Antimicrobial stewardship & healthcare epidemiology : ASHE最新文献

{"title":"Outbreak of mucocutaneous <i>Candida</i> infections in newborns: clinical implications, investigation, and control measures.","authors":"Lorenzo Chiusaroli, Giacomo Facchin, Claudia Cozzolino, Marco Bolzonella, Ottavia Facchinelli, Maria Nocera, Debora Scomparin, Ilaria Pezzani, Anna Stramare, Monia Gatto, Arianna Vidori, Vincenzo Baldo, Sabrina Marconato, Elisabetta Bressan","doi":"10.1017/ash.2025.10282","DOIUrl":"https://doi.org/10.1017/ash.2025.10282","url":null,"abstract":"<p><strong>Background: </strong>Mucocutaneous fungal infections, particularly oral and genital candidiasis, are the most common fungal diseases in neonatal populations. Although generally mild, non-invasive <i>Candida</i> infections can serve as sources of colonization increasing the risk of progression to invasive candidiasis, especially in preterm neonates.</p><p><strong>Objective design setting patients and interventions: </strong>This study aimed to describe the infection prevention and control (IPC) measures, including contact precautions, disinfection of environment and shared devices and the review of hand hygiene protocols implemented during an outbreak of neonatal <i>Candida</i> spp. infections in a newborn nursery and special care unit of a secondary hospital, and to analyze associated neonatal and maternal risk factors.An observational cohort study was conducted following the identification of an outbreak between April and June 2024. A case was defined as a neonate with clinical signs of oral or genital candidiasis and/or microbiological confirmation from mucosal swabs.</p><p><strong>Results: </strong>125 neonates and mothers were included, 16 neonates (12.8%) met the case definition. Female sex, small-for-gestational-age status, Apgar score <7, and need for phototherapy were significantly associated with infection. Maternal primiparity also showed a significant association, whereas maternal vaginal <i>Candida</i> colonization and antibiotic exposure did not. After the implementation of IPC measures, decline of cases was observed. All affected neonates received antifungal therapy and recovered fully without progression to invasive disease.</p><p><strong>Conclusion: </strong>This outbreak demonstrates that even full-term neonates can be at risk for mucocutaneous <i>Candida</i> infection. The application of IPC measures highlights the importance of surveillance, and environmental sanitation in controlling infection transmission.</p>","PeriodicalId":72246,"journal":{"name":"Antimicrobial stewardship & healthcare epidemiology : ASHE","volume":"6 1","pages":"e28"},"PeriodicalIF":0.0,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12835949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146095034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for infections after urological procedures among patients with negative urine culture screening.","authors":"Nutnicha Tantiwattanapaibul, Anucha Apisarnthanarak, Patranuch Noppakulsatit, Chatchawet Liwrotsap, Teerayut Tangpaitoon, Valeerat Swatesutipun, Dollacha Vanichakarn, Natthapitch Tangkaew, Kittiya Jantarathaneewat, Nuntra Suwantarat","doi":"10.1017/ash.2025.10271","DOIUrl":"https://doi.org/10.1017/ash.2025.10271","url":null,"abstract":"<p><p>In this retrospective cohort, chronic kidney disease stage III-V (<i>P</i> = .005), history of previous urinary tract infection within 3 months (<i>P</i> < .05), Revised Cardiac Risk Index for preoperative risk ≥2 (<i>P</i> = .002), and percutaneous nephrolithotomy procedure (<i>P</i> < .05) were associated with risks of infections after urological procedures among patients with negative urine culture screening.</p>","PeriodicalId":72246,"journal":{"name":"Antimicrobial stewardship & healthcare epidemiology : ASHE","volume":"6 1","pages":"e26"},"PeriodicalIF":0.0,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12835951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146094984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identified needs in antimicrobial stewardship education for pediatric advanced practice providers: a qualitative analysis.","authors":"Nadia Hill, Jade C Riopelle, Molly Eron, Yasaman Fatemi, Kristin D Maletsky","doi":"10.1017/ash.2025.10278","DOIUrl":"https://doi.org/10.1017/ash.2025.10278","url":null,"abstract":"<p><strong>Introduction: </strong>There is limited research investigating advanced practice provider (APP) knowledge and perspectives on education in antimicrobial stewardship (AS).</p><p><strong>Setting: </strong>Large academic children's hospital.</p><p><strong>Participants: </strong>APPs in Division of Pediatrics, Antimicrobial Stewardship Program (ASP) stakeholders.</p><p><strong>Objective design: </strong>We conducted four focus groups with APPs and one focus group with ASP stakeholders. APPs were asked eleven open questions about training, influences on prescribing practices, knowledge gaps and desired topics for education in AS as well as general barriers to learning. ASP stakeholders were asked five open-ended questions about teaching initiatives, knowledge gaps and high yield teaching topics for APPs.</p><p><strong>Results: </strong>20 APPs and 6 ASP stakeholders (1 medical director, 3 pharmacists and 2 pediatric infectious diseases fellows) participated in focus groups. Four domains and eight themes were generated. (1) Barriers to AS in Practice: lack of critical thinking and conflict between the ASP and APPs within the cultural context of the institution. (2) Approach to Education: logistical challenges to curriculum development and adopting APP centered approaches to teaching. (3) Education for New to Practice APPs: learning basics of microbiology, infectious diseases and utilizing resources to encourage AS in practice. (4) Education for Experienced APPs: learning approaches to common clinical scenarios and updates to improve AS in practice.</p><p><strong>Conclusions: </strong>Curricular content should acknowledge the cultural influences of the institution, target knowledge gaps and areas of interest of learners, and be delivered via flexible and engaging learning modalities that encourage maximal participation.</p>","PeriodicalId":72246,"journal":{"name":"Antimicrobial stewardship & healthcare epidemiology : ASHE","volume":"6 1","pages":"e25"},"PeriodicalIF":0.0,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12835947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146095014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of an interruptive electronic health record alert improves optimal antibiotic prescribing in ambulatory patients with acute bacterial sinusitis: a quasi-experiment.","authors":"Stormmy R Boettcher, Anita B Shallal, Adrienne Vaught, Steven T Fried, John R Craig, Brian M Church, Rachel M Kenney, Susan L Davis, Michael P Veve","doi":"10.1017/ash.2025.10283","DOIUrl":"https://doi.org/10.1017/ash.2025.10283","url":null,"abstract":"<p><p>Sinusitis is a leading cause for outpatient antibiotics. An interruptive electronic health record alert was implemented to promote optimal antibiotic selection and duration for acute bacterial sinusitis when suboptimal treatment is ordered. After implementation, optimal antibiotic prescribing significantly increased 7% preintervention versus 30% postintervention, (unadjOR, 5.69; 95% CI, 2.36 - 13.72; <i>P</i> < .001).</p>","PeriodicalId":72246,"journal":{"name":"Antimicrobial stewardship & healthcare epidemiology : ASHE","volume":"6 1","pages":"e24"},"PeriodicalIF":0.0,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12835937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146095026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introduction of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) nasal polymerase chain reaction testing combined with pharmacist ordering and intervention reduces anti-MRSA antibiotic use in a multi-hospital system.","authors":"Curtis D Collins, Chiraag Gupta, Jennifer Chou, James Shen, Holly Murphy","doi":"10.1017/ash.2025.10270","DOIUrl":"10.1017/ash.2025.10270","url":null,"abstract":"<p><p>Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) nasal polymerase chain reaction implementation combined with pharmacist oversight across four hospitals resulted in a 20.2% reduction in anti-MRSA agent standardized antimicrobial administration ratios with significant reductions across 17 of 23 patient care units, further supporting this approach as an effective, multi-center, antimicrobial stewardship strategy.</p>","PeriodicalId":72246,"journal":{"name":"Antimicrobial stewardship & healthcare epidemiology : ASHE","volume":"6 1","pages":"e23"},"PeriodicalIF":0.0,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12813714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146013574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postpandemic masking practices among health care personnel: beliefs, barriers, and opportunities for improving adherence in clinical settings.","authors":"Karina Ohri, Samantha E Hanley, Nicholas Allis, Telisa Stewart, Mitchell Brodey, Paul Suits, Stephen J Thomas, Jana Shaw","doi":"10.1017/ash.2025.10265","DOIUrl":"10.1017/ash.2025.10265","url":null,"abstract":"<p><strong>Objective: </strong>This study examines gaps in mask-related behaviors, beliefs, and perceptions among healthcare personnel (HCP), investigates the influence of vaccination status on masking practices, and identifies opportunities to enhance adherence in clinical settings.</p><p><strong>Methods: </strong>A survey was conducted among HCP providing direct patient care at State University of New York Upstate Medical University from November 2024 to January 2025.</p><p><strong>Results: </strong>A total of 655 HCP responded to the survey. Of these, 335 (51.1%) reported being up to date on coronavirus (COVID-19) vaccination, and 501 (76.5%) intended to receive the 2024 - 2025 influenza vaccine. Majority believed masking protects them (<i>n</i> = 381, 61%) and others (<i>n</i> = 400, 64.6%), perceived the workplace as carrying a high respiratory risk (<i>n</i> = 366, 58.6%), and believed patient masking offers protective benefits (<i>n</i> = 359, 57.4%). Self-reported masking rates were highest when participants were sick or symptomatic (<i>n</i> = 477, 72.8%) and lowest during respiratory specimen collection (<i>n</i> = 233, 35.6%). High adherence was observed when participants were symptomatic, among those who were up to date on their COVID-19 vaccination (<i>n</i> = 276, 82.4%) and who intended to receive the 2024 - 2025 influenza vaccine (<i>n</i> = 407, 81.2%).</p><p><strong>Conclusion: </strong>These findings suggest self-reported masking adherence remains suboptimal, reflecting low perceived risk of COVID-19 infection in the postpandemic period. Targeted interventions highlighting masking as an important component of broader measures including vaccination, hand hygiene, and ventilation are needed to enhance hospital infection prevention and control.</p>","PeriodicalId":72246,"journal":{"name":"Antimicrobial stewardship & healthcare epidemiology : ASHE","volume":"6 1","pages":"e22"},"PeriodicalIF":0.0,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12813722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146013611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A bundle of the top 10 OPAT publications in 2024.","authors":"Lindsey M Childs-Kean, Sara F Azimi, Alison M Beieler, Laila Castellino, Sara C Keller, Margaret Pertzborn, Alexandra Yamshchikov, Leah H Yoke, Kathleen Young, Monica V Mahoney","doi":"10.1017/ash.2025.10281","DOIUrl":"10.1017/ash.2025.10281","url":null,"abstract":"<p><strong>Objective: </strong>Outpatient parenteral antimicrobial therapy (OPAT) is a mainstay of clinical infectious diseases practice, and OPAT-related publications continue to be prominent in journals. The objective of this article is to summarize ten clinically important OPAT-related publications from 2024.</p><p><strong>Design: </strong>Narrative review.</p><p><strong>Methods: </strong>Eighty-one articles were found in a literature search, and 56 met inclusion criteria. A survey containing 25 articles was sent to an email listserv of clinicians with OPAT experience.</p><p><strong>Results: </strong>This article summarizes the top 10 OPAT articles published in 2024, based on those survey results.</p><p><strong>Conclusions: </strong>Common themes from the top 10 OPAT articles published in 2024 included OPAT clinician workload, patient perspectives of OPAT, tools for OPAT work, and dalbavancin use.</p>","PeriodicalId":72246,"journal":{"name":"Antimicrobial stewardship & healthcare epidemiology : ASHE","volume":"6 1","pages":"e20"},"PeriodicalIF":0.0,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12813723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146013540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergence of a novel genotype of extensively drug-resistant <i>Shigella sonnei</i> carrying <i>blaDHA-1</i> in diverse patient populations, Los Angeles, 2024-2025.","authors":"Shekina Gonzalez-Ferrer, Bennett Shaw, Lilian Fung, Raphael J Landovitz, Daniel Z Uslan, Shangxin Yang","doi":"10.1017/ash.2025.10280","DOIUrl":"10.1017/ash.2025.10280","url":null,"abstract":"<p><p>Extensively drug-resistant (XDR) <i>Shigella</i> is a public health threat, historically linked to <i>blaCTX-M-15</i> gene in sexually transmitted cases. We describe a novel XDR <i>S. sonnei</i> carrying an AmpC-type <i>blaDHA-1</i> gene from two unrelated cases with unknown transmission route; whole-genome sequencing revealed close genetic relatedness, signaling broader community spread.</p>","PeriodicalId":72246,"journal":{"name":"Antimicrobial stewardship & healthcare epidemiology : ASHE","volume":"6 1","pages":"e19"},"PeriodicalIF":0.0,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12813715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146013594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Education and electronic health record implementation-better together? An assessment of compliance of oral vancomycin dosing for <i>Clostridioides difficile</i> infection and the impact of different antimicrobial stewardship interventions.","authors":"Jordan Chiasson, Jeremie Sawadogo, Michael Kent","doi":"10.1017/ash.2025.10272","DOIUrl":"10.1017/ash.2025.10272","url":null,"abstract":"","PeriodicalId":72246,"journal":{"name":"Antimicrobial stewardship & healthcare epidemiology : ASHE","volume":"6 1","pages":"e21"},"PeriodicalIF":0.0,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12813713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146013586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What should infectious diseases clinicians know about pharmacy benefit managers and their impact on our patients?","authors":"Karan Raja, Antoinette Acbo, Humberto R Jimenez, David Silverman, Austin Golia, Alyssa Joy Ford, Priya Nori","doi":"10.1017/ash.2025.10277","DOIUrl":"10.1017/ash.2025.10277","url":null,"abstract":"<p><p>Pharmacy Benefit Managers (PBMs) are contracted by health plans, employers, and government programs to manage pharmacy and prescription drug benefits. They maintain drug formularies, process and pay pharmacy claims, establish and manage pharmacy networks, and negotiate prices with manufacturers and pharmacies. Despite PBMs' role in cost management, their lack of transparency and complex administrative processes can delay treatment and increase out-of-pocket costs, affecting vulnerable populations like those in pharmacy deserts. These factors influence healthcare delivery for persons living with human immunodeficiency virus, Hepatitis C Virus, and other conditions. Herein, we describe PBM practices and their impacts on infectious diseases patients and highlight mitigation strategies to facilitate timely and equitable medication access.</p>","PeriodicalId":72246,"journal":{"name":"Antimicrobial stewardship & healthcare epidemiology : ASHE","volume":"6 1","pages":"e18"},"PeriodicalIF":0.0,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12813721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146013538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}