AJSP: reviews & reports最新文献_第10页

Pancreatic Panniculitis—Not Just a Skin Disease 胰腺胰腺炎——不仅仅是一种皮肤病

AJSP: reviews & reports Pub Date : 2020-03-01 DOI: 10.1097/PCR.0000000000000361

J. Crimmins, D. Russell, T. Samulski, Carolyn M. Ziemer, P. Googe

{"title":"Pancreatic Panniculitis—Not Just a Skin Disease","authors":"J. Crimmins, D. Russell, T. Samulski, Carolyn M. Ziemer, P. Googe","doi":"10.1097/PCR.0000000000000361","DOIUrl":"https://doi.org/10.1097/PCR.0000000000000361","url":null,"abstract":"Abstract Pancreatic panniculitis is a rare sequela of pancreatic disease classically presenting with tender, erythematous subcutaneous nodules involving the lower extremities. Rarer associations include involvement of the marrow, intra-abdominal fat, intrathoracic fat, and the clinical finding of joint pain. We present the case of a patient who presented with a 1-year history of intermittent nausea, bloating, and anorexia with computed tomography scan findings of a complex pancreatic cystic lesion, omental findings concerning for carcinomatosis, and ascites. She developed tender, erythematous, and hyperpigmented subcutaneous nodules on bilateral lower extremities that were first noted on admission. Pancreatic biopsy revealed pancreatic pseudocyst and laboratory findings on admission were consistent with pancreatitis and pancreatic ascites. Laparoscopic omental biopsies revealed multifocal, nodular fat necrosis and associated inflammation with no carcinoma identified. Histologically similar to the omental biopsies, a punch biopsy of skin revealed lobular fat necrosis, inflammation, and basophilic stippling by calcium consistent with pancreatic panniculitis. Given the similar histologic findings in the skin and omentum in the setting of pancreatic ascites, her omental findings were attributed to pancreatic panniculitis. This case highlights the importance of recognizing that pancreatic panniculitis can present as a systemic disorder. We highlight the laparoscopic, dermatologic, laboratory, and biopsy findings of pancreatic panniculitis to demonstrate that the pathologic findings are similar in the various organs involved.","PeriodicalId":72144,"journal":{"name":"AJSP: reviews & reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76240442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glial Tumors 神经胶质肿瘤

AJSP: reviews & reports Pub Date : 2020-03-01 DOI: 10.1097/PCR.0000000000000364

C. Welsh

引用次数: 2

A “Double-Hit” Translocation Sarcoma—First Report of the Co-occurrence of EWSR1-FLI1 and MTMR2-NTRK2 Fusion in a Small Round Blue Cell Sarcoma 一种“双击”易位肉瘤——EWSR1-FLI1和MTMR2-NTRK2融合在小圆形蓝细胞肉瘤中共同出现的首次报道

AJSP: reviews & reports Pub Date : 2020-03-01 DOI: 10.1097/PCR.0000000000000369

A. Vargas, Caroline Kurek, F. Bonar, F. Maclean, M. Qiu, R. Boyle, R. Brookwell, A. Gill

{"title":"A “Double-Hit” Translocation Sarcoma—First Report of the Co-occurrence of EWSR1-FLI1 and MTMR2-NTRK2 Fusion in a Small Round Blue Cell Sarcoma","authors":"A. Vargas, Caroline Kurek, F. Bonar, F. Maclean, M. Qiu, R. Boyle, R. Brookwell, A. Gill","doi":"10.1097/PCR.0000000000000369","DOIUrl":"https://doi.org/10.1097/PCR.0000000000000369","url":null,"abstract":"Abstract We report a case of a 51-year-old man with primary diagnosis of Ewing sarcoma confined to the soft tissue, associated with EWSR1-FLI1 gene fusion demonstrated by fluorescence in situ hybridization (FISH). Six years after the diagnosis, immunohistochemistry for NTRK (neurotrophic receptor tyrosine kinase 1–3) was performed on this tumor using 2 Pan-Trk rabbit monoclonal antibodies, A7H6R (Cell Signaling Technology, Danvers, Mass) and EPR17341 (Abcam, Cambridge, Mass). Both clones showed diffuse moderate to strong cytoplasmic expression including presence of nuclear stain. RNA sequencing demonstrated the co-occurrence of MTMR2-NTRK2, a novel gene fusion, in the same tumor block used for EWSR1 FISH testing. While FISH for NRK2 did not confirm gene rearrangement, an atypical signal pattern was identified. This case challenges the concept that NTRK fusions are mutually exclusive with other oncogenic drivers. The clinical course of this patient has also been unusual as the tumor has followed an indolent course with no evidence of recurrent or metastatic disease.","PeriodicalId":72144,"journal":{"name":"AJSP: reviews & reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79824240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

High-Grade Gliomas in Early Adulthood: A Case-Based Review of Current Molecular Diagnostic Considerations 成年早期的高级别胶质瘤:当前分子诊断考虑的病例回顾

AJSP: reviews & reports Pub Date : 2020-03-01 DOI: 10.1097/PCR.0000000000000371

Leyla Canbeldek, H. Ames

引用次数: 0

Pitfalls and Traps in Neuropathology 神经病理学中的陷阱和陷阱

AJSP: reviews & reports Pub Date : 2020-03-01 DOI: 10.1097/PCR.0000000000000365

M. T. Smith, E. Bruner

引用次数: 0

Sialadenitis of the Major Salivary Glands: A Tumor-Like Lesion of Various Etiologies and Morphological Appearances 大唾液腺涎腺炎:一种多种病因和形态表现的肿瘤样病变

AJSP: reviews & reports Pub Date : 2020-01-01 DOI: 10.1097/PCR.0000000000000406

J. Hernandez-Prera

引用次数: 1

A Guide to Differentiating Thrombotic Microangiopathies Through a Case of Catastrophic Antiphospholipid Syndrome 从一例灾难性抗磷脂综合征鉴别血栓性微血管病变指南

AJSP: reviews & reports Pub Date : 2020-01-01 DOI: 10.1097/PCR.0000000000000417

N. Hardy, Kristen M. Stashek

引用次数: 1

The Milan System for Reporting Salivary Gland Cytopathology 唾液腺细胞病理学报告米兰系统

AJSP: reviews & reports Pub Date : 2020-01-01 DOI: 10.1097/PCR.0000000000000405

A. Zante, Patrick K. Ha, Marc P Pusztaszeri

引用次数: 5

Cytologic and Histologic Aspects of High-Grade Transformation of Salivary Gland Carcinoma 唾液腺癌高级别转化的细胞学和组织学特征

AJSP: reviews & reports Pub Date : 2020-01-01 DOI: 10.1097/PCR.0000000000000400

M. Nakaguro, W. Faquin, P. Sadow

引用次数: 2

Navigating the Differential Diagnosis for Oncocytic Salivary Gland Lesions (Cytology and Histology) 嗜瘤性唾液腺病变的鉴别诊断指南(细胞学和组织学)

AJSP: reviews & reports Pub Date : 2020-01-01 DOI: 10.1097/PCR.0000000000000402

B. Centeno, B. Wenig

{"title":"Navigating the Differential Diagnosis for Oncocytic Salivary Gland Lesions (Cytology and Histology)","authors":"B. Centeno, B. Wenig","doi":"10.1097/PCR.0000000000000402","DOIUrl":"https://doi.org/10.1097/PCR.0000000000000402","url":null,"abstract":"Abstract Oncocytic lesions of the parotid gland include nonneoplastic entities and benign and malignant neoplasms. The most common benign neoplasm is Warthin tumor, which can be correctly diagnosed using fine-needle aspiration (FNA) or core biopsy in most cases. However, accurate FNA and/or biopsy preoperative diagnosis of many entities in this category is limited by sampling and overlap in morphological features among the different entities. We report the case of a 77-year-old man who presented with a right parotid mass identified on magnetic resonance imaging and computed tomography scan that was cystic with necrosis and with possible papillary growth in the cyst. The FNA smears were scantly cellular, with a few representative groups with significant nuclear crowding and overlapping in a bloody background. The cells had oncocytic cytoplasm, an increased nuclear-to-cytoplasmic ratio, and round-to-oval nuclei with prominent nucleoli. Necrosis, mitoses, and significant nuclear pleomorphism were not identified. The findings were interpreted as consistent with an oncocytoid/oncocytic salivary gland neoplasm. The cell block was acellular, so the neoplasm could not be further characterized by ancillary studies. The patient underwent a right superficial parotidectomy. The histopathological diagnosis was oncocytic carcinoma primarily based on the identification of perineural invasion. Oncocytic carcinoma is a rare, high-grade malignancy of salivary glands. This case will be used to discuss the differential diagnosis of oncocytoid/oncocytic salivary gland lesions on both cytopathology and histopathology and provide a pragmatic approach to the diagnostic evaluation. Indications for available ancillary testing will also be reviewed.","PeriodicalId":72144,"journal":{"name":"AJSP: reviews & reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74573109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0