Annals of 3D printed medicine最新文献

{"title":"3D printed training simulator for transcatheter edge-to-edge repair of the tricuspid valve: A proof-of-concept","authors":"Michele Bertolini ,&nbsp;Luca Carlini ,&nbsp;Ludovica Clementini ,&nbsp;Martina Dall'Aglio ,&nbsp;Giorgio Colombo ,&nbsp;Claudio Capelli","doi":"10.1016/j.stlm.2024.100157","DOIUrl":"https://doi.org/10.1016/j.stlm.2024.100157","url":null,"abstract":"<div><h3>Background</h3><p>Tricuspid regurgitation (TR) treatments have gradually shifted toward a more interventional approach and transcatheter edge-to-edge repair (TEER) has assumed a first-order role. TriClip™ by Abbott (Menlo Park, USA) is one of the most widely used devices for tricuspid repair. TEER procedures are recognised as technically challenging, characterized by a steep learning curve. For this reason, specialized training is necessary. The aim of this work is to develop and test a novel 3D printed training simulator, which considers both anatomical and mechanical characteristics, specifically designed for this kind of procedure.</p></div><div><h3>Methods</h3><p>Starting from routinely acquired computed tomography (CT) images, a 3D digital model of the heart was reconstructed. This was then properly “augmented”, so that it could realistically reproduce the key features involved in the procedure. The simulator was manufactured exploiting the Polyjet 3D printed. Proper materials selection was performed to accurately reproduce mechanical properties. The manufactured prototype was then tested by a specialized professional, with the TriClip™ system.</p></div><div><h3>Results</h3><p>The simulator was assessed to practice access, navigation, catheter steering and leaflet grasping. Throughout the process, appropriately placed cameras ensured that the operators could visualize the crucial steps on a screen. Even if a deeper evaluation is needed, preliminary feedback is satisfactory.</p></div><div><h3>Conclusions</h3><p>In this study, a new training simulator for TriClip™ procedure was designed, produced, and preliminary assessed. Further studies will have to demonstrate the advantages of using this simulator design to shorten the learning curve and subsequently lead to better clinical outcomes.</p></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"15 ","pages":"Article 100157"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266696412400016X/pdfft?md5=3cf2a06a694469b1e96d97c5152312b3&pid=1-s2.0-S266696412400016X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141243745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3-Dimensional printing for training in emergency medicine","authors":"Getaw Worku Hassen ,&nbsp;Jason Hill ,&nbsp;Evan Yates ,&nbsp;Anisha Duvvi ,&nbsp;Roger Chirurgi ,&nbsp;Mohammad Ganji ,&nbsp;Jaspreet Singh ,&nbsp;Ceilim Kim ,&nbsp;Misagh Fasazadeh ,&nbsp;Selome F. Yewedalsew ,&nbsp;Shterna Seligson ,&nbsp;Hossein Kalantari","doi":"10.1016/j.stlm.2024.100158","DOIUrl":"https://doi.org/10.1016/j.stlm.2024.100158","url":null,"abstract":"","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"15 ","pages":"Article 100158"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666964124000171/pdfft?md5=1b65ad5f5d681214ac3b734ff20264a2&pid=1-s2.0-S2666964124000171-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141303289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive review on hydrogel-based bio-ink development for tissue engineering scaffolds using 3D printing","authors":"Debashish Gogoi ,&nbsp;Manjesh Kumar ,&nbsp;Jasvinder Singh","doi":"10.1016/j.stlm.2024.100159","DOIUrl":"https://doi.org/10.1016/j.stlm.2024.100159","url":null,"abstract":"<div><p>Three-dimensional (3D) bioprinting technology allows the production of porous structures with complex and varied geometries, which facilitates the development of equally dispersed cells and the orderly release of signal components. This is in contrast to the traditional methods used to produce tissue scaffolding. To date, 3D bioprinting has employed a range of cell-laden materials, including organic and synthetic polymers, to construct scaffolding systems and manufacture extracellular matrix (ECM). Still, there are several challenges in meeting the technical issues in bio-ink formulations, such as the printability of bio-inks, the customization of mechanical and biological properties in bio-implants, the guidance of cell activities in biomaterials, etc. The main objective of this article is to discuss the various strategies for preparing bio-inks to mimic native tissue's extracellular matrix environment. A discussion has also been conducted about the process parameters of bio-ink formulations and printing, structure requirements, and fabrication methods of durable bio-scaffolds. The present study also reviews various 3D-printing techniques. Conclusively, the challenges and potential paths for smart bioink/scaffolds have been outlined for tissue regeneration.</p></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"15 ","pages":"Article 100159"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666964124000183/pdfft?md5=71dadac6d5910ad1392a23a9d6c7215f&pid=1-s2.0-S2666964124000183-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141479958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applications of 3D printing in medicine: A review","authors":"Chensong Dong,&nbsp;Marko Petrovic,&nbsp;Ian J. Davies","doi":"10.1016/j.stlm.2024.100149","DOIUrl":"https://doi.org/10.1016/j.stlm.2024.100149","url":null,"abstract":"<div><p>3D printing, or additive manufacturing, has transformed various industries with its layer-by-layer fabrication approach. In medicine, 3D printing, or biofabrication, has seen significant advancements, particularly in the creation of patient-specific medical models and custom-made drug tablets. Bioprinting, a key aspect of biofabrication, encompasses three approaches: biomimicry, autonomous self-assembly, and microtissues, each with its unique advantages and disadvantages. This comprehensive review explores the merits and limitations of these bioprinting approaches and outlines the three main phases of the entire bioprinting process: pre-processing, processing, and post-processing. By enhancing patients’ quality of life, reducing healthcare costs, and tapping into the global medical device market, biofabrication technologies hold immense promise for the future of medicine. This literature review focuses on the applications of 3D printing technologies in creating medical devices, including bone tissues, joint tissues, 3D printed tablets, and medical models.</p></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"14 ","pages":"Article 100149"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666964124000080/pdfft?md5=15cfa452bb14e83f9962e24405463f3e&pid=1-s2.0-S2666964124000080-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139718919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A hybrid 3D-printed model for lateral canthotomy simulation","authors":"Getaw Worku Hassen ,&nbsp;Anisha Duvvi ,&nbsp;Evan Yates ,&nbsp;Yitzchak Goldsmith ,&nbsp;Mohammed Ganji ,&nbsp;Gregory McWhir ,&nbsp;Jaspreet Singh ,&nbsp;Ceilim Kim ,&nbsp;Getnet Tolera ,&nbsp;Sonja Jauhal ,&nbsp;Selome F. Yewedalsew ,&nbsp;Mauricio Gonzalez Aries ,&nbsp;Shterni Seligson ,&nbsp;Hossein Kalantari","doi":"10.1016/j.stlm.2024.100153","DOIUrl":"https://doi.org/10.1016/j.stlm.2024.100153","url":null,"abstract":"<div><h3>Background</h3><p>Compartment syndrome is a medical emergency. It should be diagnosed promptly, and therapeutic measures should be taken to avoid limb ischemia. Measurement of compartment pressure is extremely important.</p></div><div><h3>Model</h3><p>Knowledge about compartments and familiarity with the pressure monitoring device are important to diagnose acute compartment syndrome properly. Simulations provide an opportunity to learn the device and practice the procedure. Given their lower cost and the possibility of frequent reproduction, simulations using 3D-printed material are gaining popularity. We propose a simple low-fidelity model using a silicone-based lower leg soft tissue, 3D-printed tibia and fibula, Foley catheter, and syringes.</p></div><div><h3>Conclusion</h3><p>This low-fidelity simulator helps to improve procedural skills and retention through repeated practice.</p></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"14 ","pages":"Article 100153"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666964124000122/pdfft?md5=42ea00b93663d3bebbb3402c293df727&pid=1-s2.0-S2666964124000122-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140346966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D-printed Biphasic Calcium Phosphate Scaffold to augment cytocompatibility evaluation for load-bearing implant applications","authors":"K. Prem Ananth ,&nbsp;Naidu Dhanpal Jayram ,&nbsp;Kandasamy Muthusamy","doi":"10.1016/j.stlm.2024.100148","DOIUrl":"https://doi.org/10.1016/j.stlm.2024.100148","url":null,"abstract":"<div><p>In this work, we developed and analyzed a biphasic calcium phosphate (BC_P) bioceramic for bone regeneration using stereolithography (SLA). The SLA method is a promising additive manufacturing (AM) technique capable of creating BCp parts with high accuracy and efficiency. However, the ceramic suspension used in SLA exhibits significantly higher viscosity and is not environmentally friendly. Therefore, adequate preparation of a suspension with low viscosity and high solid loading is essential. In this paper, we optimized the effects of surfactant doses and solid loading on the BCp slurry, and initially examined the process parameters of photocuring, debinding, and sintering. The utilization of 9 wt % Disperbyk (BYK) with a 40 vol % loading of BCp bioceramics exhibited a reasonably low viscosity of 8.9 mPa·s at a shear level of 46.5 s⁻¹. Functional and structural analyses confirmed that BCp was retained after photocuring and subsequent treatment, which were incorporated into the BYK dispersion. The 3D printed objects with different sintered temperatures, specifically at 1100 °C, 1200 °C, and 1300 °C, were further optimized. Additionally, the surface roughness, porosity, and mechanical properties of BCp green parts were systematically investigated. Most importantly, <em>in vitro</em> analysis of cell attachment, differentiation, and red alizarin analysis could support the application of bone regeneration.</p></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"14 ","pages":"Article 100148"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666964124000079/pdfft?md5=3da89ec7743eb77b19fd4fb98a128884&pid=1-s2.0-S2666964124000079-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139718918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Semi-automatic design concept of 3D-printed individualized template for interstitial brachytherapy of vaginal tumors","authors":"Shuhei Sekii ,&nbsp;Kento Morita ,&nbsp;Ryuichi Yada ,&nbsp;Kayoko Tsujino","doi":"10.1016/j.stlm.2024.100147","DOIUrl":"https://doi.org/10.1016/j.stlm.2024.100147","url":null,"abstract":"<div><p>We aimed to introduce a novel semi-automatic design approach for fabricating individualized, three-dimensional printed template dedicated to interstitial brachytherapy in vaginal tumor treatment. The central component of this concept involved the development of a cylindrical template with strategically placed tunnels to optimize applicator placement. These tunnels originated from the template's base, meticulously designed to prevent any potential overlap or interference. For precise tumor localization, we employed a method wherein the tumor's mask image was projected onto a spherical surface. Subsequently, we employed the k-means algorithm to segment the terminal points, with each cluster's center serving as the terminal point. To ensure the optimal starting point for the tunnels, we utilized the conjugate gradient method, considering the following factors: inter-starting point distance, angles between tunnels, inter-tunnel distance, and the starting point's position relative to the base of the template (inside or outside). We established a semi-automatic design paradigm for fabricating three-dimensional printed template tailored for vaginal brachytherapy. While our initial findings are promising, further comprehensive investigations are imperative to validate the clinical efficacy of this innovative concept.</p></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"14 ","pages":"Article 100147"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666964124000067/pdfft?md5=381afcfb59d7a28295b6c0056e8891d1&pid=1-s2.0-S2666964124000067-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139718877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A hybrid 3D-printed model for lateral canthotomy simulation","authors":"Anisha Duvvi,&nbsp;Evan Yates,&nbsp;Shterna Seligson,&nbsp;Jaspreet Singh,&nbsp;Cei Lim Kim,&nbsp;Lara Musser,&nbsp;Gregory McWhir,&nbsp;Getnet Tolera,&nbsp;Sonja Jauhal,&nbsp;Mauricio Gonzalez Arias,&nbsp;Hossein Kalantari,&nbsp;Roger Chirurgi,&nbsp;Getaw Worku Hassen","doi":"10.1016/j.stlm.2024.100150","DOIUrl":"https://doi.org/10.1016/j.stlm.2024.100150","url":null,"abstract":"<div><h3>Background</h3><p>Ocular injuries are common complaints in the emergency department (ED). In certain instances, a hematoma builds up behind the eyeball and can lead to increased intraocular pressure (IOP), restricting circulation and threatening vision. A lateral canthotomy can be vision-saving if performed appropriately and quickly. Unfortunately, not every physician in the ED is familiar with the procedure.</p></div><div><h3>Objective</h3><p>Our objective was to build a hybrid 3D-printed model to simulate lateral canthotomy, hence improving physicians’ skills in performing the procedure.</p></div><div><h3>Method</h3><p>Using a MakerBot 3D printer, a hemi-cranium and a sphere imitating the eyeball were printed. The model is supplemented with silicon skin and other materials. A hematoma is created using chocolate pudding. We present a low-fidelity, long-lasting hybrid model for lateral canthotomies. This model simulates the pathology, anatomy, and basic technical steps required to perform the procedure.</p></div><div><h3>Conclusion</h3><p>This low-fidelity simulator helps to improve procedural skills and retention through repeated practice.</p></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"14 ","pages":"Article 100150"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666964124000092/pdfft?md5=e95f7a52e25984d83e6330279347b6ba&pid=1-s2.0-S2666964124000092-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139738069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical comparison of traditional plaster cast and 3D-printed orthosis for external coaptation of distal radius fractures","authors":"Marcelo P. D'Amado,&nbsp;João Bourbon de Albuquerque II,&nbsp;Will Bezold,&nbsp;Brett D. Crist,&nbsp;James L. Cook","doi":"10.1016/j.stlm.2024.100146","DOIUrl":"10.1016/j.stlm.2024.100146","url":null,"abstract":"<div><h3>Introduction</h3><p>Distal radius fractures make up around 20% of adult fractures, varying in type and severity, thus requiring different treatments. Cast immobilization is effective in indicated fractures, but is associated with several disadvantages such that 3D-printed orthoses (3D-Braces) have been introduced as a potentially advantageous alternative. The present study was designed to test the hypothesis that short-arm 3D-printed Polylactic Acid (PLA) orthoses would provide superior biomechanical properties when compared to plaster of Paris short-arm casts for immobilization of distal radial fractures.</p></div><div><h3>Methods</h3><p>Modified mannequin forearms were utilized as human models for the creation of both the circular casts and the 3D Braces. A total of five plaster cast prototypes were produced, based on a standard cylindrical plaster cast application technique used in the treatment of distal radius fractures, and another five samples were 3D printed braces. Each sample was then subjected to a three-point bend load test, using an Instron 68SC2 testing machine, and the data was collected and exported to an Excel spreadsheet and analyzed using SPSS Statistics version 26 (IBM Corp., Armonk, N.Y., USA).</p></div><div><h3>Results</h3><p>The 3D-Braces can withstand significantly higher forces at yield and maximum force, implying they may offer superior mechanical stability. Moreover, our findings indicated a higher strain at yield for the 3D-Braces compared to conventional plaster casts.</p></div><div><h3>Conclusions</h3><p>3D-printed Polylactic Acid short-arm orthoses demonstrated superior biomechanical properties when compared to plaster of Paris short-arm casts designed for immobilization of distal radial fractures. Taken together with data from previous studies, preclinical evidence suggests that PLA 3D-Braces can effectively maintain distal radius fracture alignment and stability with potential advantages over traditional casts with respect to biomechanical properties as well as post-fabrication adjustment, patient hygiene, comfort, and daily activities.</p></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"14 ","pages":"Article 100146"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666964124000055/pdfft?md5=8a390b6bdf9988a12c7fab951f4c4e67&pid=1-s2.0-S2666964124000055-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139820475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive review of 3D printing techniques for biomaterial-based scaffold fabrication in bone tissue engineering","authors":"K. Prem Ananth,&nbsp;Naidu Dhanpal Jayram","doi":"10.1016/j.stlm.2023.100141","DOIUrl":"https://doi.org/10.1016/j.stlm.2023.100141","url":null,"abstract":"<div><p>Three-dimensional (3D) printing technology is developing as a dominant tool for biomedical engineering by supporting 3D cell culture within compound 3D biomimetic buildings. Biomaterial and Tissue engineering has developed as a favorable alternative method in the treatment of bones, teeth, and organs. This paper summarizes the current research status and attention of the 3D biomaterials scaffolds in bone tissue engineering applications. Several 3D scaffolds fabricated from several types of biodegradable materials have been established. The crucial topics of 3D printing techniques are recognized and deliberated with the future improvement of innovative biomaterials. There has been a prompt development in the applications of 3D printing in engineering customized implants, drug delivery devices, prostheses, and 3D scaffolds for regenerative medicine and tissue engineering. Medical 3D printing technologies are classified into the following categories: Fused Deposition Modeling (FDM), Extrusion-based 3D bioprinting, Selective Laser Sintering (SLS)/Selective Laser melting (SLM), Electron Beam Manufacturing (EBM), Stereolithography (SLA) and Digital Light Processing (DLP) printing techniques, and their clinical applications, different types of biomaterials currently used by researchers, and key limitations are discussed in detail. In Addition, the most advanced and commonly used metals, bioceramics, polymers, and composites in tissue engineering are briefly reviewed as well.</p></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"13 ","pages":"Article 100141"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666964123000425/pdfft?md5=4a0070e01c548f0d9f6c56f15b576285&pid=1-s2.0-S2666964123000425-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138454229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}