Archives of rehabilitation research and clinical translation最新文献

{"title":"Cryoneurolysis for Managing Spasticity in Multiple Sclerosis: A Case Report Demonstrating Sustained Functional Gains and Cost-Effectiveness","authors":"Ava Hughes BSc ,&nbsp;Mahdis Hashemi MD ,&nbsp;Laura Schatz BSc ,&nbsp;Daniel Gatenby BSc ,&nbsp;Paul Winston MD","doi":"10.1016/j.arrct.2025.100464","DOIUrl":"10.1016/j.arrct.2025.100464","url":null,"abstract":"<div><div>Cryoneurolysis is a minimally invasive procedure that induces secondary axonotmesis while preserving the nerve’s supportive structures, offering an alternative approach to managing spasticity in multiple sclerosis (MS)—a condition affecting up to 90% of patients with MS and often leading to contractures, pain, and reduced mobility. In this case report, a 48-year-old woman with progressive MS who previously experienced side effects and limited benefits from prior botulinum toxin-A injections underwent ultrasound-guided percutaneous cryoneurolysis on targeted nerves to spastic muscles identified using the response to diagnostic nerve blocks. Range of motion and spasticity were assessed using the Modified Ashworth Scale, Modified Tardieu Scale, and numerical pain ratings. The patient demonstrated marked, sustained improvements in range of motion (shoulder flexion, abduction, and external rotation and elbow extension up to 11mo and knee flexion up to 7mo) and a reduction in spasticity (at 11mo for shoulder and elbow, 4mo for knee). The patient then experienced a progressive MS crisis, and a second treatment was offered at 1 year. There were additional gains after the second round of cryoneurolysis. The procedure showed 15-fold annual cost savings in their jurisdiction compared with botulinum toxin-A, underscoring the potential economic benefits of cryoneurolysis. These findings suggest that cryoneurolysis is a promising treatment for upper and lower limb spasticity in MS, providing significant, sustained improvements in range of motion, pain, and spasticity. Further research with larger cohorts is needed to confirm the long-term efficacy, broader applicability, and fully substantiate the cost-effectiveness of this emerging treatment modality.</div></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"7 3","pages":"Article 100464"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145011262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Test–retest Reliability, Interrater Reliability, and Convergent Validity of the Targeted Box and Block Test in an Upper Extremity Prosthesis User Population","authors":"Kimberly Kontson PhD ,&nbsp;Bin Wang PhD ,&nbsp;Nicole Leung BA ,&nbsp;John M. Miguelez CP, FAAOP(D) ,&nbsp;Lauren Trent MOT, OTR/L","doi":"10.1016/j.arrct.2025.100427","DOIUrl":"10.1016/j.arrct.2025.100427","url":null,"abstract":"<div><h3>Objective</h3><div>To provide evidence for test–retest reliability, interrater reliability, and convergent validity of the targeted Box and Block Test (tBBT) in the upper limb prosthesis user population.</div></div><div><h3>Design</h3><div>An observational study was designed to assess various psychometric properties of the novel outcome measure. Participants completed the tBBT across 2 distinct testing sessions to assess test–retest reliability, which was quantified using the intraclass correlation coefficient (ICC) (3,k) and Pearson's correlation coefficient. Multiple raters scored the tBBT to assess interrater reliability, which was quantified using the ICC(2,k) and Pearson's correlation coefficient. Convergent validity was assessed by computing the Pearson's correlation coefficient between specific subtasks of the Capacity Assessment of Prosthesis Performance for the Upper Limb (CAPPFUL) and the tBBT.</div></div><div><h3>Setting</h3><div>Clinic.</div></div><div><h3>Participants</h3><div>A convenience sample of 20 transradial, unilateral upper limb prosthesis users.</div></div><div><h3>Interventions</h3><div>Not applicable.</div></div><div><h3>Main Outcome Measures</h3><div>tBBT, Box and Block Test (BBT), and CAPPFUL.</div></div><div><h3>Results</h3><div>Interrater reliability for completion time and identification of unsuccessful transports were found to be excellent for the tBBT with ICC values of 0.97-0.99. Similarly, test–retest reliability was found to be good to excellent with ICC values &gt;0.84. There were strong correlations between the scores obtained by different sessions and the scores given by different raters, with correlation coefficients exceeding 0.75. Moderate to strong correlations were found between the tBBT and BBT and subtasks of the CAPPFUL.</div></div><div><h3>Conclusions</h3><div>The tBBT is a valid and reliable measure to assess the functional performance of individuals using an upper limb prosthetic device. This novel measure offers benefits of ease and speed of implementation; assessment of repetitive, ecologically representative movements; and quantification of performance using both speed and accuracy.</div></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"7 3","pages":"Article 100427"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145011274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Early Cardiorespiratory Rehabilitation Combined With Melatonin Supplementation During the Inpatient Period After Acute Myocardial Infarction: a Pilot Study","authors":"Mohamed Ali Hbaieb MSc ,&nbsp;Salma Charfeddine MD ,&nbsp;Tarak Driss PhD ,&nbsp;Laurent Bosquet PhD ,&nbsp;Benoit Dugué PhD ,&nbsp;Leila Abid MD ,&nbsp;Omar Hammouda PhD","doi":"10.1016/j.arrct.2025.100454","DOIUrl":"10.1016/j.arrct.2025.100454","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the safety and effectiveness of early cardiopulmonary rehabilitation (ECR) combined with melatonin supplementation on functional capacity and sleep quality during hospitalization in patients with acute myocardial infarction (AMI) treated with primary percutaneous coronary intervention (PCI).</div></div><div><h3>Design</h3><div>Single-blinded randomized controlled trial.</div></div><div><h3>Setting</h3><div>Cardiology inpatient unit where patients were hospitalized after PCI.</div></div><div><h3>Participants</h3><div>Forty-eight male patients (N=48) with AMI followed by PCI (mean age of 57.1±8.7y) were included and randomized into 3 groups: MELEX (ECR combined with 4 mg of exogenous melatonin), EX (ECR with placebo), and CON (control group with placebo).</div></div><div><h3>Interventions</h3><div>Patients in the MELEX and EX groups participated in ECR, consisting of walking, passive and active range of motion, moderate-intensity strengthening exercises, and breathing exercises. The MELEX group received a daily 4 mg dose of melatonin, while the EX and CON groups received a placebo. Participants in CON group received usual care without engaging in ECR.</div></div><div><h3>Main Outcomes Measures</h3><div>Functional capacity was evaluated by the 6-minute walking test (6mwt). Sleep quality was assessed by the Spiegel questionnaire. Rating of perceived exertion was evaluated using the Borg Scale. Assessments were conducted on the first day after PCI and at hospital discharge.</div></div><div><h3>Results</h3><div>The 6mwt distance was better in the MELEX group than in the other groups exceeding the minimal clinically important differences (<em>P</em>&lt;.001). Sleep quality was improved more in MELEX than EX and CON groups (<em>P</em>&lt;.001). A strong-graded correlation was found between the 6mwt and Spiegel Score (<em>r</em>=0.730; <em>P</em>&lt;.001). No adverse cardiac events related to ECR or melatonin supplementation were recorded during hospitalization.</div></div><div><h3>Conclusions</h3><div>ECR combined with a daily 4 mg of melatonin supplementation was safe and effective in improving functional capacity and sleep quality in patients with AMI during hospitalization after PCI.</div></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"7 3","pages":"Article 100454"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145009901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Integration of Support for Co-Occurring Substance Use-Related Needs in Interdisciplinary Traumatic Brain Injury Treatment for Military Service Members and Veterans","authors":"Katherine L. McCauley PhD ,&nbsp;Tracey Wallace MS, CCC-SLP ,&nbsp;Timothy P. Moran PhD ,&nbsp;Javier Palacios BS ,&nbsp;Dina Forehand MS, CCM ,&nbsp;Jacquelyn Breitenstein MS, CTRS, CCM ,&nbsp;Shannon C. Miller MD ,&nbsp;Russell K. Gore MD","doi":"10.1016/j.arrct.2025.100468","DOIUrl":"10.1016/j.arrct.2025.100468","url":null,"abstract":"<div><h3>Objective</h3><div>To explore initial outcomes (treatment entry and completion and staff feedback) for an interdisciplinary military traumatic brain injury (TBI) treatment program with individualized support for co-occurring substance use (SU).</div></div><div><h3>Design</h3><div>A quality improvement effort was undertaken to develop an integrated model of care for TBI with support for service members and veterans (SM/Vs) with co-occurring SU. We describe treatment entry and completion outcomes, along with staff feedback, collected over 26 months of program implementation.</div></div><div><h3>Setting</h3><div>An intensive outpatient program (IOP) for SM/Vs with TBI, administered by a not-for-profit hospital</div></div><div><h3>Participants</h3><div>Three hundred and sixty-four (N=364) SM/Vs applying for TBI treatment (85.2% men, 28.3% active service, median age of 41 (interquartile range, ±12)).</div></div><div><h3>Interventions</h3><div>An Integrated Care Model for TBI + SU was developed and flexibly applied to support client needs, including modifications to assessment, intervention, and follow-up support related to SU.</div></div><div><h3>Main Outcome Measures</h3><div>We report on instances of noncompletion because of SU, percentage of admission denials because of SU, demographic and clinical predictors of entering care, and qualitative feedback from treating clinicians.</div></div><div><h3>Results</h3><div>Over 26 months, 188 individuals entered care, and just 7 who entered the IOP did not complete, with 1 of these instances because of SU. Clinician attitudes indicate optimism about the Integrated Care Model. Predictors of entering care, analyzed using logistic regression with recursive feature elimination, included multiple demographic (sex, race, location, service status) and clinical (SU and psychiatric history, brain injury symptom severity) characteristics.</div></div><div><h3>Conclusions</h3><div>An interdisciplinary TBI treatment environment holds promise as a setting for incorporating SU-related support to enhance entry and completion for more SM/Vs.</div></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"7 3","pages":"Article 100468"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145011261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating Physical and Occupational Therapists’ and Assistants’ Experiences Implementing an Electronic Health Record-Based Intervention to Support Perioperative Patients’ Use of Nonpharmacological Pain Management Techniques","authors":"Jane T. Hein PT ,&nbsp;Sarah Redmond PhD ,&nbsp;Lina Daus DPT ,&nbsp;Monica Heinemann MOT ,&nbsp;Jon Tilburt MD ,&nbsp;Andrea Cheville MD, MSCE","doi":"10.1016/j.arrct.2025.100462","DOIUrl":"10.1016/j.arrct.2025.100462","url":null,"abstract":"<div><h3>Objective</h3><div>To explore barriers and facilitators experienced by therapists (physical therapists/assistants and occupational therapists/assistants) supporting the implementation of the electronic health record (EHR)-based Healing After Surgery (HAS) initiative, which used clinical decision support (CDS) elements to support therapists in providing perioperative education and support to patients for the use of evidence-based nonpharmacological pain care (NPPC) techniques as part of a health system-wide clinical trial.</div></div><div><h3>Design</h3><div>A cross-sectional web-based survey.</div></div><div><h3>Setting</h3><div>Three academic and 3 community-based hospitals from the same health system.</div></div><div><h3>Participants</h3><div>Therapists (N=236) who delivered the EHR-based HAS initiative.</div></div><div><h3>Interventions</h3><div>Not applicable.</div></div><div><h3>Main Outcome Measures</h3><div>Barriers and facilitators that therapists experienced implementing the EHR-based HAS initiative.</div></div><div><h3>Results</h3><div>We received survey responses from therapists (34.6% response rate). Using a numerical rating scale (1=not at all, 10=a great deal), therapists reported the highest agreement to questions regarding understanding the goal of the initiative (mean ± SD, 7.3±2.4) and alignment of the initiative with therapy practice (mean ± SD, 7.2±2.4), followed by alignment with patient needs (mean ± SD, 6.7±2.4). Ratings were slightly lower for understanding of their role (mean ± SD, 6.5±2.3), leadership support (mean ± SD, 6.3±2.4), and adequacy of training (mean ± SD, 6.2±2.4). Therapists rated the helpfulness of CDS elements at the midpoint of the scale, with mean ratings ranging from 5.0 to 5.1. Only 27% of therapists felt equipped to educate patients on all NPPC techniques.</div></div><div><h3>Conclusions</h3><div>The EHR-based HAS initiative was perceived to align with standard therapy care. However, many therapists did not feel equipped to support all NPPC techniques. Similar future efforts should address additional training needs and CDS refinement.</div></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"7 3","pages":"Article 100462"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145011267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resiliency and Mental Health Symptoms Among Active Duty Service Members With a History of Mild Traumatic Brain Injury","authors":"Rosemay A. Remigio-Baker PhD, MPH ,&nbsp;Lars D. Hungerford PhD ,&nbsp;Donald Marion MD ,&nbsp;Grace L. Reveles RN ,&nbsp;Angela G. Basham MPH ,&nbsp;Keith Stuessi MD ,&nbsp;Juan Lopez BA ,&nbsp;Jason M. Bailie PhD","doi":"10.1016/j.arrct.2025.100480","DOIUrl":"10.1016/j.arrct.2025.100480","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the associations between resilience and emotional symptoms among service members (SMs) with mild traumatic brain injury (mTBI) and determine whether these relationships vary by the number of lifetime mTBI.</div></div><div><h3>Design</h3><div>Cross-sectional.</div></div><div><h3>Setting</h3><div>Southwestern US military interdisciplinary traumatic brain injury (TBI) facility</div></div><div><h3>Participants</h3><div>N=230 SMs being treated for mTBI (92.2% of men, with a mean age of 33.8 years [SD, 8.8] and 13.5 years in active duty [SD, 8.3], and a median of 64.9 months from injury to intake).</div></div><div><h3>Interventions</h3><div>Not applicable; however, overall resilience (categorized as low, moderate, and high) and 5 themes (meaning-making and restoration, active coping, cognitive flexibility, spirituality, and self-efficacy) were measured using the Response to Stressful Experiences Scale.</div></div><div><h3>Main Outcome Measures</h3><div>Clinically elevated posttraumatic stress (PTS) and depressive symptoms were measured using the Posttraumatic Stress Disorder Checklist for Diagnostic and Statistical Manual of Mental Disorders, Fifth Ediction (score≥33) and the 8-item Patient Health Questionnaire (score≥15), respectively. The number of lifetime mTBI (single vs multiple) was ascertained using the Ohio State University TBI Identification Method and evaluated as an interaction term.</div></div><div><h3>Results</h3><div>SMs with higher (vs lower) overall resilience levels were significantly less likely to have clinically elevated PTS and depressive symptoms at pretreatment. These associations did not vary by the number of lifetime mTBIs. By resilience themes, higher levels were associated with a lower likelihood of clinically elevated PTS and depressive symptoms at pretreatment, but for active coping and cognitive flexibility, the relationship with depressive symptoms was only significant among those with a single mTBI. No significant results were found at posttreatment.</div></div><div><h3>Conclusions</h3><div>The findings may be helpful to inform expectations of recovery and optimal management of symptoms. Future longitudinal studies are needed to evaluate the effect of resilience on mental health issues and why it may not be beneficial in the presence of multiple mTBIs.</div></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"7 3","pages":"Article 100480"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145011246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Community-Based Rehabilitation and Patient-Centered Outcomes in Survivors of Critical COVID-19 Attending an Intensive Care Recovery Clinic","authors":"Felipe González-Seguel PT, MS ,&nbsp;Evan Haezebrouck PT, DPT ,&nbsp;Lindsey E. Fresenko PT, PhD ,&nbsp;Carla M. Sevin MD ,&nbsp;Stacey Slone MS ,&nbsp;Ashley Montgomery-Yates MD ,&nbsp;Anna G. Kalema MD ,&nbsp;Lori Ginoza PT ,&nbsp;Clarisa Martinez PT, DPT, MS ,&nbsp;Michelle Biehl MD ,&nbsp;Soibhan R. Kelley MD ,&nbsp;Joshua K. Johnson PT, DPT, PhD ,&nbsp;Matthew F. Mart MD, MSc ,&nbsp;Kirby P. Mayer PT, DPT, PhD","doi":"10.1016/j.arrct.2025.100484","DOIUrl":"10.1016/j.arrct.2025.100484","url":null,"abstract":"<div><h3>Objective</h3><div>To examine the occurrence of physical and cognitive impairments among survivors of critical coronavirus disease of 2019 (COVID-19) who attend an intensive care unit (ICU) recovery clinic and describe their utilization of community-based rehabilitation (physical and occupational therapy).</div></div><div><h3>Design</h3><div>Retrospective, observational cohort study and multisite practice analysis.</div></div><div><h3>Setting</h3><div>ICU recovery clinics at 4 academic medical centers.</div></div><div><h3>Participants</h3><div>Adults (median age 56 [interquartile range, {IQR}, 47–64] years, 60% female) surviving acute respiratory failure caused by COVID-19 who required advanced respiratory support.</div></div><div><h3>Main outcome measures</h3><div>Six-minute walk test (6MWT) and Montreal Cognitive Assessment (MoCA).</div></div><div><h3>Results</h3><div>Patients attended the ICU recovery clinic (n=163) in a median of 43 (IQR, 30-60) days after discharge. Ninety-four patients (58%) participated in at least 1 community-based rehabilitation session, 52 (32%) never participated, and 17 (10%) did not have data available. Patients walked a median [IQR] of 282 [150-390] meters on the 6MWT, and the median Short Physical Performance Battery (SPPB) score was 8 [4-11] with 63% of patients classified as physically frail (score ≤9/12). The median MoCA score was 26 [22-27], with 37% at least mild cognitive impairment (score of ≤26). Among patients who were driving before ICU admission, 44% had not returned to driving after hospitalization, and an additional 21% reported driving with new limitations. Patients who participated in at least 1 community-based rehabilitation session had longer ICU lengths of stay as well as worse performance on the 6MWT and SPPB at discharge compared with individuals not receiving postdischarge rehabilitation (<em>P</em>&lt;.001).</div></div><div><h3>Conclusions</h3><div>Survivors of acute respiratory failure caused by critical COVID-19 who attended an ICU recovery clinic are at high risk of physical and/or cognitive impairments. Two-thirds of survivors participated in physical or occupational therapy at home or an outpatient center after hospital discharge. Patients with longer lengths of stay and more physical impairments at discharge are more likely to participate in community-based rehabilitation interventions.</div></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"7 3","pages":"Article 100484"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145009898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remotely Delivered Task-Oriented Training and Evaluation (reTOTE) for Stroke Rehabilitation","authors":"Veronica T. Rowe PhD, OTR/L ,&nbsp;Emily A. Wilcox MHS, OTR/L ,&nbsp;Charlotte A. Chatto PT, PhD ,&nbsp;Ryan M. Carrick PhD, MHS, OTR/L","doi":"10.1016/j.arrct.2025.100491","DOIUrl":"10.1016/j.arrct.2025.100491","url":null,"abstract":"<div><h3>Objective</h3><div>To determine the effect of a multifaceted task-oriented training intervention delivered through telerehabilitation (Remote Task-Oriented Training and Evaluation [reTOTE]) on stroke survivors’ activity, performance, quality of life, and confidence.</div></div><div><h3>Design</h3><div>Cohort study with repeated measures at pre- and post-reTOTE intervention and 1-month follow-up.</div></div><div><h3>Setting</h3><div>Virtual through telerehabilitation.</div></div><div><h3>Participants</h3><div>Twelve (N=12) stroke survivors.</div></div><div><h3>Interventions</h3><div>The reTOTE intervention was individualized for each participant during 8 sessions designed with evidence-based components of constraint-induced movement therapy, principles of experience-dependent plasticity, and use of the Cognitive Orientation to daily Occupational Performance approach.</div></div><div><h3>Main Outcome Measures</h3><div>Motor Activity Log, Canadian Occupational Performance Measure, Stroke Impact Scale, and the Activities-specific Balance Confidence Scale.</div></div><div><h3>Results</h3><div>The results demonstrated an increase in performance of functional abilities in stroke survivors’ lives immediately and at 1-month follow-up after completing reTOTE compared with preintervention.</div></div><div><h3>Conclusions</h3><div>This study indicates the importance of using an evidence-based, individualized, task-oriented therapeutic intervention for stroke survivors and the feasibility of remote delivery through telerehabilitation. Implementation of reTOTE may allow for access to rehabilitation that could improve meaningful therapeutic outcomes for stroke survivors.</div></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"7 3","pages":"Article 100491"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145009900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Impact of Muscle Vibration Therapy in Neurologic Rehabilitation: A Systematic Review","authors":"Andrea Calderone MSc ,&nbsp;Svonko Galasso PhD ,&nbsp;Alessandro Marco De Nunzio PhD ,&nbsp;Antonio Leo PhD ,&nbsp;Tina Balletta PhD ,&nbsp;Angelo Quartarone PhD ,&nbsp;Rocco Salvatore Calabrò PhD","doi":"10.1016/j.arrct.2025.100478","DOIUrl":"10.1016/j.arrct.2025.100478","url":null,"abstract":"<div><h3>Objective</h3><div>To consolidate evidence on the efficacy of muscle vibration therapy for neurorehabilitation, providing health care practitioners with insights for enhancing treatment protocols and guiding future research.</div></div><div><h3>Data Sources</h3><div>Studies were identified from an online search of PubMed, Web of Science, and Embase databases, with a search time range of 2014-2024.</div></div><div><h3>Study Selection</h3><div>A total of 26 studies involving 787 individuals were included in this systematic review, including diverse neurologic conditions and intervention protocols.</div></div><div><h3>Data Extraction</h3><div>Keywords, Boolean operators, and controlled vocabulary were combined and tested in a gradual and iterative manner to achieve the highest possible sensitivity and specificity. The PRISMA flowchart was used to depict the process of selecting relevant studies.</div></div><div><h3>Data Synthesis</h3><div>Research on segmental and local muscle vibration in upper limb rehabilitation for poststroke patients is promising, as it can improve motor function, decrease spasticity, and enhance muscle control. Whole-body vibration interventions also show advantages in lower limb spasticity and balance, with specific studies adducing better results when paired with task-specific training. Vibration therapy has shown promising outcomes for alleviating pain, managing spasticity, and improving motor function in various neurologic conditions such as SCI and cerebral palsy, highlighting its potential in treating different neurologic disorders.</div></div><div><h3>Conclusions</h3><div>This review emphasizes the potential of muscle vibration therapy in neurorehabilitation, showing benefits in motor control, spasticity, and functional outcomes, while underscoring the importance of rigorous methods and further extensive research to improve result dependability.</div></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"7 3","pages":"Article 100478"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145011265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive and Psychological Symptoms in Post-COVID-19 Condition: A Systematic Review of Structural and Functional Neuroimaging, Neurophysiology, and Intervention Studies","authors":"Eva Pettemeridou PhD ,&nbsp;Maria Loizidou MSc ,&nbsp;Jelena Trajkovic PhD ,&nbsp;Maria Constantinou PhD ,&nbsp;Stefanie De Smet MSc ,&nbsp;Chris Baeken PhD ,&nbsp;Alexander T. Sack PhD ,&nbsp;Steven C.R. Williams PhD ,&nbsp;Fofi Constantinidou PhD","doi":"10.1016/j.arrct.2025.100461","DOIUrl":"10.1016/j.arrct.2025.100461","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the structural, functional, and neurophysiological brain changes associated with post-COVID-19 condition (PCC)-related cognitive and psychological issues and evaluate the efficacy of noninvasive brain stimulation (NIBS) and cognitive rehabilitation interventions.</div></div><div><h3>Data Sources</h3><div>Electronic databases, including Web of Science, PubMed, and Embase, were systematically searched for articles published before February 1, 2025, using terms such as “post-COVID-19 condition,” “cognitive dysfunction,” “brain changes,” “noninvasive brain stimulation,” and “cognitive rehabilitation.” Language was restricted to English, and only studies involving human participants were included.</div></div><div><h3>Study Selection</h3><div>Studies with human participants aged ≥18 years diagnosed with PCC, employing magnetic resonance imaging, functional magnetic resonance imaging, positron emission tomography, and electroencephalography, and interventions such as NIBS and cognitive rehabilitation were included. Articles were selected through independent review by multiple authors, with consensus resolving discrepancies. Of the 123 studies initially identified, 78 met the inclusion criteria.</div></div><div><h3>Data Extraction</h3><div>Data on participant demographics, methodologies, neurophysiological changes, and intervention outcomes were extracted by 2 independent reviewers using predefined guidelines. Study quality was assessed using the Newcastle-Ottawa Scale and Critical Appraisal Skills Program tools.</div></div><div><h3>Data Synthesis</h3><div>Seventy-eight studies with over 5900 participants met the inclusion criteria. Significant cognitive impairments were observed in attention, executive function, and memory (N=78). Key findings included mixed evidence of gray matter (N=16) and white matter volume changes (N=20), cortical thickness alterations (N=9), variations in functional connectivity (N=14), electrophysiology (N=9), and blood flow (N=8). NIBS, including transcranial magnetic stimulation (N=8) and transcranial direct current stimulation (N=2), showed potential benefits for managing depression and cognitive impairments. Although cognitive rehabilitation (N=3) showed promise, it requires further investigation.</div></div><div><h3>Conclusions</h3><div>This review highlights the complex neurologic underpinnings of PCC and the potential of NIBS and cognitive rehabilitation as interventions. Further research is essential to refine these interventions and establish evidence-based strategies for addressing long-term cognitive and psychological effects of PCC.</div></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"7 3","pages":"Article 100461"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145011266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}