Advanced Powder Technology最新文献

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Role of ultraviolet modification in enrichment and upgrading of graphite ores via triboelectric separation 紫外改性在石墨矿石摩擦电分离富集升级中的作用
IF 4.2 2区 工程技术
Advanced Powder Technology Pub Date : 2025-04-12 DOI: 10.1016/j.apt.2025.104870
Jingfeng He, Zilin Zhang, Lixiang Fu, Helang Xu, Lingtao Zhu, Bin Yang
{"title":"Role of ultraviolet modification in enrichment and upgrading of graphite ores via triboelectric separation","authors":"Jingfeng He,&nbsp;Zilin Zhang,&nbsp;Lixiang Fu,&nbsp;Helang Xu,&nbsp;Lingtao Zhu,&nbsp;Bin Yang","doi":"10.1016/j.apt.2025.104870","DOIUrl":"10.1016/j.apt.2025.104870","url":null,"abstract":"<div><div>Graphite is an important mineral resource, in this era of growing global demand for high-grade graphite, the advancement of its purification and separation technology is of great significance. This paper focused on the enhancement of ultraviolet (UV) modification on the enrichment and purification of graphite ores. Through charge-to-mass ratio sensing, SEM and FTIR, it was found that the superficial properties of the modified graphite particles were smoother and flatter, and the amount of O-containing functional groups connected with C was reduced, which strengthened the full contact between graphite particles and friction rods with the graphite’s charging ability and improved the charge-to-mass ratio of graphite minerals. Accordingly, UV irradiation significantly improved the triboelectric separation performance, in which the separation efficiencies of graphite ores increased by up to 14.14 %. This work provided crucial information for resource purification and impurity elimination of graphite ores.</div></div>","PeriodicalId":7232,"journal":{"name":"Advanced Powder Technology","volume":"36 6","pages":"Article 104870"},"PeriodicalIF":4.2,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143823895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of additives and operating conditions on tablet weight variation: Analysis based on powder flowability 添加剂和操作条件对片剂重量变化的影响基于粉末流动性的分析
IF 4.2 2区 工程技术
Advanced Powder Technology Pub Date : 2025-04-11 DOI: 10.1016/j.apt.2025.104860
Yozo Kudo , Tsukasa Nakanishi , Akira Uno , Shuji Matsusaka
{"title":"Effect of additives and operating conditions on tablet weight variation: Analysis based on powder flowability","authors":"Yozo Kudo ,&nbsp;Tsukasa Nakanishi ,&nbsp;Akira Uno ,&nbsp;Shuji Matsusaka","doi":"10.1016/j.apt.2025.104860","DOIUrl":"10.1016/j.apt.2025.104860","url":null,"abstract":"<div><div>The flowability and compressibility of powders during tableting are crucial for determining the quality of pharmaceutical products. Although silicon compounds are additives that improve compressibility, their type and addition ratio could impair flowability. Therefore, formulation and operating conditions for tablet preparation should be considered. In this study, first, the physical properties of the four types of silicon compounds, that is, particle size distribution, packing fraction, and cohesion, were measured. Next, various powder mixtures were prepared by adding each silicon compound to a diluent at different ratios. Experiments were performed by changing the operating conditions of a rotary tableting machine equipped with a paddle feeder. The tablet weight variation increased with the addition of a highly cohesive silicon compound. However, this variation decreased with an increase in the peripheral velocity of the paddle. A flowability index combining static and dynamic friction properties was proposed to analyze the experimental results, allowing the quantification of the effects of silicon compounds and operating conditions on tablet weight variation.</div></div>","PeriodicalId":7232,"journal":{"name":"Advanced Powder Technology","volume":"36 6","pages":"Article 104860"},"PeriodicalIF":4.2,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143815706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coarse-grained DEM simulation for mixing and segregation of binary-sized particles 二元颗粒混合和偏析的粗粒度DEM模拟
IF 4.2 2区 工程技术
Advanced Powder Technology Pub Date : 2025-04-10 DOI: 10.1016/j.apt.2025.104875
Naoki Kishida, Hideya Nakamura, Shuji Ohsaki, Satoru Watano
{"title":"Coarse-grained DEM simulation for mixing and segregation of binary-sized particles","authors":"Naoki Kishida,&nbsp;Hideya Nakamura,&nbsp;Shuji Ohsaki,&nbsp;Satoru Watano","doi":"10.1016/j.apt.2025.104875","DOIUrl":"10.1016/j.apt.2025.104875","url":null,"abstract":"<div><div>While the Discrete Element Method (DEM) are promising tools for analyzing and predicting powder mixing and segregation, the DEM simulation of large-scale powder handling processes remains computationally challenging. To address this issue, we developed a Coarse-Grained (CG) method for granular shear flow (CGSF). Considering the CGSF has been applied exclusively for monodisperse particles with homogeneous particle sizes, an extended CG model for particles with inhomogeneous properties under a granular shear flow is required. As segregation progresses, microscopic particle mixing and segregation can occur on a smaller scale than the CG particle size. Hence, a new method is proposed by which the composition of the original intra-CG particles can change dynamically. Consequently, we propose a coarse-grained model for powder mixing and segregation under dense granular shear flow by extending the CGSF to a binary-sized particle system and developing a method for estimating the microscopic mixing and segregation of the original particles based on the Dynamically Changing Composition (DCC) of the original particles. Using the extended CGSF with DCC, we simulated the powder mixing and segregation of binary-sized particles in a rotating drum, with the performance of the proposed model evaluated in terms of powder mixing, segregation behavior, and computing speed.</div></div>","PeriodicalId":7232,"journal":{"name":"Advanced Powder Technology","volume":"36 6","pages":"Article 104875"},"PeriodicalIF":4.2,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143815707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanoparticle formation of β-carotene by mixing supercritical carbon dioxide antisolvent with liquefied dimethyl ether feed solution using swirl mixer 超临界二氧化碳抗溶剂与液化二甲醚饲料溶液旋流混合形成β-胡萝卜素纳米颗粒
IF 4.2 2区 工程技术
Advanced Powder Technology Pub Date : 2025-04-10 DOI: 10.1016/j.apt.2025.104871
Li Mei, Hideki Kanda, Li Zhu, Tao Wang, Tetsuya Yamamoto
{"title":"Nanoparticle formation of β-carotene by mixing supercritical carbon dioxide antisolvent with liquefied dimethyl ether feed solution using swirl mixer","authors":"Li Mei,&nbsp;Hideki Kanda,&nbsp;Li Zhu,&nbsp;Tao Wang,&nbsp;Tetsuya Yamamoto","doi":"10.1016/j.apt.2025.104871","DOIUrl":"10.1016/j.apt.2025.104871","url":null,"abstract":"<div><div>The production of β-carotene nanoparticles using non-toxic and environmentally-friendly liquefied dimethyl ether (DME) via a supercritical antisolvent (SAS) process, which produces no residue, is a major challenge in food processes. Preparations of nanoparticles have previously been conducted with toxic organic feed solvents. In this work, β-carotene was micronized with two feed solutions, liquefied DME and ethyl acetate, using a swirl mixer mixing in a turbulent field by the SAS method for comparison. The effects of operating pressure, temperature, and solution flow rate were investigated on the size of nanoparticles. Field-emission-scanning electron microscopy (FE-SEM) images showed that dispersed β-carotene nanoparticles, 43.9 nm in size, were successfully prepared at 40 °C and 8 MPa, and no residual DME was present in the nanoparticles. Using an ethyl acetate solution to precipitate β-carotene at 40 °C and 10 MPa and successfully obtained nanoparticles 62.12 nm in size. Compared to the previous study (12 MPa, normal nozzle), the smallest β-carotene particles precipitated from the optimal conditions of DME and ethyl acetate, respectively, were obtained at lower pressures and smaller particles with the swirl mixer. X-ray diffraction (XRD) and differential thermal analysis (DTA) confirmed that the obtained nanoparticles were amorphous. By contrast, residual ethyl acetate solution was present in the nanoparticles precipitated from ethyl acetate; this phenomenon was confirmed using Fourier transform infrared spectroscopy (FT-IR) and gas chromatography-mass spectrometry (GC–MS).</div></div>","PeriodicalId":7232,"journal":{"name":"Advanced Powder Technology","volume":"36 6","pages":"Article 104871"},"PeriodicalIF":4.2,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143815708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimization of efficiency of lactose drying process in an industrial continuous fluidized bed dryer using dynamic flowsheet simulation 用动态流程模拟优化工业连续流化床干燥机乳糖干燥过程的效率
IF 4.2 2区 工程技术
Advanced Powder Technology Pub Date : 2025-04-08 DOI: 10.1016/j.apt.2025.104864
Xiye Zhou , Vasyl Skorych , Katja Milkreiter , Ricarda Leister , Stefan Heinrich
{"title":"Optimization of efficiency of lactose drying process in an industrial continuous fluidized bed dryer using dynamic flowsheet simulation","authors":"Xiye Zhou ,&nbsp;Vasyl Skorych ,&nbsp;Katja Milkreiter ,&nbsp;Ricarda Leister ,&nbsp;Stefan Heinrich","doi":"10.1016/j.apt.2025.104864","DOIUrl":"10.1016/j.apt.2025.104864","url":null,"abstract":"<div><div>The fluidized bed drying of wet lactose plays a crucial role in the industrial production of lactose powder for pharmaceutical purposes. Currently, such a process is often controlled using empirical operating parameters, which may result in variability in product properties and suboptimal consumption of resources and energy. Hence, the work presented in our paper aims to address this issue by proposing a new dynamic fluidized bed dryer model for wet lactose drying in the flowsheet simulation framework Dyssol. This model was implemented based on fundamental equations for heat and mass balance, thermodynamics, and powder drying kinetics. It enables a fast and accurate prediction of the product moisture content and the exhaust air temperature for a wide range of wet lactose flow rates, fluidization air flow rates, and fluidization air temperatures. Optimization was conducted based on the proposed model, offering a pathway to reduce energy consumption and stabilize product properties. Furthermore, this model contributes to establishing a digital twin, which provides real-time simulation and optimization of the entire lactose production process beyond conventional flowsheet modelling. Incorporating further process units for the upstream and downstream treatments will allow for faster and more efficient control of existing processes and facilitate the implementation of more advanced optimization techniques.</div></div>","PeriodicalId":7232,"journal":{"name":"Advanced Powder Technology","volume":"36 6","pages":"Article 104864"},"PeriodicalIF":4.2,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding the dynamic caking behavior of tobacco granules for heated tobacco products via glass transition and water state 通过玻璃化转变和水态研究加热烟草制品中烟草颗粒的动态结块行为
IF 4.2 2区 工程技术
Advanced Powder Technology Pub Date : 2025-04-05 DOI: 10.1016/j.apt.2025.104869
Xiaoyu Zhang , Jianbiao Gao , Jin Zhang , Yonghong Lin , Weijian Chen , Haiying Liu , Xiaofeng Wang , Yun Cao , Huijuan Tian , Shun Zhou , Qinqin Chen
{"title":"Understanding the dynamic caking behavior of tobacco granules for heated tobacco products via glass transition and water state","authors":"Xiaoyu Zhang ,&nbsp;Jianbiao Gao ,&nbsp;Jin Zhang ,&nbsp;Yonghong Lin ,&nbsp;Weijian Chen ,&nbsp;Haiying Liu ,&nbsp;Xiaofeng Wang ,&nbsp;Yun Cao ,&nbsp;Huijuan Tian ,&nbsp;Shun Zhou ,&nbsp;Qinqin Chen","doi":"10.1016/j.apt.2025.104869","DOIUrl":"10.1016/j.apt.2025.104869","url":null,"abstract":"<div><div>Tobacco granules for heated tobacco products (TGHTPs) were at amorphous state and prone to caking during processing and storage. Hence, it was essential to understand the dynamic caking behavior of TGHTPs for quality control. Moisture sorption isotherms of TGHTPs were of type III and could be well fitted by both DLP and GAB model. Homogeneous caking was observed in TGHTP1 while TGHTP2 ∼ TGHTP4 presented non-homogeneous caking behavior. The basic flow energy (BFE) of TGHTPs increased with rising of relative humidity (RH) and exposure time. BFE value (4093 mJ) of TGHTP3 after 48 h exposure to 90% RH was five times than that of 53% RH (806 mJ). Bound water was found predominant in TGHTPs, the migration of immobilized water to bound state was observed during the moisture uptake process. When the RH was over 56.83 ∼ 58.65% at 25°C, glass transition of TGHTPs was happened from “amorphous glassy” to “amorphous rubbery”.</div></div>","PeriodicalId":7232,"journal":{"name":"Advanced Powder Technology","volume":"36 6","pages":"Article 104869"},"PeriodicalIF":4.2,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143783554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding particle adhesion in CaCO3–CaO powder at high temperatures 了解高温下CaCO3-CaO粉末的颗粒粘附性
IF 4.2 2区 工程技术
Advanced Powder Technology Pub Date : 2025-04-05 DOI: 10.1016/j.apt.2025.104872
Genki Horiguchi , Tsuyoshi Fujimoto , Naoya Konakahara , Hidehiro Kamiya , Yohei Okada
{"title":"Understanding particle adhesion in CaCO3–CaO powder at high temperatures","authors":"Genki Horiguchi ,&nbsp;Tsuyoshi Fujimoto ,&nbsp;Naoya Konakahara ,&nbsp;Hidehiro Kamiya ,&nbsp;Yohei Okada","doi":"10.1016/j.apt.2025.104872","DOIUrl":"10.1016/j.apt.2025.104872","url":null,"abstract":"<div><div>Handling of particulate looping materials at high temperatures (500–800 °C) is important for the effective operation of chemical looping. Particles can exhibit high adhesion at high temperatures, which can lead to operational problems in chemical looping. Herein, particle adhesion in CaCO<sub>3</sub>–CaO, a looping material, was carefully investigated at 500–800 °C. Particle adhesion in CaCO<sub>3</sub> increased with increasing temperature and retention time under most of the investigated conditions. The increase in tensile strength was attributed to weak sintering of CaCO<sub>3</sub>. However, the tensile strength decreased with increasing retention time at 800 °C. This phenomenon was specific to 800 °C, where decarboxylation progressed rapidly. The CO<sub>2</sub> gas generated by decarboxylation formed voids in the powder bed, which increased the porosity of the powder bed, resulting in a decrease in the tensile strength. In addition, gas release via decarboxylation broke the weak sintered structure, resulting in a brittle powder bed.</div></div>","PeriodicalId":7232,"journal":{"name":"Advanced Powder Technology","volume":"36 6","pages":"Article 104872"},"PeriodicalIF":4.2,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143783555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microwave sintering of lithium hydride by powder metallurgy: Grain growth kinetics and densification mechanism 粉末冶金微波烧结氢化锂:晶粒生长动力学和致密化机理
IF 4.2 2区 工程技术
Advanced Powder Technology Pub Date : 2025-04-05 DOI: 10.1016/j.apt.2025.104867
Guozhen Zhao , Xiaobao Zhu , Zheng Xu , Yunhai Ma , Yuanjia Lu , Yongsheng Shu , Li Yang , Shenghui Guo , Xiaolei Ye , Kaihua Chen
{"title":"Microwave sintering of lithium hydride by powder metallurgy: Grain growth kinetics and densification mechanism","authors":"Guozhen Zhao ,&nbsp;Xiaobao Zhu ,&nbsp;Zheng Xu ,&nbsp;Yunhai Ma ,&nbsp;Yuanjia Lu ,&nbsp;Yongsheng Shu ,&nbsp;Li Yang ,&nbsp;Shenghui Guo ,&nbsp;Xiaolei Ye ,&nbsp;Kaihua Chen","doi":"10.1016/j.apt.2025.104867","DOIUrl":"10.1016/j.apt.2025.104867","url":null,"abstract":"<div><div>In this study, the effect of microwave sintering on the densification and microstructure of lithium hydride (LiH) cylindrical bulk samples was investigated. The lithium hydride powders were cold pressed into cylindrical shapes and then sintered at temperatures ranging from 450 °C to 550 °C. Microwave sintering demonstrates substantial advantages in achieving accelerated densification and superior microstructural uniformity. Analyses of phase composition, bulk density and micromorphology show that microwave-sintered LiH has a denser grain structure and fewer surface pores. The change in bulk density of bulk LiH sample during microwave sintering shows that the activation temperature of densification is about 475 °C. The average grain size of the bulk LiH sample grows from 46 μm to 53.2 μm. In addition, kinetic modelling showed that microwave sintering was carried out by grain boundary diffusion with lower activation energy, resulting in improved sintering efficiency and shorter processing time. The activation energy for grain growth is 73 kJ/mol. These findings highlight the potential of microwave sintering as an energy-efficient and effective method to produce high-quality bulk LiH materials, paving the way for advanced applications in hydrogen storage and energy systems.</div></div>","PeriodicalId":7232,"journal":{"name":"Advanced Powder Technology","volume":"36 6","pages":"Article 104867"},"PeriodicalIF":4.2,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143783579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experimental study on floc-bubble interaction in the flotation of drilling wastewater at the micro-scale 微尺度下钻井废水浮选中絮凝-气泡相互作用的实验研究
IF 4.2 2区 工程技术
Advanced Powder Technology Pub Date : 2025-04-04 DOI: 10.1016/j.apt.2025.104873
Xiao Ma , Jian-Yi Chen , Ji-Wen Xu , Hao-Di Chi , Yao-Dong Wei
{"title":"Experimental study on floc-bubble interaction in the flotation of drilling wastewater at the micro-scale","authors":"Xiao Ma ,&nbsp;Jian-Yi Chen ,&nbsp;Ji-Wen Xu ,&nbsp;Hao-Di Chi ,&nbsp;Yao-Dong Wei","doi":"10.1016/j.apt.2025.104873","DOIUrl":"10.1016/j.apt.2025.104873","url":null,"abstract":"<div><div>Flotation is an effective solid–liquid separation technique, in which floc-bubble interactions are crucial in determining separation efficiency. This study used polyaluminum silicate ferric (PSAF) to coagulate suspended solids (SS) in drilling wastewater, agglomerating them into flocs. The interactions between bubbles and flocs of varying sizes were observed at the micro-scale using a custom-designed system. The effects of floc size on induction time, bubble relative velocity and floc-bubble interaction force were analyzed. The results indicate that small-size flocs (=50 μm) contribute to the stabilization of the liquid film while sliding along the bubble surface. In contrast, large-size flocs (=170 μm), due to their higher settling velocities, undergo multiple ‘approach-bounce’ cycles, which significantly reduce the contact time with bubbles and impair the adhesion efficiency. As floc size increases, the induction time is markedly extended. Bubbles maintain relatively stable sliding velocities on small-size flocs, while larger flocs induce pronounced velocity fluctuations, thereby heightening the separation instability. The interaction force between the floc and the bubble increases as the deformation of the floc intensifies but subsequently decreases due to the gravity of the floc.</div></div>","PeriodicalId":7232,"journal":{"name":"Advanced Powder Technology","volume":"36 6","pages":"Article 104873"},"PeriodicalIF":4.2,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143769043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Composites of graphene oxide and gold Nanospheres: A dual-targeted Recognition and dual-responsive release Chemophotothermal therapeutic platform 氧化石墨烯与金纳米球复合材料:双目标识别和双响应释放的化学光热治疗平台
IF 4.2 2区 工程技术
Advanced Powder Technology Pub Date : 2025-04-03 DOI: 10.1016/j.apt.2025.104874
Yijie Wang , Ruolan Feng , Meijuan Shi , Huirui Zhu , Moxuan Zhao , Jinyu Li , Hongqin Wang , Xiaoning Li , Tao Gong , Rui Guo
{"title":"Composites of graphene oxide and gold Nanospheres: A dual-targeted Recognition and dual-responsive release Chemophotothermal therapeutic platform","authors":"Yijie Wang ,&nbsp;Ruolan Feng ,&nbsp;Meijuan Shi ,&nbsp;Huirui Zhu ,&nbsp;Moxuan Zhao ,&nbsp;Jinyu Li ,&nbsp;Hongqin Wang ,&nbsp;Xiaoning Li ,&nbsp;Tao Gong ,&nbsp;Rui Guo","doi":"10.1016/j.apt.2025.104874","DOIUrl":"10.1016/j.apt.2025.104874","url":null,"abstract":"<div><div>The negative effects of conventional chemotherapy have been significantly reduced in the past several years by the widespread use of nanomedicine delivery systems in conjunction with conventional liver cancer treatments. This study reports the construction of a novel multifunctional nanocomposite by attaching folic acid (FA) and triformylcholic acid (TCA) to the surface of graphene oxide-gold nanospheres (GO-AuNSs). Doxorubicin hydrochloride (DOX) was used as a model drug to form GO-AuNSs-FA-TCA@DOX on GO-AuNSs-FA-TCA, which has excellent photothermal conversion efficiency, dual-targeted drug delivery, endogenous tumor microenvironment (TME) and near-infrared light (NIR) dual-responsive drug release. More importantly, in vitro and in vivo experiments have shown that the combination therapy shows a higher therapeutic effect than chemotherapy or photothermal therapy alone. Compared with normal cells and other cancer cells, the treatment effect of liver cancer cells is stronger. Therefore, the new nano drug carrier synthesized in this paper has potential application value in the combination therapy of liver cancer.</div></div>","PeriodicalId":7232,"journal":{"name":"Advanced Powder Technology","volume":"36 6","pages":"Article 104874"},"PeriodicalIF":4.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143758988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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