American journal of preventive cardiology最新文献

{"title":"The future of CV prevention science depends on how we communicate: why simultaneous publication matters","authors":"Khurram Nasir","doi":"10.1016/j.ajpc.2026.101674","DOIUrl":"10.1016/j.ajpc.2026.101674","url":null,"abstract":"","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"27 ","pages":"Article 101674"},"PeriodicalIF":5.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148196006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential of oral combination lipid‑lowering therapy beyond statins: a simulation‑based perspective from the SANTORINI study","authors":"Raul D. Santos","doi":"10.1016/j.ajpc.2026.101596","DOIUrl":"10.1016/j.ajpc.2026.101596","url":null,"abstract":"","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"27 ","pages":"Article 101596"},"PeriodicalIF":5.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148196015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between cardio-kidney-metabolic syndrome and early or very early onset atrial fibrillation","authors":"Abdallah Elshafeey ,&nbsp;Zhiqi Yao ,&nbsp;Omar Mhaimeed ,&nbsp;John Ehrabor ,&nbsp;Nino Isakadze ,&nbsp;Hugh Calkins ,&nbsp;Michael J. Blaha","doi":"10.1016/j.ajpc.2026.101561","DOIUrl":"10.1016/j.ajpc.2026.101561","url":null,"abstract":"<div><h3>Introduction</h3><div>Early onset atrial fibrillation (AF), occurring at younger ages, is understudied. The Cardiovascular-Kidney-Metabolic (CKM) syndrome highlights the interplay between cardiovascular disease (CVD), chronic kidney disease (CKD), and metabolic syndrome. We aimed to explore the longitudinal association between CKM and its components and early onset AF.</div></div><div><h3>Methods</h3><div>We used data from the All of Us Research Program, including participants ≤65 years of age with linked electronic health records (EHR), evaluating presence of individual CKM components (including obesity, obstructive sleep apnea, diabetes, CKD, hypertension, and heart failure), and AF status. In those without baseline AF, incident AF was ascertained using the EHR. We calculated the prevalence and incidence rate of AF by CKM status and used Cox Proportional Hazard models to explore the multivariable-adjusted associations between CKM and AF across the different baseline age strata: ≤65 years (early onset) and ≤45 years (very early onset).</div></div><div><h3>Results</h3><div>A total of 296,428 individuals were included. Mean age was 44.9 years, 63.5% were female, 41.8% were White. The prevalence of baseline AF was significantly higher for participants with CKM compared to those without. During follow-up, CKM was associated with increased risk for AF across all age groups. The risk for AF was increased across all components of CKM, with results most pronounced in participants ≤45. The addition of CKM components improved prediction of incident AF beyond the basic model.</div></div><div><h3>Conclusion</h3><div>Our findings reveal an association between CKM and both early and very early onset AF. The particularly strong associations in the youngest adults points to need for early intervention on CKM syndrome to potentially reduce very early onset AF.</div></div>","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"27 ","pages":"Article 101561"},"PeriodicalIF":5.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148195742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in cardiovascular mortality among disaggregated Asian American subgroups: 2018-2022","authors":"David H. Yang ,&nbsp;So Hee Naomi Ahn ,&nbsp;Thirumagal Gowrikanthan ,&nbsp;Franco Miguel Valencia ,&nbsp;Karin Kai Wing Wang ,&nbsp;Jasmin Choi ,&nbsp;Lester Andrew Uy ,&nbsp;Armaan Jamal ,&nbsp;Nilay S. Shah ,&nbsp;Nitya Rajeshuni ,&nbsp;Gloria Kim ,&nbsp;Malathi Srinivasan ,&nbsp;Latha Palaniappan ,&nbsp;Adrian Matias Bacong","doi":"10.1016/j.ajpc.2026.101515","DOIUrl":"10.1016/j.ajpc.2026.101515","url":null,"abstract":"<div><h3>Background</h3><div>Asian Americans, one of the fastest-growing racial groups, experienced an increase in cardiovascular disease (CVD) mortality during the COVID-19 pandemic. The objective of our study was to examine specific trends in CVD mortality rates in Asian American subgroups from 2018 through 2022 to better contextualize trends before and after the pandemic.</div></div><div><h3>Methods</h3><div>We analyzed US death certificate data for ischemic heart disease (IHD) and heart failure (HF) in non-Hispanic Asian American subgroups (Chinese, Filipino, Asian Indian, Japanese, Korean, and Vietnamese) and Non-Hispanic White individuals before and during the pandemic. We calculated age-standardized mortality rates, proportional mortality ratios, and annual percent change of age-standardized mortality rates for IHD and HF.</div></div><div><h3>Results</h3><div>During the study period, there was no significant change in IHD mortality rate for all Asian American subgroups and for Non-Hispanic Whites during the study period. HF mortality rate significantly increased in Vietnamese American females (11.6% per year [95% CI, 2.2–23.0]). The highest mortality rates were found in Asian Indian and Filipino American males and Asian Indian American females.</div></div><div><h3>Conclusions</h3><div>There was heterogeneity in cardiovascular mortality rates among Asian American subgroups, with IHD mortality rate stagnant in all subgroups between 2018 to 2022 and HF mortality rate increasing among Vietnamese American females during the study period. Greater surveillance of the burden of and mortality from CVD is needed for all Asian American subgroups.</div></div>","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"27 ","pages":"Article 101515"},"PeriodicalIF":5.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148195685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Small, dense LDL-C as a predictor of cardiovascular risk and benefit of alirocumab in patients with recent acute coronary syndrome receiving optimized statin treatment","authors":"Gregory G. Schwartz ,&nbsp;Michael Szarek ,&nbsp;Christa M. Cobbaert ,&nbsp;L. Renee Ruhaak ,&nbsp;Markus Schwertfeger ,&nbsp;Deepak L. Bhatt ,&nbsp;Vera A. Bittner ,&nbsp;Shaun G. Goodman ,&nbsp;Robert A. Harrington ,&nbsp;Irena Stevanovic ,&nbsp;Hagai Tavori ,&nbsp;Esther Reijnders ,&nbsp;Fred Romijn ,&nbsp;Nicolaas J.M. van Neer ,&nbsp;Harvey D. White ,&nbsp;J.W. Jukema ,&nbsp;P. Gabriel Steg","doi":"10.1016/j.ajpc.2026.101643","DOIUrl":"10.1016/j.ajpc.2026.101643","url":null,"abstract":"<div><h3>Introduction</h3><div>Small, dense low-density lipoprotein (sdLDL) particles are considered a highly atherogenic subfraction of LDL. Automated biochemical measurement of sdLDL cholesterol (sdLDL-C) has good fidelity to gold-standard measurements. We evaluated relationships of sdLDL-C and LDL-C to risk of major adverse cardiovascular events (MACE) and treatment benefit of the PCSK9-directed monoclonal antibody alirocumab in patients with recent acute coronary syndrome (ACS) and elevated atherogenic lipoproteins despite optimized statin treatment.</div></div><div><h3>Methods</h3><div>Analyses comprised 11,837 participants in the ODYSSEY OUTCOMES trial randomized to receive alirocumab or placebo. sdLDL-C was measured using the Denka method; baseline LDL-C was calculated with the Friedewald formula. In the placebo group (<em>n</em> = 5920), cubic splines depicted relationships of sdLDL-C, LDL-C, and their ratio to risk of MACE (cardiovascular death, non-fatal myocardial infarction, ischemic stroke, hospitalization for unstable angina, and ischemia-driven coronary revascularization). Treatment hazard ratio (HR) was calculated across sdLDL-C and LDL-C ranges.</div></div><div><h3>Results</h3><div>Over 2.8 years median follow-up, risk of MACE in the placebo group increased with higher baseline sdLDL-C or LDL-C with nearly superimposable splines and without variation according to sdLDL-C/LDL-C. Findings were similar in patients with greater or lesser degrees of insulin resistance. Alirocumab reduced risk of MACE (HR 0.87, 95% CI 0.79, 0.95). Treatment HR did not vary significantly across the range of LDL-C or sdLDL-C.</div></div><div><h3>Conclusion</h3><div>In patients with recent ACS on optimized statin treatment, sdLDL-C and LDL-C similarly predict risk of MACE and benefit of alirocumab treatment. Measurement of sdLDL-C does not appear to provide additional prognostic or predictive information in this population.</div></div>","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"27 ","pages":"Article 101643"},"PeriodicalIF":5.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148195687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marked underutilization of lipoprotein(a) testing in peripheral artery disease: a national analysis of 8.3 million patients","authors":"Mustafa Naguib ,&nbsp;Ava J. Fascetti ,&nbsp;Elsie G. Ross ,&nbsp;Edward J. Wang ,&nbsp;Michael Wilkinson ,&nbsp;Ehtisham Mahmud ,&nbsp;Pam Taub ,&nbsp;Harpreet S. Bhatia ,&nbsp;Mattheus Ramsis","doi":"10.1016/j.ajpc.2026.101628","DOIUrl":"10.1016/j.ajpc.2026.101628","url":null,"abstract":"","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"27 ","pages":"Article 101628"},"PeriodicalIF":5.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148195691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre- and post-discharge physical activity in acute myocardial infarction: Relation to clinical events across 5-year follow-up","authors":"Rik Dijkman ,&nbsp;Sophie H. Kroesen ,&nbsp;Bram M.A. van Bakel ,&nbsp;Robert Jan M. van Geuns ,&nbsp;Aukelien C. Dimitriu-Leen ,&nbsp;Thijs M.H. Eijsvogels ,&nbsp;Dick H.J. Thijssen","doi":"10.1016/j.ajpc.2026.101641","DOIUrl":"10.1016/j.ajpc.2026.101641","url":null,"abstract":"","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"27 ","pages":"Article 101641"},"PeriodicalIF":5.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148195692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of carbohydrate restriction on heart rate variability in people with type 2 diabetes during weight loss. A secondary analysis of a randomized controlled trial","authors":"Philip Weber ,&nbsp;Mads N. Thomsen ,&nbsp;Mads J. Skytte ,&nbsp;Amirsalar Samkani ,&nbsp;Jens J. Holst ,&nbsp;Ahmad Sajadieh ,&nbsp;Preman Kumarathurai ,&nbsp;Sten Madsbad ,&nbsp;Faidon Magkos ,&nbsp;Thure Krarup ,&nbsp;Steen B. Haugaard","doi":"10.1016/j.ajpc.2026.101544","DOIUrl":"10.1016/j.ajpc.2026.101544","url":null,"abstract":"","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"27 ","pages":"Article 101544"},"PeriodicalIF":5.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148195693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular disease mortality attributable to monthly non-optimal temperature in the united states: a county-level analysis","authors":"Pedro Rafael Vieira de Oliveira Salerno ,&nbsp;Ricardo J. Estrada-Mendizabal ,&nbsp;Weichuan Dong ,&nbsp;Avery Hum ,&nbsp;Zhuo Chen ,&nbsp;Colin Capenter ,&nbsp;Mohamed Bassiony ,&nbsp;Sanjay Rajagopalan ,&nbsp;Sadeer Al-Kindi ,&nbsp;Salil V Deo","doi":"10.1016/j.ajpc.2026.101514","DOIUrl":"10.1016/j.ajpc.2026.101514","url":null,"abstract":"","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"27 ","pages":"Article 101514"},"PeriodicalIF":5.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148195701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disrupting clinical inertia: Personalizing cardiovascular risk to transform cardiometabolic care in the real world","authors":"Layla A. Abushamat ,&nbsp;Jane E.B. Reusch ,&nbsp;Christie M. Ballantyne","doi":"10.1016/j.ajpc.2026.101463","DOIUrl":"10.1016/j.ajpc.2026.101463","url":null,"abstract":"","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"27 ","pages":"Article 101463"},"PeriodicalIF":5.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148196017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}