AJSP: reviews & reports最新文献_第9页

Adenosquamous Carcinoma of the Prostate: A Unique Presentation of a Rare Entity and Review of the Literature 前列腺腺鳞癌:一种罕见疾病的独特表现及文献回顾

AJSP: reviews & reports Pub Date : 2020-05-01 DOI: 10.1097/PCR.0000000000000376

James Long, J. Moncur

引用次数: 1

Blue Nevus of the Prostate: A Report of Two Cases and Review of the Literature 前列腺蓝色痣2例报告及文献复习

AJSP: reviews & reports Pub Date : 2020-05-01 DOI: 10.1097/PCR.0000000000000383

T. Legesse, I. Sesterhenn, A. Paulk

引用次数: 0

Prostatic Carcinoma With Aberrant Expression of p63: A Case Report and Review of the Literature 前列腺癌伴p63异常表达1例报告及文献复习

AJSP: reviews & reports Pub Date : 2020-05-01 DOI: 10.1097/PCR.0000000000000378

A. Paulk, I. McCool, I. Sesterhenn, A. Burke

引用次数: 0

Rhabdomyosarcoma of the Adult Prostate: Two Cases With Molecular and Cytogenetic Analyses 成人前列腺横纹肌肉瘤:两例分子和细胞遗传学分析

AJSP: reviews & reports Pub Date : 2020-05-01 DOI: 10.1097/PCR.0000000000000380

I. Samarska, M. V. D. van den Hout, Xiaofei Li, J. V. van Roermund, T. Marcelissen, I. Vanden Bempt, R. Sciot, A. Hausen

{"title":"Rhabdomyosarcoma of the Adult Prostate: Two Cases With Molecular and Cytogenetic Analyses","authors":"I. Samarska, M. V. D. van den Hout, Xiaofei Li, J. V. van Roermund, T. Marcelissen, I. Vanden Bempt, R. Sciot, A. Hausen","doi":"10.1097/PCR.0000000000000380","DOIUrl":"https://doi.org/10.1097/PCR.0000000000000380","url":null,"abstract":"Abstract Primary rhabdomyosarcoma (RMS) of the adult prostate is a very rare tumor with only 45 cases published to date. The clinical course of RMS of the prostate is very aggressive, and prognosis is very poor. Here we describe two cases of primary RMS of the prostate of adult patients and discuss the differential diagnosis of RMS with other mesenchymal tumors of prostate. The first patient was a 50-year-old man who clinically presented with urinary retention and hematuria, low serum prostate-specific antigen, moderate prostatomegaly, and multiple metastases as shown by computed tomography. Histological examination revealed a diffuse “small round blue cell” proliferation with an intermingled population of larger cells with rhabdomyoblastic differentiation that showed immunoreactivity for desmin and MYF4 (myogenin). Molecular and cytogenetic studies did not reveal recurrent chromosomal translocations associated with RMSs and other sarcomas. The patient underwent doxorubicin (adriamycin) treatment without disease progression during the whole follow-up period of 7 months. The second patient was a 39-year-old man who presented with urinary retention, an increased serum prostate-specific antigen level, extensive prostatomegaly, enlarged abdominal and inguinal lymph nodes, and skeletal metastases. Histological examination revealed a tumoral proliferation with a small round blue aspect and diffuse immunoreactivity for desmin and MYF4 (myogenin). Fluorescence in situ hybridization revealed a FOXO1 translocation, consistent with a diagnosis of alveolar-type RMS. The patient followed a multimodal treatment and died of the disease after its progression.","PeriodicalId":72144,"journal":{"name":"AJSP: reviews & reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84798454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histopathologic Changes in a Hypogonadal Male on Exogenous Testosterone Diagnosed With Prostatic Adenocarcinoma: A Case Report 外源性睾酮诊断为前列腺腺癌的性腺功能低下男性的组织病理学改变:1例报告

AJSP: reviews & reports Pub Date : 2020-05-01 DOI: 10.1097/PCR.0000000000000381

David Yang, Yue Sun

引用次数: 0

Diffuse Synaptophysin Expression in Aggressive Recurrent Castration-Resistant Acinar (Usual) Prostate Cancer: Case Report and Review of Prostatic Neuroendocrine Tumors 侵袭性复发性去势抵抗性腺泡性前列腺癌弥漫性突触素表达:前列腺神经内分泌肿瘤病例报告及综述

AJSP: reviews & reports Pub Date : 2020-05-01 DOI: 10.1097/PCR.0000000000000354

D. Russell, Salvatore E. Mignano

引用次数: 0

Case Report: Benign Phyllodes Tumor of the Vulva 病例报告:外阴良性叶状瘤

AJSP: reviews & reports Pub Date : 2020-03-01 DOI: 10.1097/PCR.0000000000000287

J. Vella, Michael P. Thomas, Ruchira Singh, A. Shaaban

引用次数: 0

When the Horse Has Stripes: Central Nervous System Blastomycosis Presenting as a Ring-Enhancing Lesion in an Immunocompetent Patient

AJSP: reviews & reports Pub Date : 2020-03-01 DOI: 10.1097/PCR.0000000000000373

N. Hardy, Janina Markidan, P. Luethy, H. Ames

{"title":"When the Horse Has Stripes: Central Nervous System Blastomycosis Presenting as a Ring-Enhancing Lesion in an Immunocompetent Patient","authors":"N. Hardy, Janina Markidan, P. Luethy, H. Ames","doi":"10.1097/PCR.0000000000000373","DOIUrl":"https://doi.org/10.1097/PCR.0000000000000373","url":null,"abstract":"Abstract A new, single, ring-enhancing lesion in the cortex of an immunocompetent individual has a broad differential diagnosis, although primary or metastatic malignancies are usually highest on the list. The presence of inflammation without overt malignancy, however, is cause for considerations that may require ancillary testing with fresh tissue and obtaining multiple frozen samples. Central nervous system (CNS) infection with blastomycosis is a rare but potentially fatal complication, with a mortality rate approaching 20% secondary to multiple factors including delay in presentation and diagnosis (Clin Infect Dis 2010;50:797–804). What makes CNS blastomycosis so difficult to diagnose, along with other rare fungal infections, is that it can masquerade as a primary neural tumor. Infectious etiologies should always be considered in ring-enhancing lesions that show inflammation, necrosis, and no significant glial atypia on frozen section. Here we describe a case in an otherwise healthy woman, who presented with seizures and was found to have a peripherally enhancing intraparenchymal lesion on imaging. Differential diagnosis, frozen-section management, histology, and microbiology in the workup of CNS blastomycosis are discussed.","PeriodicalId":72144,"journal":{"name":"AJSP: reviews & reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84296848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Tale of Two Hedgehogs: Central Nervous System Embryonal Tumor Diagnosis in 3 Acts 两只刺猬的故事:中枢神经系统胚胎肿瘤的诊断

AJSP: reviews & reports Pub Date : 2020-03-01 DOI: 10.1097/PCR.0000000000000372

Rosanna Drake, H. Ames

引用次数: 0

A Posterior Fossa Mass in a 6-Year-Old 6岁儿童后颅窝肿块

AJSP: reviews & reports Pub Date : 2020-03-01 DOI: 10.1097/PCR.0000000000000366

T. G. Baker, M. T. Smith

{"title":"A Posterior Fossa Mass in a 6-Year-Old","authors":"T. G. Baker, M. T. Smith","doi":"10.1097/PCR.0000000000000366","DOIUrl":"https://doi.org/10.1097/PCR.0000000000000366","url":null,"abstract":"Abstract Medulloblastoma is a high-grade embryonal tumor of the central nervous system arising in the infratentorium of patients of all ages with a peak incidence in childhood. Within the last decade, advances in molecular profiling of gene expression and epigenetics have advanced general understanding of previously perceived intertumoral heterogeneity. Currently, 4 subtypes of medulloblastoma are recognized: wingless (WNT)–activated, sonic hedgehog (SHH)–activated, and the non-WNT/non-SHH group, which combines groups 3 and 4. The new subgroups, which continue to evolve, have greatly complicated the process of rendering a pathologic diagnosis through integration of histopathologic and molecular data. The criterion-standard techniques for identifying these subgroups include gene expression and methylation profiling; however, such complicated and expensive laboratory techniques may not be accessible to all laboratories. Although recommendations for the approach to an integrated diagnosis have been made, no specific algorithm has been put forth. We present a case of pediatric medulloblastoma in which hematoxylin-eosin–stained tissue sections, reticulin special stain, immunohistochemistry, cytogenetics, and next-generation sequencing were implemented for the purpose of identifying subgroup and other markers of prognosis, such as TP53 mutation and MYC family member amplification. The discussion herein is aimed at reviewing current opinions on the integration of histomorphologic and molecular subgroups of medulloblastoma and providing a foundation for designing a practical and clinically meaningful approach to diagnosis.","PeriodicalId":72144,"journal":{"name":"AJSP: reviews & reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74897311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0