Advances in Bioengineering最新文献_第3页

Cell Motility in Microfabricated Models of the Tissue Microenvironment 组织微环境微制造模型中的细胞运动

Advances in Bioengineering Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23075

K. Parker, D. Ingber

引用次数: 0

Hydrodynamic Pressurization of a Trapped Lubricant Pool Between a Rippled Rigid Indenter and an Elastic Layer: An Investigation Into the Role of Surface Roughness on Cartilage Lubrication 波纹刚性压头与弹性压头间润滑油池的动水加压:表面粗糙度对软骨润滑作用的研究

Advances in Bioengineering Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23063

Ines M. Basalo, G. Ateshian

{"title":"Hydrodynamic Pressurization of a Trapped Lubricant Pool Between a Rippled Rigid Indenter and an Elastic Layer: An Investigation Into the Role of Surface Roughness on Cartilage Lubrication","authors":"Ines M. Basalo, G. Ateshian","doi":"10.1115/imece2001/bed-23063","DOIUrl":"https://doi.org/10.1115/imece2001/bed-23063","url":null,"abstract":"\u0000 In recent studies of articular diarthrodial joint lubrication, it has been proposed that hydrostatic pressurization of the cartilage interstitial fluid upon joint loading contributes significantly to the load support across the articular layers, thus reducing frictional forces and wear [1–3]. This boundary contact mechanism for porous media can explain the observed time-dependent response of the frictional coefficient. Nevertheless, alternative hypotheses have been also proposed which attribute the low friction coefficient to hydrodynamic lubrication [4]. In our recent analysis of a mixed lubrication problem where a lubricant pool is trapped between a rippled rigid indenter and a biphasic cartilage layer [5], it was observed that the hydrostatic pressurization of the trapped lubricant can enhance the fluid load support to a certain extent, but typically for a short duration on the order of 1 s only, until the lubricant is depleted by flowing into the cartilage layer. Furthermore, under steady-state sliding, it was found that a lubricant pool could not be sustained due to lubricant depletion. These analyses employed an inviscid model for the lubricant as they focused on hydrostatic pressurization only. In the current study, we investigate whether lubricant viscosity, which can promote hydrodynamic pressurization, might further enhance the fluid load support mechanism or alter the conclusions gathered from our earlier studies. To investigate these fundamental mechanisms, an elastic layer is used instead of a biphasic layer at first; a more elaborate biphasic analysis could be employed subsequently if warranted by the current findings.","PeriodicalId":7238,"journal":{"name":"Advances in Bioengineering","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2001-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79497995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Micromechanics of Fibroblast Contraction of a Collagen-Gag Matrix 胶原- gag基质成纤维细胞收缩的微观力学

Advances in Bioengineering Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23150

T. M. Freyman, I. Yannas, Y. Pek, Rayka Yokoo, L. Gibson

引用次数: 1

Flow and Compression in Collapsible Asymmetric Stenosis Models of Arterial Disease 可折叠不对称动脉狭窄模型的血流和压缩

Advances in Bioengineering Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23141

Shunichi Kobayashi, Takeshi Horie, Tomohito Amaya, H. Morikawa, D. Tang, D. Ku

引用次数: 0

In-Vitro Measurements of Microgravity Induced Kinematics Changes on Spine 微重力诱导的脊柱运动学变化的体外测量

Advances in Bioengineering Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23043

D. Reiter, N. Sarigul-Klijn, Munish C. Gupta, F. Fathallah

引用次数: 0

Effect of Thrombus in AAA on Pressure and Dilation Experienced by the Aneurysm Wall AAA血栓对动脉瘤壁压力和扩张的影响

Advances in Bioengineering Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23118

M. Thubrikar, F. Robicsek, M. Labrosse, V. Chervenkoff, B. Fowler

引用次数: 1

Femorotibial Articulation: 3-D Morphometry and Contact Analysis 股胫关节:三维形态测量和接触分析

Advances in Bioengineering Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23053

N. Nuño, A. M. Ahmed

引用次数: 0

Platelet Activation in Flow Past Mechanical Heart Valves 流过机械心脏瓣膜的血小板活化

Advances in Bioengineering Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23110

D. Bluestein, J. Jesty, A. Saltman, I. Krukenkamp, Krishnamurthy Suresh

{"title":"Platelet Activation in Flow Past Mechanical Heart Valves","authors":"D. Bluestein, J. Jesty, A. Saltman, I. Krukenkamp, Krishnamurthy Suresh","doi":"10.1115/imece2001/bed-23110","DOIUrl":"https://doi.org/10.1115/imece2001/bed-23110","url":null,"abstract":"\u0000 Numerical studies, in vitro, and in vivo measurements were conducted, aimed at quantifying free emboli formation and procoagulant properties of platelets induced by flow past mechanical heart valves (MHV). Pulsatile turbulent flow simulation was conducted past a St. Jude medical MHV in the aortic position, to study the effects of valve implantation technique on the thromboembolic potential of the valve. A misaligned valve with subannualarly sutured pledgets produced accelerating jet flow through the valve orifices and a wider wake of shed vortices. Shear stress histories of platelets along turbulent trajectories exposed the platelets to elevated shear stresses around the leaflets, leading them to entrapment within the shed vortices. In vitro platelet studies were conducted past the MHV mounted in a recirculation flow loop, by measuring the platelets ability to support the activation of acetylated human prothrombin by factor xa, which enables sequestering flow induced effects and quantification of the platelets activity state. The platelet activation state increased monotonically as a function of the recirculation time past the valve, as measured by the thrombin generation rates in the assay. Finally, platelet activity state measurements were conducted in vivo, from a sheep with an implanted MHV, showing marked increase of platelet activation after valve implantation.","PeriodicalId":7238,"journal":{"name":"Advances in Bioengineering","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2001-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90864559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Automated Methdology for Investigating the Correlation Between Abdominal Aortic Aneurysm Wall Stress and Risk of Rupture 研究腹主动脉瘤壁应力与破裂风险相关性的自动化方法

Advances in Bioengineering Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23119

M. L. Raghavan, M. Fillinger, S. P. Marra, F. Kennedy

引用次数: 2

Anisotropic Nonlinear Friction at Biomaterial Interfaces: Theory and Application 生物材料界面的各向异性非线性摩擦:理论与应用

Advances in Bioengineering Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23086

W. Mesfar, A. Shirazi-Adl, M. Dammak

{"title":"Anisotropic Nonlinear Friction at Biomaterial Interfaces: Theory and Application","authors":"W. Mesfar, A. Shirazi-Adl, M. Dammak","doi":"10.1115/imece2001/bed-23086","DOIUrl":"https://doi.org/10.1115/imece2001/bed-23086","url":null,"abstract":"\u0000 The interface friction exists in natural and artificial joints as well as many engineering systems in which different bodies articulate. It often plays an important role in mechanics of the system. In the cementless arthroplasty, the friction between the prosthesis (including stems and screws) and the host bone is exploited to increase the stability of the operation. Our previous experimental studies have shown that the interface between bone and various porous coated surfaces exhibit a nonlinear friction that remains nearly the same in different directions; a nonlinear isotropic friction [1,2]. More recent bidirectional friction tests between cancellous bone or polyurethane cubes and a metallic porous coated plate have demonstrated that the interface load-displacement curve is highly nonlinear with significant coupling between two perpendicular directions [3]. Model studies incorporating measured nonlinear response have demonstrated the importance of proper simulation of nonlinear response as compared with Coulomb friction and of the coupling between orthogonal directions [3–5]. In this study, we aim to extend the earlier model studies to incorporate nonlinear direction-dependent anisotropic friction between two surfaces. Our objectives are set to: (a) develop constitutive equations to present interfaces with nonlinear anisotropic friction properties; and (b) implement and apply in a finite element study of a cube resting on a block subjected to normal and shear loads.","PeriodicalId":7238,"journal":{"name":"Advances in Bioengineering","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2001-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86692538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0