Timothy Woodacre, Nooshin Jahromi, Geraldine Goh, Thomas Clifton, David Dillon
{"title":"Bilateral recurrent laryngeal nerve palsy following anterior cervical surgery subsequent to contralateral apical lung radiotherapy.","authors":"Timothy Woodacre, Nooshin Jahromi, Geraldine Goh, Thomas Clifton, David Dillon","doi":"10.22551/2022.37.0904.10223","DOIUrl":"https://doi.org/10.22551/2022.37.0904.10223","url":null,"abstract":"<p><p>Unilateral recurrent laryngeal nerve palsy is a potential complication of the anterior approach for cervical surgery. It is a rare complication of radiotherapy to the neck. Only one case has been reported following radiotherapy apical lung cancer. It can result in unilateral vocal cord paralysis. We report a patient who demonstrated bilateral vocal cord paralysis immediately following right-sided anterior cervical surgery, with significant consequences, including aphonia, respiratory distress and subsequent takotsubo cardiomyopathy. She was diagnosed with acute, (temporary) post-operative right recurrent laryngeal nerve palsy, on the background of undetected and previously asymptomatic left recurrent laryngeal nerve palsy following radiotherapy for left apical lung cancer. The possibility of recurrent laryngeal nerve palsy should be considered in patients with previous apical lung cancer and/ or radiotherapy. Patents undergoing subsequent anterior cervical surgery should be considered for the appropriate precautions in the form of same-side surgery or pre-operative investigation for vocal cord paralysis.</p>","PeriodicalId":72274,"journal":{"name":"Archive of clinical cases","volume":"9 4","pages":"154-156"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cc/96/acc-09-04-154.PMC9769081.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10511188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A rare presentation of pulmonary thromboembolism as seizure.","authors":"Toktam Alirezaei, SeyedehFatemeh Mousavi, Hamed Hesami","doi":"10.22551/2022.37.0904.10219","DOIUrl":"https://doi.org/10.22551/2022.37.0904.10219","url":null,"abstract":"<p><p>Acute pulmonary thromboembolism is a critical and sometimes fatal event that is difficult for clinicians to diagnose because of its various initial manifestations. Here, we report a previously healthy 50-year-old man without any history of seizures who presented to the emergency ward with the new-onset seizure. Neurology consult was performed, but found no focal neurological deficits. The diagnosis of massive pulmonary embolism was confirmed by echocardiography and pulmonary CT angiography. Alteplase and heparin with therapeutic dosage were started for the patient. After initiating treatment, patient's dyspnea, arterial O2 saturation, and general condition were significantly improved. Echocardiography was repeated and showed a smaller right ventricle size and lower pulmonary artery pressure than the first echocardiography.</p>","PeriodicalId":72274,"journal":{"name":"Archive of clinical cases","volume":"9 4","pages":"136-139"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/29/86/acc-09-04-136.PMC9769075.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10511192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Archive of clinical casesPub Date : 2021-12-29eCollection Date: 2021-01-01DOI: 10.22551/2021.32.0803.10187
Nariman Khan, Saadia Waheed, Rahaf Alkhateb
{"title":"Triple whammy: a rare case of epithelioid hemangioendothelioma with synchronous angiomyomatous hamartoma complicated by <i>Actinomyces meyeri</i>.","authors":"Nariman Khan, Saadia Waheed, Rahaf Alkhateb","doi":"10.22551/2021.32.0803.10187","DOIUrl":"https://doi.org/10.22551/2021.32.0803.10187","url":null,"abstract":"<p><p>Epithelioid hemangioendothelioma is a rare vascular malignancy that originates from vascular endothelial or pre-endothelial cells and is composed of epithelioid or histiocytoid cells. This malignancy has an incidence of approximately one per one million individuals and can occur in various regions of the body including the lungs, liver, bones, and soft tissues. The behavior of this cancer can range from indolent to aggressive and diagnosis and treatment are often delayed due to variable presentations and lack of established treatment guidelines. Here we present the case of a 27-year-old Hispanic male that presented with right groin pain, abdominal pain, and a fifty-pound weight loss over one year. The patient had a complex hospital course during which he was found to have an angiomyomatous hamartoma of his right groin area, postsurgical right inguinal wound infection with <i>Actinomyces meyeri</i>, and epithelioid hemangioendothelioma distal to the right iliac bifurcation. The patient is currently pending further imaging studies to evaluate candidacy for surgical resection and following with oncology for chemotherapeutic options.</p>","PeriodicalId":72274,"journal":{"name":"Archive of clinical cases","volume":"8 3","pages":"56-61"},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/46/9a/acc-08-03-56.PMC8717002.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39662314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Archive of clinical casesPub Date : 2021-12-29eCollection Date: 2021-01-01DOI: 10.22551/2021.32.0803.10185
Brandon W Knopp, Parvathi Perumareddi
{"title":"An atypical presentation of type 1 diabetes.","authors":"Brandon W Knopp, Parvathi Perumareddi","doi":"10.22551/2021.32.0803.10185","DOIUrl":"https://doi.org/10.22551/2021.32.0803.10185","url":null,"abstract":"<p><p>Type 1 and type 2 diabetes have been described historically as occurring in distinct patient populations; however, atypical demographics are becoming more frequent as the prevalence of diabetes increases, crossing boundaries of ages. Some of these cases can be challenging to diagnose clinically as the patient symptomatology and progression can differ from the standard features of type 1 and 2 diabetes. Our case is an example of a patient whose type 1 diabetes presented atypically with characteristics often associated with type 2 diabetes. Patient presentations such as this are uncommon, with our patient having presented with the \"textbook\" characteristics of type 2 diabetes. When first diagnosed with diabetes mellitus type 2, the patient was 60 years old, had a BMI around 30 and experienced a gradual onset of symptoms over the course of several months. At the age of 64, the patient tested positive for GAD65 autoantibodies following a year of declining glycemic control and was re-evaluated and classified as a type 1 diabetes patient. Subsequent insulin injections resolved his diabetes-related complications which included polyuria, weakness and weight loss and improved his glycemic control. This case provides an example of an unusual clinical presentation of type 1 diabetes and serves to raise awareness for atypical presentations of diabetes to improve accurate classifications at earlier stages.</p>","PeriodicalId":72274,"journal":{"name":"Archive of clinical cases","volume":"8 3","pages":"46-49"},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e4/0a/acc-08-03-46.PMC8717001.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39646278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Archive of clinical casesPub Date : 2021-12-29eCollection Date: 2021-01-01DOI: 10.22551/2021.32.0803.10186
Mihaela Mărioara Stana, Sandra Deac, Călin Cainap, Patriciu Achimaș-Cadariu, Mădălina Bota, Liliana Resiga, Dan Ștefan Luchian, Ovidiu Vasile Bochiș
{"title":"What to do when nothing else is left to be done - metastatic non-HPV vulvar squamous cell carcinoma with multiple lines of chemotherapy.","authors":"Mihaela Mărioara Stana, Sandra Deac, Călin Cainap, Patriciu Achimaș-Cadariu, Mădălina Bota, Liliana Resiga, Dan Ștefan Luchian, Ovidiu Vasile Bochiș","doi":"10.22551/2021.32.0803.10186","DOIUrl":"https://doi.org/10.22551/2021.32.0803.10186","url":null,"abstract":"<p><p>Recurrent vulvar squamous cell carcinoma with multiple site metastases is a rare entity - (up to 14.2% of the total number of recurrences), with a poor prognosis (only 15% of the patients alive at 5 years). Due to its \"hard to find\" character, there are no standardized guidelines available and the treatment is extrapolated from advanced cervical carcinoma, anal carcinoma and other squamous cell carcinomas. Immunotherapy has shown some positive results in vulvar carcinoma with PD-L1 positive, high TMB, high MSI or with MMR deficiency. An alternative for selected cases without therapeutic resources could be the HPV vaccine. We present the case of a 64-year-old woman diagnosed in 2014 with vulvar squamous cell carcinoma stage II for which she underwent radical vulvectomy with bilateral inguinal lymphadenectomy followed by external radiotherapy. In 2019 she developed local recurrence associated with lung, pleural, lymph nodes and subcutaneous metastasis, treated with three lines of chemotherapy: paclitaxel/carboplatin followed by cisplatin/5-fluorouracil and carboplatin/gemcitabine. The patient's general health status altered progressively, and she died after the 4<sup>th</sup> cycle of carboplatin/gemcitabine. This case's management could be a starting point for the vulvar carcinoma cases where the standard therapeutical options do not represent a choice anymore, providing the necessary example on how to approach it.</p>","PeriodicalId":72274,"journal":{"name":"Archive of clinical cases","volume":"8 3","pages":"50-55"},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c3/ea/acc-08-03-50.PMC8716999.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39646279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Archive of clinical casesPub Date : 2021-12-29eCollection Date: 2021-01-01DOI: 10.22551/2021.32.0803.10183
Budumuri Gautam V Kumar, Purna Ch Sethy, Rohit Gupta
{"title":"A rare etiology of persistent jaundice in type 1 autoimmune hepatitis.","authors":"Budumuri Gautam V Kumar, Purna Ch Sethy, Rohit Gupta","doi":"10.22551/2021.32.0803.10183","DOIUrl":"https://doi.org/10.22551/2021.32.0803.10183","url":null,"abstract":"<p><p>A 24-year-old male without previously known comorbidities presented with progressive jaundice and hepatomegaly. Autoimmune serology and liver biopsy revealed features of autoimmune hepatitis. A treatment by oral prednisolone and azathioprine was initiated, after which he achieved remission. However, hyperbilirubinemia persisted, with a predominantly unconjugated fraction. Hemolytic causes of unconjugated hyperbilirubinemia were ruled out, and the diagnosis of Gilbert syndrome was established.</p>","PeriodicalId":72274,"journal":{"name":"Archive of clinical cases","volume":"8 3","pages":"37-41"},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4e/c2/acc-08-03-37.PMC8717003.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39646276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Archive of clinical casesPub Date : 2021-12-29eCollection Date: 2021-01-01DOI: 10.22551/2021.32.0803.10184
Gonçalo José Pereira Carneiro, Carla Martins
{"title":"Total occlusion of abdominal aorta: still a deadly event in the very elderly.","authors":"Gonçalo José Pereira Carneiro, Carla Martins","doi":"10.22551/2021.32.0803.10184","DOIUrl":"https://doi.org/10.22551/2021.32.0803.10184","url":null,"abstract":"<p><p>Total occlusion of the abdominal aorta is an uncommon but potentially devastating event. Clinical symptoms are usually sudden and may vary depending on the level of the aortic occlusion. Associated morbidity and mortality remain substantial with high rates of limb loss, acute renal failure, rhabdomyolysis, and death. We report a case of a bedridden 91-year-old woman with history of hypertension, hyperlipidemia, anemia and dementia, carried to the emergency department because of bilateral lower limb pallor. She had been at the same department the week before because of the same problems and high blood pressure (BP), but had been discharged after administration of hypotensive drugs and a short period of observation. No attention was paid to those perfusion alterations, or the global picture at all. The physical examination revealed cooling of the lower limbs and significant BP differential between upper and lower limbs (ankle-brachial index of 0.173), leading to the suspicion of bilateral acute limb ischemia. Abdominal, pelvic and lower limb CT was conducted, revealing calcification and important atheromatosis of the thoracic-abdominal aorta and a mural thrombus beginning above the origin of the celiac trunk, with complete occlusion below the origin of the renal arteries. After discussion with Vascular Surgery Department, given the advanced age, known co-morbidities and the timing of diagnosis, the patient was considered not eligible for revascularization surgery and comfort measures were honored. This case highlights the importance of stablishing a timely and correct diagnosis, even in the very elderly, emphasizing that they too benefit from secondary and tertiary prophylaxis, in order to prevent devastating outcomes as this.</p>","PeriodicalId":72274,"journal":{"name":"Archive of clinical cases","volume":"8 3","pages":"42-45"},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b6/12/acc-08-03-42.PMC8717000.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39646277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Archive of clinical casesPub Date : 2021-10-27eCollection Date: 2020-01-01DOI: 10.22551/2020.29.0704.10176
Nariman Khan, Zehra Hasan Kazmi, Rahaf Alkhateb
{"title":"A rare case of NXP-2 positive dermatomyositis.","authors":"Nariman Khan, Zehra Hasan Kazmi, Rahaf Alkhateb","doi":"10.22551/2020.29.0704.10176","DOIUrl":"https://doi.org/10.22551/2020.29.0704.10176","url":null,"abstract":"<p><p>Dermatomyositis is an idiopathic inflammatory myopathy with variable cutaneous manifestations. Several autoantibodies each with distinct clinical phenotypes are associated with the disease. Here we present the case of a 36-year-old Laotian woman with hypothyroidism who presented with severe proximal and distal muscle weakness, dysphagia, diffuse rash, and anasarca that was diagnosed with NXP-2 (nuclear matrix protein 2) antibody positive dermatomyositis. The patient's hospitalization was complicated by disease resistant to conventional therapy.</p>","PeriodicalId":72274,"journal":{"name":"Archive of clinical cases","volume":"7 4","pages":"68-71"},"PeriodicalIF":0.0,"publicationDate":"2021-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ff/90/acc-07-04-68.PMC8565706.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39712403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lower lateral crural turnover flap combined with alar batten graft for the long-term result of the treatment of alar convexities.","authors":"Philippine Merlin, Amanda Fanous, Jean-Paul Marie, Nicolas Bon Mardion, Nadia Benmoussa","doi":"10.22551/2019.22.0601.10147","DOIUrl":"https://doi.org/10.22551/2019.22.0601.10147","url":null,"abstract":"<p><strong>Introduction: </strong>Concave lower lateral cartilages not only cause an esthetic defect but can also lead to external nasal valve insufficiency. The objective of this article is to analyze the combination of two well-known surgical techniques: turning over the alar cartilages as well as the addition of grafts in order to obtain satisfying esthetic and functional long term results.</p><p><strong>Materials and methods: </strong>From August 2016 to July 2018, 62 rhinoplasties, a combination of both primary and revision cases, were performed at the Rouen University Hospital in France. Six of these involved the correction of concave alar cartilages. The turnover technique alone or in combination with Batten grafts was performed.</p><p><strong>Results: </strong>Immediate and 3-months post-operative esthetic results using the turnover flap technique were satisfactory. Alar batten grafts were occasionally employed in order to maintain the newly positioned alar cartilages and avoid long-term contour depressions.</p><p><strong>Conclusion: </strong>The combination of these two techniques seems to be an interesting solution to maintain long-term esthetic results.</p>","PeriodicalId":72274,"journal":{"name":"Archive of clinical cases","volume":"6 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2021-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c4/86/acc-06-01-1.PMC8565695.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39605220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cephalic undifferentiated carcinoma with osteoclast-like giant cells arising from the main pancreatic duct: case report and literature review.","authors":"Andreea Rusu, Simona Eliza Giuşcă, Delia Gabriela Ciobanu Apostol, Lidia Ionescu, Irina-Draga Căruntu","doi":"10.22551/2019.22.0601.10148","DOIUrl":"https://doi.org/10.22551/2019.22.0601.10148","url":null,"abstract":"<p><p>Undifferentiated carcinoma with osteoclast-like giant cell (UCOGC) is a ductal carcinoma variant with a recently reported more protracted survival and pathognomonic histology comprising two cell populations: the mononuclear tumoral cells and nontumoral multinucleated giant cells. It usually presents as a large heterogenic tumor with mixed solid-cystic components. The tumor develops from the ductal epithelium but the sequence of epithelial changes is often not identified due to the rapid tumoral growth and associated necrotic changes. We report a case of a 76-year-old patient diagnosed with cephalic UCOGC originating in the epithelium of the main pancreatic duct with endoluminal growth and foci of other ductal neoplasms (high-grade pancreatic intraepithelial neoplasia (PanIN) and conventional ductal carcinoma). The particularity of our case consists in the identification of the columnar epithelium conversion, through high-grade PanIN, into UCOGC specific malignant features, in a large size tumor - aspect usually reported in small tumors. Alongside our case we also present a brief literature review of cephalic UCOGC case reports and case series.</p>","PeriodicalId":72274,"journal":{"name":"Archive of clinical cases","volume":"6 1","pages":"6-21"},"PeriodicalIF":0.0,"publicationDate":"2021-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0a/f2/acc-06-01-6.PMC8565694.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39605674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}