Andrea C Kozai, Bethany Barone Gibbs, Lisa D Levine, Abbi D Lane, Mitali Ray, William Grobman, Philip Greenland, Matthew K Hoffman, C Noel Bairey Merz, Phyllis C Zee, Lisa Mims, Natalie A Cameron, George Saade, Robert M Silver, Natalie A Bello, Eliza C Miller, Uma M Reddy, Judith H Chung, Kara M Whitaker, Janet M Catov
{"title":"Health behavior profiles in early pregnancy are associated with adverse pregnancy outcomes and maternal blood pressure 2–7 years after delivery","authors":"Andrea C Kozai, Bethany Barone Gibbs, Lisa D Levine, Abbi D Lane, Mitali Ray, William Grobman, Philip Greenland, Matthew K Hoffman, C Noel Bairey Merz, Phyllis C Zee, Lisa Mims, Natalie A Cameron, George Saade, Robert M Silver, Natalie A Bello, Eliza C Miller, Uma M Reddy, Judith H Chung, Kara M Whitaker, Janet M Catov","doi":"10.1016/j.ajpc.2026.101489","DOIUrl":"10.1016/j.ajpc.2026.101489","url":null,"abstract":"<div><h3>Background</h3><div>The joint effects of individual health behaviors on pregnancy health are rarely considered. We examined associations between combinations of first trimester health behaviors with adverse pregnancy outcomes (APOs) and blood pressure (BP) 2–7 years after delivery, and estimated the proportion of associations with later BP mediated by APOs.</div></div><div><h3>Methods</h3><div>Participants in the nuMoM2b Heart Health Study prospective cohort were included. Physical activity, diet, sleep duration, and smoking were scored using the Life’s Essential 8 framework. APOs included hypertensive disorders of pregnancy, preterm birth, gestational diabetes, small-for-gestational-age birth, or stillbirth. We constructed latent profiles of health behaviors using the Life’s Essential 8 scores. Risk of APOs and differences in continuous BP 2–7 years after delivery based on behavioral profiles were assessed with Poisson and linear regression. Mediation analysis examined the proportion of associations between behavioral profiles and BP mediated by APOs. Where appropriate, analyses were stratified by first trimester obesity status.</div></div><div><h3>Results</h3><div>Among 8700 nulliparas, four behavioral profiles were identified: Healthiest Behaviors (36%), Healthy Activity/Sleep with Poor Diet/Smoking (21%), Healthy Sleep Only (32%), and Least Healthy Behaviors (11%). Adjusted risk of APOs was 9–18% higher across the less healthy behavioral profiles compared to the Healthiest Behaviors profile. Among women without first trimester obesity, adjusted systolic and diastolic BP were 0.93 and 0.85 mmHg higher, respectively, 2–7 years after delivery in those with less healthy behavioral patterns. Associations were not significant among women with first trimester obesity. APOs did not mediate a significant proportion of the association with later-life BP.</div></div><div><h3>Conclusions</h3><div>Less healthy behavioral profiles in early pregnancy were associated with APOs and higher BP 2–7 years after delivery, and early pregnancy obesity was an important effect modifier for later-life BP. Associations with later BP were predominately direct, with no mediation through APOs.</div></div>","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"29 ","pages":"Article 101489"},"PeriodicalIF":5.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149159100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Work Begins","authors":"David J. Maron MD","doi":"10.1016/j.ajpc.2026.101837","DOIUrl":"10.1016/j.ajpc.2026.101837","url":null,"abstract":"","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"29 ","pages":"Article 101837"},"PeriodicalIF":5.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149159098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"From paper to practice: What AJPC owes its readers","authors":"Khurram Nasir","doi":"10.1016/j.ajpc.2026.101834","DOIUrl":"10.1016/j.ajpc.2026.101834","url":null,"abstract":"","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"29 ","pages":"Article 101834"},"PeriodicalIF":5.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149159099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"As the picture gets prettier the bar must rise higher","authors":"Khurram Nasir","doi":"10.1016/j.ajpc.2026.101773","DOIUrl":"10.1016/j.ajpc.2026.101773","url":null,"abstract":"","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"28 ","pages":"Article 101773"},"PeriodicalIF":5.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148730906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Artificial intelligence, preventive cardiology and making time for what matters: a fellow’s voice","authors":"Rodolfo A. Lopes","doi":"10.1016/j.ajpc.2026.101754","DOIUrl":"10.1016/j.ajpc.2026.101754","url":null,"abstract":"","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"28 ","pages":"Article 101754"},"PeriodicalIF":5.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148730909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Beyond the apnea-hypopnea index: Precision cardiovascular risk stratification in obstructive sleep apnea","authors":"Allison E. Gaffey, Filipe A. Moura","doi":"10.1016/j.ajpc.2026.101690","DOIUrl":"10.1016/j.ajpc.2026.101690","url":null,"abstract":"","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"28 ","pages":"Article 101690"},"PeriodicalIF":5.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148730905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Work Continues","authors":"Michael D. Shapiro","doi":"10.1016/j.ajpc.2026.101774","DOIUrl":"10.1016/j.ajpc.2026.101774","url":null,"abstract":"","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"28 ","pages":"Article 101774"},"PeriodicalIF":5.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148730907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The polypill after acute coronary syndrome: A feasible pill to swallow?","authors":"Safi U. Khan , Kershaw V. Patel","doi":"10.1016/j.ajpc.2026.101500","DOIUrl":"10.1016/j.ajpc.2026.101500","url":null,"abstract":"","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"27 ","pages":"Article 101500"},"PeriodicalIF":5.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148196019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Klaus J. Stark , Martina E. Zimmermann , Janina M. Herold , Caroline Brandl , Ralph Burkhardt , Lars S. Maier , Andreas Luchner , Maria A. Heinrich , Iris M. Heid , Alexander Dietl
{"title":"Association of high-sensitivity cardiac troponin T with all-cause and cardiovascular mortality in a mobile cohort of older adults aged 70 to 95 years – Results from the AugUR study","authors":"Klaus J. Stark , Martina E. Zimmermann , Janina M. Herold , Caroline Brandl , Ralph Burkhardt , Lars S. Maier , Andreas Luchner , Maria A. Heinrich , Iris M. Heid , Alexander Dietl","doi":"10.1016/j.ajpc.2026.101520","DOIUrl":"10.1016/j.ajpc.2026.101520","url":null,"abstract":"<div><h3>Background</h3><div>It remains unclear whether high-sensitivity cardiac troponin T (hsTnT) independently predicts mortality in older adults.</div></div><div><h3>Objective</h3><div>To estimate mortality rate and association of hsTnT with all-cause and cardiovascular death in the older, mobile population.</div></div><div><h3>Methods</h3><div>This analysis was conducted in 2055 subjects of the AugUR-study, a prospective population-based cohort study in individuals aged 70 years and older with up to 10-year mortality follow-up. We used Cox proportional hazard models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for association of hsTnT with all-cause, cardiovascular, non-cardiovascular and premature mortality risk. Association results of hsTnT with mortality were reported for tertiles and per 1 standard deviation (SD) of log-transformed values.</div></div><div><h3>Results</h3><div>Participants were 70 to 95 years old with 48% men and 56% with prevalent cardiovascular disease (CVD). In a median follow-up period of 6.0 years, 385 (113 cardiovascular) deaths were recorded. For all-cause mortality, HR was 1.66 [95%CI=1.49–1.85] after adjustment for age and sex (p-value<0.001). For cardiovascular mortality, the effect was more pronounced (HR=2.17 [95%CI=1.79–2.63]; <em>p</em> < 0.001). The association between hsTnT with non-cardiovascular mortality was also significant (HR=1.61 [95%CI=1.41–1.83]; <em>p</em> < 0.001). In a full model adjusting for factors influencing mortality and hsTnT levels, in participants with prevalent CVD, hsTnT showed still association with cardiovascular mortality (HR=1.65 [95%CI=1.30–2.10]; <em>p</em> < 0.001) but also with non-cardiovascular mortality (HR=1.32 [95%CI=1.10–1.58]; <em>p</em> < 0.01).</div></div><div><h3>Conclusion</h3><div>Elevated levels of hsTnT were associated with increased cardiovascular and non-cardiovascular mortality risk in an old-aged population. Measurement of hsTnT in subjects with prevalent CVD may help identify individuals at high risk for mortality.</div></div>","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"27 ","pages":"Article 101520"},"PeriodicalIF":5.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148195754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lea R. Goren , Allison W. Peng , Alexander C. Razavi , Michael J. Blaha , Roger S. Blumenthal , Aaron L. Troy
{"title":"The ABCs of cardiovascular disease prevention: communicating what we know in 2026","authors":"Lea R. Goren , Allison W. Peng , Alexander C. Razavi , Michael J. Blaha , Roger S. Blumenthal , Aaron L. Troy","doi":"10.1016/j.ajpc.2026.101570","DOIUrl":"10.1016/j.ajpc.2026.101570","url":null,"abstract":"<div><div>Despite numerous breakthroughs in Preventive Cardiology, control of key cardiovascular disease (CVD) risk factors including blood pressure and diabetes has stagnated in the past decade, driven in part by the obesity epidemic and population aging. Improving dissemination and implementation of the latest guidelines and evidence-based recommendations is a key national priority for CVD prevention. The ABCs of CVD Prevention is a structured framework identifying actionable domains for CVD prevention, first published in 2001 and last updated in 2021, designed to maximize clarity and uptake of key preventive recommendations. In this State-of-the-Art review, we provide a comprehensively updated version of the ABCs reflecting what we know in 2026, with two practice pearls per domain and accompanying figures and materials to support dissemination. The ABCs of CVD Prevention are: <strong>A</strong>ssess CVD Risk, <strong>A</strong>ntiplatelets, <strong>B</strong>lood Pressure, <strong>B</strong>ody Fat, <strong>C</strong>holesterol, <strong>C</strong>igarettes & Alcohol, <strong>D</strong>iet, <strong>D</strong>iabetes & Cardiovascular-Kidney-Metabolic Syndrome, <strong>E</strong>xercise, <strong>E</strong>xtend Healthspan, Heart <strong>F</strong>ailure, and Atrial <strong>F</strong>ibrillation. The ABCs have the potential for population-level impact with clinical uptake and educational efforts across specialties and settings, supported by the evidence and materials herein.</div></div>","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"27 ","pages":"Article 101570"},"PeriodicalIF":5.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148195855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}