Annals of 3D printed medicine最新文献_第6页

Semi-solid extrusion 3D-printing of eucalypt extract-loaded polyethylene oxide gels intended for pharmaceutical applications 用于制药应用的桉树提取物负载聚乙烯氧化物凝胶的半固体挤出3d打印

Annals of 3D printed medicine Pub Date : 2023-08-12 DOI: 10.1016/j.stlm.2023.100123

Oleh Koshovyi , Jyrki Heinämäki , Ivo Laidmäe , Niklas Sandler Topelius , Andriy Grytsyk , Ain Raal

{"title":"Semi-solid extrusion 3D-printing of eucalypt extract-loaded polyethylene oxide gels intended for pharmaceutical applications","authors":"Oleh Koshovyi , Jyrki Heinämäki , Ivo Laidmäe , Niklas Sandler Topelius , Andriy Grytsyk , Ain Raal","doi":"10.1016/j.stlm.2023.100123","DOIUrl":"10.1016/j.stlm.2023.100123","url":null,"abstract":"<div><p>In pharmaceutics, 3D printing is considered as a promising future technology for fabricating more complex patient-specific drug delivery systems (DDSs). An anti-staphylococcal herbal preparation, “Chlorophyllipt”, is produced mainly in a liquid form by the pharmaceutical industry in Ukraine, and it is composed of an ethanolic eucalypt extract (EE). Since staphylococcal infections have become a true challenge for the health care in all over the world, it would be relevant and justified to develop the aqueous gels of the present EE applicable for the 3D printing of the corresponding solid DDSs. The aim of the present study was to develop a novel polyethylene oxide (PEO) gel loaded with EE for a semi-solid extrusion (SSE) 3D printing and to print the corresponding oral solid DDSs with different sizes and shapes. For SSE 3D printing, we prepared and tested total ten (10) different aqueous PEO gel formulations loaded with EE. Prior to 3D printing, the physical appearance, homogeneity, injection force and viscosity of the gels were investigated. The EE-PEO gels were printed to lattice- and round-shaped solid DDSs with the head speed of 0.5 mm/s, and the weight (mass uniformity) and effective surface area of the printed systems were determined. The most feasible EE-PEO gel for SSE 3D printing comprised of 10 mg/ml of EE, 30 mg/ml of eumulgin and 20 mg/ml of ascorbic acid in a 20-% aqueous PEO gel. The key process parameters of the SSE 3D printing were identified and verified. The printing quality of EE-PEO DDSs were very good, thus showing compatibility of a plant extract and carrier polymer. Such 3D-printed antimicrobial DDSs can be used for example in the treatment of skin wounds and infections of the oral cavity.</p></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"12 ","pages":"Article 100123"},"PeriodicalIF":0.0,"publicationDate":"2023-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44366454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Clinical implementation of 3D printed plesiotherapy moulds using free open source software 使用免费开源软件实现3D打印的蛇颈疗法模具

Annals of 3D printed medicine Pub Date : 2023-08-11 DOI: 10.1016/j.stlm.2023.100124

Luis Ángel Quiñones Rodríguez , Joaquín Pérez Pavón , Ignacio Castro Ramírez , Lucía Gutiérrez Bayard , Maria Amparo Iborra Oquendo

{"title":"Clinical implementation of 3D printed plesiotherapy moulds using free open source software","authors":"Luis Ángel Quiñones Rodríguez , Joaquín Pérez Pavón , Ignacio Castro Ramírez , Lucía Gutiérrez Bayard , Maria Amparo Iborra Oquendo","doi":"10.1016/j.stlm.2023.100124","DOIUrl":"10.1016/j.stlm.2023.100124","url":null,"abstract":"<div><h3>Purpose</h3><p>From May 2021 the European regulation EU2017/745 covers the manufacture of medical devices in healthcare facilities under certain conditions. In this context, the use of 3D printing and free software can be combined to provide a solution to some of the problems for which no commercial product can be found in brachytherapy.</p><p>What we present here is a procedure for the design, using open source software, and manufacture, with Fused Deposition Modeling technology, of brachytherapy surface moulds.</p></div><div><h3>Material and methods</h3><p>The procedure starts with a CT scan of the patient treatment area with radiopaque markers. 3D slicer software is then used to delimit the applicator mould that follows the patient's surface. After this, we use the Freecad software to design the channels where we will insert the plastic tubes through which the radiation source will deliver the treatment. We also use the Meshmixer software to make the final delimitation of the applicator edges as well as to find and correct any inconsistency.</p></div><div><h3>Results</h3><p>Moulds created by means of 3D printing allow us to combine the precise fit to the patient's surface of homemade solutions with the geometric accuracy between catheters of commercial products. This is clearly seen when treating small and irregular surfaces such as the ear pinna.</p></div><div><h3>Conclusion</h3><p>Manufacture of brachytherapy surface moulds with FDG technology is a good example of customized solutions in healthcare facilities supported by new European legistation. If we add to this the use of free open source software, we are facing an alternative to classics solutions used up to now in superficial brachytherapy.</p></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"12 ","pages":"Article 100124"},"PeriodicalIF":0.0,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43346756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perspective approaches of 3D printed stuffs for personalized nutrition: A comprehensive review 3D打印个性化营养的透视方法:综述

Annals of 3D printed medicine Pub Date : 2023-08-10 DOI: 10.1016/j.stlm.2023.100125

Hemananthan Eswaran , Renuka Devi Ponnuswamy , Rajesh Pungampalayam Kannapan

{"title":"Perspective approaches of 3D printed stuffs for personalized nutrition: A comprehensive review","authors":"Hemananthan Eswaran , Renuka Devi Ponnuswamy , Rajesh Pungampalayam Kannapan","doi":"10.1016/j.stlm.2023.100125","DOIUrl":"10.1016/j.stlm.2023.100125","url":null,"abstract":"<div><p>Food printing technology is going to be the promising technology of future. Advances in 3D food Printing or additive manufacturing technology adds extra dimension to the established food practices and offer opportunities for new interactive experiences. This paper aims to deliver the central flow of 3D food printing process and extends to summarize its knowledge towards the perception of personalized nutrition. The initial flow emphasizes the broad categories of food printing materials and further, to stream the concept of personalized nutrition, a unique attention is focused on latest technological innovations in the 3D printed foodstuffs with different nutritional approaches viz., nutrition enhancement, minerals/vitamins fortification, functional ingredients enrichment and the development of alternative foods. In addition to current prominent scientific researches, literature stuffing adds a new flavor drawing attention on several industrially developed 3D food printed products that are reached and inline to the market. A prominent highlight was embarked on recent technical progress in the development of pharma foods, insect and plant based meat alternatives using 3D printing techniques. It is strongly believed that personalization and customization of 3D printed foods could be a future talk in compromising, unsatisfied nutritional problems and eradicating several chronical diseases in the pandemic era.</p></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"12 ","pages":"Article 100125"},"PeriodicalIF":0.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48998632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Preliminary assessment on the effects of line width, layer height and orientation on strength and print time for FDM printing of total contact casts for the treatment of diabetic foot ulcers 全接触型FDM打印治疗糖尿病足溃疡时线宽、层高和方向对强度和打印时间影响的初步评估

Annals of 3D printed medicine Pub Date : 2023-08-01 DOI: 10.1016/j.stlm.2023.100115

Niall Mulcahy , Kevin J. O'Sullivan , Aidan O'Sullivan , Leonard O'Sullivan

{"title":"Preliminary assessment on the effects of line width, layer height and orientation on strength and print time for FDM printing of total contact casts for the treatment of diabetic foot ulcers","authors":"Niall Mulcahy , Kevin J. O'Sullivan , Aidan O'Sullivan , Leonard O'Sullivan","doi":"10.1016/j.stlm.2023.100115","DOIUrl":"10.1016/j.stlm.2023.100115","url":null,"abstract":"<div><p>The application of 3D Printing (3DP) for use in fracture casts and orthopaedic splints has been explored in several studies. The challenge of 3D printed casts is their size and relatively long production time compared to traditional/fibreglass casts. This preliminary study aims to determine the effects of three specific parameters specifically in the context of manufacturing Total Contact Casts (TCCs) for the treatment of diabetic foot ulcers.</p><p>The effects of printing parameters have been evaluated previously in the literature. However, there are little data in single experiments on layer height ratio dependent on line width; typically, lower values of layer height have been assessed that remain constant with all line widths. The combination of line width, layer height and print orientation have been evaluated here, with a focus on achieving quickest possible print time without sacrificing part strength in the context of 3D printed TCCs.</p><p>Flexural testing was conducted on FDM-printed PLA test specimens with 36 different treatments, adjusting the above parameters. The relationship between part strength (flexural modulus and maximum flexural stress) and print time was investigated.</p><p>It was determined that a low layer height could be paired with a high line width to achieve optimal part strength, considering also print time. The specific application, and associated direction of forces/loads is an important consideration when selecting a print orientation to optimise mechanical performance. A case example applied to the printing of a TCC is also presented.</p></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"11 ","pages":"Article 100115"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48376933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Current use of 3D printing in plastic surgery 目前3D打印在整形手术中的应用

Annals of 3D printed medicine Pub Date : 2023-08-01 DOI: 10.1016/j.stlm.2023.100119

Yannis CLAUDIC , David A. ZOPF , Melis OZKAN , Remi DI FRANCIA , Weiguo HU

引用次数: 0

3D printed twin block: A feasibility study 3D打印双块:可行性研究

Annals of 3D printed medicine Pub Date : 2023-08-01 DOI: 10.1016/j.stlm.2023.100118

Eryn Ling Yi Chan , Yi Lin Song , Kelvin Weng Chiong Foong , Ming Tak Chew

{"title":"3D printed twin block: A feasibility study","authors":"Eryn Ling Yi Chan , Yi Lin Song , Kelvin Weng Chiong Foong , Ming Tak Chew","doi":"10.1016/j.stlm.2023.100118","DOIUrl":"10.1016/j.stlm.2023.100118","url":null,"abstract":"<div><h3>Aims</h3><p>Twin blocks are appliances used for Class II skeletal discrepancies, where the lower jaw is positioned more posteriorly compared to the upper. The conventional method of fabrication of this appliance is tedious and labour-intensive; hence this study intends to explore the feasibility of a digital workflow to three-dimensionally (3D) print them.</p></div><div><h3>Methods</h3><p>Three sets of twin blocks, identical except for amount of offset (0.0 mm, 0.1 mm and 0.2 mm), were designed and 3D printed for 5 anonymized scans of patients with Class II skeletal discrepancies. The intaglio surfaces of the 0.0 mm offset twin blocks were scanned and superimposed onto their original computer-aided-design files. The resultant colour maps, root mean square (RMS) deviations, and percentage in-tolerance values at thresholds of 0.1 mm and 0.2 mm were assessed. The fit and retention of all twin blocks were assessed on their 3D printed models via a fit and retention score (FRS).</p></div><div><h3>Results</h3><p>The median RMS deviation was 0.10 mm; percentage in-tolerance values at thresholds of 0.1 mm and 0.2 mm were 79.90%, and 94.51%. Printing deviations occurred most often at labial and incisal edges anteriorly, and buccal and occlusal surfaces posteriorly. There was no significant difference between the total FRS for the three groups (<em>p</em> = 0.076). However, the frequency of satisfactory scores for upper fit (<em>p</em> = 0.049), lower fit (<em>p</em> = 0.018), upper retention (<em>p</em> = 0.038) and lower retention (<em>p</em> = 0.015) differed significantly between the three groups.</p></div><div><h3>Conclusion</h3><p>This study demonstrated the viability of a digital workflow to 3D print twin blocks. Print accuracy was satisfactory, with 0.1 mm offset providing the best fit and retention.</p></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"11 ","pages":"Article 100118"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44432314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biometrics and three-dimensional alignment of the acromioclavicular joint. A biomechanical proof of concept study using the “reversed cadaver model”(RCM) 肩锁关节的生物力学和三维定位。使用“反向尸体模型”（RCM）的生物力学概念验证研究

Annals of 3D printed medicine Pub Date : 2023-08-01 DOI: 10.1016/j.stlm.2023.100114

Marius Junker , Milad Farkhondeh Fal , Jörn Kircher

引用次数: 0

Aortic arch repair in chronic dissection using 3D-printing planning 应用3d打印规划修复慢性夹层主动脉弓

Annals of 3D printed medicine Pub Date : 2023-08-01 DOI: 10.1016/j.stlm.2023.100116

Paolo Magagna, Michele Gallo, Loris Salvador

引用次数: 0

Computational modeling of probiotic recovery from 3D-bioprinted scaffolds for localized vaginal application 局部阴道应用的3d生物打印支架中益生菌恢复的计算模型

Annals of 3D printed medicine Pub Date : 2023-08-01 DOI: 10.1016/j.stlm.2023.100120

Veeresh Rai , Anthony J. Kyser , Dylan A. Goodin , Mohamed Y. Mahmoud , Jill M. Steinbach-Rankins , Hermann B. Frieboes

{"title":"Computational modeling of probiotic recovery from 3D-bioprinted scaffolds for localized vaginal application","authors":"Veeresh Rai , Anthony J. Kyser , Dylan A. Goodin , Mohamed Y. Mahmoud , Jill M. Steinbach-Rankins , Hermann B. Frieboes","doi":"10.1016/j.stlm.2023.100120","DOIUrl":"10.1016/j.stlm.2023.100120","url":null,"abstract":"<div><p>Lactobacilli, play a beneficial role in the female reproductive tract (FRT), regulating pH via lactic acid metabolism to help maintain a healthy environment. Bacterial vaginosis (BV) is characterized by a dysregulated flora in which anaerobes such as <em>Gardnerella vaginalis</em> (<em>Gardnerella</em>) create a less acidic environment. Current treatment focuses on antibiotic administration, including metronidazole, clindamycin, or tinidazole; however, lack of patient compliance as wel as antibiotic resistance may contribute to 50% recurrence within a year. Recently, locally administered probiotic such as <em>Lactobacillus crispatus</em> (<em>L. crispatus</em>) have been evaluated as a prophylactic against recurrence. To mitigate the lack of patient compliance, sustained probiotic delivery has been proposed via 3D-bioprinted delivery vehicles. Successful delivery depends on a variety of vehicle fabrication parameters influencing timing and rate of probiotic recovery; detailed evaluation of these parameters would benefit from computational modeling complementary to experimental evaluation. This study implements a novel simulation platform to evaluate sustained delivery of probiotics from 3D-bioprinted scaffolds, taking into consideration bacterial lactic acid production and associated pH changes. The results show that the timing and rate of probiotic recovery can be realistically simulated based on fabrication parameters that affect scaffold degradation and probiotic survival. Longer term, the proposed approach could help personalize localized probiotic delivery to the FRT to advance women's health.</p></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"11 ","pages":"Article 100120"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10075812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accuracy of 3D printed spine models for pre-surgical planning of complex adolescent idiopathic scoliosis (AIS) in spinal surgeries: a case series 3D打印脊柱模型在脊柱手术中用于复杂青少年特发性脊柱侧凸(AIS)术前规划的准确性:一个病例系列

Annals of 3D printed medicine Pub Date : 2023-08-01 DOI: 10.1016/j.stlm.2023.100117

Abir Dutta , Menaka Singh , Kathryn Kumar , Aida Ribera Navarro , Rodney Santiago , Ruchi Pathak Kaul , Sanganagouda Patil , Deepak M Kalaskar

{"title":"Accuracy of 3D printed spine models for pre-surgical planning of complex adolescent idiopathic scoliosis (AIS) in spinal surgeries: a case series","authors":"Abir Dutta , Menaka Singh , Kathryn Kumar , Aida Ribera Navarro , Rodney Santiago , Ruchi Pathak Kaul , Sanganagouda Patil , Deepak M Kalaskar","doi":"10.1016/j.stlm.2023.100117","DOIUrl":"10.1016/j.stlm.2023.100117","url":null,"abstract":"<div><p>Adolescent idiopathic scoliosis (AIS) is a noticeable spinal deformity in both adult and adolescent population. In majority of the cases, the gold standard of treatment is surgical intervention. Technological advancements in medical imaging and 3D printing have revolutionised the surgical planning and intraoperative decision making for surgeons in spinal surgery. However, its applicability for planning complex spinal surgeries is poorly documented with human subjects. The objective of this study is to evaluate the accuracy of 3D printed models for complex spinal deformities based on Cobb angles between 40° to 95°.This is a retrospective cohort study where, five CT scans of the patients with AIS were segmented and 3D printed for evaluating the accuracy. Consideration was given to the Inter-patient and acquisition apparatus variability of the CT-scan dataset to understand the effect on trueness and accuracy of the developed CAD models. The developed anatomical models were re-scanned for analysing quantitative surface deviation to assess the accuracy of 3D printed spinal models. Results show that the average of the root mean square error (RMSE) between the 3DP models and virtual models developed using CT scan of mean surface deviations for the five 3d printed models was found to be 0.5±0.07 mm. Based on the RMSE, it can be concluded that 3D printing based workflow is accurate enough to be used for presurgical planning for complex adolescent spinal deformities. Image acquisition and post processing parameters, type of 3D printing technology plays key role in acquiring required accuracy for surgical applications.</p></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"11 ","pages":"Article 100117"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10427719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10047342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1