AJSP: reviews & reports最新文献_第7页

A Rare Case of NUT Carcinoma and Review of the Literature NUT癌1例及文献复习

AJSP: reviews & reports Pub Date : 2021-01-01 DOI: 10.1097/PCR.0000000000000464

B. Zelman, Hannah H. Chen, S. Pambuccian, Razan Massarani‐Wafai, S. Mehrotra, V. Ananthanarayanan

{"title":"A Rare Case of NUT Carcinoma and Review of the Literature","authors":"B. Zelman, Hannah H. Chen, S. Pambuccian, Razan Massarani‐Wafai, S. Mehrotra, V. Ananthanarayanan","doi":"10.1097/PCR.0000000000000464","DOIUrl":"https://doi.org/10.1097/PCR.0000000000000464","url":null,"abstract":"Abstract Nuclear protein in testis (NUT) carcinoma is a rare, aggressive, poorly differentiated malignant neoplasm. NUT carcinoma (NC) is hallmarked by its chromosomal translocation involving the NUT/NUTM1 gene, which leads to a fusion oncoprotein that blocks epithelial differentiation and maintains proliferation in tumor cells. The translocation occurs with members of the BET (bromodomain and extraterminal domain) protein family, with 70% of the cases forming the NUTM1-BRD4 fusion. It most frequently involves the thoracic cavity followed by the head and neck, with a preference for midline areas of the body, especially the sinonasal tract and mediastinum. This led to NC formerly being known as NUT midline carcinoma. However, studies have shown that NC can occur widely throughout the body, thus leading to the updated name. NUT carcinoma is histologically defined as a tumor of primitive appearing round monomorphic cells with possible foci of abrupt keratinization. Given its rarity and its morphologic and immunohistochemical overlap with other tumors, NC has been largely underdiagnosed and misdiagnosed in the past few decades. However, with the improvement of genetic testing and the availability of an anti-NUT monoclonal antibody for diagnostic immunohistochemistry, the number of cases classified as NCs has vastly increased in the recent past.","PeriodicalId":72144,"journal":{"name":"AJSP: reviews & reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80788334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Diagnosis of Sinonasal Ectopic Pituitary Adenomas 鼻窦异位垂体腺瘤的诊断

AJSP: reviews & reports Pub Date : 2021-01-01 DOI: 10.1097/PCR.0000000000000454

D. Berry, D. Ornan, M. Lopes

{"title":"Diagnosis of Sinonasal Ectopic Pituitary Adenomas","authors":"D. Berry, D. Ornan, M. Lopes","doi":"10.1097/PCR.0000000000000454","DOIUrl":"https://doi.org/10.1097/PCR.0000000000000454","url":null,"abstract":"Supplemental digital content is available in the text. Abstract Ectopic pituitary adenomas (EPAs) are uncommon sinonasal neoplasms that present a diagnostic challenge in practice. We present a case of a patient presenting with progressive headache. Workup revealed an enhancing mass on magnetic resonance imaging at the anterior clivus with extension into the sphenoid sinus. Resection of the tumor was performed, and microscopic examination showed a neuroendocrine tumor composed of monomorphic cells arranged in nests. The tumor expressed synaptophysin, chromogranin, growth hormone, prolactin, thyroid-stimulating hormone, follicle-stimulating hormone, α-subunit of the glycoproteins, and transcription factors steroidogenic factor 1 and Pit-1, diagnosed as a plurihormonal pituitary adenoma. Given the radiologic and surgical impression of an intact and uninvolved pituitary gland, the lesion was identified as a pituitary adenoma arising in ectopic adenohypophyseal tissue. This case demonstrates the multitude of possible tissue types involved in tumor histogenesis in the sinonasal cavity. We highlight the radiographic, intraoperative, cytologic, and histologic features of sinonasal pituitary adenoma to emphasize the role of an expanded differential, including central nervous system lesions, for neoplasms in this anatomic region.","PeriodicalId":72144,"journal":{"name":"AJSP: reviews & reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91334123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Salivary Hyalinizing Clear Cell Carcinoma: Report of a Genetically Confirmed Pediatric Case and Review of the Literature 涎腺透明细胞癌:1例遗传证实的儿科病例报告及文献复习

AJSP: reviews & reports Pub Date : 2021-01-01 DOI: 10.1097/PCR.0000000000000463

Doreen N. Palsgrove, P. Wilson, B. R. Oliai, J. Bishop

{"title":"Salivary Hyalinizing Clear Cell Carcinoma: Report of a Genetically Confirmed Pediatric Case and Review of the Literature","authors":"Doreen N. Palsgrove, P. Wilson, B. R. Oliai, J. Bishop","doi":"10.1097/PCR.0000000000000463","DOIUrl":"https://doi.org/10.1097/PCR.0000000000000463","url":null,"abstract":"Abstract Hyalinizing clear cell carcinoma (HCCC) is a rare but well-recognized low-grade salivary gland malignancy. In addition to being a morphologically distinct neoplasm with cords and nests of predominantly clear cells in hyalinized fibrous stroma, it harbors a characteristic EWSR1 gene rearrangement that can be readily exploited as a diagnostic marker to help distinguish it from other salivary gland tumors with overlapping histomorphology. We herein report a pediatric case of salivary HCCC arising in the oral cavity of an 11-year-old girl. The tumor cells contained moderate amounts of eosinophilic to clear cytoplasm and hyperchromatic nuclei. The stroma was notable for a biphasic spatial arrangement alternating between fibrocellular regions and hyalinized basement membrane–like areas immediately adjacent to tumor cell nests. By immunohistochemistry, the tumor was positive for p40 and negative for SOX10, S100 protein, and smooth muscle actin. Fluorescence in situ hybridization was positive for an EWSR1 chromosomal rearrangement. This is the first reported, molecularly confirmed pediatric case of HCCC. It further expands the diagnostic age range of HCCC to include the pediatric population and highlights the potential risk of misdiagnosis.","PeriodicalId":72144,"journal":{"name":"AJSP: reviews & reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75929067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heterotopic Ossification of the Mesentery: A Rare Postoperative Complication 肠系膜异位骨化:一种罕见的术后并发症

AJSP: reviews & reports Pub Date : 2021-01-01 DOI: 10.1097/PCR.0000000000000429

Gloria H Sura, Nicole R. Jackson, Shirley Yodzis, S. Fox

{"title":"Heterotopic Ossification of the Mesentery: A Rare Postoperative Complication","authors":"Gloria H Sura, Nicole R. Jackson, Shirley Yodzis, S. Fox","doi":"10.1097/PCR.0000000000000429","DOIUrl":"https://doi.org/10.1097/PCR.0000000000000429","url":null,"abstract":"Abstract Heterotopic ossification is a rare, reactive condition, sometimes classified as a “pseudotumor,” involving the formation of bone within the soft tissues (Int J Surg Case Rep 2014;5:476–479), This process can occur as an undesirable pathologic sequela of trauma and surgery (J Am Acad Orthop Surg 2004;12:116–125). The few cases reported in the literature are almost exclusively in men with a predominance in people of African ancestry (J Am Acad Orthop Surg 2004;12:116–125; Bone Joint J 2016;98-B:761–766; Case Rep Surg 2019;2019:4036716). Reports of heterotopic ossification have been described in medical literature since 1692 as myositis ossificans progressiva (JBJS 1938;20:661–674). It was not until 1999 that the term “heterotopic mesenteric ossification” was formally used by Wilson et al to describe a complication found in post–abdominal surgical patients (Am J Surg Pathol 1999;23:1464–1470). Although the exact pathologic mechanism of heterotopic mesenteric ossification has not been elucidated, some hypotheses include differentiation of mesenchymal progenitor cells toward an osteogenic lineage, as well as proliferation of dislocated fragments of bone from other regions of the body (J Gastrointest Surg 2015;19:579–580). Since the late 1900s, fewer than 40 cases of mesenteric ossification have been reported. Limited gross and histologic description is available for pathologists and surgeons to identify this phenomenon; however, further data can be acquired at autopsy. Awareness of this condition on the part of clinicians, and early review and recognition by pathologists, may alter surgical management decisions and improve upon morbidity and mortality in these patients. We present gross and histologic examination of an advanced case of heterotopic ossification at autopsy, with a review of current management recommendations.","PeriodicalId":72144,"journal":{"name":"AJSP: reviews & reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77386432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polyostotic Fibrous Dysplasia With Extensive Cartilaginous Differentiation: A Rare Case Clinically Mimicking Ollier Disease 多骨纤维发育不良伴广泛软骨分化:一例临床模拟脂肪肝疾病的罕见病例

AJSP: reviews & reports Pub Date : 2021-01-01 DOI: 10.1097/PCR.0000000000000427

Melanie H Hakar, C. Chapman, B. Hansford, Jessica L. Davis

引用次数: 2

SARS-CoV-2–Associated Myocarditis at Autopsy 尸检发现sars - cov -2相关心肌炎

AJSP: reviews & reports Pub Date : 2021-01-01 DOI: 10.1097/PCR.0000000000000438

Ravikant Singh, Geunyoung Jung, Erin G. Brooks

引用次数: 1

Spindle Cell Sinonasal Rhabdomyosarcoma in a 73-Year-Old Man: A Case Report 73岁男性鼻窦梭形细胞横纹肌肉瘤1例

AJSP: reviews & reports Pub Date : 2021-01-01 DOI: 10.1097/PCR.0000000000000428

Bronson Wessinger, Justin C Morse, J. Lewis, J. Shinn, R. Chandra

{"title":"Spindle Cell Sinonasal Rhabdomyosarcoma in a 73-Year-Old Man: A Case Report","authors":"Bronson Wessinger, Justin C Morse, J. Lewis, J. Shinn, R. Chandra","doi":"10.1097/PCR.0000000000000428","DOIUrl":"https://doi.org/10.1097/PCR.0000000000000428","url":null,"abstract":"Introduction Rhabdomyosarcoma (RMS) is a malignant soft tissue neoplasm differentiating into primitive mesenchymal cells with partial skeletal muscle differentiation. It is rare, especially in the sinonasal cavity. We review available literature on sinonasal RMS and present a case report involving spindle cell sinonasal RMS, one of the rarest subtypes. Case Report A 73-year-old man with months of right-sided epiphora and nasal obstruction had abnormal soft tissue and calcification in the right nasal cavity on computed tomography. Nasal endoscopy revealed a smooth, firm mass involving the inferior turbinate. The mass was removed en bloc via endoscopic partial medial maxillectomy and ethmoidectomy. Gross pathologic examination revealed a mottled red, tan, firm, bosselated, and glistening mass, with irregular fragments of soft tissue and bone. Histologic examination showed a variably myxoid and fibrous neoplasm with hyalinization. Tumor cells were spindled with moderate pleomorphism and low mitotic activity. Immunohistochemistry was extensively positive for desmin and myoD1 and focally positive for smooth muscle actin. A diagnosis of sinonasal RMS, grade 2, was made. Discussion/Conclusion This is the first reported case of spindle cell RMS originating from the inferior turbinate. Sinonasal RMS has the worst prognosis of all primary sites, especially with age older than 65 years, alveolar subtype, primary tumor greater than 5 cm, high stage/group, and distant metastases. While the risk stratification system accounts for surgical and pathologic factors, more research is needed to determine how this guides selection of resection and/or chemoradiation.","PeriodicalId":72144,"journal":{"name":"AJSP: reviews & reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88700159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tertiary Syphilis Involving the Larynx: A Rare Case Report 三期梅毒累及喉部:一罕见病例报告

AJSP: reviews & reports Pub Date : 2021-01-01 DOI: 10.1097/PCR.0000000000000468

B. Thakkar, Wesley D. Carlisle, S. Redfield, Andrew T. Meram

引用次数: 0

Lung Adenocarcinoma Metastatic to the Cervix: Report of a Rare Case and Review of the Literature 肺腺癌转移至子宫颈:一例罕见病例报告及文献复习

AJSP: reviews & reports Pub Date : 2021-01-01 DOI: 10.1097/PCR.0000000000000447

H. Hosseini, Jordan M. Steinberg, Fanni Ratzon, P. Unger, Alyssa Yurovitsky

引用次数: 0

Common Differential Diagnostic Issues in Lung Cytopathology: 3 Case Reports and a Review 肺细胞病理学中常见的鉴别诊断问题:3例报告和综述

AJSP: reviews & reports Pub Date : 2021-01-01 DOI: 10.1097/PCR.0000000000000443

R. Fanaroff, T. Legesse, K. Geisinger

引用次数: 1