Alpha psychiatry最新文献

{"title":"Effect of Dance Intervention on Cognitive Function and Related Cerebellar Dynamic Functional Connectivity in Patients With Schizophrenia.","authors":"Hui He, Gujing Li, Yuanyuan Yu, Yayun Liu, Tianhuan Li, Kexin Gao, Ping Xi, Frank Pollick, Jing Lu, Lixue Yin, Dezhong Yao, Li Mi, Cheng Luo","doi":"10.31083/AP45310","DOIUrl":"10.31083/AP45310","url":null,"abstract":"<p><strong>Background: </strong>The cerebellum is a critical node implicated in the pathology of schizophrenia. Previous studies have demonstrated that dance interventions can enhance cerebellar functional connectivity in healthy individuals. These findings suggest that dance intervention might represent a promising treatment for patients with schizophrenia.</p><p><strong>Methods: </strong>A total of 32 patients with schizophrenia were randomly assigned to two groups: a dance group (n = 18) and an aerobic exercise group (n = 14). Clinical symptoms and cognitive function, along with resting-state functional magnetic resonance imaging (fMRI) data, were collected from all participants at baseline and post-intervention. The cerebellar motor (CBCm) and cerebellar cognitive (CBCc) regions were defined for the calculation of dynamic functional connectivity (dFC). Repeated-measures analyses of covariance (ANCOVAs) were conducted for statistical analysis.</p><p><strong>Result: </strong>Significant interaction effects were observed for cognitive function and dFC. Dance intervention specifically enhanced cognitive function, as assessed by the Continuous Performance Test-Identical Pairs (CPT-IP) and the Hopkins Verbal Learning Test-Revised (HVLT-R). Moreover, increased dFC was observed between the CBCm and the left medial superior frontal gyrus, left superior occipital gyrus, and right cuneus, as well as between the CBCc and the right median cingulate cortex and the left inferior temporal gyrus in the dance intervention group. Additionally, dFC between the CBCc and the median cingulate gyrus showed a positive correlation with CPT-IP (r = 0.412, <i>p</i> = 0.026) and HVLT-R (r = 0.414, <i>p</i> = 0.021) scores.</p><p><strong>Conclusions: </strong>These findings suggest that dance intervention specifically enhances cerebellar connectivity patterns, potentially improving attention and verbal memory in patients with schizophrenia.</p><p><strong>Clinical trial registration: </strong>No: ChiCTR2100049273, https://www.chictr.org.cn/showproj.html?proj=65597.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"27 2","pages":"45310"},"PeriodicalIF":2.9,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13156061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147870501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Hypoxic Exposure May Contribute to Depressive-Like Behaviors in Mice Through Disruption of Gut Microbiota Homeostasis.","authors":"Ruiying Cheng, Yajun Qiao, Huimin Zheng, Xiaohui Li, Qiannan Wang, Xingfang Zhang, Jianv Wang, Lixin Wei, Tingting Gao, Hongtao Bi","doi":"10.31083/AP47626","DOIUrl":"10.31083/AP47626","url":null,"abstract":"<p><strong>Background: </strong>Depression represents a major global disease burden. High-altitude hypoxia is closely associated with an increased incidence of depressive symptoms; however, the underlying mechanisms remain unclear.</p><p><strong>Methods: </strong>In this study, mice were subjected to 7 days of hypoxic exposure simulating high-altitude environments at 3000 m (14.4% O₂) and 4000 m (12.7% O₂). Depressive-like behaviors were assessed using the open field test, tail suspension test, and forced swim test. Enzyme-linked immunosorbent assays were employed to measure markers related to inflammatory responses, oxidative stress, and hypothalamic-pituitary-adrenal (HPA) axis activity. Additionally, 16S ribosomal RNA sequencing was performed to analyze alterations in the gut microbiota. Untargeted metabolomics was used to examine metabolite changes in the colon and hippocampus. Validation analyses included measurements of hippocampal immunofluorescence density and cortical neurotransmitter levels.</p><p><strong>Results: </strong>Hypoxic exposure induced depressive-like behaviors, as well as colonic and hippocampal tissue damage. It also exacerbated inflammation and oxidative stress, reduced gut microbiota diversity, disrupted tryptophan metabolism, decreased cortical neurotransmitter levels and brain-derived neurotrophic factor (BDNF), and increased the immunofluorescence density of hippocampal neuron-glial antigen 2 and oligodendrocyte transcription factor 2. These effects exhibited an intensity-toxicity relationship.</p><p><strong>Conclusions: </strong>Acute hypoxia is associated with gut microbiota imbalance, disrupted tryptophan metabolism, inflammatory responses, and dysfunction of the HPA axis, alongside negative emotional states. These multidimensional alterations are strongly correlated, suggesting a potential regulatory network involving the gut microbiota-tryptophan metabolism axis in hypoxia-induced emotional changes.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"27 2","pages":"47626"},"PeriodicalIF":2.9,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13156067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147870795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Serum Vitamin D and Lipid Levels in Patients With Depression: A Cross-Sectional Study.","authors":"Lihua Yao, Honggang Lv, Zhaowen Nie, Wei Wang, Simeng Ma, Zhili Niu, Ying Wang, Lijun Kang, Dan Xiang, Wei Yuan, Hexiang Chen, Zhongchun Liu","doi":"10.31083/AP46265","DOIUrl":"10.31083/AP46265","url":null,"abstract":"<p><strong>Background: </strong>Vitamin D deficiency is prevalent among individuals with depression; however, clinical findings regarding this association have been inconsistent. Additionally, a significant proportion of depressed patients present with dyslipidemia, yet the interplay between vitamin D status, lipid metabolism, and depression remains poorly understood. We aimed to explore the role of vitamin D in depression and to investigate the potential associations between vitamin D status, lipid metabolism, and depressive symptoms.</p><p><strong>Methods: </strong>We recruited 412 first-episode, drug-naïve patients with depression and 180 age-matched healthy controls. Fasting venous blood samples were collected in the morning to quantify serum vitamin D and lipid profiles. Depressive symptoms were assessed on the day of blood collection using both the Patient Health Questionnaire-9 (PHQ-9) and the 17-item Hamilton Depression Rating Scale (HAMD-17). Spearman's rank correlation was employed to examine associations between serum vitamin D concentrations and depressive symptom severity. Binary logistic regression analysis was subsequently performed to identify potential risk factors for depression.</p><p><strong>Results: </strong>Compared with healthy controls, depressed patients had significantly lower serum vitamin D and high-density lipoprotein cholesterol (HDL-C) levels. This sex-specific pattern showed that male patients had lower vitamin D, while female patients had lower HDL-C. Spearman's correlation analysis revealed significant inverse correlations of vitamin D and triglyceride (TG) with PHQ-9 and HAMD-17 scores among depressed patients. Logistic regression analysis indicated that individuals with higher vitamin D levels had a reduced likelihood of depression compared with those with low vitamin D levels (adjusted odds ratio (OR) = 0.950, 95% confidence interval (CI): 0.920-0.982, <i>p</i> = 0.002). Similarly, subjects with elevated HDL-C levels were associated with a lower likelihood of depression relative to those with diminished HDL-C levels (adjusted OR = 0.317, 95% CI: 0.173-0.583, <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>Serum vitamin D and HDL-C levels were lower in patients with depression than in healthy individuals. Both vitamin D and HDL-C may be inversely associated with depression.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"27 2","pages":"46265"},"PeriodicalIF":2.9,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13156060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147870505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychobiotics in Mental Health - Between Hope, Evidence, and the Need for Precision.","authors":"Alberto Sá Filho, James Oluwagbamigbe Fajemiroye, Sergio Machado","doi":"10.31083/AP45973","DOIUrl":"10.31083/AP45973","url":null,"abstract":"","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"27 2","pages":"45973"},"PeriodicalIF":2.9,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13156054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147870468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological and Non-Pharmacological Interventions for Non-Suicidal Self-Injury: A Narrative Review.","authors":"Jieying Tan, Lulu Zhang","doi":"10.31083/AP48183","DOIUrl":"10.31083/AP48183","url":null,"abstract":"<p><p>Non-suicidal self-injury (NSSI), particularly among youth, is an increasing, global, public health concern. Some studies have shown that NSSI is an independent risk factor for suicidal behavior. However, evidence-based treatment guidelines remain underdeveloped. We searched PubMed, Web of Science, and the China National Knowledge Infrastructure (CNKI) for studies on adolescent or adult NSSI published between January 2005 and August 2025 to try to determine the most effective treatment strategies. We included 50 studies. Interventions were categorized into psychotherapy, pharmacotherapy, neuromodulation, and digital health approaches. Psychotherapy, especially dialectical behavior therapy (DBT), showed the most consistent efficacy in reducing NSSI frequency and improving emotion regulation. Adjunctive pharmacotherapy with antidepressants and atypical antipsychotics alleviated comorbid symptoms, but caution is warranted in younger patients due to potential risks. Neuromodulation techniques, including repetitive transcranial magnetic stimulation (rTMS) and transcranial electrical stimulation (TES), may reduce NSSI through modulation of prefrontal cortex activity, and deep brain stimulation (DBS) show promise for treatment-resistant cases. Digital tools such as mobile applications, ecological momentary assessment, and artificial intelligence (AI)-assisted technologies enable real-time monitoring and risk prediction but remain complementary to traditional crisis intervention. Ultimately, in this review, we highlight the importance of multimodal and individualized strategies in managing NSSI and provide insights to guide future clinical practice and research.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"27 2","pages":"48183"},"PeriodicalIF":2.9,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13156066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147870462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Overdose-Induced Hypoxia on Neurocognitive Performance in Individuals With Opioid Dependence: A Prospective Multicenter Study.","authors":"Sunsha Chamakalayil, Serge Brand, Marc Vogel, Markus Gerber, Kenneth M Dürsteler","doi":"10.31083/AP45138","DOIUrl":"10.31083/AP45138","url":null,"abstract":"<p><strong>Background: </strong>Severe opioid dependence is associated with neurocognitive impairments, potentially aggravated by recurrent overdose-induced hypoxia and long-term opioid use-induced hypoperfusion. Although hypoxia-related impairments seem to vary with severity, duration, and frequency, findings are inconsistent. Moreover, evidence specific to opioid-related hypoxia is scarce. Given this gap, this prospective pilot study examined whether hypoxic incidents predict poorer neurocognitive performance and reduced improvement during three months of opioid agonist treatment.</p><p><strong>Methods: </strong>Forty-seven individuals with opioid dependence (mean age = 34.3 years; 27.7% female) completed a neuropsychological assessment that included 12 validated tests covering a broad range of neurocognitive domains at baseline and at study end (n = 33; 33% female).</p><p><strong>Results: </strong>The repeated-measures ANOVA yielded no significant effects of Time, Group (hypoxic incidents vs. no hypoxic incidents), or their interaction on neurocognitive performance in the domains of attention, memory, or executive functions. This suggests that changes in neurocognitive performance over time did not differ significantly between participants with and without a history of hypoxic incidents. However, post-hoc analyses indicated that hypoxic incidents requiring resuscitation may adversely affect neurocognitive functioning.</p><p><strong>Conclusions: </strong>These findings suggest that hypoxic incidents without resuscitation may not aggravate long-term neurocognitive impairments, supporting previous findings that brain cells can tolerate transient hypoxia. These results may also suggest that treatment planning should prioritize history of resuscitation incidents along with other prognostic factors such as duration of opioid use, baseline neurocognitive impairments, co-occurring mental health conditions, and socioeconomic factors. Future studies with larger samples and more precise assessments of hypoxia are essential to further clarify these findings and optimize treatment approaches.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"27 2","pages":"45138"},"PeriodicalIF":2.9,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13156058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147870467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Assessment of Neurodevelopmental Scales Correlates With Positive M-CHAT Screening in 24-Month-Old Infants.","authors":"Haixia Chang, Yali Liu, Jinfang Lv, Qin Li, Junqiang Xue, Xia Wang","doi":"10.31083/AP42936","DOIUrl":"10.31083/AP42936","url":null,"abstract":"<p><strong>Background: </strong>Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by deficits in social communication and repetitive behaviors. Early identification of high-risk infants is crucial for intervention and long-term outcomes. This study explored the association between early neurological development from 12 to 15 months and the related risk factors for ASD, with a primary focus on M-CHAT status at 24 months as the screening outcome, and the impact of family history, prematurity, and sleep disorders.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of 50 children aged 24 months who tested positive on the Modified Checklist for Autism in Toddlers (M-CHAT) and 50 matched controls with negative results. Neurodevelopmental status was assessed using the Gesell Developmental Diagnosis Scale (GDDS), the Peabody Developmental Motor Scales, Second Edition (PDMS-2), and the Sensory Integration Schedule (SIS). Statistical analyses, including logistic regression, were used to evaluate associations among baseline characteristics, neurodevelopmental scores, and ASD risk factors.</p><p><strong>Results: </strong>A total of 100 infants were included, with 50 classified as high risk and 50 as low risk. High-risk infants had significantly higher rates of family history of ASD, prematurity, and sleep disorders. They showed impairments across several PDMS-2 subscales, including stationary, locomotion, and grasping, as well as GDDS subscales such as adaptability and language. Logistic regression analysis revealed that neurodevelopmental impairments were significantly associated with M-CHAT positivity at 24 months.</p><p><strong>Conclusions: </strong>Early neurodevelopmental impairments in infants aged 12 to 15 months may serve as important indicators of ASD risk. Identifying these factors may facilitate timely intervention and improve outcomes for high-risk children.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"27 2","pages":"42936"},"PeriodicalIF":2.9,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13156057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147870524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Operationalizing Population Salutogenesis Through Recovery-Oriented Cognitive Therapy: Evidence from Schizophrenia.","authors":"Shin-Ichiro Sasahara, Kei Muroi, Shun Nakajima","doi":"10.31083/AP48857","DOIUrl":"10.31083/AP48857","url":null,"abstract":"","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"27 2","pages":"48857"},"PeriodicalIF":2.9,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13156045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147870529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Computerized Cognitive Remediation Therapy on Executive Functions and Clinical Symptoms in Children and Adolescents With ADHD: A Meta-Analysis of Randomized Controlled Trials.","authors":"Junrong Ye, Yuhan Zhang, Na Ma, Tian Zhou, Lexin Yuan, Yanheng Wei, Jinrong Li, Xueyu Zheng, Dingjie Liu, Jianxiong Guo, Aixiang Xiao","doi":"10.31083/AP39972","DOIUrl":"10.31083/AP39972","url":null,"abstract":"<p><strong>Background: </strong>This meta-analysis of randomized clinical trials (RCTs) aimed to determine whether computer-assisted cognitive remediation therapy (CCRT) is a feasible adjunctive treatment to improve executive function and clinical symptoms in adolescents and children with attention deficit hyperactivity disorder (ADHD).</p><p><strong>Methods: </strong>We systematically searched 9 English and Chinese databases from database inception until May 2025. Randomized controlled trials investigating CCRT in children and adolescents with ADHD were collected. The risk of bias was assessed using the Cochrane Collaboration's tool for assessing risk of bias (RoB 2.0) and the Jadad Scale. Standardized mean differences in post-intervention data were calculated using RevMan 5.4 software. This study adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and was registered on the International Prospective Register of Systematic Reviews (PROSPERO) platform.</p><p><strong>Results: </strong>This review included 17 RCTs comprising 1087 cases. In the CCRT intervention groups, there was a significant decrease in overall executive function (standardized mean difference (SMD) = -0.23; 95% CI = [-0.45, -0.01]; <i>p</i> = 0.04), working memory (SMD = -0.25; 95% CI = [-0.46, -0.03]; <i>p</i> = 0.03), inhibition (SMD = -0.25; 95% CI = [-0.44, -0.05]; <i>p</i> = 0.01), planning (SMD = -0.26; 95% CI = [-0.50, -0.01]; <i>p</i> = 0.04), and inattention (SMD = -0.22; 95% CI = [-0.39, -0.05]; <i>p</i> = 0.01) compared to the control groups; however, results did not show significant effects on cognitive flexibility, overall clinical symptoms, or hyperactivity/impulsivity compared to the control group.</p><p><strong>Conclusion: </strong>CCRT played an important role in improving specific executive functions and attention symptoms in children and adolescents with ADHD. However, high-quality research is needed to validate these preliminary findings.</p><p><strong>The prospero registration: </strong>CRD42024619958, https://www.crd.york.ac.uk/PROSPERO/view/CRD42024619958.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"27 2","pages":"39972"},"PeriodicalIF":2.9,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13156065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147870476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotypic Clustering of Addictions Reveals Impulsivity Links to Internalizing Disorders: A Network Analysis.","authors":"Ardıl Bayram Şahin, Yusuf Huseyin Berrak, Duru Besen, Hilal Askin, Hale Yapici Eser","doi":"10.31083/AP49511","DOIUrl":"10.31083/AP49511","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Substance-related and behavioral addictions frequently co-occur and are increasingly conceptualized as part of an interconnected psychopathological framework. Addictive behaviors are linked to internalizing symptoms, including depression, anxiety, and stress, through shared vulnerability. Although impulsivity, anhedonia, and stress-related processes have been proposed as transdiagnostic factors, their relative roles as central or bridging mechanisms remain unclear. This study aimed to clarify the network structure of multiple addictions by jointly modeling substance-related and behavioral addictions with multidimensional psychological features.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A total of 169 university students completed standardized self-report measures assessing four substance-related addictions (alcohol, tobacco, cannabis, cocaine) and six behavioral addictions (gambling, shopping, gaming, eating, sexual activity, and work), alongside measures of impulsivity, anhedonia, depression, anxiety, stress, chronic stress, and childhood adversities. Three Extended Bayesian Information Criterion Graphical Least Absolute Shrinkage and Selection Operator (EBICglasso) network models were estimated: (i) an addiction-only network, (ii) an addictions-psychometric features network, and (iii) a focused network integrating selected addictions with affective symptoms, stress, and adversities. Centrality, bridge indices, and predictability were evaluated.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Substance-related and behavioral addictions formed a coherent and interconnected network, with alcohol (0.89), sexual activity (0.77), and cannabis (0.70) emerging as the most central hubs. Impulsivity and anxiety functioned as the primary bridge nodes linking addictive behaviors with internalizing symptomatology, with anxiety exhibiting the highest bridge strength (0.29), followed by impulsivity (0.20). The affective distress cluster, comprising depression, anxiety, and stress, demonstrated the strongest internal connectivity and the highest predictability (R&lt;sup&gt;2&lt;/sup&gt;), with explained variance values of R&lt;sup&gt;2&lt;/sup&gt; = 0.33 for depression and R&lt;sup&gt;2&lt;/sup&gt; = 0.30 for both anxiety and stress. Stress exposure and childhood adversity showed cross-domain connections involving sexual activity and alcohol use.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;This study models substance-related and behavioral addictions together with internalizing symptoms, impulsivity, anhedonia, and stress-related factors to examine how addictive behaviors are organized within an interconnected network. Alcohol, cannabis, and sexual activity showed relatively high connectivity, while impulsivity and anxiety were consistently positioned as bridge variables linking addictive behaviors with affective distress. These findings provide a descriptive transdiagnostic framework in which shared regulatory traits emerge as key organizing features of addiction comorbidity; however, their potent","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":"27 2","pages":"49511"},"PeriodicalIF":2.9,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13156064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147870515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}