Archives of rehabilitation research and clinical translation最新文献

{"title":"Effectiveness of Telerehabilitation in the Treatment of Shoulder Injuries: A Systematic Review of Randomized Clinical Trials","authors":"Danilo Santos Rocha MSc,&nbsp;Edilaine Aparecida da Silva MSc,&nbsp;Julia Tannus de Souza MSc,&nbsp;Eduardo Lázaro Martins Naves PhD","doi":"10.1016/j.arrct.2025.100553","DOIUrl":"10.1016/j.arrct.2025.100553","url":null,"abstract":"<div><h3>Objective</h3><div>To critically analyze evidence on the effectiveness of telerehabilitation in the treatment of shoulder injuries through a systematic review of randomized controlled trials.</div></div><div><h3>Data Sources</h3><div>A comprehensive literature search was conducted in PubMed, Cochrane Library, Embase, and LILACS databases, covering studies published from 2019 to 2024.</div></div><div><h3>Study Selection</h3><div>Studies were included if they were randomized controlled trials, published in English or Spanish, and focused on telerehabilitation interventions targeting shoulder injuries with outcomes related to pain and/or function.</div></div><div><h3>Data Extraction</h3><div>Two reviewers independently selected and extracted data on study characteristics, participant demographics, intervention protocols, and reported outcomes. Disagreements were resolved by a third reviewer.</div></div><div><h3>Data Synthesis</h3><div>Five studies involving 196 participants were included. Interventions varied in duration, frequency, and technological platforms. Most studies reported improvements in pain and function comparable to those achieved with in-person therapy, with high adherence and satisfaction rates.</div></div><div><h3>Conclusions</h3><div>Telerehabilitation is a promising approach for managing shoulder injuries, providing effective, accessible, and personalized care. However, standardization of protocols and further research on complex pathologies are needed.</div></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"8 2","pages":"Article 100553"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148246634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimum Detectable Change and Minimal Clinically Important Difference for the Box and Block Test and Fugl-Meyer Assessment in Moderate to Severe Chronic Stroke","authors":"David Aaby MS ,&nbsp;Jane E. Sullivan PT, DHS, MS ,&nbsp;Carolina Carmona PT, DPT ,&nbsp;Justin Drogos DPT ,&nbsp;Jun Yao PhD","doi":"10.1016/j.arrct.2026.100623","DOIUrl":"10.1016/j.arrct.2026.100623","url":null,"abstract":"<div><h3>Objectives</h3><div>To quantify the Minimum Detectable Change (MDC) and the Minimal Clinically Important Difference (MCID) of the Box and Blocks Test (BBT) and Upper Extremity Fugl-Meyer Assessment (FMA-UE), and to determine whether there is a BBT floor effect for individuals with chronic stroke and moderate to severe motor impairment.</div></div><div><h3>Design</h3><div>Analysis of pre- and postinterventional data using anchor and distribution-based methods.</div></div><div><h3>Setting</h3><div>Research laboratory.</div></div><div><h3>Participants</h3><div>Fifty-three adults (N=53) with chronic stroke. Age (mean ± SD)=58.5±10.7; 71% men; mean time poststroke=7.4±6.8 years; baseline FMA=20.6±7.6.</div></div><div><h3>Interventions</h3><div>Randomized controlled trial, including 24 sessions over 8 weeks. Each session included 40 trials of reach-grasp-retrieve-release practice using the ReIn-Hand, with or without robotic support of the arm weight.</div></div><div><h3>Main Outcome Measures</h3><div>A BBT floor effect emerged among participants with baseline FMA-UE (FMA_bl)≤18. Above this threshold, the linear regression model reported that for every 1-unit increase in FMA_bl, MDC for the BBT (MDC_BBT) increased by 0.46 blocks/min. MDC for the FMA (MDC_FMA) followed a concave quadratic pattern with FMA_bl, increasing until reaching a peak when FMA_bl was 21-26, then declining. Global Rating of Change was not correlated with changes in BBT (ρ=0.22; <em>P</em>=.29) or FMA (ρ=0.19; <em>P</em>=.23). Using distribution-based methods, we found that MCID for the BBT (MCID_BBT) increased linearly with baseline FMA-UE: for every 10-unit increase in FMA_bl, MCID_BBT increased by 1 block/min. There is no linear relationship between baseline FMA-UE and MCID_FMA. Overall MCID_FMA=2.1 points.</div></div><div><h3>Conclusions</h3><div>Because of its floor effect, the BBT may not be appropriate for those with severe motor impairment poststroke. MDC values for both BBT and FMA-UE depend on motor impairment severity and should be interpreted using regression model-based estimates. In valid ranges of BBT and FMA-UE, subjective perceived change (Global Rating of Change) showed limited association with them. Distribution-based MCID values were small but meaningful, though they may not reflect participants’ perceived importance.</div></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"8 2","pages":"Article 100623"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148247201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stakeholder Perceptions of an Abbreviated Survey to Assess the Accessibility of Community-Based Physical Activity for People With Limited Mobility","authors":"Christen J. Mendonca PhD ,&nbsp;Sangeetha Mohanraj PhD ,&nbsp;Devdutt Upadhye PhD ,&nbsp;Mohanraj Thirumalai PhD","doi":"10.1016/j.arrct.2026.100616","DOIUrl":"10.1016/j.arrct.2026.100616","url":null,"abstract":"<div><h3>Objective</h3><div>An abbreviated Community Accessibility Snapshot (CAS) was developed to provide a rapid, user‑friendly method for assessing the accessibility of community physical activity environments for individuals with limited mobility. This study aimed to explore stakeholder perceptions of the CAS and its accompanying rating tiers to inform refinement of the instrument.</div></div><div><h3>Design</h3><div>We used a focus group design with thematic analysis.</div></div><div><h3>Setting</h3><div>Focus group interviews were conducted through remote meetings.</div></div><div><h3>Participants</h3><div>Sixteen adults (N=16) representing 2 stakeholder groups: adults with mobility limitations (n=14) and professionals working in fitness or recreational sport facilities (n=2). Participants were adults spanning a wide age range (mean±SD: 52±15y). Convenience sampling and recruitment through national disability‑focused platforms may limit generalizability, and the small number of professionals constrains provider‑specific insights.</div></div><div><h3>Interventions</h3><div>Not applicable.</div></div><div><h3>Main Outcome Measures</h3><div>Stakeholder feedback on survey clarity, feasibility, and interpretability, collected through focus group transcripts coded independently by 2 researchers.</div></div><div><h3>Results</h3><div>Four focus groups yielded themes related to (1) factors shaping accessibility experiences, (2) strengths of the CAS, and (3) recommended revisions. Participants highlighted the need for clear distinctions among rating tiers, reduced respondent burden, and inclusion of visual aids. Intercoder agreement was 97%. Stakeholder input guided revisions to survey wording, domain structure, and rating tier definitions. Although thematic saturation was reached among adults with mobility limitations, the small professional sample represents a limitation. Future research should examine age‑related differences in CAS usability and conduct a psychometric evaluation of the revised instrument.</div></div><div><h3>Conclusions</h3><div>The CAS shows promise as a brief, end‑user–focused tool to communicate accessibility of community-based physical activity settings for adults with mobility limitations. Incorporating stakeholder feedback strengthens the tool’s clarity and usability. Further work is needed to assess reliability, validity, and applicability across diverse age groups and facility types.</div></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"8 2","pages":"Article 100616"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148247203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Feasibility and Patient Acceptance of RAGT for Overground Ambulation in Adults With Guillain–Barré Syndrome: A Scoping Review","authors":"Joon Sin Ser MBBS, MMED ,&nbsp;Siew Kwaon Lui MBBS","doi":"10.1016/j.arrct.2026.100596","DOIUrl":"10.1016/j.arrct.2026.100596","url":null,"abstract":"<div><h3>Objective</h3><div>To review the current literature on the feasibility as well as weaknesses and strengths of robot-assisted gait training (RAGT) in the rehabilitation of gait in adult patients with Guillain–Barré syndrome (GBS).</div></div><div><h3>Data Sources</h3><div>This scoping review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis for Scoping Reviews guidelines. A systematic search between November 2024 and May 2025 of PubMed, Cochrane Library, Embase, Canadian Agency for Drugs and Technologies in Health (CADTH) Grey Matters, and citation mining was performed to evaluate for relevant studies.</div></div><div><h3>Study Selection</h3><div>All studies involving the use of RAGT in adults (≥18y) diagnosed with acute inflammatory demyelinating polyneuropathy or GBS were included. Eligible study designs comprised case reports, case series, feasibility studies, and randomized controlled trials. The search yielded 11 potentially relevant articles.</div></div><div><h3>Data Extraction</h3><div>Study selection was conducted in 2 stages: title and abstract screening followed by full-text review. Discrepancies between the 2 independent reviewers were resolved through discussion until consensus was achieved.</div></div><div><h3>Data Synthesis</h3><div>Four studies met the inclusion criteria, comprising 2 case reports, 1 mixed-methods feasibility study, and 1 cross-sectional study, with a total of 19 participants. Across studies, RAGT was generally reported to be feasible, well tolerated, and acceptable to patients, with no major safety concerns. Reported benefits included the ability to initiate overground ambulation, high-intensity repetitive gait practice, and reduced physical burden on therapists. Patient acceptance was supported by positive user experiences, adherence to training sessions, and completion of prescribed protocols, although outcome measures and reporting were inconsistent.</div></div><div><h3>Conclusions</h3><div>The current evidence base for RAGT in adults with GBS is limited but suggests that it is a feasible and acceptable adjunct to conventional rehabilitation. Although functional improvements were reported, conclusions regarding effectiveness remain constrained by small sample sizes and study heterogeneity. Further prospective and methodologically robust studies are needed to better characterize feasibility, patient experience, and implementation considerations of RAGT in this population.</div></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"8 2","pages":"Article 100596"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148247515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uneven Landscape of Cognitive–Motor Dual-Task Research Across Rehabilitation Fields: A State-of-the-Field and Pattern Analysis","authors":"Jun Woo Kwon MEd","doi":"10.1016/j.arrct.2026.100597","DOIUrl":"10.1016/j.arrct.2026.100597","url":null,"abstract":"<div><div>Cognitive–motor dual-task (CMDT) research has expanded rapidly over the past 2 decades, yet this growth has occurred almost exclusively within geriatric and neurologic rehabilitation. In contrast, musculoskeletal, sports, cardiopulmonary, pediatric, and pain rehabilitation fields demonstrate markedly limited engagement with CMDT despite its relevance to motor control and functional performance. This Special Communication synthesizes the current state-of-the-field and examines the structural mechanisms that have produced this persistent interdisciplinary imbalance. Drawing from existing literature, the analysis identifies a set of recurring patterns: (1) CMDT emerged historically within domains where gait, balance, and cognitive decline are central clinical outcomes, creating an early advantage for geriatric and neurologic research; (2) CMDT-sensitive outcomes are not equally prioritized across all rehabilitation fields, reducing its perceived relevance in others; (3) standardization of dual-task assessments has developed primarily within neurologic and aging research, limiting methodological accessibility elsewhere; (4) clinician-level barriers—including time, expertise, and tool availability—restrict CMDT implementation even within well established settings; and (5) evidence and expertise have accumulated most rapidly in the fields where CMDT was first adopted, reinforcing its continued concentration in those domains. Collectively, these patterns suggest that the uneven distribution of CMDT research is not a transient artifact but a reflection of deeper disciplinary structures within rehabilitation science. By clarifying these mechanisms, this work provides a conceptual foundation for understanding why CMDT has flourished in some fields but not others, without presuming uniform applicability or advocating for indiscriminate expansion.</div></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"8 2","pages":"Article 100597"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148247517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Qualitative Analysis of User Experiences of a mHealth Self-Care Intervention for Care Partners of Individuals with Traumatic Brain Injury","authors":"Rongqi Bei MS ,&nbsp;Christopher M. Graves BS ,&nbsp;Sung Won Choi MD ,&nbsp;Angelle M. Sander PhD ,&nbsp;Madison J. Fansher PhD ,&nbsp;Jennifer A. Miner MBA ,&nbsp;Zhenke Wu PhD ,&nbsp;Predrag Klasnja PhD ,&nbsp;Mark W. Newman PhD ,&nbsp;Noelle E. Carlozzi PhD","doi":"10.1016/j.arrct.2026.100608","DOIUrl":"10.1016/j.arrct.2026.100608","url":null,"abstract":"<div><h3>Objective</h3><div>To identify challenges and solutions for conducting mobile health (mHealth) research in a rehabilitation care partner population that involved personalized self-care push notifications and self-monitoring data collection.</div></div><div><h3>Design</h3><div>Qualitative semistructured debriefing interviews with participants who completed a 6-month app-based self-care intervention involving self-monitoring alone or self-monitoring plus personalized push notifications. Interviews were guided by a data-prompted approach to aid participants’ recall.</div></div><div><h3>Setting</h3><div>Two academic medical centers.</div></div><div><h3>Participants</h3><div>Thirty-six care partners (N=36) of individuals with complicated mild to severe traumatic brain injury requiring assistance with daily activities.</div></div><div><h3>Interventions</h3><div>The CareQOL app is a mHealth intervention that delivers personalized self-care push notifications based on daily self-monitoring data, including self-reported caregiver strain, depression, and anxiety, plus Fitbit-tracked sleep and step data.</div></div><div><h3>Main Outcome Measures</h3><div>Qualitative interview data about participants’ experiences with, impressions of, and suggestions for the CareQOL app: (1) self-monitoring components (ie, daily questions, health data dashboard); (2) personalized self-care notifications, including overall experience and perceptions of selected messages.</div></div><div><h3>Results</h3><div>Deductive thematic analysis was used to uncover participants’ experiences with the CareQOL app and identify considerations across intervention and study design. Intervention-wise, push notifications personalized solely based on passive sensing and self-report can be misaligned with participants’ needs, reducing support relevance; limited contextual cues in dashboard displays constrained meaningful self-reflection. Study-wise, technical breakdowns disrupted engagement during the extended study duration; data-prompted interviews effectively supported recall, with participant preferences informing methodological considerations.</div></div><div><h3>Conclusions</h3><div>Findings identified critical considerations and practical recommendations for designing personalized mHealth interventions for self-care and evaluating them in longitudinal randomized controlled trials.</div></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"8 2","pages":"Article 100608"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148246632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Clinical Effectiveness of Intra-Articular Leukocyte-Rich Platelet-Rich Plasma and Hyaluronic Acid in Treating Knee Osteoarthritis Pain: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials","authors":"Yu-Ning Peng MD ,&nbsp;Di Huang MBChB, MPH ,&nbsp;I-Ling Chou MD ,&nbsp;Henry L. Lew MD, PhD","doi":"10.1016/j.arrct.2025.100573","DOIUrl":"10.1016/j.arrct.2025.100573","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the clinical effectiveness of intra-articular leukocyte-rich-platelet-rich plasma (LR-PRP) injections versus hyaluronic acid (HA) for pain management in patients with knee osteoarthritis (OA).</div></div><div><h3>Data Sources</h3><div>Four electronic databsases were searched, including PubMed, EMBASE, Scopus, and Web of Science. Studies included in our analysis were published between November 1, 2011, and July 14, 2023.</div></div><div><h3>Study Selection</h3><div>Randomized controlled trials (RCTs) that compared intra-articular LR-PRP versus HA injections in human adults diagnosed with knee OA.</div></div><div><h3>Data Extraction</h3><div>The Cochrane Risk of Bias Tool was used to assess the risk of bias and methodological quality of included RCTs. The mean differences (MDs) and SDs with 95% CIs were used to compare continuous outcomes, using the Review Manager 5.4 software. Two reviewers independently extracted data on patient demographics and study outcome, including Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores, Visual Analog Scale scores, and adverse events.</div></div><div><h3>Data Synthesis</h3><div>Nineteen RCTs involving 1771 patients were included. LR-PRP demonstrated significant pain relief compared with HA at 3 months posttreatment, but not at 1, 6, or 12 months. At 12 months, LR-PRP was associated with improved WOMAC physical function (MD=−6.37; 95% CI, −12.51 to −0.24; <em>I</em>²=85%) and stiffness scores (MD=−0.63; 95% CI, −0.98 to −0.27; <em>I</em>²=0%), but no differences were observed at earlier timepoints or in total WOMAC scores. Adverse event rates were similar between groups.</div></div><div><h3>Conclusions</h3><div>LR-PRP provides long-term functional improvements in patients with chronic knee OA, though evidence for short-term functional benefits remains limited. LR-PRP shows no long-term advantage over intra-articular HA injections in pain relief. Overall, the evidence does not support the superiority of LR-PRP over HA in managing knee OA.</div></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"8 2","pages":"Article 100573"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148246636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peer Exercise Leaders Can Accurately and Reliably Rate Intensity of Older Adult Exercisers With the Balance Intensity Scale: A Prospective Cohort Study","authors":"Kathryn M. Sibley PhD ,&nbsp;Emily Zacharias BSc ,&nbsp;Danielle R. Bouchard PhD ,&nbsp;Melanie K. Farlie PhD","doi":"10.1016/j.arrct.2026.100588","DOIUrl":"10.1016/j.arrct.2026.100588","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the accuracy and reliability of peer exercise leader ratings of balance exercise intensity using the Balance Intensity Scale Therapist version – Global Rating of Effort (BIS-T GRE).</div></div><div><h3>Design</h3><div>Prospective cohort study.</div></div><div><h3>Setting</h3><div>Two community peer-led exercise programs in Canada.</div></div><div><h3>Participants</h3><div>Fourteen leaders (N=14) who were currently teaching or had taught a class in the past year and had completed introductory training on the BIS-T GRE.</div></div><div><h3>Interventions</h3><div>A 90-minute online facilitated training, including practice rating videos of older adults performing balance exercise tasks and moderated discussion.</div></div><div><h3>Main Outcome Measures</h3><div>(1) Accuracy of peer exercise leaders’ BIS-T GRE ratings for 8 videos of older adults performing balance exercise tasks in 2 independent rating sessions compared with expert ratings; and (2) interrater and test–retest reliability of BIS-T GRE ratings.</div></div><div><h3>Results</h3><div>Mean ratings were the same or lower than expert scores, with significant differences in 4 videos in session 1 and 5 videos in session 2 (all <em>P</em>&lt;.03). A total of 97% of ratings had acceptable accuracy in session 1, and 90% in session 2 (<em>P</em>=.027). Interrater reliability was excellent (intraclass coefficient range=0.980-0.988), and test–retest reliability was good to excellent (intraclass coefficient range=0.744-0.986).</div></div><div><h3>Conclusions</h3><div>Peer exercise leaders in Canadian community programs can accurately and reliably rate balance exercise intensity in older adults using the BIS-T GRE.</div></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"8 2","pages":"Article 100588"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148246728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of Life Assessment Using the Leg Activity Measure in Ambulatory Individuals With Leg Spasticity: Findings From a Longitudinal, Observational Study Evaluating the Effectiveness of AbobotulinumtoxinA in Routine Practice","authors":"Stephen Ashford PhD ,&nbsp;Alberto Esquenazi MD ,&nbsp;Richard D. Zorowitz MD ,&nbsp;Mathieu Beneteau MSc ,&nbsp;Pascal Maisonobe MSc ,&nbsp;Christian Hannes PhD ,&nbsp;Jorge Jacinto MD ,&nbsp;AboLiSh Study group","doi":"10.1016/j.arrct.2026.100611","DOIUrl":"10.1016/j.arrct.2026.100611","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the effect of repeat abobotulinumtoxinA treatment on quality of life (QOL) in patients with leg spasticity.</div></div><div><h3>Design</h3><div>Secondary analysis of the prospective, longitudinal (16mo), observational AboLiSh study.</div></div><div><h3>Setting</h3><div>Specialist neurorehabilitation centers across 9 countries.</div></div><div><h3>Participants</h3><div>Ambulatory adults (66.4% men, mean age 53.9y) with unilateral lower limb spasticity able to take ≥5 steps with or without assistance.</div></div><div><h3>Interventions</h3><div>Patients were treated with abobotulinumtoxinA (up to 6 cycles) per local guidelines to achieve individualized treatment goals.</div></div><div><h3>Main Outcome Measures</h3><div>QOL was assessed at the start of each cycle using the symptom-specific Leg Activity measure (LegA; Parts A: passive function, B: active function, C: QOL impact) and the generic EQ-5D-5L scale.</div></div><div><h3>Results</h3><div>At the population level, QOL improved on both scales across the first 4 treatment cycles. LegA Part C scores decreased and EQ-5D-5L index values increased with repeat treatment. LegA Part C scores showed moderate-to-strong inverse correlations with EQ-5D-5L index values at each cycle (Pearson’s <em>R</em>: Cycle 1: −0.66; Cycle 2: −0.57; Cycle 3: −0.60; Cycle 4: −0.59; all <em>P</em>&lt;.0001). LegA Part A scores were moderately-to-strongly correlated with EQ-5D-5L self-care domain scores across cycles 1-3 (Pearson’s <em>R</em>: Cycle 1: 0.60; Cycle 2: 0.58; Cycle 3: 0.50; Cycle 4: 0.34; all <em>P</em>&lt;.0001). LegA Part B scores were moderately-to-strongly correlated with EQ-5D-5L mobility domain scores across all cycles (Pearson’s <em>R</em>: Cycle 1, 0.58; Cycle 2, 0.57; Cycle 3, 0.57; Cycle 4, 0.59; all <em>P</em>&lt;.0001).</div></div><div><h3>Conclusions</h3><div>Repeat lower limb treatment with abobotulinumtoxinA improved QOL as assessed by both symptom-specific and generic instruments. The significant correlations between LegA Part C and EQ-5D-5L support validity of the LegA to assess the impact of treatment on QOL in patients with leg spasticity.</div></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"8 2","pages":"Article 100611"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148247205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Adjunctive Photobiomodulation in Patellofemoral Pain Syndrome: A Systematic Review and Meta-Analysis","authors":"Hongxiu Chen PhD ,&nbsp;Somkiat Asawaphureekorn MD ,&nbsp;Nuttaset Manimmanakorn MD, PhD ,&nbsp;Xingze Wang PhD ,&nbsp;Wichai Eungpinichpong PhD","doi":"10.1016/j.arrct.2026.100585","DOIUrl":"10.1016/j.arrct.2026.100585","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the effectiveness and safety of adjunctive photobiomodulation (PBM) or low-level laser therapy (LLLT) combined with exercise-based rehabilitation in reducing pain and improving function in individuals with patellofemoral pain syndrome (PFPS).</div></div><div><h3>Data Sources</h3><div>PubMed, Scopus, Embase, Web of Science, PEDro, the Cochrane Library, and China National Knowledge Infrastructure were searched from inception to October 2025.</div></div><div><h3>Study Selection</h3><div>Randomized controlled trials (RCTs) were included if they examined PBM/LLLT with clearly reported parameters compared with placebo, sham, or no-intervention controls in individuals with PFPS. Studies with mixed knee pathologies or nonrandomized designs were excluded.</div></div><div><h3>Data Extraction</h3><div>Two reviewers independently extracted data on participant features, PBM parameters, interventions, comparators, outcomes, and adverse events. Risk of bias was assessed using the Cochrane tool, with disagreements resolved by consensus.</div></div><div><h3>Data Synthesis</h3><div>Four RCTs (n=162) were eligible. Meta-analysis using a random-effects model showed a statistically nonsignificant trend favoring PBM for pain reduction (effect size=−1.520; 95% confidence interval: −3.542 to 0.502; <em>P</em>=.097), with substantial heterogeneity (I²=91.1%) and a wide 95% prediction interval (−5.880 to 2.840). Importantly, the 4 included trials used distinct PBM delivery approaches, including laser acupuncture, PBM combined with trigger point therapy, classic PBM, and monochromatic infrared energy. This diversity may limit the validity of pooling these heterogeneous interventions within a single meta-analysis. Individually, PBM produced greater short-term pain reduction and some functional improvements in certain trials. No adverse events were reported.</div></div><div><h3>Conclusions</h3><div>PBM/LLLT may provide short-term pain relief and modest functional benefits for young adults with PFPS and appears to be safe. However, the considerable variability among PBM modalities, including acupuncture-based laser stimulation, PBM combined with trigger point therapy, conventional PBM, and monochromatic infrared energy, introduces important methodological heterogeneity and raises concerns regarding the appropriateness of aggregating these interventions. In addition, the limited sample sizes and heterogeneous PBM protocols reduce confidence in these findings. Larger, standardized RCTs are needed.</div></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"8 2","pages":"Article 100585"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148247514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}