Fernando H Centeno, Todd Lasco, Ahmed M Hamdi, Mayar Al Mohajer
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Utility of microbial cell-free DNA sequencing in the diagnosis of mycobacterial infections in a quaternary care center.
We examine the performance of microbial cell-free DNA (mcfDNA) next-generation sequencing (NGS) testing on patients admitted to a quaternary care hospital in Houston, Texas. The test was 75.0% sensitive and 97.8% specific for all mycobacterial infections. mcfDNA NGS results led to adjustments in antimicrobial therapy for seven of nine patients with positive results.
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