Archive of clinical cases最新文献

Spontaneous resolution of pemphigus vulgaris-induced desquamative gingivitis. A case report and brief review of the literature.

IF 0.8

Archive of clinical cases Pub Date : 2025-02-06 eCollection Date: 2025-01-01 DOI: 10.22551/2025.46.1201.10304

Dante Migliari

引用次数: 0

Non-toxigenic Vibrio cholerae - just another cause of vibriosis or a potential new pandemic?

IF 0.8

Archive of clinical cases Pub Date : 2025-02-06 eCollection Date: 2025-01-01 DOI: 10.22551/2025.46.1201.10305

George Sebastian Gherlan, Dragos Stefan Lazar, Simin Aysel Florescu, Raluca Mihaela Dirtu, Daniel Romeo Codreanu, Stefan Lupascu, Maria Nica

{"title":"Non-toxigenic Vibrio cholerae - just another cause of vibriosis or a potential new pandemic?","authors":"George Sebastian Gherlan, Dragos Stefan Lazar, Simin Aysel Florescu, Raluca Mihaela Dirtu, Daniel Romeo Codreanu, Stefan Lupascu, Maria Nica","doi":"10.22551/2025.46.1201.10305","DOIUrl":"10.22551/2025.46.1201.10305","url":null,"abstract":"Although nontoxigenic Vibrio cholerae usually stands in the shadow of the two serogroups (O1 and O139) that cause pandemic cholera, its role in human pathology is increasingly recognized and described in the literature. The habitat of these pathogens is brackish seawater or even freshwater, and the infections caused by them include contact with these waters or consumption of seafood originating in this habitat, which is constantly expanding because of global warming. This habitat extension is a typical example of climate change's impact on infectious diseases. Although nontoxigenic Vibrio cholerae strains are rarely capable of producing the classical cholera toxin, they possess many other virulence factors, can secrete various other toxins, and thus produce illnesses that are sometimes even severe or life-threatening, more frequently in immunocompromised patients. Vibriosis may manifest as gastrointestinal illnesses, wounds, skin or subcutaneous tissue infections, or septicemia. To establish the correct etiological diagnosis for these infections, a high index of suspicion must be maintained, as the diagnostic techniques require targeted investigations and specific collection and transportation of the samples. Empiric treatment recommendations are available, but owing to the increasing resistance of this pathogen, susceptibility testing is needed for every diagnosed case. We intend to raise awareness regarding these infections, as they tend to be more frequent than they were in the past and to appear in areas where they had not been recognized before.","PeriodicalId":72274,"journal":{"name":"Archive of clinical cases","volume":"12 1","pages":"5-16"},"PeriodicalIF":0.8,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11801190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pembrolizumab-induced simultaneous and multiple immune-related adverse events including myasthenia gravis, myositis, hepatitis, and pityriasis lichenoides in a non-small cell lung cancer patient.

IF 0.8

Archive of clinical cases Pub Date : 2025-02-06 eCollection Date: 2025-01-01 DOI: 10.22551/2025.46.1201.10306

Mi-Ran Han, Chang-Hoon Lee, So-Yeon Jeon, Ho-Young Yhim, Na-Ri Lee, Jae-Yong Kwak, Ho-Sung Park, Eun-Kee Song

{"title":"Pembrolizumab-induced simultaneous and multiple immune-related adverse events including myasthenia gravis, myositis, hepatitis, and pityriasis lichenoides in a non-small cell lung cancer patient.","authors":"Mi-Ran Han, Chang-Hoon Lee, So-Yeon Jeon, Ho-Young Yhim, Na-Ri Lee, Jae-Yong Kwak, Ho-Sung Park, Eun-Kee Song","doi":"10.22551/2025.46.1201.10306","DOIUrl":"10.22551/2025.46.1201.10306","url":null,"abstract":"Pembrolizumab, an immune checkpoint inhibitor (ICI) targeting the programmed cell death protein 1 (PD-1) receptor on T cells, enhances the immune system's ability to recognize and attack cancer cells. However, immune-related adverse events (irAEs) may arise, necessitating careful monitoring during treatment. Here, we present the case of a 47-year-old woman who developed multiple irAEs following pembrolizumab therapy. Initially diagnosed with Stage IIIB non-small cell lung cancer, she underwent chemotherapy followed by concurrent chemoradiotherapy. After two years of monitoring, progression of disease was observed, and pembrolizumab was initiated as second-line chemotherapy. Shortly thereafter, she presented with left-sided ptosis and weakness in both upper and lower extremities. Diagnostic evaluation, including a tensilon test and laboratory findings, confirmed with myositis, hepatitis, and myasthenia gravis. Treatment with steroids and neostigmine led to marked clinical improvement. Two months later, the patient developed additional dermatological symptoms, including rash and pruritus. Skin biopsy confirmed a diagnosis of pityriasis lichenoides. She is currently receiving antihistamines therapy, with no further exacerbation. This case underscores the importance of recognizing and promptly managing irAEs associated with ICIs to ensure patient safety and treatment efficacy.","PeriodicalId":72274,"journal":{"name":"Archive of clinical cases","volume":"12 1","pages":"17-21"},"PeriodicalIF":0.8,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11801189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuropsychiatric symptoms as early indicators of brain tumors. 神经精神症状是脑肿瘤的早期指标。

IF 0.8

Archive of clinical cases Pub Date : 2024-12-20 eCollection Date: 2024-01-01 DOI: 10.22551/2024.45.1104.10302

George-Cătălin Moroşan, Andreea-Cătălina Moroşan, Cătălina Ionescu, Anca Sava

{"title":"Neuropsychiatric symptoms as early indicators of brain tumors.","authors":"George-Cătălin Moroşan, Andreea-Cătălina Moroşan, Cătălina Ionescu, Anca Sava","doi":"10.22551/2024.45.1104.10302","DOIUrl":"10.22551/2024.45.1104.10302","url":null,"abstract":"Brain tumors, despite the high mortality and morbidity, they are a rare type of heterogenous tumors that are highly dependent on sex, age, race, level of education, and socioeconomic status. Due to their high mortality rates, it is important to identify as many potential biomarkers for early detection as the earlier the tumor is discovered, the better the prognosis. One such early biomarker we propose in the current paper is the assessment of anxiety, depression, and cognitive changes. In most cancer patients, a certain degree of anxiety and depression is expected upon receiving the diagnosis as it triggers fears regarding the prognosis, possible side effects of the treatment, and even the possibility of the treatment failing. In this paper we analyzed the way anxiety, depression, and cognitive changes present themselves in the case of several types of tumors and whether these could be used as early markers. We have observed that most of the cognitive changes present are due to the location, size, and type of the tumor with some highly connected to anxiety and depression. Moreover, in the case of certain tumors, the removal of the mass has not improved the mood or cognitive function.","PeriodicalId":72274,"journal":{"name":"Archive of clinical cases","volume":"11 4","pages":"120-126"},"PeriodicalIF":0.8,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11661549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Superior pancreaticoduodenal artery pseudoaneurysm with subsequent hemosuccus pancreaticus: an unusual complication of chronic pancreatitis. 胰十二指肠上动脉假性动脉瘤并发胰血浆液：一种罕见的慢性胰腺炎并发症。

IF 0.8

Archive of clinical cases Pub Date : 2024-12-20 eCollection Date: 2024-01-01 DOI: 10.22551/2024.45.1104.10301

Ali Safar, Abdullah AlFawaz

{"title":"Superior pancreaticoduodenal artery pseudoaneurysm with subsequent hemosuccus pancreaticus: an unusual complication of chronic pancreatitis.","authors":"Ali Safar, Abdullah AlFawaz","doi":"10.22551/2024.45.1104.10301","DOIUrl":"10.22551/2024.45.1104.10301","url":null,"abstract":"The development of an arterial pseudoaneurysm is an unusual complication of chronic pancreatitis. The most commonly involved artery is the splenic artery. This is a case report describing a case of a superior pancreaticoduodenal artery pseudoaneurysm in a patient with chronic pancreatitis who developed hemosuccus pancreaticus. A 46-year-old man with history of binge ethanol intake presented to the emergency department with abdominal pain. A computed tomography (CT) scan showed features of chronic pancreatitis along with a 2 x 1.8 cm enhancing mass at the level of the pancreatic head, consistent with an arterial pseudoaneurysm in close proximity to the pancreatic duct as confirmed on endoscopic ultrasound. He underwent an endoscopic retrograde cholangiopancreatography in the context of a rise in his liver enzymes with the presence of gallbladder sludge. This was complicated by hemosuccus pancreaticus, which was successfully managed with percutaneous angioembolization. Despite its unusual incidence, pseudoaneurysm remains an important complication of chronic pancreatitis with a high mortality rate in case of acute hemorrhage. Diagnostic modalities include abdominal CT and Color Doppler ultrasound. Endovascular techniques are considered to be the first line of therapy in most cases. Early recognition and management of pancreatic pseudoaneurysms is important to avoid life-threatening hemorrhage.","PeriodicalId":72274,"journal":{"name":"Archive of clinical cases","volume":"11 4","pages":"114-119"},"PeriodicalIF":0.8,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11661550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of peripartum cardiomyopathy in dichorionic diamniotic twin pregnancy. 双绒毛膜双羊膜双胎妊娠围生期心肌病1例。

IF 0.8

Archive of clinical cases Pub Date : 2024-12-11 eCollection Date: 2024-01-01 DOI: 10.22551/2024.45.1104.10299

Kanis Fatema, Zhi Ying Tan, Uduwarage Ranaweera

引用次数: 0

Innovative surgical management of gestational gigantomastia. 妊娠期巨乳症的创新外科治疗。

IF 0.8

Archive of clinical cases Pub Date : 2024-12-11 eCollection Date: 2024-01-01 DOI: 10.22551/2024.45.1104.10300

Shafic Abdulkarim, Ammar Saed Aldien, Abdulaziz Alazzam, Karyne Martel

引用次数: 0

Incidental diagnosis of medullary thyroid microcarcinoma in COVID-19 patient with elevated procalcitonin levels. 降钙素原升高的COVID-19患者甲状腺髓样微癌的偶然诊断。

IF 0.8

Archive of clinical cases Pub Date : 2024-12-03 eCollection Date: 2024-01-01 DOI: 10.22551/2024.45.1104.10297

Milka Jandric, Biljana Zlojutro, Danica Momcicevic, Sasa Dragic, Sandra Topolovac, Tijana Kovacevic, Pedja Kovacevic

{"title":"Incidental diagnosis of medullary thyroid microcarcinoma in COVID-19 patient with elevated procalcitonin levels.","authors":"Milka Jandric, Biljana Zlojutro, Danica Momcicevic, Sasa Dragic, Sandra Topolovac, Tijana Kovacevic, Pedja Kovacevic","doi":"10.22551/2024.45.1104.10297","DOIUrl":"10.22551/2024.45.1104.10297","url":null,"abstract":"A 38-year-old male patient was admitted to the Medical Intensive Care Unit during the second wave of the coronavirus disease (COVID-19) pandemic presenting with fever, headache, muscle pain, and cough. The low-dose chest computed tomography (CT) result was normal, but an increased serum level of procalcitonin (PCT) was detected. Due to COVID-19, pronounced symptoms, and increased inflammatory markers, empiric antibiotic therapy was started. PCT level remained elevated despite 7 days of antimicrobial treatment. Hence, the diagnostic evaluation of the patient was expanded, and we identified medullary thyroid microcarcinoma. After diagnosis, a total thyroidectomy with cervical lymph node resection was performed, and the patient was discharged with oral levothyroxine. Control measurements of serum calcitonin and 18F-fluorodihydroxyphenylalanine positron emission tomography (18F-PET/CT) showed cervical and mediastinal lymph node metastases. Beside surgical treatment, the patient was not motivated for any adjuvant therapy and no new lesions were detected on control PET/CT two years after. In conclusion, clinicians should also consider malignancies such as medullary thyroid carcinoma as a potential cause of increased PCT levels, and as a next step should measure serum calcitonin level and perform neck ultrasound.","PeriodicalId":72274,"journal":{"name":"Archive of clinical cases","volume":"11 4","pages":"98-101"},"PeriodicalIF":0.8,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11615157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent pneumothoraces in a patient with pulmonary Langerhans cell histiocytosis accompanied with unexpected histological changes. 肺朗格汉斯组织细胞增多症患者复发性气胸伴意外组织学改变。

IF 0.8

Archive of clinical cases Pub Date : 2024-12-03 eCollection Date: 2024-01-01 DOI: 10.22551/2024.45.1104.10298

Clement Tan, Prahalath Sundaram

引用次数: 0

Unveiling the uncommon: a captivating case of multiple autoimmune syndrome. 揭开不寻常的面纱：多发性自身免疫综合征的迷人病例。

IF 0.8

Archive of clinical cases Pub Date : 2024-10-09 eCollection Date: 2024-01-01 DOI: 10.22551/2024.44.1103.10293

Karan J Yagnik, Payal Chhabria, Hardikkumar Bhanderi, Peter N Fish

引用次数: 0