterinary medicine","volume":"48 ","pages":"e007526"},"PeriodicalIF":0.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13577607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148978953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"SOD1:c.118G>A mutation in the Cimarrón Uruguayo dog: prevalence, drift dynamics, and structural effects.","authors":"Rody Artigas, Carolina Menchaca, Eugenio Jara, Alejandra Mondino, Noelia Vázquez, Andrea Branda Sica, Silvia Llambí","doi":"10.29374/2527-2179.bjvm005526","DOIUrl":"10.29374/2527-2179.bjvm005526","url":null,"abstract":"<p><p>Canine degenerative myelopathy (DM) is associated with a missense mutation in the <i>SOD1</i> gene (c.118G>A), which results in the E40K amino acid substitution and promotes protein aggregation mechanisms similar to those described in human amyotrophic lateral sclerosis. The present study estimated the frequency of the SOD1:c.118G>A mutation in the Cimarrón Uruguayo dog and evaluated its structural and population implications. A total of 82 dogs were genotyped. The mutant allele was detected at a frequency within the range of common variants (q = 0.177), and genotype distribution did not deviate from Hardy-Weinberg equilibrium. Wright-Fisher simulations showed that stochastic processes alone may substantially influence allele-frequency trajectories over time. Additionally, a high-resolution melting (HRM) assay was optimized and enabled clear discrimination of the three genotypes, supporting its use as a rapid genotyping approach. Sanger sequencing of SOD1 exons 2-5 was performed in a subset of individuals to identify additional coding variants. Sequencing revealed no additional non-synonymous variants, except for a synonymous substitution in exon 4. Structural inspection indicated that the E40K substitution does not alter the local hydrogen-bonding pattern but produces a charge inversion that modifies the electrostatic environment surrounding residues 40 and 91. These findings support the hypothesis that electrostatic alterations in this region may contribute to an increased aggregation propensity of mutant SOD1 and provide new insights into the molecular and population context of this mutation in the Cimarrón Uruguayo breed.</p>","PeriodicalId":72458,"journal":{"name":"Brazilian journal of veterinary medicine","volume":"48 ","pages":"e005526"},"PeriodicalIF":0.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13577606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148979009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luisa Bittencourt de Lima Yamamoto, Diego Rodrigues Gomes, Luiz Paulo Nogueira Aires, Anna Carolina Mazeto Ercolin, Fredderico Garcia, Camila Silveira Stanquini, Desirée Rodrigues da Silva Alves, Andrea Degiovanni, Sâmara Turbay Pires, Javier Enrique Jerez Arevalo, Fernando Sebastiãn Baldi Rey, Marcus Antonio Rossi Feliciano
{"title":"Testicular vascularization in healthy dogs using a microvascular flow imaging technique - MicroV.","authors":"Luisa Bittencourt de Lima Yamamoto, Diego Rodrigues Gomes, Luiz Paulo Nogueira Aires, Anna Carolina Mazeto Ercolin, Fredderico Garcia, Camila Silveira Stanquini, Desirée Rodrigues da Silva Alves, Andrea Degiovanni, Sâmara Turbay Pires, Javier Enrique Jerez Arevalo, Fernando Sebastiãn Baldi Rey, Marcus Antonio Rossi Feliciano","doi":"10.29374/2527-2179.bjvm004626","DOIUrl":"10.29374/2527-2179.bjvm004626","url":null,"abstract":"<p><p>Testicular health significantly impacts the overall health and reproductive capacity of dogs, making early diagnosis of testicular conditions crucial. Neoplasms, orchitis, degeneration of the seminiferous epithelium, cryptorchidism, and testicular atrophy are among the most common testicular diseases in dogs. Ultrasonography is essential in andrological examinations, as it is a safe, easy-to-perform, and minimally invasive method. However, conventional Doppler techniques are often insufficient for characterizing testicular vascularization, particularly for detecting small-caliber blood vessels and low-velocity blood flow. This study evaluated the applicability of microvascular flow imaging (MicroV) in assessing testicular microvascularization in healthy dogs. Twenty-five intact male dogs aged 1-12 years were evaluated. The examination included physical and reproductive assessments, followed by B-mode and color Doppler ultrasonography of the testes. The MicroV technique was applied to provide detailed hemodynamic information, including the visualization of diffusely branched microvessels within the parenchyma. The technique offered advantages over color Doppler in characterizing testicular vascularization and microvascularization in dogs, particularly in detecting low-flow vascular calibers, thus representing a promising complementary tool for future clinical studies on testicular abnormalities.</p>","PeriodicalId":72458,"journal":{"name":"Brazilian journal of veterinary medicine","volume":"48 ","pages":"e004626"},"PeriodicalIF":0.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13577605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148979016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ERRATUM: Effect of the duration of visual exposure to the male on the reproductive performance of nulliparous guinea pigs.","authors":"","doi":"10.29374/2527-2179.bjvm013226","DOIUrl":"https://doi.org/10.29374/2527-2179.bjvm013226","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.29374/2527-2179.bjvm003926.].</p>","PeriodicalId":72458,"journal":{"name":"Brazilian journal of veterinary medicine","volume":"48 ","pages":"e013226"},"PeriodicalIF":0.0,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13543566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148898351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuan Góes Ribeiro Campos, Murilo Henrique Dias da Silva, Isadora Villas Bôas Souza, Rafaela de Oliveira Cunha, Daniel de Pinho Alves, Carolina Camargo Zani Marinho, Adriano de Abreu Corteze, Paulo Vinícius Tertuliano Marinho
{"title":"Ventral stabilization of C1-C2 with additional fixation of C3 using screws and polymethylmethacrylate in a toy breed dog with atlantoaxial instability.","authors":"Yuan Góes Ribeiro Campos, Murilo Henrique Dias da Silva, Isadora Villas Bôas Souza, Rafaela de Oliveira Cunha, Daniel de Pinho Alves, Carolina Camargo Zani Marinho, Adriano de Abreu Corteze, Paulo Vinícius Tertuliano Marinho","doi":"10.29374/2527-2179.bjvm008726","DOIUrl":"10.29374/2527-2179.bjvm008726","url":null,"abstract":"<p><p>Atlantoaxial instability (AAI) predominantly affects toy and miniature breed dogs, causing spinal cord compression and variable neurological deficits. This study aims to report a case of ventral stabilization of C1-C2 with additional fixation of C3 using screws and polymethylmethacrylate (PMMA) in a 5-month-old, 0.8 kg female Yorkshire Terrier with AAI. The patient presented with non-ambulatory tetraparesis after mild cervical trauma. Neurological examination revealed signs consistent with C1-C5 myelopathy and cervical pain. Radiographs and computed tomography of the cervical spine indicated dorsal displacement of C2 and severe spinal cord compression, confirming the diagnosis. After failure of conservative treatment, ventral stabilization was performed using 8 locked screws distributed between C1 and C3, combined with PMMA. Progressive clinical improvement was observed, with return to ambulation within 7 days and excellent neurological recovery at 165 days, with no complications during 12 months of follow-up. The stabilization technique using multiple screws and PMMA proved effective and safe in this case, enabling excellent neurological recovery even in the presence of severe neurological deficits. The inclusion of C3 in the stabilization process may have provided greater biomechanical resistance and reduced the risk of implant-related complications, representing a potentially relevant surgical approach in very small-sized patients.</p>","PeriodicalId":72458,"journal":{"name":"Brazilian journal of veterinary medicine","volume":"48 ","pages":"e008726"},"PeriodicalIF":0.0,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13543567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148898372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Isabella Abreu Castro, Delcio Almeida Magalhães, Beatriz Caroline Cabral Ibelli, Laura Castro Silva, Bruna Candelori Vaz, Ana Rita Barbosa Lessa, Debora Aroeira Mueller, Márcio de Barros Bandarra
{"title":"Serological detection of <i>Leptospira interrogans</i> serovar Wolffi and clinical management of a crab-eating raccoon (<i>Procyon cancrivorus</i>) from the Brazilian Cerrado.","authors":"Isabella Abreu Castro, Delcio Almeida Magalhães, Beatriz Caroline Cabral Ibelli, Laura Castro Silva, Bruna Candelori Vaz, Ana Rita Barbosa Lessa, Debora Aroeira Mueller, Márcio de Barros Bandarra","doi":"10.29374/2527-2179.bjvm002526","DOIUrl":"https://doi.org/10.29374/2527-2179.bjvm002526","url":null,"abstract":"<p><p>The crab-eating raccoon (<i>Procyon cancrivorus</i>) is a widely distributed South American mesocarnivore that frequently inhabits human-modified landscapes, where it may play a role in the transmission of zoonotic pathogens. Leptospirosis is an important but underreported disease in free-ranging wildlife, particularly in South America. This report describes the clinical management of a free-ranging crab-eating raccoon rescued after a road accident in southeastern Brazil, presenting systemic, hepatic, renal, and neurological alterations. Given the epidemiological context and compatible clinical findings, serological testing for <i>Leptospira</i> spp. was performed using the microscopic agglutination test, which revealed a titer of 1:200 for serovar Wolffi. Although the titer was relatively low, it was interpreted as clinically relevant when integrated with laboratory abnormalities and clinical signs, supporting initiation of antimicrobial therapy. The animal received doxycycline and comprehensive supportive care, including analgesia, hepatoprotective treatment, nutritional support via esophageal tube, and management of neurological signs. Progressive clinical and laboratory improvement was observed, allowing tube removal after 10 days and transfer to rehabilitation. No recurrence of clinical signs was noted during a 60-day follow-up. This case highlights the importance of integrating serology, clinical evaluation, and epidemiology for the diagnosis of leptospirosis in wildlife and underscores the relevance of <i>P. cancrivorus</i> to One Health surveillance.</p>","PeriodicalId":72458,"journal":{"name":"Brazilian journal of veterinary medicine","volume":"48 ","pages":"e002526"},"PeriodicalIF":0.0,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13492169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sofía Perini-Perera, Grazziana Cigliuti-Falero, Paula Pessina, Alejandro Benech-Gulla, Valérie Cayssials
{"title":"Incidence of kidney disease in the canine population treated at a small animal hospital in Uruguay.","authors":"Sofía Perini-Perera, Grazziana Cigliuti-Falero, Paula Pessina, Alejandro Benech-Gulla, Valérie Cayssials","doi":"10.29374/2527-2179.bjvm013725","DOIUrl":"https://doi.org/10.29374/2527-2179.bjvm013725","url":null,"abstract":"<p><p>Kidney disease (KD) is a major cause of morbidity and mortality in dogs; however, epidemiological data remain limited. This study estimated the incidence of KD and characterized chronic kidney disease (CKD) and acute kidney injury (AKI) through an observational study of dogs treated at a small animal hospital. A case-control study was subsequently conducted to identify factors associated with KD. Among 2,393 newly registered dogs in 2023, 91 cases of KD were identified, and an equal number of controls were randomly selected. Adjusted odds ratios were estimated using logistic regression models adjusted for age and body condition score (BCS). The overall annual cumulative incidence of KD was 3.8% (95% confidence interval [CI]: 3.0-4.6). The incidence of early-stage CKD was 2.5% (95% CI: 1.9-3.2), followed by advanced-stage CKD at 0.9% (95% CI: 0.5-1.3) and AKI at 0.3% (95% CI: 0.1-0.5). Age was a significant risk factor for KD, with dogs aged ≥10 years having higher odds of KD than younger dogs. Dogs with KD were also more likely to have a poor BCS, and this association was strongest in advanced-stage CKD. To our knowledge, this is the first reported epidemiological study from Latin America to estimate the incidence of KD in dogs. The observed association between KD, advanced age, and poor BCS is based on a detailed review of medical records and the use of appropriate paraclinical investigations, which are essential for early diagnosis and timely intervention to influence the course of the disease.</p>","PeriodicalId":72458,"journal":{"name":"Brazilian journal of veterinary medicine","volume":"48 ","pages":"e013725"},"PeriodicalIF":0.0,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148765750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Necati Öztürk, Onur Ülgenalp, Nihan Dikbaş Tsatsaronis, Özgecan Kuleyinoğlu, Burak Gümürçinler, Emre Küllük, Ahmet Gülçubuk, Fatma Eser Özgencil
{"title":"Approach to the diagnosis of bilateral ureteral transitional cell carcinoma in a cat.","authors":"Necati Öztürk, Onur Ülgenalp, Nihan Dikbaş Tsatsaronis, Özgecan Kuleyinoğlu, Burak Gümürçinler, Emre Küllük, Ahmet Gülçubuk, Fatma Eser Özgencil","doi":"10.29374/2527-2179.bjvm006826","DOIUrl":"10.29374/2527-2179.bjvm006826","url":null,"abstract":"<p><p>A cat with bilateral ureteral obstruction and long-term urolithiasis that had been medically managed for a year was presented to the emergency department of our hospital. Severe azotemia and metabolic acidosis were identified. Ultrasonography and computed tomography supported a diagnosis of ureteral calculi, with no evidence of other underlying abnormalities. During exploratory laparotomy, irreversible renal failure secondary to bilateral ureteral obstruction was suspected, and euthanasia was elected. Histopathological and immunohistochemical examination of the ureters revealed tubulopapillary urothelial carcinoma (transitional cell carcinoma). This case is noteworthy because it represents only the second reported case of feline ureteral transitional cell carcinoma associated with ureteral calculi causing bilateral ureteral obstruction. It also highlights that ureteral calculi may coexist with ureteral transitional cell carcinoma in cats, potentially masking the underlying neoplasm and delaying its diagnosis.</p>","PeriodicalId":72458,"journal":{"name":"Brazilian journal of veterinary medicine","volume":"48 ","pages":"e006826"},"PeriodicalIF":0.0,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13466038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148726081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hilario Noberto Pujada Abad, Edinson Collas Ostos, Roberto Carlos Tamayo Diaz, Rufino Máximo Maguiña Maza, Víctor Joselito Linares Cabrera, Julio César Valencia Bardales, Miguel Edmundo Lucho-Cerga, Javier Hernán Luyo Flores, Felix Esteban Airahuacho-Bautista
{"title":"Effect of the duration of visual exposure to the male on the reproductive performance of nulliparous guinea pigs.","authors":"Hilario Noberto Pujada Abad, Edinson Collas Ostos, Roberto Carlos Tamayo Diaz, Rufino Máximo Maguiña Maza, Víctor Joselito Linares Cabrera, Julio César Valencia Bardales, Miguel Edmundo Lucho-Cerga, Javier Hernán Luyo Flores, Felix Esteban Airahuacho-Bautista","doi":"10.29374/2527-2179.bjvm003926","DOIUrl":"10.29374/2527-2179.bjvm003926","url":null,"abstract":"<p><p>With the aim of determining the optimal duration of visual male exposure on the reproductive performance of nulliparous guinea pigs (<i>Cavia porcellus</i>), this study evaluated key reproductive indicators from mating to parturition. Sixty 60-day-old females were distributed into three treatments: traditional continuous mating (T<sub>0</sub>), controlled mating with 14-day prior visual male exposure (T<sub>1</sub>), and controlled mating with 7-day prior visual male exposure (T<sub>2</sub>). Results showed that T<sub>1</sub> significantly increased the frequency of first estrus between days 6 and 10 (67%; p = .02) compared to T<sub>0</sub> and T<sub>2</sub> (38%). Additionally, T<sub>1</sub> showed the highest frequency of afternoon estrus (42%; p < .05) and a higher rate of estrus repetition (p < .05). Regarding reproductive efficiency, T<sub>0</sub> and T<sub>2</sub> females exhibited significantly fewer non-productive days (10.5 and 11.3 d, respectively) compared to T<sub>1</sub> (17.0 d; p < .01). Conversely, the feed cost per female was lowest in T<sub>1</sub> (7.23 PEN), followed by T<sub>2</sub> (9.27 PEN) and T<sub>0</sub> (10.05 PEN; p < .01). No significant differences were observed in litter size (p = .08) or litter weight (p = .23). In conclusion, while 14 days of visual biostimulation prior to mating optimizes estrus synchronization but increases reproductive failures, a 7-day exposure successfully reduces non-productive days and feed expenditure in nulliparous guinea pigs, improving the economic merit of the intensive system without compromising productive parameters.</p>","PeriodicalId":72458,"journal":{"name":"Brazilian journal of veterinary medicine","volume":"48 ","pages":"e003926"},"PeriodicalIF":0.0,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13466040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148724084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Florencia Sollier Podestá, Federico García Balbiani, Fabio Funcasta Michelena, Daniela Izquierdo Caquías, Valerie Cayssials da Cunha
{"title":"Cutaneous mast cell tumors in dogs: Association with gonadectomy.","authors":"Florencia Sollier Podestá, Federico García Balbiani, Fabio Funcasta Michelena, Daniela Izquierdo Caquías, Valerie Cayssials da Cunha","doi":"10.29374/2527-2179.bjvm000726","DOIUrl":"10.29374/2527-2179.bjvm000726","url":null,"abstract":"<p><p>A retrospective case-control study was conducted using the clinical records of dogs treated at the Veterinary Teaching Hospital of Uruguay between 2017 and 2022 with a confirmed diagnosis of cutaneous mast cell tumor (MCT). A total of 141 affected dogs were compared with a randomly selected control group of 141 dogs without cutaneous tumors that attended the hospital during the same period. The association between gonadectomy and cutaneous MCT was evaluated by estimating crude and sex- and age-adjusted odds ratios (ORs) using univariate and multivariable logistic regression models. Overall, gonadectomy was associated with lower odds of cutaneous MCT. However, effect modification by sex was detected in the association between gonadectomy and MCT (<i>p</i>-interaction = 0.04). Sex-stratified analyses showed that gonadectomy was significantly associated with lower odds of MCT in males (OR = 0.16, 95% confidence interval [CI], 0.06-0.41), whereas the association in females was weaker and not statistically significant (OR = 0.56, 95% CI, 0.25-1.27). In addition, dogs aged ≥7 years had substantially higher odds of MCT than adult dogs aged 2-6 years. These findings suggest that the association between reproductive status and cutaneous MCT is complex and may differ by sex. However, given the observational nature of the case-control design, the results should not be interpreted as evidence of a causal relationship. Further prospective studies, particularly those evaluating the timing of gonadectomy, are warranted.</p>","PeriodicalId":72458,"journal":{"name":"Brazilian journal of veterinary medicine","volume":"48 ","pages":"e000726"},"PeriodicalIF":0.0,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13466041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148726680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}