Advances in Bioengineering最新文献

Mechanical Design and Analysis for a Scanning Fiber Endoscope 扫描光纤内窥镜的机械设计与分析

Advances in Bioengineering Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23082

Christopher M. Brown, M. Fauver, P. Reinhall, E. Seibel

引用次数: 8

Design of a V-Plate-Wire Mandibular Fixation System v型钢板-金属丝下颌固定系统的设计

Advances in Bioengineering Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23078

M. Trabia, K. G. Zobotkin, Robert C. Wang

引用次数: 1

A Matlab-Based Cardiac Mechanics Course: Exportable Tools for Graduate-Level Soft Tissue Biomechanics 基于matlab的心脏力学课程:研究生水平软组织生物力学的可导出工具

Advances in Bioengineering Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23021

J. Holmes

引用次数: 0

Tangential Stress in Cortical Bone Subjected to Dynamic Axial Loading 动态轴向载荷下皮质骨的切向应力

Advances in Bioengineering Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23029

J. Choi, C. Dharan

{"title":"Tangential Stress in Cortical Bone Subjected to Dynamic Axial Loading","authors":"J. Choi, C. Dharan","doi":"10.1115/imece2001/bed-23029","DOIUrl":"https://doi.org/10.1115/imece2001/bed-23029","url":null,"abstract":"\u0000 Cortical bone is a complex hierarchical composite lamallae structure consisting, in general, of a mineral phase (calcium hydroxyapatite), an organic phase (collagen) and fluid [1]. In the analysis of bone, the liquid phase is usually neglected, an assumption that is reasonable for steady state or quasi-static loading. However, when cortical bone is loaded dynamically in the axial direction, the presence of the constrained fluid generates time-dependent stresses in the tangential direction. Since the tangential stress acts perpendicular to the weak transverse direction of the bone, it can create damage in this direction. Cyclic axial compressive loading will result in cyclic tensile loading in the tangential direction which can eventually result in fatigue damage. Such damage has actually been observed in studies conducted on heavily exercised race horses where damage was observed in the form of micro cracks oriented perpendicular to the tangential direction and whose fracture planes lie along the axial direction [2].\u0000 In this work, cortical bone is modeled as a biphasic material consisting of a permeable composite material filled with fluid. The geometry considered is that of a hollow cylinder made up of multiple concentric permeable lamellae filled with fluid (Fig. 1). When this structure is loaded axially in compression, a tensile tangential stress is developed which decays with time. The decay rate is a function of permeability and radial position. The greater the permeability, the faster the decay rate. The tangential stress peaks at the inner radius and decreases with radial position (Fig. 2). The tangential stress also peaks earlier at the inner radius. The rate of decay is slower at the outside surface where the bone is subjected to the tangential stress for a much longer time than at the inner surface (Fig. 2).\u0000 This view of bone as a biphasic structure subjected to dynamic loading may provide a rationale for some of the damage modes observed in vivo in bones subjected to cyclic and impact loading.","PeriodicalId":7238,"journal":{"name":"Advances in Bioengineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75119146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic Hydrostatic Pressurization Increases Matrix Gene Expression by Chondrocytes in 3D Culture 动态静水加压增加三维培养软骨细胞基质基因表达

Advances in Bioengineering Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23147

R. Mauck, M. Soltz, G. Ateshian, C. Hung

{"title":"Dynamic Hydrostatic Pressurization Increases Matrix Gene Expression by Chondrocytes in 3D Culture","authors":"R. Mauck, M. Soltz, G. Ateshian, C. Hung","doi":"10.1115/imece2001/bed-23147","DOIUrl":"https://doi.org/10.1115/imece2001/bed-23147","url":null,"abstract":"\u0000 Articular cartilage is the load-bearing substance that covers the bony surfaces of articulating bones. With its high water content and small pore size, deformation of cartilage induces a very high hydrostatic pressure within the cartilage. This hydrostatic pressure has been shown both theoretically and experimentally to support upwards of 90% of the applied load (1), and can be on the order of 6–12 MPa. Chondrocytes, the cells within cartilage respond to this pressure by altering their rates of biosynthesis. Studies utilizing radionucleotide incorporation in both explant and monolayer cultures (2–4) have shown that in general dynamic pressurization increases synthesis, while static pressurization decreases synthesis. More recently, Smith et al have shown that dynamic pressurization (10MPa, 1 Hz) of cells in monolayer culture can upregulate matrix gene expression (5,6). Further, a study in PGA constructs has shown that long term application of dynamic pressure can increase matrix deposition (7). In this study, we seek to expand on these findings by examining the response in gene expression of articular chondrocytes encapsulated in alginate, a charged, 3D hydrogel.","PeriodicalId":7238,"journal":{"name":"Advances in Bioengineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77669845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Customized Resurfacing of the Knee: Design of the Shell Knee Replacement 定制膝关节表面:壳式膝关节置换术的设计

Advances in Bioengineering Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23085

Naphysah O. Duncan, P. Walker, H. Potter

引用次数: 0

An Axisymmetric Elastic Layered Half-Space Model for Micropipette Aspiration of the Chondrocyte Pericellular Matrix 微吸管吸入软骨细胞周基质的轴对称弹性层状半空间模型

Advances in Bioengineering Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23156

L. Alexopoulos, M. Haider, F. Guilak

引用次数: 1

Measurement of the Spatial Motion of the Ankle-Subtalar Complex 踝-距下复合体空间运动的测量

Advances in Bioengineering Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23055

Ning Ying, Wangdo Kim

引用次数: 0

Use of Burmester’s Circular Theory in the Determination of the Optimal Four-Bar Link Reproducing Actual Tibia-Femur Relative Motion 利用Burmester的圆形理论确定再现胫骨-股骨实际相对运动的最佳四杆连杆

Advances in Bioengineering Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23048

G. Danieli, D. Mundo, V. Sciarra

{"title":"Use of Burmester’s Circular Theory in the Determination of the Optimal Four-Bar Link Reproducing Actual Tibia-Femur Relative Motion","authors":"G. Danieli, D. Mundo, V. Sciarra","doi":"10.1115/imece2001/bed-23048","DOIUrl":"https://doi.org/10.1115/imece2001/bed-23048","url":null,"abstract":"\u0000 The paper presents an application of Burmester’s circular theory to the determination of the optimal mechanism used to reproduce the motion of the tibia with respect to the femur. The research takes its start from the idea of studying an external fixator to guide the motion of a tibia in a way physically compatible to the actual patient’s anatomy, in order to firmly guide the two bones after, for instance, joint reconstructive surgery, while avoiding any contact between the articular surfaces. The physiological data were determined in researches presented in other papers.\u0000 However, in the initial research phases the idea was to determine the best position of an existing four-bar link, produced for an orthopaedic tutor, without any attempt at synthesising an ad hoc one. The idea of using Burmester’s theory in this operation was in reality an old one, but previous attempts were not successful.\u0000 Naturally, the required four-bar link had also to be small in order to fit on the external fixator. The results of the research are extremely satisfactory, since it was possible to determine a mechanism which allows relative motion with errors in the order of fractions of millimetres, when the imposed motion had to keep the two bones separated by a minimum of one millimetre. As a consequence the two bones will never go in compression, while a gentle pulling of the ligaments will always be present.\u0000 Using the approach, typical four-bar links for different human typologies were also determined.","PeriodicalId":7238,"journal":{"name":"Advances in Bioengineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77837402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

A Constitutive Framework for the Inelastic Mechanical Behavior of Arteries 动脉非弹性力学行为的本构框架

Advances in Bioengineering Pub Date : 2001-11-11 DOI: 10.1115/imece2001/bed-23117

G. Holzapfel, T. Gasser

引用次数: 0