American journal of preventive cardiology最新文献

{"title":"Addressing adherence challenges in long-term statin treatment among Asian populations: Current gaps and proposed solutions","authors":"Elmer Jasper B Llanes ,&nbsp;Nuntakorn Thongtang ,&nbsp;Zhen-Vin Lee ,&nbsp;Tran Hoa ,&nbsp;Ong Hean Yee ,&nbsp;Renan Sukmawan","doi":"10.1016/j.ajpc.2025.101019","DOIUrl":"10.1016/j.ajpc.2025.101019","url":null,"abstract":"<div><div>Statin therapy, known for its lipid-lowering properties, substantially lowers the risk of cardiovascular events in patients vulnerable to atherosclerotic cardiovascular disease (ASCVD) across diverse demographic groups. Despite evidence supporting their benefits, statins are often underutilized or even discontinued. Disparities in statin utilization exist across Asian countries due to healthcare system policies and economic circumstances. Addressing these disparities is essential, especially in the context of global initiatives designed to enhance affordability and raise awareness. Healthcare practitioners (HCPs) must assess ASCVD risks and take proactive measures aimed at lowering these risks, particularly through the management of low-density lipoprotein cholesterol (LDL-C) levels. It is imperative for HCPs and patients to collaborate for effective management of ASCVD risk, prioritizing improved adherence, treatment continuity, and better health outcomes. This review focuses on statin utilization and adherence in six Asian countries—Thailand, Malaysia, Philippines, Vietnam, Singapore, and Indonesia. It aims to explore the common factors that influence long-term adherence to statin treatment and also offers practical recommendations to improve adherence, ultimately leading to better cardiovascular outcomes in the Asian population.</div></div>","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"23 ","pages":"Article 101019"},"PeriodicalIF":4.3,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144291616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health inequity in metabolic disorders and lifestyle behaviors in under-resourced adolescents: a cross-sectional study from E-DUCASS Program","authors":"Esther Porras-Pérez ,&nbsp;Patricia J. Peña-Orihuela ,&nbsp;Alberto Díaz-Cáceres ,&nbsp;Alejandro Serrán-Jiménez ,&nbsp;Javier Arenas-Montes ,&nbsp;Antonio P. Arenas-de Larriva ,&nbsp;Juan F. Alcalá-Díaz ,&nbsp;Fan-Yun Lan ,&nbsp;Javier Delgado-Lista ,&nbsp;Elena M. Yubero-Serrano ,&nbsp;Jose M. Ordovás ,&nbsp;Juan L. Romero-Cabrera ,&nbsp;Pablo Pérez-Martínez","doi":"10.1016/j.ajpc.2025.101012","DOIUrl":"10.1016/j.ajpc.2025.101012","url":null,"abstract":"<div><h3>Purpose</h3><div>Childhood obesity is a growing public health crisis with significant cardiometabolic and mental health implications throughout life. Socioeconomic adversity, family discord, and childhood stress are strongly associated with a higher prevalence of obesity, disproportionately affecting adolescents from under-resourced families. This study aims to assess the metabolic health and lifestyle behaviors of adolescents in these vulnerable populations and their potential implications for long-term health.</div></div><div><h3>Methods</h3><div>Baseline metabolic characteristics and lifestyle behaviors of 138 adolescents (aged 12–19 years) enrolled in the E-DUCASS program (NCT05379842), a 24-month randomized intervention for food-insecure families, were analyzed. Anthropometric and clinical variables, adherence to the Mediterranean diet, physical activity, and screen time were assessed using WHO-aligned, validated methods. Parental health literacy was evaluated for its influence on adolescent behaviors.</div></div><div><h3>Results</h3><div>Among participants, 43 % were classified as having overweight or obesity, with metabolic syndrome (MetS) prevalence at 31.9 % (NCEP-ATPIII criteria) and 11 % (IDF definition). Mediterranean diet adherence was poor in 44.2 %, moderate in 53.6 %, and high in only 2.2 %. Physical activity guidelines were met by 8 % of adolescents, while compliance with screen time recommendations was low (14.5 % on weekdays and 7.2 % on weekends). Adolescents whose parents exhibited higher health literacy showed better dietary adherence but no significant differences in other outcomes.</div></div><div><h3>Conclusions</h3><div>Adolescents from under-resourced families demonstrate poor adherence to healthy behaviors and high rates of obesity and MetS, exceeding levels reported in general European and Spanish cohorts. These findings highlight the urgent need for targeted interventions, such as the E-DUCASS program, to address these disparities.</div></div>","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"22 ","pages":"Article 101012"},"PeriodicalIF":4.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of high lipoprotein (a) level with carotid atherosclerosis and all-cause mortality","authors":"Anthony Matta ,&nbsp;Dorota Taraszkiewicz ,&nbsp;Pauline Cougoul ,&nbsp;Sylvie Lemozy ,&nbsp;Jean Ferrières","doi":"10.1016/j.ajpc.2025.101023","DOIUrl":"10.1016/j.ajpc.2025.101023","url":null,"abstract":"<div><h3>Background</h3><div>Lipoprotein (a) Lp(a) is a genetically inherited low-density lipoprotein like particle with proinflammatory, prothrombotic and proatherogenic properties. Current guidelines recommend at least one-time measurement of Lp(a) in cardiovascular risk assessment in each adult person’s lifetime.</div></div><div><h3>Aims</h3><div>The present study evaluates the association between exposure to a high circulating level of Lp(a) (≥50mg/dl or ≥125nmol/L) and atherosclerosis and all-cause of death after a very long-term follow-up.</div></div><div><h3>Methods</h3><div>A retrospective analysis was performed on 11,990 subjects admitted to the department of preventive cardiology at Toulouse University Hospital, Rangueil, France and who underwent at least one Lp (a) measurement between September 1995 and December 2023. The living status (alive or dead) of each of study’s participants was assessed by March 2024. The study population was divided into two groups: first, according to Lp (a) level (normal versus high circulating Lp (a) level), and second, according to the living status.</div></div><div><h3>Results</h3><div>High-Lp(a) level group includes 3195 participants. They were significantly more women (47.5 % vs.41.4 %), non-obese (89.1 % vs.84.7 %), sportier (71 % vs. 68.1 %) and normotensive (70.5 % vs. 67.6 %). The adjusted logistic regression on traditional cardiovascular risk factors reveal a positive association between High Lp(a) level and atherogenic findings on doppler ultrasound of carotid arteries [ORa = 1.308;95 %CI(1.182–1.447), <em>p</em> = 0.001]. The all-cause mortality rate was comparable between the two study groups over 13 years of follow-up (7.4 % vs. 8 %). Survival analyses with Kaplan-Meier curves (<em>p</em> = 0.643) and Cox regression [HR = 0.981, 95 %CI (0.844–1.141), <em>p</em> = 0.811] showed no significant difference in survival outcomes.</div></div><div><h3>Conclusion</h3><div>Long-term exposure to high Lp(a) is a predictor for atherosclerotic cardiovascular disease, but not significantly associated with risk of death from any cause.</div></div>","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"23 ","pages":"Article 101023"},"PeriodicalIF":4.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144231698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronary inflammation and atherosclerosis by CCTA in young adults (aged 18-45)","authors":"Annalisa Filtz ,&nbsp;Daniel Lorenzatti ,&nbsp;Henry A Dwaah ,&nbsp;Carlos Espiche ,&nbsp;Santiago F Galgani ,&nbsp;Jake T Gilman ,&nbsp;Alexandrina Danilov ,&nbsp;Andrea Scotti ,&nbsp;Piotr J Slomka ,&nbsp;Daniel S Berman ,&nbsp;Salim S Virani ,&nbsp;Mario J Garcia ,&nbsp;Khurram Nasir ,&nbsp;Leslee J. Shaw ,&nbsp;Ron Blankstein ,&nbsp;Michael D Shapiro ,&nbsp;Damini Dey ,&nbsp;Leandro Slipczuk","doi":"10.1016/j.ajpc.2025.101010","DOIUrl":"10.1016/j.ajpc.2025.101010","url":null,"abstract":"<div><h3>Background</h3><div>Peri-coronary adipose tissue attenuation (PCAT), a marker of coronary inflammation, is linked to coronary artery disease (CAD), but data on the role of PCAT in young individuals are limited.</div></div><div><h3>Aims</h3><div>This study explores the interplay of PCAT and CAD by CCTA, in a symptomatic young cohort.</div></div><div><h3>Methods and Results</h3><div>Patients aged 18–45 years without prior CAD, from Montefiore CCTA registry (2016–2022), were studied retrospectively. Atherosclerosis and PCAT of the left circumflex (LCX), left anterior descending (LAD), and right coronary artery (RCA) were measured. Youden index determined optimal PCAT thresholds for the risk of CAD, defined as presence of any coronary plaque. Multivariable logistic regression analyses assessed the relationship between PCAT and CAD. The study included 733 consecutive patients (37±5 years, 55 % women, 44 % Hispanic, 23 % non-Hispanic Black); 15 % had CAD. Patients with CAD had higher overall PCAT (-77.5 HU vs -79.5, <em>p</em> = 0.026). Higher PCAT was independently associated with CAD, adjusting for age, sex, BMI, smoking, hyperlipidemia, diabetes, hypertension, and family history of CAD (Adj-OR: 2.07, 95 % CI: 1.30–3.57, <em>p</em> = 0.009). High PCAT on LCX remained associated with CAD in CAC=0 population (Adj-OR: 3.37; 95 % CI: 1.41–8.06; <em>p</em> = 0.006). Adding PCAT to a multivariable model including traditional modifiable risk factors significantly improved the association with any CAD, increasing the AUC from 0.65 to 0.68 (<em>p</em> = 0.027).</div></div><div><h3>Conclusion</h3><div>Coronary inflammation is associated with CAD in young patients, independently of traditional risk factors, even among patients with CAC=0 score. These findings highlight its potential as an early marker for guiding preventive strategies.</div></div>","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"22 ","pages":"Article 101010"},"PeriodicalIF":4.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144220909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASPC president’s page: Preventive cardiology in a Global context — Fostering collaboration and shared learning","authors":"Michael D. Shapiro","doi":"10.1016/j.ajpc.2025.101026","DOIUrl":"10.1016/j.ajpc.2025.101026","url":null,"abstract":"","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"22 ","pages":"Article 101026"},"PeriodicalIF":4.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144271200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular disease prevention in sexual minorities, A fellow’s voice","authors":"Natdanai Punnanithinont","doi":"10.1016/j.ajpc.2025.101017","DOIUrl":"10.1016/j.ajpc.2025.101017","url":null,"abstract":"","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"22 ","pages":"Article 101017"},"PeriodicalIF":4.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144253844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASPC 2025","authors":"","doi":"10.1016/S2666-6677(25)00113-8","DOIUrl":"10.1016/S2666-6677(25)00113-8","url":null,"abstract":"","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"22 ","pages":"Article 101038"},"PeriodicalIF":4.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Association of thoracic aortic calcium with incident cardiovascular disease and all-cause mortality across the spectrum of coronary artery calcium burden” [American Journal of Preventive Cardiology 21 (2025) 100916]","authors":"Alexander C. Razavi ,&nbsp;Omar Dzaye ,&nbsp;Miguel Cainzos-Achirica ,&nbsp;Zeina Dardari ,&nbsp;Marly Van Assen ,&nbsp;Arshed A. Quyyumi ,&nbsp;Khurram Nasir ,&nbsp;J. Jeffrey Carr ,&nbsp;Matthew J. Budoff ,&nbsp;Roger S. Blumenthal ,&nbsp;Paolo Raggi ,&nbsp;Carlo N. De Cecco ,&nbsp;Laurence S. Sperling ,&nbsp;Michael J. Blaha ,&nbsp;Seamus P. Whelton","doi":"10.1016/j.ajpc.2025.100989","DOIUrl":"10.1016/j.ajpc.2025.100989","url":null,"abstract":"","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"22 ","pages":"Article 100989"},"PeriodicalIF":4.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex and racial differences in prevalence and clinical characteristics of people living with LDLR and PCSK9 familial hypercholesterolemia genetic variants: Data from the All of Us Research program","authors":"Jeffery Osei ,&nbsp;Alexander C. Razavi ,&nbsp;Arshed A. Quyyumi ,&nbsp;Danny J. Eapen ,&nbsp;Yan V. Sun ,&nbsp;Muin J. Khoury ,&nbsp;Laurence Sperling","doi":"10.1016/j.ajpc.2025.101024","DOIUrl":"10.1016/j.ajpc.2025.101024","url":null,"abstract":"<div><h3>Background</h3><div>Data on the prevalence and clinical characteristics of people with Familial hypercholesterolemia (FH) genetic variants across sex and diverse racial and ethnic groups in the United States are limited.</div></div><div><h3>Methods</h3><div>Using data from the <em>All of Us</em> research program, we examined the prevalence and clinical characteristics of FH variant carriers in a diverse U.S. population. <em>LDLR</em> and <em>PCSK9</em> FH genetic variants were identified using the ClinVar database. Atherosclerotic cardiovascular disease (ASCVD) and lipid-lowering therapy (LLT) use were ascertained from electronic health records. Prevalence, ASCVD burden, and LLT use among FH variant carriers were estimated and stratified by sex, race, and ethnicity</div></div><div><h3>Results</h3><div>Among 245,388 participants (mean age 51.8 years, 59.3 % women, 51.3 % non-Hispanic White, 20.4 % non-Hispanic Black, 3 % non-Hispanic Asian, 19.3 % Hispanic), 448 were identified as FH genetic variant carriers, yielding a prevalence of 1 in 546 (95 % CI: 1/602- 1/500). Prevalence was highest among Asian non-Hispanics (1 in 286) and lowest in Hispanics (1 in 694); p-value = 0.003. Males had a higher prevalence of FH variants than females (1 in 485 vs. 1 in 602, p-value = 0.03). Regardless of LDL-C levels, FH variant carriers had a higher prevalence of ASCVD history than those without FH variants (p-value = 0.04). Black non-Hispanics, Asian non-Hispanics, and Hispanics had lower ASCVD prevalence and LLT use than White non-Hispanics. ASCVD prevalence was higher in males with FH variants than females (25 % vs. 18 %, p-value = 0.04).</div></div><div><h3>Conclusion</h3><div>Significant racial, ethnic, and sex disparities exist in the prevalence, ASCVD burden, and LLT use among FH variant carriers. Further targeted efforts, including increased genetic testing, are needed to improve FH detection and optimize treatment, particularly in racial and ethnic minority groups where LLT use remains inadequate.</div></div>","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"22 ","pages":"Article 101024"},"PeriodicalIF":4.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144220910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editors’ message – June 2025","authors":"Erin D. Michos ,&nbsp;Nathan D. Wong","doi":"10.1016/j.ajpc.2025.101025","DOIUrl":"10.1016/j.ajpc.2025.101025","url":null,"abstract":"","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"22 ","pages":"Article 101025"},"PeriodicalIF":4.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144253843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}