Annals of 3D printed medicine最新文献

{"title":"Total navicular and cuboid replacement utilizing patient specific 3D printed implants for treatment of osteonecrosis of the midfoot: Case report and technique guide","authors":"John R. Constantino ,&nbsp;Adam D. Perler","doi":"10.1016/j.stlm.2023.100140","DOIUrl":"https://doi.org/10.1016/j.stlm.2023.100140","url":null,"abstract":"<div><p>Osteonecrosis of the midfoot is a rare but debilitating pathology that can severely decrease quality of life. Surgical treatment is often complex and can lead to suboptimal outcomes. Additive manufacturing or 3D printing can provide a more patient specific approach to address these difficult entities. This case report highlights the successful use of custom 3D printed implants to replace the navicular and cuboid bones for treatment of osteonecrosis by providing a unique mixture of joint fusion and resurfacing interfaces in a 47-year-old active female. At the final follow up of 30 months, the patient continues to express satisfaction with her procedure and perform physical activities without pain.</p></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"13 ","pages":"Article 100140"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666964123000413/pdfft?md5=b2e68ee3e2c219fe056615b22d3e2df5&pid=1-s2.0-S2666964123000413-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138453639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amalgamation of nano and 3-D printing technology: Design, optimization, and assessment","authors":"Hardik Rana,&nbsp;Dipika Chavada,&nbsp;Vaishali Thakkar","doi":"10.1016/j.stlm.2024.100144","DOIUrl":"10.1016/j.stlm.2024.100144","url":null,"abstract":"<div><p>Personalized medicine is the need of today's era, as one therapy does not fit all. The study aims to develop a novel patient-customized formulation using the integration of 3-D printing and Nanotechnology concepts. Valsartan (VLS) was chosen as a model drug for the study due to its poor bioavailability and dose-dependent toxicity. The Polycaprolactone (PCL)-VLS bionanoparticles (PCVBio) were formulated using a modified solvent evaporation method, inculcating the approach of Quality by Design (QbD). The amount of PCL and Polaxomer-188 (PLX) significantly influenced the PCVBio properties, which central composite design (CCD) ascertained. The results of DSC confirm the conversion of crystalline to amorphous structure. The zeta potential, PDI, and particle size ensure stability and nano size. The optimized PCVBio was further loaded into the multi-channel 3-D printed tablet (M3DPT). M3DPT was formulated by the fused deposition modeling method. The process parameters,% infill, and layer height significantly influenced the tablet's quality. The PCVbio M3DPT was able to release the VLS up to 12 h. The optimal formulation was found stable and effective. The new conjugated advanced formulation will improve the effectiveness, safety, and patient adherence. It unlocks the new research direction toward improving patients' lives.</p></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"13 ","pages":"Article 100144"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666964124000031/pdfft?md5=763ab9035eadb4656cb5f134de4b763f&pid=1-s2.0-S2666964124000031-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139395728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An adjustable and customised finger splint to improve mallet finger treatment compliance and outcomes","authors":"Shi Lei Teng ,&nbsp;Yoke Rung Wong ,&nbsp;Peggy Poh Hoon Lim ,&nbsp;Duncan Angus McGrouther","doi":"10.1016/j.stlm.2024.100142","DOIUrl":"10.1016/j.stlm.2024.100142","url":null,"abstract":"<div><h3>Objective</h3><p>Tendinous mallet finger injuries are normally treated conservatively by finger splinting, whereby the injured finger is immobilised in extension to allow the ruptured extensor tendon to heal. However, current splints including the Stack and Zimmer reported high failure rates of almost 50 %. Reasons are attributed to poor splint fit, skin complications and discomfort which cause non-compliance to splint regimens. To address the above mentioned issues, we designed and developed a 3D printed adjustable and customised finger splint.</p></div><div><h3>Participants and interventions</h3><p>The 3D printed finger splint, Zimmer and Stack splint were worn by 24 healthy volunteers on their middle fingers for 24 h.</p></div><div><h3>Main outcome measures</h3><p>The finger extension angle, splint fit, splint comfort and skin maceration were assessed via angle measurement and subjects’ feedback using a questionnaire.</p></div><div><h3>Results</h3><p>The 3D printed finger splint was capable to maintain the distal interphalangeal joint at an extended angle of 8.1° However, 70.8 % of the subjects reported that the 3D printed finger splint shifted or came off wholly during 24 h of wear. This proportion is higher compared to the Zimmer (45.8 %) and the Stack (37.5 %). While 91.7 % of the subjects were satisfied with the ease of wearing and removing the 3D printed finger splint, subjects experienced difficulty performing work and washing activities owing to the design and material.</p></div><div><h3>Conclusion</h3><p>Our proposed design fulfils its function of holding the fingertip in extension and improves ease of application. The design of 3D printed finger splint could be further refined to provide better splint fit and comfort, so as to achieve better treatment compliance.</p></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"13 ","pages":"Article 100142"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666964124000018/pdfft?md5=6170706bec2d4641b8733208f0a3d61c&pid=1-s2.0-S2666964124000018-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139457156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical Comparison of Traditional Plaster Cast and 3D-Printed Orthosis for External Coaptation of Distal Radius Fractures","authors":"Marcelo P. D'Amado, João Bourbon de Albuquerque, W. Bezold, Brett D. Crist, James L. Cook","doi":"10.1016/j.stlm.2024.100146","DOIUrl":"https://doi.org/10.1016/j.stlm.2024.100146","url":null,"abstract":"","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"21 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139880303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Creating a 3D-printed pelvic phantom to explore the impact of Magnetic Resonance (MR) scanner noise in radiomics analysis, a technical note.","authors":"Richard Collier ,&nbsp;Michelle Leech ,&nbsp;Laure Marignol ,&nbsp;John Gaffney ,&nbsp;Ralph Leijenaar ,&nbsp;Ciaran Malone","doi":"10.1016/j.stlm.2024.100143","DOIUrl":"10.1016/j.stlm.2024.100143","url":null,"abstract":"<div><p>Reproducibility of radiomics features necessitates that scanner noise be considered prior to feature extraction. Phantom research provides the opportunity for such ‘ground truth’ measurements, without the additional complication of patient-related factors. The aim of this technical note was to create a 3D printed Magnetic Resonance Imaging (MRI)-compatible pelvic phantom that can be used for subsequent analysis of the impact of scanner noise on the reproducibility of radiomics features.</p><p>A 3D printed phantom of a male pelvis was created using fused deposition modelling technology. It was 3D printed using the high density MRI-compatible acrylonitrile butadiene styrene (ABS). The ‘negative’ mould created was then filled with silicone, and the prostate gland and femoral heads were also simulated.</p><p>We successfully created an MRI-compatible 3D printed pelvic phantom, with a test scan. The phantom will subsequently be utilised to determine the impact of MRI scanner noise on radiomics feature reproducibility.</p></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"13 ","pages":"Article 100143"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266696412400002X/pdfft?md5=59d77aaebd690ce9c87e3924132fd3c6&pid=1-s2.0-S266696412400002X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139457376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A perspective on 3D printing in the medical field","authors":"Alberto Boretti","doi":"10.1016/j.stlm.2023.100138","DOIUrl":"https://doi.org/10.1016/j.stlm.2023.100138","url":null,"abstract":"<div><p>The work proposes a perspective on 3D printing in the medical field. The current core applications, which are primarily bioprinting, models in surgery preparation, surgical instruments, prosthetics, drugs, drug delivery systems, streamlined drug development process, and educational medical models, are first reported. The challenges and opportunities of the technology are highlighted, and the present and expected future markets of the technology are considered. The further developments from synergies with artificial intelligence (AI), 4D printing, and the Internet of Things (IoT) is finally examined to provide a comprehensive outlook of where we are, and where we are after, subjected to which constraints.</p></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"13 ","pages":"Article 100138"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666964123000395/pdfft?md5=9e6baedc76a4c3314f7c462fe5ae612e&pid=1-s2.0-S2666964123000395-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138436241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of a low-cost 3-D printed microscope for evaluating esophageal biopsies","authors":"Daniel G. Rosen ,&nbsp;Evandro Sobroza de Mello ,&nbsp;Sadhna Dhingra ,&nbsp;Sanford M. Dawsey ,&nbsp;Joe Knapper ,&nbsp;Richard Bowman ,&nbsp;Sharmila Anandasabapathy","doi":"10.1016/j.stlm.2024.100145","DOIUrl":"10.1016/j.stlm.2024.100145","url":null,"abstract":"<div><p>In this manuscript we assessed the utility of a low-cost 3D printed microscope to evaluate esophageal biopsies. We conducted a comparative analysis between the traditional microscope and our 3-D printed microscope, utilizing a set of esophageal biopsy samples obtained from patients undergoing screening endoscopy. Two pathologists independently examined 30 esophageal biopsies by light microscopy and digital images obtained using a low-cost 3D printed microscope (Observer 1 and 2). The glass slide consensus diagnosis was compared to the findings of 2 additional pathologist who independently just reviewed the digital images (Observer 3 and 4). The intra-observer agreement was substantial to almost perfect for observer 1 (k:0.64) and 2 (k:0.84). All four observers had 100 % sensitivity and negative predictive value, whereas specificity ranged from 59 % to 100 % and positive predictive value ranged from 21 % to 100 %. The PPV and specificity were lower for the two Observers (3 and 4) who just examined the digital images. Overall, our results suggest that telepathology may be used with high sensitivity and specificity, utilizing the pictures produced by our 3D-printed microscope.</p></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"13 ","pages":"Article 100145"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666964124000043/pdfft?md5=20599d8cd70420b473c241a29607bbed&pid=1-s2.0-S2666964124000043-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139453563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D-print as a template for reassembly of skull fragments in a homicide case","authors":"Søren Reinhold Jakobsen,&nbsp;Christina Carøe Pedersen,&nbsp;Asser H. Thomsen,&nbsp;Kasper Hansen","doi":"10.1016/j.stlm.2023.100137","DOIUrl":"https://doi.org/10.1016/j.stlm.2023.100137","url":null,"abstract":"<div><p>In this technical note we report a case where 3D-printing aided the reassembly of skull fragments in a homicide with severe tampering of the bones. A young male was shot, the body was incinerated and crushed with garden tools resulting in hundreds of brittle, calcine bone fragments from the skull. An antemortem computed tomography (CT)-scan of the skull was available from a previous assault of the victim. To aid the process of reassembly we used the antemortem CT-data to develop a 3D fixture-grid of the cranial cavity. The 3D grid was utilized as an anatomically correct template for bone reconstruction. This novel technique was based solely on open-source software including 3D Slicer and Blender and could have the potential to aid similar cases.</p></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"12 ","pages":"Article 100137"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49734302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender differences in Glenoid and Coracoid Dimensions evaluated through 3D Printed bone models in the context of Anterior Shoulder Instability Surgery – An exploratory study","authors":"Vitor La Banca ,&nbsp;Ana Victoria Palagi Viganó ,&nbsp;Luiz Giglio ,&nbsp;Guilherme Henrique Vieira Lima ,&nbsp;Henrique de Lazari Schaffhausser ,&nbsp;Luiz Fernando Michaelis ,&nbsp;Roberto Yukio Ikemoto","doi":"10.1016/j.stlm.2023.100122","DOIUrl":"10.1016/j.stlm.2023.100122","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;p&gt;Nonrecognition of smaller bone anatomy in the context of the Latarjet procedure may increase the chance of complications and worsen it outcomes, and this should be addressed preoperatively by accurate measuring of bone anatomy. Measurement of bone dimension can be performed through 3d printed bone models nowadays and therefore we aimed to evaluate glenoid and coracoid process dimensions obtained in 3D printed bone models, assess differences between genders, and compare the results with previously published anatomical studies. We hypothesized that the values obtained in the 3D models would be similar to those previously reported in other anatomical studies and gender differences would also be present.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;p&gt;We retrospectively retrieved shoulder computer tomography scans from 39 adult patients with uninjured scapula. Using the DICOM file of the CT, we performed three-dimensional reconstructions of the scapula, including the glenoid and coracoid. The resulting digital model was then printed in an FDM technology 3D printer. With the 3D Printed models, one of the authors measured the models using a digital caliper. The measurements collected on the Glenoid were Glenoid Superior-Inferior length (GlenSI); and Glenoid Antero-Inferior length (GlenAP) .On the coracoid, the measurements collected were the Coracoid Anterior-Posterior length (CoracAP), the Coracoid Medial-Lateral (CoracML) distance and the Coracoid Superior-Inferior (CoracSI) distance. Those measurements were summarized and underwent statistical comparison between genders. The results were compared with other anatomical studies in the same bone anatomy.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;We recorded a mean glenoid length (GlenAP) of 28.03 mm (SD = 0.45) and mean glenoid height (GlenSI) of 37,18 mm (SD =0,55). The mean glenoid dimensions differ significantly between male and female gender (p=0,002 and p=0,001, respectively).The coracoid mean length was 22,35 mm (SD=0.47), mean coracoid width was 14,97 mm (SD=0,30), mean coracoid height was9,51 mm (SD=0,22), and those measures also differ significantly between genders. The observed mean values were similar to those previously reported in other anatomical studies.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Discussion&lt;/h3&gt;&lt;p&gt;We observed that coracoid and glenoid dimensions significantly vary between genders for all of the measurements performed. Measurements obtained in this series are comparable with other similar anatomic studies. Although some limitations exists in our study, we consider 3D-printed bone models in the setting of anatomical studies as a relevant option to traditional cadaveric studies.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;p&gt;Gender differences in coracoid and glenoid dimensions were observed and must be considered for the Latarjet procedure. Our results suggest that 3d printed bone models may be used for such evaluation with a good degree of reproducibility of the measurements observed in already publish","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"12 ","pages":"Article 100122"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41452424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of additively manufacturing synthetic bone for sports personal protective equipment applications","authors":"Gemma Leslie ,&nbsp;Keith Winwood ,&nbsp;Andy Sanderson ,&nbsp;Peter Zioupos ,&nbsp;Tom Allen","doi":"10.1016/j.stlm.2023.100121","DOIUrl":"10.1016/j.stlm.2023.100121","url":null,"abstract":"<div><p>Human limb surrogates, of varying biofidelity, are used in the performance assessment of sports personal protective equipment (PPE). Such biofidelic surrogates have incorporated soft tissue simulants (silicones) and synthetic bone (short fibre filled epoxy). Testing surrogates incorporating realistic synthetic bone could help to further our knowledge of fracture trauma mechanics, and applications such as the effectiveness of sports PPE. Limb surrogates with embedded synthetic bone are rarely tested to fracture, mainly due to the effort and cost of replacing them. This paper proposes additive manufacturing of synthetic bones, with appropriate bone like fracture characteristics, potentially making them more accessible and cost effective. A Markforged® X7™ printer was used as it prints a base filament (Onyx™) alongside a continuous strand of reinforcement (e.g., carbon fibre). The properties of specimens from this printer vary with the type, volume fraction and position of reinforcement. Bar specimens (10 × 4 × 120 mm) with varying amounts of carbon fibre reinforcement were printed for three-point bend testing to determine the feasibility of achieving mechanical properties close to compact bone (bending modulus of ∼15 GPa, bending strength of ∼180 MPa). Bending strength for the various bar specimens ranged from 32 to 378 MPa, and modulus values ranged from 1.5 to 25.8 GPa. Based on these results, four 140 mm long oval shaped cylindrical specimens of ø14 and ø16 mm were printed to represent a basic radius bone model. Three-point bend testing of these bone models showed similar bending modulus (3.8 to 5.3 GPa vs. 3.66 to 14.8 GPa) to radius bones reported in the literature, but higher bending strength (147 to 200 MPa vs. 80.31 ± 14.55 MPa).</p></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"12 ","pages":"Article 100121"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43782158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}