Annals of Ibadan postgraduate medicine最新文献

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MENSTRUAL PATTERN CHANGES AMONG WOMEN DURING THE COVID-19 PANDEMIC IN IBADAN, A CROSS-SECTIONAL STUDY. 横断面研究:伊巴丹省2019冠状病毒病大流行期间女性月经模式的变化
F M Akinlusi, R A Abdus-Salam, Y Bello, O C Idowu, I O Morhason-Bello
{"title":"MENSTRUAL PATTERN CHANGES AMONG WOMEN DURING THE COVID-19 PANDEMIC IN IBADAN, A CROSS-SECTIONAL STUDY.","authors":"F M Akinlusi, R A Abdus-Salam, Y Bello, O C Idowu, I O Morhason-Bello","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Coronavirus disease (COVID-19) is an infectious respiratory disease characterised by a spectrum of symptoms ranging from asymptomatic to severe. The COVID-19 pandemic and subsequent lockdowns were associated with varying degrees of stress among individuals. The hypothalamus-pituitary-ovarian axis, which regulates the menstrual cycle, may be significantly affected by stress.</p><p><strong>Objective: </strong>To investigate the effect of COVID-19 infection and pandemic lockdown on the menstrual pattern of women.</p><p><strong>Methods: </strong>A cross-sectional study of women exposed to COVID-19 was conducted using a questionnaire to collect data on socio-demographic characteristics, COVID-19 exposure, and menstrual patterns. Participants were categorised based on their COVID-19 test results. Analyses were conducted using STATA (StataCorp L.L.C.) version 15.0 and at a significance level of p < 0.05.</p><p><strong>Results: </strong>Among the 218 respondents, only 93 (42.7%) had testing for COVID- 19. Among those who tested, only 36 (16.5% of all participants) tested positive for COVID-19 infection. Majority of respondents (80.7%) had regular menses before pandemic lockdown. About 1 in 5 (21.4%) respondents reported changes in menstrual pattern. The odds of experiencing changes in menstrual pattern was not significantly higher among women who tested positive for SARS-CoV2 (aOR = 1.71, 95% CI: 0.47 - 6.23). Extremes of reproductive age was associated with menstrual irregularities before the pandemic and changes in menstrual pattern during the lockdown.</p><p><strong>Conclusion: </strong>Irregularities in menstrual pattern remains common especially in the early and late reproductive years. Changes in menstrual pattern was common among respondents during the pandemic lockdown. Infection with SARS-CoV2 virus was not associated changes in menstrual pattern during the pandemic.</p>","PeriodicalId":72221,"journal":{"name":"Annals of Ibadan postgraduate medicine","volume":"21 1","pages":"92-99"},"PeriodicalIF":0.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13399168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CARDIOVASCULAR COMPLICATIONS OF CHEMOTHERAPY IN BREAST CANCER: A SCOPING REVIEW. 乳腺癌化疗的心血管并发症:范围综述。
O A Orimolade, O S Ogah, O A Ajagbe, D A Adebayo, O O Ayandipo, A A Adebiyi, T O Ogundiran
{"title":"CARDIOVASCULAR COMPLICATIONS OF CHEMOTHERAPY IN BREAST CANCER: A SCOPING REVIEW.","authors":"O A Orimolade, O S Ogah, O A Ajagbe, D A Adebayo, O O Ayandipo, A A Adebiyi, T O Ogundiran","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Chemotherapy remains a cornerstone in breast cancer management but is associated with significant cardiovascular toxicity, which may adversely affect long-term outcomes. Anthracyclines are particularly implicated due to their dose-dependent cardiotoxic effects.</p><p><strong>Objective: </strong>To synthesize current evidence on chemotherapy-induced cardiotoxicity in breast cancer, with emphasis on anthracycline-related cardiac dysfunction, including epidemiology, mechanisms, risk factors, detection, and prevention.</p><p><strong>Methods: </strong>A scoping review of peer-reviewed literature was conducted using PubMed, Scopus, Web of Science, and Google Scholar. Studies evaluating cardiovascular complications of chemotherapy in breast cancer were included.</p><p><strong>Results: </strong>Cardiotoxicity risk is associated with cumulative anthracycline dose, concurrent use of cardiotoxic agents such as trastuzumab, and pre-existing cardiovascular disease. Mechanisms include oxidative stress, mitochondrial dysfunction, and topoisomerase II inhibition. Early detection using speckletracking echocardiography and biomarkers such as troponins and natriuretic peptides allows identification of subclinical myocardial injury. Preventive strategies-including dose modification, liposomal anthracyclines, and cardioprotective agents such as dexrazoxane, beta-blockers, and ACE inhibitors-demonstrate benefit.5/13/2026.</p><p><strong>Conclusion: </strong>Chemotherapy-induced cardiotoxicity remains a major clinical challenge. Early detection, risk stratification, and integrated cardio-oncology care are essential to improving outcomes in breast cancer patients.</p>","PeriodicalId":72221,"journal":{"name":"Annals of Ibadan postgraduate medicine","volume":"24 1","pages":"63-73"},"PeriodicalIF":0.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13418214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148622851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MULTIPLE INFANTILE HEPATIC HAEMANGIOMA WITH KASABACH-MERRITT SYNDROME PRESENTING WITH RAISED INTRABDOMINAL PRESSURE AND TREATED WITH PROPRANOLOL: A CASE REPORT. 多发性婴儿肝血管瘤伴卡萨巴赫-梅里特综合征,以腹内压升高为表现,用心得安治疗:一例报告。
J O Ugwu, E J Irem, N O Ugwu, O H Ekwunife, V I Modekwe
{"title":"MULTIPLE INFANTILE HEPATIC HAEMANGIOMA WITH KASABACH-MERRITT SYNDROME PRESENTING WITH RAISED INTRABDOMINAL PRESSURE AND TREATED WITH PROPRANOLOL: A CASE REPORT.","authors":"J O Ugwu, E J Irem, N O Ugwu, O H Ekwunife, V I Modekwe","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Infantile hepatic haemangioma is a common benign vascular malformation in the liver, however, its association with Kasabach-Merritt syndrome, raised intrabdominal pressure and intestinal obstruction is rare. We report this case of syndromic infantile hepatic haemangioma to raise awareness for its suspicion in this unusual presentation and the role of propranolol in the management.</p><p><strong>Case summary: </strong>We report a case of a 3-month-old female who presented with abdominal swelling, difficulty in breathing, constipation, bilateral inguinal swellings and protrusion of the rectal mucosa. There were multiple cutaneous vascular lesions on the palms, chest and abdomen. Examination under mild sedation revealed multiple kernel-like nodules in the enlarged liver. She had thrombocytopenia and a computerised tomographic scan of the abdomen showed multiple rim enhancing hyperdense vascular lesions involving the entire liver. She was placed on oral propranolol with regression of the lesion and resolution of symptoms.</p><p><strong>Conclusion: </strong>Multiple Hepatic haemangiomas with Kasabach-Merritt syndrome can present with raised intrabdominal pressure and features of intestinal obstruction. This possibility should be considered particularly in infants also presenting with cutaneous vascular conditions. Conservative care with propranolol is an effective treatment option.</p>","PeriodicalId":72221,"journal":{"name":"Annals of Ibadan postgraduate medicine","volume":"21 1","pages":"151-155"},"PeriodicalIF":0.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13399172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AN UNUSUAL PRESENTATION OF A HUGE BILATERAL TUBO-OVARIAN ABSCESS: A CASE REPORT. 一个不寻常的巨大双侧输卵管卵巢脓肿:1例报告。
S A Adebayo, R O Balogun, B A Esan
{"title":"AN UNUSUAL PRESENTATION OF A HUGE BILATERAL TUBO-OVARIAN ABSCESS: A CASE REPORT.","authors":"S A Adebayo, R O Balogun, B A Esan","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Tubo-ovarian abscess (TOA) is a documented and severe complication of untreated pelvic inflammatory disease. It is a life threatening infection that involves the ovaries, the fallopian tubes, and or any other adjacent tissue with a significant risk of infertility and pelvic adhesions. It is most commonly unilateral.</p><p><strong>Case summary: </strong>This report presents a rare and unusual presentation of a huge bilateral tubo-ovarian abscess in a young woman, who presented with recurrent abdominal pain with no clear signs of infection. Clinical and laboratory findings were suggestive of a complex ovarian mass with elevated CA-125. She had exploratory laparotomy with bilateral ovarian salpingectomy and bilateral ovarian cystectomy based on intraoperative findings.</p><p><strong>Conclusion: </strong>The management of this case underscores the need for having a high index of suspicion for unusual presentations of pelvic masses.</p>","PeriodicalId":72221,"journal":{"name":"Annals of Ibadan postgraduate medicine","volume":"24 1","pages":"165-168"},"PeriodicalIF":0.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13399546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TREND OF EARLY CHILDHOOD CARIES IN A TERTIARY HEALTH INSTITUTION: A 7-YEAR RETROSPECTIVE STUDY. 三级卫生机构儿童早期龋齿趋势:一项7年回顾性研究
O E Ayebameru, A Abe, O I Olaoye, A S Omotuyole, J O Eigbobo
{"title":"TREND OF EARLY CHILDHOOD CARIES IN A TERTIARY HEALTH INSTITUTION: A 7-YEAR RETROSPECTIVE STUDY.","authors":"O E Ayebameru, A Abe, O I Olaoye, A S Omotuyole, J O Eigbobo","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Early childhood caries (ECC) is a common chronic infectious disease affecting young children and it constitutes a significant public health problem. It is the presence of one or more decayed, missing (due to caries), or filled tooth surfaces in any primary tooth in a child under the age of six.</p><p><strong>Aim: </strong>To determine the trend of ECC and its prevalence in a tertiary health institution in Lagos State.</p><p><strong>Methodology: </strong>A retrospective study was carried out among children aged 0-5 years presenting with ECC at the Paediatric Dentistry clinic of the Lagos State University Teaching Hospital (LASUTH) between 2017 and 2023. Data was analyzed using the Statistical Package for the Social Sciences (SPSS) version 21.0, employing the chi-square test for bivariate associations.</p><p><strong>Results: </strong>A total of 5,879 patients presented to the dental clinic during the study period, of whom 451 (7.7%) presented with ECC. Two hundred and twenty (48.8%) of them were boys, while 51.2% were girls. Their mean age was 3.94 ± 1.01 years. Most patients presented with incipient lesions/ simple cavitation (50.3%). The Association between the age of presentation and affected teeth was statistically significant atp -value of < 0.05.</p><p><strong>Conclusion: </strong>The prevalence of ECC was 7.7% and the presentation was at its lowest in the year 2020 and 2021.The majority of patients presented with relatively early (incipient) lesions, hence Glass Ionomer Cement, (GIC) restoration was the treatment mostly carried out.</p>","PeriodicalId":72221,"journal":{"name":"Annals of Ibadan postgraduate medicine","volume":"21 1","pages":"118-124"},"PeriodicalIF":0.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13399214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RELATIONSHIP BETWEEN OPTICAL COHERENCE TOMOGRAPHY FINDINGS AND OPTIC NERVE HEAD FINDINGS AMONG A NIGERIAN POPULATION: A RETROSPECTIVE STUDY. 尼日利亚人群中光学相干断层扫描结果与视神经头结果之间的关系:一项回顾性研究。
T S Obajolowo, S O Adebusoye, I A Yusuf, V A Olatunji, B T Ojibara-Adegboye, A O Ambali
{"title":"RELATIONSHIP BETWEEN OPTICAL COHERENCE TOMOGRAPHY FINDINGS AND OPTIC NERVE HEAD FINDINGS AMONG A NIGERIAN POPULATION: A RETROSPECTIVE STUDY.","authors":"T S Obajolowo, S O Adebusoye, I A Yusuf, V A Olatunji, B T Ojibara-Adegboye, A O Ambali","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Glaucoma is a leading cause of irreversible blindness worldwide. Early detection remains challenging, particularly in resource-limited settings where disc-based assessment is subjective. Optical Coherence Tomography (OCT) provides objective structural measurements such as retinal nerve fiber layer (RNFL) thickness and Bruch's membrane opening (BMO)-minimum rim width (MRW), which may improve diagnostic accuracy.</p><p><strong>Aim: </strong>To evaluate the relationship between OCT-derived parameters and optic nerve head findings among individuals classified as glaucoma suspects or cases using International Society of Geographical and Epidemiological Ophthalmology (ISGEO) criteria in a Nigerian population.</p><p><strong>Methods: </strong>This retrospective study included 310 participants screened during the 2024 World Glaucoma Week at a tertiary hospital. Glaucoma and suspects were defined using ISGEO criteria. OCT imaging (Spectralis SD-OCT) was performed in 55 participants (39.9% of suspects/cases). Global and sectoral RNFL thickness and MRW were analyzed using linear mixed-effects models adjusting for age, sex, and family history.</p><p><strong>Results: </strong>Of the 310 participants, 138 (44.5%) were classified as glaucoma suspects or cases, including 24 (7.7%) with glaucoma. RNFL thickness did not differ significantly between groups (all p≥0.46). In contrast, MRW was significantly thinner in glaucoma cases globally (b = µ26.5 mm; p = 0.043) and in multiple sectors (p < 0.05). Family history was independently associated with glaucoma status (adjusted OR = 1.98; p = 0.031).</p><p><strong>Conclusion: </strong>MRW demonstrated superior discriminatory ability compared to RNFL thickness in differentiating ISGEO-defined glaucoma cases from suspects. These findings support the complementary role of MRW in glaucoma assessment where OCT is available.</p>","PeriodicalId":72221,"journal":{"name":"Annals of Ibadan postgraduate medicine","volume":"24 1","pages":"139-145"},"PeriodicalIF":0.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13418212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148622828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RADICAL HYSTERECTOMY FOR EARLY-STAGE CERVICAL CANCER IN A LOWRESOURCE SETTING: SURGICAL OUTCOMES AND LESSONS FROM A RETROSPECTIVE CROSS-SECTIONAL STUDY. 低资源环境下早期宫颈癌根治性子宫切除术:手术结果和回顾性横断面研究的经验教训
A M Olumodeji, A K Adefemi, M O Adedeji, O Q Edun, U O Olumodeji, K A Rabiu, O I Akinola
{"title":"RADICAL HYSTERECTOMY FOR EARLY-STAGE CERVICAL CANCER IN A LOWRESOURCE SETTING: SURGICAL OUTCOMES AND LESSONS FROM A RETROSPECTIVE CROSS-SECTIONAL STUDY.","authors":"A M Olumodeji, A K Adefemi, M O Adedeji, O Q Edun, U O Olumodeji, K A Rabiu, O I Akinola","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Cervical cancer remains the leading cause of cancer-related deaths among women in low- and middle-income countries, with Sub- Saharan Africa bearing a disproportionate burden. In low-resource settings, cervical cancer often presents at advanced stages due to delayed diagnosis, limiting options for curative surgery.</p><p><strong>Objective: </strong>This study describes the feasibility and outcomes of radical hysterectomy (RH)-an infrequently performed surgical procedure in our context-for early-stage disease at Lagos State University Teaching Hospital (LASUTH), Nigeria.</p><p><strong>Methods: </strong>A retrospective review of all radical hysterectomies performed in 2024 at LASUTH included 7 cases (5.3% of 132 cervical cancer evaluations). Radical hysterectomy represented 0.87% of 804 major gynecologic surgeries. Data collected encompassed demographics, operative details, histopathology, and outcomes. Bilateral internal iliac artery ligation was routine. Statistical analysis was descriptive.</p><p><strong>Results: </strong>The cohort (mean age 48 years, median parity 4) presented after a mean of 28.29 symptom weeks, with 71.4% (5/7) delaying care for more than one month. No patients had prior screening; 28.6% (2/7) wrongly had screening tests requested post-symptom onset. Mean surgery duration was 177.14 minutes and estimated blood loss was 655 mL. Histology showed squamous cell carcinoma (85.7%, 6/7) and adenocarcinoma (14.3%, 1/7). Postoperatively, 28.6% (2/7) had parametrial involvement and 20% (1/5) had nodal metastasis. Adjuvant therapy was initiated in 71.4% (5/7: chemoradiation 42.9%, chemotherapy 28.6%), while 28.6% (2/7) declined due to cost. One post-operative complication of neurogenic bladder (14.3%) was observed, which resolved with conservative management. All patients survived at 12 months.</p><p><strong>Conclusion: </strong>Despite the small series and short follow-up, our findings suggest that radical hysterectomy is safe and feasible within a tertiary centre in Nigeria. This study also highlights the persisting gaps in cervical cancer screening and timely referral in our setting, which limit the number of women eligible for curative surgery.</p>","PeriodicalId":72221,"journal":{"name":"Annals of Ibadan postgraduate medicine","volume":"24 1","pages":"39-45"},"PeriodicalIF":0.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13425399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148655057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PSEUDOMYOPIA IN YOUNG ADULTS, A REPORT OF THREE CASES FROM A SINGLE TERTIARY FACILITY IN IBADAN, NIGERIA. 青年人假性近视:尼日利亚伊巴丹一家三级医疗机构的三例报告。
M O Ugalahi, A B Ogunbiyi, E O Ogbobine, B A Olusanya
{"title":"PSEUDOMYOPIA IN YOUNG ADULTS, A REPORT OF THREE CASES FROM A SINGLE TERTIARY FACILITY IN IBADAN, NIGERIA.","authors":"M O Ugalahi, A B Ogunbiyi, E O Ogbobine, B A Olusanya","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Pseudomyopia is a myopic shift in the refractive power of the eye due to overstimulation of the mechanism of accommodation. It is most common among children and may occur in all types of refractive errors, especially in hyperopia. The usual symptoms of pseudomyopia include asthenopia, intermittent blurry vision and sometimes diplopia. The management starts with recognition, which involves a high index of suspicion, cycloplegic refraction and relaxation of accommodation. This case series describes the management of three young adult female patients who presented with clinical features of pseudomyopia, with a focus on identifying predisposing risk factors and establishing the diagnosis.</p>","PeriodicalId":72221,"journal":{"name":"Annals of Ibadan postgraduate medicine","volume":"24 1","pages":"146-150"},"PeriodicalIF":0.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13399170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DETECTION OF SARS-COV-2 IN MULTIPLE CLINICAL SPECIMENS: A PILOT PREVALENCE STUDY FROM NORTHEAST NIGERIA. 在多个临床标本中检测sars-cov-2:尼日利亚东北部的一项试点流行病学研究
U M Hassan, A A Yarma, A Hayatu, U M Ishiyaku, I Mohammed, A Fatima-Baba, R A Mahdi, M M Manga
{"title":"DETECTION OF SARS-COV-2 IN MULTIPLE CLINICAL SPECIMENS: A PILOT PREVALENCE STUDY FROM NORTHEAST NIGERIA.","authors":"U M Hassan, A A Yarma, A Hayatu, U M Ishiyaku, I Mohammed, A Fatima-Baba, R A Mahdi, M M Manga","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Diagnosis of SARS-CoV-2 infection primarily relies on RTPCR analysis of nasopharyngeal swab (NPS) specimens; however, viral RNA has also been detected in other clinical samples. In Northeast Nigeria, data comparing SARS-CoV-2 detection across multiple specimen types, alongside serological evidence of exposure, remain limited.</p><p><strong>Aim: </strong>This pilot study aimed to determine the prevalence of SARS-CoV-2 RNA in stool, serum, and NPS, and the seroprevalence of anti-SARSCoV- 2 antibodies among hospitalized patients in Gombe, Nigeria.</p><p><strong>Materials and methods: </strong>A cross-sectional study was conducted between March and May 2022 at Federal Teaching Hospital, Gombe. A total of 384 inpatients without prior confirmed COVID-19 were enrolled. Stool, serum, and NPS samples were collected from each participant. Viral RNA was detected using RT-PCR, and SARS-CoV-2-specific IgM and IgG antibodies were assessed separately using a rapid immunochromatographic assay, allowing differentiation between recent and past exposure.</p><p><strong>Results: </strong>Among 384 participants, the overall RT-PCR prevalence of SARSCoV- 2 RNA was 2.1% (8/384). Stool samples yielded the highest positivity rate (1.8%; 7/384), followed by NPS (0.8%; 3/384) and serum (0.3%; 1/ 384). In sharp contrast, the overall antibody seroprevalence was 48.6% (187/384). Among the 362 unvaccinated participants, 46.4% had detectable antibodies.</p><p><strong>Conclusion: </strong>This study revealed a low prevalence of active viral shedding but a high seroprevalence of SARS-CoV-2 antibodies, suggesting widespread, under-detected community exposure. Stool specimens showed a higher detection rate than NPS in this cohort, warranting further investigation as a potential diagnostic sample in resource-limited settings.</p>","PeriodicalId":72221,"journal":{"name":"Annals of Ibadan postgraduate medicine","volume":"21 1","pages":"100-106"},"PeriodicalIF":0.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13399292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RETROSPECTIVE ANALYSIS OF CLINICAL PRESENTATIONS AND MANAGEMENT OUTCOMES OF PATIENTS MANAGED FOR CERVICOFACIAL NECROTIZING FASCIITIS AT THE UNIVERSITY COLLEGE HOSPITAL, IBADAN. 伊巴丹大学附属医院颈面坏死性筋膜炎患者的临床表现和治疗结果的回顾性分析。
T O Aladelusi, A A Salami, S O Agboola, O O Gbolahan, A A Olusanya
{"title":"RETROSPECTIVE ANALYSIS OF CLINICAL PRESENTATIONS AND MANAGEMENT OUTCOMES OF PATIENTS MANAGED FOR CERVICOFACIAL NECROTIZING FASCIITIS AT THE UNIVERSITY COLLEGE HOSPITAL, IBADAN.","authors":"T O Aladelusi, A A Salami, S O Agboola, O O Gbolahan, A A Olusanya","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Cervicofacial necrotizing fasciitis is a rare, rapidly progressive and fatal polymicrobial necrotizing infection of the fascial and subcutaneous tissue of the head and neck resulting from the vascular thrombosis and ischemia within the fascial plane.</p><p><strong>Aim: </strong>The aim of this study was to evaluate the clinical presentations and management outcomes of patients managed for cervicofacial necrotizing fasciitis at the University College Hospital, Ibadan.</p><p><strong>Methods: </strong>The data of patients managed for cervicofacial necrotizing fasciitis between January 2018 and December 2023 were extracted from case notes obtained from the medical records. All patients were admitted and those with comorbidities were co-managed with the physicians. Antibiotics were administered empirically after samples for microbiology culture and sensitivity were taken. Patients had extraction of offending teeth, serial debridement and honey dressing until no visible sign of infection and wounds epithelized. SPSS was used for data analysis.</p><p><strong>Results: </strong>During this period, seventeen patients with cervicofacial necrotizing fasciitis were managed. The male to female ratio was 1.8:1 with mean age of 57.65 (+17.674) years. Most (88.2%) of the patients were of low socio-economic status. Anaemia was the commonest underlying systemic condition while about half (47.1%) of the patients were diagnosed with diabetes mellitus. The only identified aetiology was odontogenic infection among all patients. Seventyfive percent of patients with diabetes presented with features of sepsis. The Chi-test test showed statistical significance association between the diagnosis of diabetes mellitus and sepsis at presentation (P-value=0.030) . Submandibulocervical region was the commonest affected site and average hospital stay was 13.59 (+8.382) days. The major complication encountered was scar formation with no mortality recorded.</p><p><strong>Conclusion: </strong>Cervicofacial necrotizing fasciitis is a rare but debilitating disease which is usually associated with poverty and presence of comorbidities. Its non-specific symptoms make late presentations common. Hence, the need for high index of suspicion for prompt management.</p>","PeriodicalId":72221,"journal":{"name":"Annals of Ibadan postgraduate medicine","volume":"21 1","pages":"132-138"},"PeriodicalIF":0.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13399543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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