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Primary Appendiceal Gastrointestinal Stromal Tumor 原发性阑尾胃肠道间质瘤
AJSP: reviews & reports Pub Date : 2021-12-21 DOI: 10.1097/PCR.0000000000000410
Joseph S. Kim, A. Jhala, Kristen M. Stashek, R. Tondon
{"title":"Primary Appendiceal Gastrointestinal Stromal Tumor","authors":"Joseph S. Kim, A. Jhala, Kristen M. Stashek, R. Tondon","doi":"10.1097/PCR.0000000000000410","DOIUrl":"https://doi.org/10.1097/PCR.0000000000000410","url":null,"abstract":"Abstract Primary appendiceal gastrointestinal stromal tumor is extremely rare. To our knowledge, only 17 cases have been reported so far. Presented is a case of an 84-year-old woman who underwent elective laparoscopic right partial colectomy for an ileocecal mass found during colonoscopy. On gross examination, a 0.8-cm well-defined tan-white nodule was present in the distal portion of the appendix. Histology of the nodule showed proliferation of irregular fascicles of bland spindle cells, which stained positive for DOG1 (Ano1) and CD117 (KIT) and negative for S-100 and SMA. We report the incidental primary gastrointestinal stromal tumor of the appendix and discuss its biological behavior.","PeriodicalId":72144,"journal":{"name":"AJSP: reviews & reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74686070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Too Young for Clear Cell Sarcoma of the Kidney? A Case Report With Review of Differential Considerations 过早得肾透明细胞肉瘤?一个病例报告，回顾不同的考虑
AJSP: reviews & reports Pub Date : 2021-11-01 DOI: 10.1097/PCR.0000000000000408
D. Russell
{"title":"Too Young for Clear Cell Sarcoma of the Kidney? A Case Report With Review of Differential Considerations","authors":"D. Russell","doi":"10.1097/PCR.0000000000000408","DOIUrl":"https://doi.org/10.1097/PCR.0000000000000408","url":null,"abstract":"Abstract Clear cell sarcoma of the kidney (CCSK) comprises 3% of all childhood renal cancers. Accurate diagnosis is vital for appropriate therapy, which results in a 70% to 90% overall survival rate in this previously lethal tumor. Renowned for its ability to mimic and be mimicked by every other pediatric renal tumor, and even some extrarenal retroperitoneal tumors, CCSK has a unique metastatic pattern and molecular aberrations, as well as a generally consistent clinical presentation which is of great utility in the differential. A case of CCSK in a 4-month-old boy is presented, only the fifth case reported in a patient younger than 6 months.","PeriodicalId":72144,"journal":{"name":"AJSP: reviews & reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73100009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mucinous Cystic Neoplasm of the Liver With Associated Neuroendocrine Carcinoma: A Case Report 肝脏粘液囊性肿瘤伴神经内分泌癌1例报告
AJSP: reviews & reports Pub Date : 2021-11-01 DOI: 10.1097/PCR.0000000000000470
Ane Kongsgaard, K. Brudvik, T. Syversveen, H. Reims
{"title":"Mucinous Cystic Neoplasm of the Liver With Associated Neuroendocrine Carcinoma: A Case Report","authors":"Ane Kongsgaard, K. Brudvik, T. Syversveen, H. Reims","doi":"10.1097/PCR.0000000000000470","DOIUrl":"https://doi.org/10.1097/PCR.0000000000000470","url":null,"abstract":"Abstract Mucinous cystic neoplasms (MCNs) of the liver are relatively rare tumors that constitute less than 5% of liver cysts and are subcategorized into low/intermediate- and high-grade lesions based on the degree of epithelial dysplasia. An associated invasive carcinoma component occurs in 6% of cases, usually as adenocarcinoma with tubular growth. The liver is a frequent metastatic site for neuroendocrine carcinomas (NECs), whereas primary hepatic NECs are extremely rare. We present the case of a 63-year-old woman with a history of choledochal cyst, who now presented with abdominal pain. Computed tomography showed a multilocular cystic lesion in the liver. The cyst was surgically enucleated, and the histological examination revealed an MCN with low-grade dysplasia, with an associated invasive large cell NEC. To our knowledge, this is the first report in the literature of a biliary MCN with associated NEC.","PeriodicalId":72144,"journal":{"name":"AJSP: reviews & reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86192744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uterine Sarcoma With a Novel WWOX-NTRK2 Fusion in a Postmenopausal Woman With Li-Fraumeni–Like Syndrome: A Case That Expands the Spectrum of NTRK-Rearranged Uterine Tumors 绝经后li - fraumeni样综合征女性子宫肉瘤伴新型WWOX-NTRK2融合:一例扩展了ntrk重排子宫肿瘤谱系的病例
AJSP: reviews & reports Pub Date : 2021-11-01 DOI: 10.1097/PCR.0000000000000476
Michelle Moh, Colin M. Johnson, Jennifer L. Geurts, E. Bishop
{"title":"Uterine Sarcoma With a Novel WWOX-NTRK2 Fusion in a Postmenopausal Woman With Li-Fraumeni–Like Syndrome: A Case That Expands the Spectrum of NTRK-Rearranged Uterine Tumors","authors":"Michelle Moh, Colin M. Johnson, Jennifer L. Geurts, E. Bishop","doi":"10.1097/PCR.0000000000000476","DOIUrl":"https://doi.org/10.1097/PCR.0000000000000476","url":null,"abstract":"Abstract NTRK-rearranged tumors are being increasingly recognized and targeted with TRK inhibitor therapies. A novel NTRK2 fusion–positive uterine sarcoma arising in a patient with Li-Fraumeni–like syndrome is described in this article.","PeriodicalId":72144,"journal":{"name":"AJSP: reviews & reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79730414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Primary Peritoneal Ependymoma: A Case Report and Literature Review 原发性腹膜室管膜瘤1例报告及文献复习
AJSP: reviews & reports Pub Date : 2021-11-01 DOI: 10.1097/PCR.0000000000000462
J. Vazzano, B. Swanson, P. Wakely
{"title":"Primary Peritoneal Ependymoma: A Case Report and Literature Review","authors":"J. Vazzano, B. Swanson, P. Wakely","doi":"10.1097/PCR.0000000000000462","DOIUrl":"https://doi.org/10.1097/PCR.0000000000000462","url":null,"abstract":"Abstract Extra-axial ependymoma is a rare neoplasm. Reported anatomic sites include the ovary, para-ovarian tissues, pelvis, paracervical soft tissue, lung, omentum, small bowel, and posterior mediastinum. Primary peritoneal ependymomas are extremely rare. We report such an example in a 58-year-old woman who presented with abdominal pain, bloating, and history of a 70-lb weight loss over the prior year. Computed tomography scan showed a 20-cm pelvic mass extending into the abdomen and a 3.5-cm peritoneal-based right hepatic lobe/diaphragm mass. Histologic examination of the pelvic mass revealed an ovarian mucinous cystadenoma. The peritoneal mass showed a highly cellular solid neoplasm containing perivascular pseudorosettes and true ependymal rosettes. Tumor cell nuclei were rounded, oval, and elongated with coarse, granular chromatin and occasional small nucleoli. Mitoses were rare. Immunophenotype showed positive staining with bcl-2 and GFAP and scattered staining with keratins MNF116, CAM5.2, and cytokeratin AE1/AE3, along with chromogranin and EMA, but negative staining with inhibin, HMB45, SOX10, TLE-1, CD10, synaptophysin, Olig2, CD34, CD117, STAT-6, smooth muscle actin, and S-100. Conventional cytogenetic analysis showed normal chromosomes. Foundation One molecular profiling showed no actionable mutations. Ependymoma is an entity that rarely exists outside the central neuraxis having no connection with its central nervous system counterpart. Pathologic diagnosis is based primarily on presence of unequivocal ependymal differentiation.","PeriodicalId":72144,"journal":{"name":"AJSP: reviews & reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88590844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Composite Renal Cell Carcinoma and Angiomyolipoma: A Rare Case and Possible Diagnostic Pitfalls 复合肾细胞癌和血管平滑肌脂肪瘤:一个罕见的病例和可能的诊断缺陷
AJSP: reviews & reports Pub Date : 2021-11-01 DOI: 10.1097/PCR.0000000000000461
C. Dehner, Jennifer K Sehn
{"title":"Composite Renal Cell Carcinoma and Angiomyolipoma: A Rare Case and Possible Diagnostic Pitfalls","authors":"C. Dehner, Jennifer K Sehn","doi":"10.1097/PCR.0000000000000461","DOIUrl":"https://doi.org/10.1097/PCR.0000000000000461","url":null,"abstract":"Abstract Angiomyolipomas are benign renal neoplasms commonly associated with tuberous sclerosis complex (Semin Diagn Pathol 1998;15(1):21–40). However, angiomyolipoma with concurrent renal cell neoplasia is very uncommon, with fewer than 50 reported cases. Even less common is direct admixture of renal cell carcinoma (RCC) and angiomyolipoma within 1 tumor mass, with only rare possible cases reported in the literature. A multi-institutional study of 36 cases of synchronous renal cell neoplasm and angiomyolipoma found that clear cell RCC was the most common concurrent cancer in patients with sporadic or tuberous sclerosis-associated angiomyolipoma; angiomyolipoma in these cases was incidental (Mod Pathol 2001;14(3):157–163). Here, we report the exceptionally uncommon occurrence of a composite RCC and angiomyolipoma, occurring as an intimate admixture within a single tumor mass.","PeriodicalId":72144,"journal":{"name":"AJSP: reviews & reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86812650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sinonasal Ameloblastoma: A Case Report and a Review of Gnathic Lesions That Occur in the Sinonasal Tract 鼻窦成釉细胞瘤:一例报告并回顾发生在鼻窦道的颌骨病变
AJSP: reviews & reports Pub Date : 2021-07-01 DOI: 10.1097/PCR.0000000000000455
Rachel M. Whitehair, E. B. Stelow
{"title":"Sinonasal Ameloblastoma: A Case Report and a Review of Gnathic Lesions That Occur in the Sinonasal Tract","authors":"Rachel M. Whitehair, E. B. Stelow","doi":"10.1097/PCR.0000000000000455","DOIUrl":"https://doi.org/10.1097/PCR.0000000000000455","url":null,"abstract":"Abstract Primary sinonasal ameloblastomas are rare, benign odontogenic lesions that are locally aggressive. We report a case of a primary sinonasal ameloblastoma in a 65-year-old man who presented with sinonasal obstruction and rhinorrhea. The clinicopathologic features of this entity are discussed, along with the differential diagnosis and other gnathic lesions that present as sinonasal lesions.","PeriodicalId":72144,"journal":{"name":"AJSP: reviews & reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79299196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human Papillomavirus–Related Multiphenotypic Sinonasal Carcinoma 人乳头瘤病毒相关的多表型鼻窦癌
AJSP: reviews & reports Pub Date : 2021-07-01 DOI: 10.1097/PCR.0000000000000465
M. P. Crawford, E. Stelow
{"title":"Human Papillomavirus–Related Multiphenotypic Sinonasal Carcinoma","authors":"M. P. Crawford, E. Stelow","doi":"10.1097/PCR.0000000000000465","DOIUrl":"https://doi.org/10.1097/PCR.0000000000000465","url":null,"abstract":"Abstract Human papillomavirus–related mulitphenotypic sinonasal carcinoma is a recently described high-grade malignancy demonstrating significant morphologic overlap with adenoid cystic carcinoma and other salivary-type malignancies. We present a prototypical case of human papillomavirus–related mulitphenotypic sinonasal carcinoma in a 51-year-old woman and discuss the diagnosis, as well as the differential diagnosis.","PeriodicalId":72144,"journal":{"name":"AJSP: reviews & reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73823473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Sinonasal Lymphoma: Extranodal Natural Killer/T-Cell Lymphoma and Its Differential Diagnosis 鼻窦淋巴瘤:结外自然杀伤/ t细胞淋巴瘤及其鉴别诊断
AJSP: reviews & reports Pub Date : 2021-07-01 DOI: 10.1097/PCR.0000000000000458
M. Girton, N. Aguilera, Henry R Bateman
{"title":"Sinonasal Lymphoma: Extranodal Natural Killer/T-Cell Lymphoma and Its Differential Diagnosis","authors":"M. Girton, N. Aguilera, Henry R Bateman","doi":"10.1097/PCR.0000000000000458","DOIUrl":"https://doi.org/10.1097/PCR.0000000000000458","url":null,"abstract":"Abstract Lymphoma is the second most common malignancy in the nasal tract and paranasal sinuses after squamous cell carcinoma (Acta Oncol 1997;36:45–50). Sinonasal lymphoma is the most common hematolymphoid lesion at the site, accounting for approximately 1% of all lymphomas (Virchows Arch A Pathol Anat Histopathol 1989;414:399–405). These neoplasms are diverse, including B cell, T cell, and natural killer cell differentiation. This group of lymphomas includes chronic and aggressive entities, some with clearly defined etiologies and associations including Epstein-Barr virus, HIV, and human T-cell leukemia virus infections, with variable differentiation and distinctive growth patterns. In this report, we will review the most prevalent entities with a focus on extranodal natural killer/T-cell lymphoma. A sinonasal lymphoma differential diagnosis is provided with review of the epidemiologic, histomorphologic, and immunophenotypic characteristics and discuss diagnostic pitfalls. The discussion is accompanied by representative micrographs, with an explanation of the particular features of each diagnosis. Lastly, we will briefly discuss important clinical characteristics.","PeriodicalId":72144,"journal":{"name":"AJSP: reviews & reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86696797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Low-Grade Biphenotypic Sinonasal Sarcoma: Case Report, Current Understanding, and Differential Diagnosis 低级别双表型鼻窦肉瘤:病例报告，目前的认识和鉴别诊断
AJSP: reviews & reports Pub Date : 2021-07-01 DOI: 10.1097/PCR.0000000000000453
J. Coppock, E. Stelow
{"title":"Low-Grade Biphenotypic Sinonasal Sarcoma: Case Report, Current Understanding, and Differential Diagnosis","authors":"J. Coppock, E. Stelow","doi":"10.1097/PCR.0000000000000453","DOIUrl":"https://doi.org/10.1097/PCR.0000000000000453","url":null,"abstract":"Abstract Low-grade biphenotypic sinonasal sarcoma (BSS) is a rare, locally aggressive mesenchymal neoplasm of the sinonasal tract defined by dual expression of neural and myogenic antigens and recurrent PAX3 (paired box gene 3) gene rearrangements. We herein present the case of a 53-year-old woman with an incidentally identified lesion on surveillance magnetic resonance imaging for a pituitary microadenoma, ultimately leading to biopsy and resection of a low-grade BSS. Because of its relatively indolent behavior and extensive differential diagnosis, recognition and appropriate diagnostic workup of this entity are of utmost importance. The current understanding of low-grade BSS, its diagnosis, and differential diagnosis in the sinonasal tract are discussed.","PeriodicalId":72144,"journal":{"name":"AJSP: reviews & reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90884787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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