AJSP: reviews & reports最新文献_第6页

SMARCB1 (INI1)–Deficient Sinonasal Carcinoma With Yolk Sac Tumor Differentiation: Case Report and Review of the Literature SMARCB1 (INI1)缺陷鼻窦癌伴卵黄囊肿瘤分化1例报告及文献复习

AJSP: reviews & reports Pub Date : 2021-07-01 DOI: 10.1097/PCR.0000000000000456

Sarah E Gradecki, Sarah Kelting, E. Stelow

{"title":"SMARCB1 (INI1)–Deficient Sinonasal Carcinoma With Yolk Sac Tumor Differentiation: Case Report and Review of the Literature","authors":"Sarah E Gradecki, Sarah Kelting, E. Stelow","doi":"10.1097/PCR.0000000000000456","DOIUrl":"https://doi.org/10.1097/PCR.0000000000000456","url":null,"abstract":"Abstract SMARCB1 (INI1)–deficient sinonasal carcinoma is a recently described primary neoplasm of the sinonasal tract that occurs infrequently and displays aggressive clinical behavior. Classic histopathologic findings of INI1-deficient sinonasal carcinoma include sheets and nests of basaloid tumors cells with a monomorphic appearance. Variable amounts of rhabdoid and glandular differentiation have been reported. Diagnosis of this lesion can be challenging because of significant morphologic and immunohistochemical overlap between other primary lesions of the sinonasal tract, including basaloid and other nonkeratinizing squamous cell carcinomas, sinonasal undifferentiated carcinoma, and the newly described BRG1-deficient sinonasal carcinoma, among others. Recently, yolk sac tumor (YST)–like differentiation has been described in multiple reports of INI1-deficient sinonasal carcinoma, which expands both the histologic spectrum of this lesion and its differential diagnosis. Although there is significant immunophenotypic overlap between primary YST and INI1-deficient sinonasal carcinoma with YST differentiation, loss of INI1 expression by immunohistochemistry is not seen in YST. INI1 immunohistochemistry is a sensitive and specific marker for identifying INI1-deficient sinonasal carcinoma, and pathologists should have a low threshold for performing this test on tumors with a myriad of histologic features.","PeriodicalId":72144,"journal":{"name":"AJSP: reviews & reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81640739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Rapid Autopsy Programs and Research Support: The Pre– and Post–COVID-19 Environments 快速尸检项目和研究支持:covid -19之前和之后的环境

AJSP: reviews & reports Pub Date : 2021-03-05 DOI: 10.1097/PCR.0000000000000435

J. Hooper

{"title":"Rapid Autopsy Programs and Research Support: The Pre– and Post–COVID-19 Environments","authors":"J. Hooper","doi":"10.1097/PCR.0000000000000435","DOIUrl":"https://doi.org/10.1097/PCR.0000000000000435","url":null,"abstract":"Abstract Each rapid autopsy is a powerful opportunity to supply multiple researchers with many valuable tissue specimens at the same time. Since the beginning of the development of rapid autopsy, the overriding organizing principle for all rapid autopsy programs has been that the samples or organs must be removed and processed as rapidly as possible. To accomplish this, some rapid autopsy programs are focused on only 1 tumor type, whereas others accept patients demonstrating all tumor types and sometimes other diseases as well. Rapid autopsy programs are logistically complicated and labor-intensive structures; therefore, the key to their success is program flexibility and maintaining a multidisciplinary focus. The necessary collaborations in the complex relationships between clinicians and researchers can be broken down into a series of thought and action steps that must be understood, accepted, and practiced by all participants. A crucial part of the precase steps (prior to death) for a rapid autopsy is the study consenting process. It is extremely important that this individualized consent is obtained for postmortem specimens and that it is written in terms general enough to be used for patients with all types of diseases and for an appropriate range of future research uses. The advent of SARS-CoV-2/COVID-19 (severe acute respiratory syndrome coronavirus 2/coronavirus disease 2019) has presented new challenges and opportunities to the field of autopsy pathology. Guidelines and practice had to be created and adapted to protect physicians and staff while maximizing diagnostic yield. However, any autopsy performed on a patient dying of or with COVID-19 represents a unique opportunity to contribute to understanding the disease mechanisms and to improve death certification, thus assisting in both clinical care and the development of health public policy.","PeriodicalId":72144,"journal":{"name":"AJSP: reviews & reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84850077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Rapid Autopsy Programs and Research Support: The Pre- and Post-COVID-19 Environments. 快速尸检项目和研究支持:covid -19之前和之后的环境。

AJSP: reviews & reports Pub Date : 2021-03-01

Jody E Hooper

{"title":"Rapid Autopsy Programs and Research Support: The Pre- and Post-COVID-19 Environments.","authors":"Jody E Hooper","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Each rapid autopsy is a powerful opportunity to supply multiple researchers with many valuable tissue specimens at the same time. Since the beginning of the development of rapid autopsy, the overriding organizing principle for all RAPs has been that the samples or organs must be removed and processed as rapidly as possible. To accomplish this some rapid autopsy programs are focused just on one tumor type, while others accept patients demonstrating all tumor types and sometimes other diseases as well. RAPs are logistically complicated and labor-intensive structures, therefore, the key to their success is program flexibility and maintaining a multidisciplinary focus. The necessary collaborations in the complex relationships between clinicians and researchers can be broken down into a series of thought and action steps that must be understood, accepted, and practiced by all participants. A crucial part of the pre-case steps (prior to death) for a rapid autopsy is the study consenting process. It is extremely important that this individualized consent is obtained for postmortem specimens and that it is written in general enough terms to be used for patients with all types of diseases and for an appropriate range of future research uses. The advent of Sars-CoV-2/COVID-19 has presented new challenges and opportunities to the field of autopsy pathology. Guidelines and practice had to be created and adapted to protect physicians and staff while maximizing diagnostic yield. However, any autopsy performed on a patient dying of or with COVID-19 represents a unique opportunity to contribute to understanding of disease mechanisms and to improve death certification, thus assisting in both clinical care and the development of health public policy.</p>","PeriodicalId":72144,"journal":{"name":"AJSP: reviews & reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7954201/pdf/nihms-1664369.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25487792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The End 结束

AJSP: reviews & reports Pub Date : 2021-03-01 DOI: 10.1097/PCR.0000000000000440

A. Wiles

引用次数: 0

Pandemic Autopsy Biosafety Considerations 流行病尸检生物安全考虑

AJSP: reviews & reports Pub Date : 2021-03-01 DOI: 10.1097/PCR.0000000000000434

Erin G. Brooks

引用次数: 0

Nodal Merkel Cell Carcinoma With Neuroblastoma Differentiation: A Case Report and Review of the Literature 结性默克尔细胞癌伴神经母细胞瘤分化:1例报告及文献复习

AJSP: reviews & reports Pub Date : 2021-01-25 DOI: 10.1097/PCR.0000000000000412

L. Mahapatra, M. Mansour, D. Chatterjee, R. Fields, H. Maluf, L. Dehner

引用次数: 0

Education in Autopsy: More Than the Y-Shaped Incision: Entrusting Trainees for the Future 解剖教育:不只是y形切口:托付学员的未来

AJSP: reviews & reports Pub Date : 2021-01-01 DOI: 10.1097/PCR.0000000000000436

W. Humphrey, S. Mount

{"title":"Education in Autopsy: More Than the Y-Shaped Incision: Entrusting Trainees for the Future","authors":"W. Humphrey, S. Mount","doi":"10.1097/PCR.0000000000000436","DOIUrl":"https://doi.org/10.1097/PCR.0000000000000436","url":null,"abstract":"Abstract Training in autopsy encompasses the acquisition of skills and knowledge beyond the Y-shaped incision. In addition to learning basic tissue examination and processing skills, the autopsy service provides education in teamwork, professionalism and leadership, communication, public health, research, and self-reflection. Regardless of future specialization or practice setting, education provided by the autopsy has the potential to influence both the professional and personal lives of the trainees. Despite widespread agreement that autopsy education improves patient care, challenges to building and maintaining a dynamic and educational autopsy service exist and include factors that are both intrinsic and extrinsic to the practice of autopsy itself. Challenges including adequate volume of cases, knowledge of the procedure and skill in obtaining consent for autopsies, inclusion of an autopsy experience in medical school curriculums, competition for resident time, lack of subspecialists such as pediatric/perinatal and cardiac pathologists, and political action to gain support from regulatory bodies are addressed. Finally, we explore the way forward in autopsy education. Solutions such as the standardization of the educational autopsy, valuing the quality of competence over quantity of cases, and benefits of the Office of Decedent Affairs are discussed. By rededicating ourselves to the education of trainees via experiences on the autopsy service, we empower them to harness the many opportunities offered by the postmortem examination and ensure autopsy's seat at the table in 21st-century medicine.","PeriodicalId":72144,"journal":{"name":"AJSP: reviews & reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82755864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Dedifferentiated Solitary Fibrous Tumor of Soft Tissue With Retiform and Papillary Features: Report of a Case and Review of the Literature 具有网状和乳头状特征的软组织去分化孤立性纤维性肿瘤1例报告并文献复习

AJSP: reviews & reports Pub Date : 2021-01-01 DOI: 10.1097/PCR.0000000000000424

P. Roitman, N. Cóccaro, F. Jauk, N. Rene, J. Pandolfi, A. Castiglioni

{"title":"A Dedifferentiated Solitary Fibrous Tumor of Soft Tissue With Retiform and Papillary Features: Report of a Case and Review of the Literature","authors":"P. Roitman, N. Cóccaro, F. Jauk, N. Rene, J. Pandolfi, A. Castiglioni","doi":"10.1097/PCR.0000000000000424","DOIUrl":"https://doi.org/10.1097/PCR.0000000000000424","url":null,"abstract":"Abstract We report a case of a dedifferentiated solitary fibrous tumor (SFT) arising in the arm of a 74-year-old man, with the dedifferentiated component showing a unique retiform and papillary architecture. The patient presented with a tumor first noticed 12 years ago, which was diagnosed as a schwannoma. It remained clinically stable for about 10 years until he noticed growth of the mass 2 years ago. On comparative magnetic resonance imaging scans, while most of the tumor did not show major changes, a proximal lobule demonstrated increase in its size. After a new biopsy, which was interpreted as malignant, preoperative radiotherapy and surgical excision were performed. The surgical specimen had areas of typical SFT, with diffuse immunohistochemical expression of STAT6 and only focal CD34 and p16. The lobule that demonstrated growth showed a much more cellular, retiform/papillary proliferation, with plump atypical cells, necrosis, diffuse expression of STAT6 and p16, and complete lack of CD34 expression. With next-generation sequencing, the NAB2(3)-STAT6(18) fusion transcript was detected in both areas of the tumor. Only a few cases of SFT with papillary or retiform/papillary features were reported, most of them in the central nervous system, and none of them interpreted as a dedifferentiated SFT. To the best of our knowledge, these morphological features have not been reported in SFT of the soft tissue or in dedifferentiated SFT of any site. We think pathologists should be aware of this rare finding, which becomes particularly challenging in small biopsies or if classic areas of SFT are not found.","PeriodicalId":72144,"journal":{"name":"AJSP: reviews & reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76722228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Malignant Diffuse Tenosynovial Giant Cell Tumor: Case Report and Review of the Literature 恶性弥漫性腱鞘巨细胞瘤1例报告及文献复习

AJSP: reviews & reports Pub Date : 2021-01-01 DOI: 10.1097/PCR.0000000000000422

A. MacMahon, Y. Chaudhry, A. James, E. McCarthy, Nicolas J. Llosa, S. Ahlawat, C. Morris

{"title":"Malignant Diffuse Tenosynovial Giant Cell Tumor: Case Report and Review of the Literature","authors":"A. MacMahon, Y. Chaudhry, A. James, E. McCarthy, Nicolas J. Llosa, S. Ahlawat, C. Morris","doi":"10.1097/PCR.0000000000000422","DOIUrl":"https://doi.org/10.1097/PCR.0000000000000422","url":null,"abstract":"Abstract Diffuse-type tenosynovial giant cell tumor (TGCT) is a neoplasm that exhibits infiltrative growth, tends to recur locally, and is often located within a joint. We describe a challenging diagnosis and clinical course of a 14-year-old girl with malignant diffuse TGCT, highlighting the difficulty of acquiring a representative biopsy. The patient presented with a painful foot mass, which was diagnosed initially through open biopsy as chronic osteomyelitis. Because her pain persisted, additional open biopsies were performed 1 and 2.5 years after the initial biopsy, which also showed features of benign TGCT. At age 16 years, she underwent marginal resection but developed local recurrence with metastatic disease 1 year later. Core needle biopsy of the foot mass again confirmed diffuse TGCT and showed no evidence of atypical or malignant features. Malignant features were confirmed only through excisional biopsy of chest wall metastasis. The patient started chemotherapy and underwent below-the-knee amputation at age 17 years. Amputation specimen showed malignant diffuse TGCT. She died of disease progression approximately 1 year later. Metastasis of diffuse TGCT with benign histology is challenging to diagnose. Previous studies have also found that benign diffuse TGCT can transform into an aggressive, malignant tumor. This case highlights that biopsy sampling can be challenging in histologically heterogeneous tumors. Initial evaluation by a multidisciplinary team, as well as image-guided biopsy techniques, may increase diagnostic accuracy of the biopsy.","PeriodicalId":72144,"journal":{"name":"AJSP: reviews & reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84767354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fraternal Coopers Develop Sinonasal Intestinal-Type Adenocarcinoma 兄弟兄弟发展为鼻窦肠型腺癌

AJSP: reviews & reports Pub Date : 2021-01-01 DOI: 10.1097/PCR.0000000000000459

Wesley Mallinger, P. Read, E. Stelow

引用次数: 0