AJSP: reviews & reports最新文献_第4页

Papillary Endothelial Hyperplasia of the Adrenal Gland: A Case Report and Review of the Literature 肾上腺乳头状内皮增生:1例报告及文献复习

AJSP: reviews & reports Pub Date : 2022-01-01 DOI: 10.1097/PCR.0000000000000481

Abberly A. Lott Limbach, P. Wakely

引用次数: 1

When Blind Pathologists Lead Mute Clinicians: Autopsy of a Misdiagnosis Involving a Metastatic Lung Adenocarcinoma to the Breast Mimicking Primary Invasive Ductal Carcinoma 当盲人病理学家领导沉默的临床医生:尸检误诊转移性肺腺癌为乳腺模拟原发性浸润性导管癌

AJSP: reviews & reports Pub Date : 2022-01-01 DOI: 10.1097/PCR.0000000000000498

A. Gama, J. Novo

引用次数: 0

Metastatic Hepatobiliary Cystadenocarcinoma Mimicking a Gynecologic Malignancy 模拟妇科恶性肿瘤的转移性肝胆囊腺癌

AJSP: reviews & reports Pub Date : 2022-01-01 DOI: 10.1097/PCR.0000000000000460

E. O'Donnell, Kalpana M. Devaraj, M. Post

{"title":"Metastatic Hepatobiliary Cystadenocarcinoma Mimicking a Gynecologic Malignancy","authors":"E. O'Donnell, Kalpana M. Devaraj, M. Post","doi":"10.1097/PCR.0000000000000460","DOIUrl":"https://doi.org/10.1097/PCR.0000000000000460","url":null,"abstract":"Abstract Hepatobiliary cystadenocarcinoma is a rare malignancy associated with ovarian-like stroma and overtly malignant glands that has a favorable prognosis if completely resected, analogous to minimally invasive adenocarcinoma arising in mucinous cystic neoplasms of the pancreas. Ovarian mucinous neoplasms may have a similar histologic appearance and are known to occasionally contain mural nodules of anaplastic carcinoma. We report a case of hepatobiliary cystadenocarcinoma that subsequently presented as metastatic disease mimicking a primary gynecological malignancy. The 30-year-old patient had a history of a completely resected hepatobiliary cystadenocarcinoma 2 years prior to presentation, without adjuvant therapy. She presented to her gynecologist with pelvic pain and vaginal bleeding. Physical examination revealed diffuse nodularity along the anterior vaginal wall, and imaging showed a 5.8 × 4.1 cm pelvic mass with diffuse metastatic disease. Biopsies of the vaginal wall and an inguinal lymph node showed nests of pleomorphic cells with squamoid and glandular features concerning for metastatic ovarian carcinoma; however, immunohistochemistry was negative for PAX8 and ER, but positive for CDX2. Subsequent review of the patient's prior resection revealed a cystic mucinous neoplasm with mural nodules of adenosquamous and anaplastic carcinoma, the latter previously reported only rarely in hepatobiliary cystadenocarcinoma. This case highlights the histologic overlap between hepatobiliary and ovarian neoplasms, which may present a diagnostic challenge, particularly in the setting of incomplete history. In addition, the unusual presence of an anaplastic component in the patient's original tumor portends a worse prognosis; therefore, additional therapy should be considered in these patients.","PeriodicalId":72144,"journal":{"name":"AJSP: reviews & reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75747026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anaplastic Large Cell Lymphoma of the Breast With Simultaneous Peripheral Blood and Marrow Involvement 同时累及外周血和骨髓的乳腺间变性大细胞淋巴瘤

AJSP: reviews & reports Pub Date : 2022-01-01 DOI: 10.1097/PCR.0000000000000485

Venkatesh Dhanasekaran, B. Srinivas, D. Basu, B. Dubashi, D. Gochhait

引用次数: 0

Kikuchi Disease Masquerading as a T-Cell Lymphoma 伪装成t细胞淋巴瘤的菊池病

AJSP: reviews & reports Pub Date : 2022-01-01 DOI: 10.1097/PCR.0000000000000496

Barina Aqil, Amandeep Kaur

引用次数: 0

Primary Sclerosing Epithelioid Fibrosarcoma of the Kidney: A Case Report and Review of the Literature 原发性肾硬化上皮样纤维肉瘤1例报告及文献复习

AJSP: reviews & reports Pub Date : 2022-01-01 DOI: 10.1097/PCR.0000000000000483

Mercedes Bravo-Taxa, Rafael Garatea-Grau, Ulises Nuñez-Romero, Lourdes Huanca-Amesquita

引用次数: 0

Malignant Melanoma Arising in a Primary Mediastinal Teratoma: Case Report of a Rare Phenomenon and Review of the Literature 恶性黑色素瘤起源于原发性纵隔畸胎瘤:罕见现象1例报告及文献复习

AJSP: reviews & reports Pub Date : 2022-01-01 DOI: 10.1097/PCR.0000000000000484

Youssef Khafateh, C. Preciado, D. Elder, L. Litzky, D. Vaughn, S. Singhal, P. Lal, M. Palmer

{"title":"Malignant Melanoma Arising in a Primary Mediastinal Teratoma: Case Report of a Rare Phenomenon and Review of the Literature","authors":"Youssef Khafateh, C. Preciado, D. Elder, L. Litzky, D. Vaughn, S. Singhal, P. Lal, M. Palmer","doi":"10.1097/PCR.0000000000000484","DOIUrl":"https://doi.org/10.1097/PCR.0000000000000484","url":null,"abstract":"Abstract Primary mediastinal germ cell tumors (GCTs) account for a small subset of all GCTs. Teratoma is the most common GCT of the mediastinum and usually occurs in adults from 20 to 40 years of age. Malignant somatic transformation is a rare phenomenon that has been described in both primary and metastatic mediastinal GCTs. The most common types of malignant somatic transformation described in mediastinal GCTs are sarcomas and carcinomas, with very few cases of melanoma found in the literature. We report the case of a 21-year-old male patient who presented with anterior mediastinal mass that on initial biopsy and workup revealed a mediastinal mixed GCT with teratoma and yolk sac components. Following chemotherapy, the resected mass demonstrated residual teratoma with malignant transformation into melanocytic, neuroectodermal, and undifferentiated sarcomatous elements. The patient rapidly developed metastases to the lung, liver, spleen, and spine. Biopsy of the bone marrow and liver confirmed metastatic dissemination by melanocytic transformed GCT. Molecular analysis for BRAF mutation was negative. The rapid multiorgan pattern of metastatic spread indicates a very aggressive phenotype. This case represents the second reported case of malignant melanocytic tumor as part of multilineage malignant differentiation arising from mediastinal GCT.","PeriodicalId":72144,"journal":{"name":"AJSP: reviews & reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84461032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wolves in Sheep's Clothing and Vice Versa: Fine-Needle Aspiration of Low-Grade Spindle Cell Lesions 披着羊皮的狼，反之亦然:低级别纺锤体细胞病变的细针穿刺

AJSP: reviews & reports Pub Date : 2022-01-01 DOI: 10.1097/PCR.0000000000000492

T. Bronson, B. Choy

{"title":"Wolves in Sheep's Clothing and Vice Versa: Fine-Needle Aspiration of Low-Grade Spindle Cell Lesions","authors":"T. Bronson, B. Choy","doi":"10.1097/PCR.0000000000000492","DOIUrl":"https://doi.org/10.1097/PCR.0000000000000492","url":null,"abstract":"Abstract The morphologic overlap between low-grade spindle cell lesions can lead to diagnostic dilemmas, particularly when attempting to interpret limited material. Evaluation of such specimens frequently requires correlating with clinical and imaging findings, as well as ancillary studies. We discuss the case of a 78-year-old woman with a remote history of breast carcinoma who presented with a left base of neck nodule. While imaging findings were highly suggestive of schwannoma, fine-needle aspiration biopsy of the nodule was performed for diagnostic confirmation. The patient reported tingling and an electrical shock sensation traveling down her arm during the fine-needle aspiration procedure. Cytomorphologic findings demonstrating a low-grade spindle cell neoplasm further supported a diagnosis of schwannoma, despite early immunohistochemistry results not being supportive. A last-minute suggestion that the differential diagnosis be broadened prompted additional immunohistochemical workup and follow-up molecular testing that confirmed an alternative diagnosis of solitary fibrous tumor. This case demonstrates the importance of correlating clinical, radiologic, and pathologic findings when approaching the differential diagnosis of low-grade spindle cell lesions on fine-needle biopsy specimens. Ancillary testing including immunohistochemistry, molecular studies, or fluorescence in situ hybridization is frequently utilized to establish a definitive diagnosis.","PeriodicalId":72144,"journal":{"name":"AJSP: reviews & reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78844522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Desmoplastic Small Round Cell Tumor Is an Important Mimic of High-Grade Carcinoma in Colonic Biopsy Samples 结缔组织增生小圆细胞瘤是结肠活检标本中高级别癌的重要模拟物

AJSP: reviews & reports Pub Date : 2022-01-01 DOI: 10.1097/PCR.0000000000000499

Erika Hissong, R. Yantiss

引用次数: 0

A Case of Benign Breast Inclusions in an Axillary Sentinel Lymph Node Mimicking a Low-Grade Carcinoma 腋窝前哨淋巴结良性乳腺包体1例，表现为低级别癌

AJSP: reviews & reports Pub Date : 2022-01-01 DOI: 10.1097/PCR.0000000000000497

J. Rytych, Carissa LaBoy

{"title":"A Case of Benign Breast Inclusions in an Axillary Sentinel Lymph Node Mimicking a Low-Grade Carcinoma","authors":"J. Rytych, Carissa LaBoy","doi":"10.1097/PCR.0000000000000497","DOIUrl":"https://doi.org/10.1097/PCR.0000000000000497","url":null,"abstract":"Abstract Benign inclusions in lymph nodes are a rare phenomenon that has been described throughout the body. These foci of nonneoplastic, ectopic tissue in the axillary lymph nodes can mimic low-grade metastatic breast carcinomas and result in a diagnosis of false-positive nodes that would lead to unnecessary treatment. We present a challenging case of a patient with a left breast grade 1 invasive ductal carcinoma undergoing an intraoperative axillary sentinel lymph node frozen-section consultation that contained numerous small tubules in the subcapsular space. The lymph node was interpreted as positive for carcinoma, and the patient underwent an axillary lymph node dissection. On permanent sections, myoepithelial cells and surrounding basement membranes were identified around some of the tubules, and a large, squamous inclusion cyst became visible. Immunohistochemical stains were performed that showed that p63 and smooth muscle myosin heavy chain highlighted myoepithelial cells around the tubules, whereas cytokeratin 5/6 and estrogen receptor stains showed a mosaic pattern of positivity. Combined, these findings supported a revised diagnosis of benign glandular and benign squamous inclusions. This case underscores the importance of thoroughly examining the location and histologic and cytologic features of a low-grade–appearing epithelium before determining lymph node positivity and, if it is unclear, deferring the diagnosis to permanent sections where immunohistochemical stains can be performed. Knowledge of this uncommon finding is important to avoid false-positive results, unnecessary treatments, and their associated comorbidities.","PeriodicalId":72144,"journal":{"name":"AJSP: reviews & reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86892709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0