胶原- gag基质成纤维细胞收缩的微观力学

Advances in Bioengineering Pub Date : 2001-11-11 DOI:10.1115/imece2001/bed-23150

T. M. Freyman, I. Yannas, Y. Pek, Rayka Yokoo, L. Gibson

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引用次数: 1

摘要

收缩成纤维细胞在皮肤损伤后瘢痕组织的合成和重塑中起主要作用。可收缩成纤维细胞使用胶原- gag基质抑制皮肤创面收缩，与瘢痕形成的阻断有关[1]。疤痕组织在机械和功能上都不如它所取代的真皮组织。具体来说，疤痕组织较弱，身体毁容，并可能导致关节活动受限。

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Micromechanics of Fibroblast Contraction of a Collagen-Gag Matrix

Contractile fibroblasts play a major role in the synthesis and remodeling of scar tissue following dermal injury. Inhibition of dermal wound contraction by contractile fibroblasts, using a collagen-GAG matrix, has been linked to the blocking of scar formation[1]. Scar tissue is mechanically and functionally inferior to the dermal tissue which it replaces. Specifically, scar tissue is weaker, physically disfiguring, and can lead to restricted joint mobility.

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Advances in Bioengineering

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