Aging brain最新文献

{"title":"Dopamine D1-signaling modulates maintenance of functional network segregation in aging","authors":"Robin Pedersen ,&nbsp;Jarkko Johansson ,&nbsp;Alireza Salami","doi":"10.1016/j.nbas.2023.100079","DOIUrl":"10.1016/j.nbas.2023.100079","url":null,"abstract":"<div><p>Past research has shown that as individuals age, there are decreases in within-network connectivity and increases in between-network connectivity, a pattern known as functional dedifferentiation. While the mechanisms behind reduced network segregation are not fully understood, evidence suggests that age-related differences in the dopamine (DA) system may play a key role. The DA D1-receptor (D1DR) is the most abundant and age-sensitive receptor subtype in the dopaminergic system, known to modulate synaptic activity and enhance the specificity of the neuronal signals. In this study from the DyNAMiC project (N = 180, 20-79y), we set out to investigate the interplay among age, functional connectivity, and dopamine D1DR availability. Using a novel application of multivariate Partial Least squares (PLS), we found that older age, and lower D1DR availability, were simultaneously associated with a pattern of decreased within-network and increased between-network connectivity. Individuals who expressed greater distinctiveness of large-scale networks exhibited more efficient working memory. In line with the maintenance hypotheses, we found that older individuals with greater D1DR in caudate exhibited less dedifferentiation of the connectome, and greater working memory, compared to their age-matched counterparts with less D1DR. These findings suggest that dopaminergic neurotransmission plays an important role in functional dedifferentiation in aging with consequences for working memory function at older age.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"3 ","pages":"Article 100079"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10180412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overcoming hurdles: Enhancing post-mortem capabilities for neurological investigations in Africa","authors":"Abdullahi Tunde Aborode ,&nbsp;Ayah Karra-Aly ,&nbsp;Seto Charles Ogunleye ,&nbsp;Mercy Mayowa Olorunshola ,&nbsp;Tayo Nafisat Folorunso ,&nbsp;Christianah Oreoluwa Aloba ,&nbsp;Adedayo Emmanuel Ogunware","doi":"10.1016/j.nbas.2023.100099","DOIUrl":"10.1016/j.nbas.2023.100099","url":null,"abstract":"","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"4 ","pages":"Article 100099"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10556755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41156059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related reduction in brain ACE-2 is not exacerbated by Alzheimer’s disease pathology in mouse models of Alzheimer’s disease","authors":"Robert MacLachlan ,&nbsp;Charles E. Evans ,&nbsp;Siew Yeen Chai ,&nbsp;Mark A. Good ,&nbsp;Patrick Gavin Kehoe ,&nbsp;J. Scott Miners","doi":"10.1016/j.nbas.2022.100062","DOIUrl":"10.1016/j.nbas.2022.100062","url":null,"abstract":"<div><p>An imbalance in the circulatory and organ-specific renin-angiotensin system (RAS) pathways is associated with age-related dysfunction and disease including cardiovascular burden and more recently Alzheimer’s disease (AD). It is currently unclear whether an age-associated imbalance in components of the RAS within the brain precedes the onset of AD or whether a RAS imbalance is associated with the onset of disease pathology and cognitive decline.</p><p>Angiotensin-converting enzyme-1 (ACE-1) and -2 (ACE-2) protein (ELISA) and enzyme activity (FRET assay), markers of the classical and counter-regulatory RAS axis respectively, and Ang-II and Ang-(1–7) peptide levels (ELISA), were measured in the left cortex across four transgenic AD mouse models of amyloid pathology (5xFAD – 2, 6, and 12 months of age; Apd9 – 3-4, 12, and 18 months of age; Tg2576 – 3-4 and 24 months of age; and PDAPP – 3-4, 7, 11, 15, and 18 months of age) and littermate wild-type (WT) controls.</p><p>ACE-1 level, and enzyme activity, was unaltered in relation to age in WT mice and across all four models. In contrast, ACE-2 level and enzyme activity, was reduced and Ang-II increased with ageing in both WT animals and disease models. The changes in ACE-2 and Ang-II in AD models mirrored WT mice, except for the 5xFAD model, when the reduction in ACE-2 (and elevated Ang-II) was observed at a younger age.</p><p>These data indicate an age-related dysregulation of brain RAS is likely to be driven by a reduction in ACE-2. The reduction in ACE-2 occurs at a young age, coinciding with early pathological changes and the initial deposition of Aβ, and preceding neuronal loss and cognitive decline, in the transgenic AD models. However, the age-related loss was mirrored in WT mice suggesting that the change was independent of pathological Aβ deposition.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"3 ","pages":"Article 100062"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/40/b7/main.PMC9997187.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9455814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rostral anterior cingulate connectivity in older adults with subthreshold depressive symptoms: A preliminary study","authors":"Andrew M. Gradone ,&nbsp;Gabriell Champion ,&nbsp;Keith M. McGregor ,&nbsp;Joe R. Nocera ,&nbsp;Sarah J. Barber ,&nbsp;Lisa C. Krishnamurthy ,&nbsp;Vonetta M. Dotson","doi":"10.1016/j.nbas.2022.100059","DOIUrl":"10.1016/j.nbas.2022.100059","url":null,"abstract":"<div><p>Subthreshold depressive symptoms are highly prevalent among older adults and are associated with numerous health risks including cognitive decline and decreased physical health. One brain region central to neuroanatomical models of depressive disorders is the anterior cingulate cortex (ACC). The rostral portion of the ACC—comprised of the pregenual ACC and subgenual ACC—is implicated in emotion control and reward processing. The goal of the current study was to examine how functional connectivity in subregions of the rostral ACC relate to depressive symptoms, measured by the Beck Depression Inventory-Second Edition, in an ethnically diverse sample of 28 community-dwelling older adults. Based on <em>meta</em>-analyses of previous studies in primarily young adults with clinical depression, we hypothesized that greater depressive symptoms would be associated with primarily increased resting-state functional connectivity from both the subgenual ACC and pregenual ACC to default mode network regions and the dorsolateral PFC. We instead found that higher depressive symptoms were associated with lower functional connectivity of the ACC to the dorsolateral PFC and regions within the default mode network, including from the subgenual ACC to the dorsolateral PFC and anterior cingulate and from the pregenual ACC to the middle cingulate gyrus. This preliminary study highlights brain alterations at subthreshold levels of depressive symptoms in older adults, which could serve as targets for interventions.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"3 ","pages":"Article 100059"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/99/68/main.PMC9997166.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9983878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal imaging of the aging brain: Baseline findings of the LoCARPoN study","authors":"Pallavi Nair ,&nbsp;Kameshwar Prasad ,&nbsp;Parthiban Balasundaram ,&nbsp;Deepti Vibha ,&nbsp;Sada Nand Dwivedi ,&nbsp;Shailesh B. Gaikwad ,&nbsp;Achal K. Srivastava ,&nbsp;Vivek Verma","doi":"10.1016/j.nbas.2023.100075","DOIUrl":"10.1016/j.nbas.2023.100075","url":null,"abstract":"<div><p>We quantified and investigated multimodal brain MRI measures in the LoCARPoN Study due to lack of normative data among Indians. A total of 401 participants (aged 50–88 years) without stroke or dementia completed MRI investigation. We assessed 31 brain measures in total using four brain MRI modalities, including macrostructural (global &amp; lobar volumes, white matter hyperintensities [WMHs]), microstructural (global and tract-specific white matter fractional anisotropy [WM-FA] and mean diffusivity [MD]) and perfusion measures (global and lobar cerebral blood flow [CBF]). The absolute brain volumes of males were significantly larger than those of females, but such differences were relatively small (&lt;1.2% of intracranial volume). With increasing age, lower macrostructural brain volumes, lower WM-FA, greater WMHs, higher WM-MD were found (<em>P</em> = 0.00018, Bonferroni threshold). Perfusion measures did not show significant differences with increasing age. Hippocampal volume showed the greatest association with age, with a reduction of approximately 0.48%/year. This preliminary study augments and provides insight into multimodal brain measures during the nascent stages of aging among the Indian population (South Asian ethnicity). Our findings establish the groundwork for future hypothetical testing studies.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"3 ","pages":"Article 100075"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8a/7f/main.PMC10173278.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9469910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Larger dlPFC and vmPFC grey matter volumes are associated with high adherence to the Mediterranean diet: A cross-sectional study in older adults","authors":"Belina Rodrigues ,&nbsp;Carlos Portugal-Nunes ,&nbsp;Ricardo Magalhães ,&nbsp;Liane Schmidt ,&nbsp;Pedro Silva Moreira ,&nbsp;José Miguel Soares ,&nbsp;Teresa Costa Castanho ,&nbsp;Paulo Marques ,&nbsp;Nuno Sousa ,&nbsp;Nadine Correia Santos","doi":"10.1016/j.nbas.2023.100064","DOIUrl":"10.1016/j.nbas.2023.100064","url":null,"abstract":"<div><p>Dietary self-control is associated with inter-individual differences in neuroanatomy. Yet, whether such inter-individual differences are also associated with healthier dietary patterns is yet to be determined. In this cross-sectional study, a total of 100 northern Portuguese older community-dwellers were assessed with regards to i) the adherence to a healthy dietary eating pattern – the Mediterranean diet (MedDiet), and ii) grey matter density (GMD) of brain regions associated with valuation and dietary self-regulation, the ventromedial (vmPFC) and dorsolateral prefrontal cortex (dlPFC), through voxel-based morphometry. Healthy food choices were ascertained through the Mediterranean Diet Adherence Screener (MEDAS) where higher scores indicated greater adherence to the MedDiet. Voxel-based morphometry showed that greater grey matter density in the dlPFC and vmPFC associated with a higher adherence to the MedDiet. These results replicate previous links between dietary decision-making measured under laboratory conditions and the neuroanatomy of the brain's valuation and self-control system. Importantly, they shed new light on the potential relevance of inter-individual differences in the neuroanatomy of these two brain regions for adhering to healthier dietary patterns in everyday life.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"3 ","pages":"Article 100064"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c8/3c/main.PMC9997170.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9471629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep deprivation aggravated amyloid β oligomers-induced damage to the cerebellum of rats: Evidence from magnetic resonance imaging","authors":"Wensheng Guo ,&nbsp;Xin Mao ,&nbsp;Ding Han ,&nbsp;Hongqi Wang ,&nbsp;Wanning Zhang ,&nbsp;Guitao Zhang ,&nbsp;Ning Zhang ,&nbsp;Binbin Nie ,&nbsp;Hui Li ,&nbsp;Yizhi Song ,&nbsp;Yan Wu ,&nbsp;Lirong Chang","doi":"10.1016/j.nbas.2023.100091","DOIUrl":"10.1016/j.nbas.2023.100091","url":null,"abstract":"<div><p>For quite a long time, researches on Alzheimer's disease (AD) primarily focused on the cortex and hippocampus, while the cerebellum has been ignored because of its abnormalities considered to appear in the late stage of AD. In recent years, increasing evidence suggest that the cerebellar pathological changes possibly occur in the preclinical phase of AD, which is also associated with sleep disorder. Sleep disturbance is a high risk factor of AD. However, the changes and roles of cerebellum has rarely been reported under conditions of AD accompanied with sleep disorders. In this study, using an amyloid-β oligomers (AβO)-induced rat model of AD subjected to sleep deprivation, combining with a 7.0 T animals structural magnetic resonance imaging (MRI), we assessed structural changes of cerebellum in MRI. Our results showed that sleep deprivation combined with AβO led to an increased FA value in the anterior lobe of cerebellum, decreased ADC value in the cerebellar lobes and cerebellar nuclei, and increased cerebellum volume. Besides that, sleep deprivation exacerbated the damage of AβO to the cerebellar structural network. This study demonstrated that sleep deprivation could aggravate the damage to cerebellum induced by AβO. The present findings provide supporting evidence for the involvement of cerebellum in the early pathology of AD and sleep loss. Our data would contribute to advancing the understanding of the mysterious role of cerebellum in AD and sleep disorders, as well as would be helpful for developing non-invasive MRI biomarkers for screening early AD patients with self-reported sleep disturbances.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"4 ","pages":"Article 100091"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/55/3b/main.PMC10432242.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10051620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling Parkinson’s risk factors","authors":"Sadashiva K. Pai","doi":"10.1016/j.nbas.2023.100073","DOIUrl":"10.1016/j.nbas.2023.100073","url":null,"abstract":"","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"3 ","pages":"Article 100073"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10112142/pdf/main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9740114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating associations of RNFL thickness and multifocal VEP with cognitive assessment and brain MRI volumes in older adults: Optic nerve decline and cognitive change (ONDCC) initiative","authors":"Ting Shen ,&nbsp;Samran Sheriff ,&nbsp;Yuyi You ,&nbsp;Jiyang Jiang ,&nbsp;Angela Schulz ,&nbsp;Heather Francis ,&nbsp;Mehdi Mirzaei ,&nbsp;Danit Saks ,&nbsp;Nitin Chitranshi ,&nbsp;Veer Gupta ,&nbsp;Maria Fiatarone Singh ,&nbsp;Alexander Klistorner ,&nbsp;Wei Wen ,&nbsp;Perminder Sachdev ,&nbsp;Vivek K. Gupta ,&nbsp;Stuart L. Graham","doi":"10.1016/j.nbas.2022.100049","DOIUrl":"10.1016/j.nbas.2022.100049","url":null,"abstract":"<div><p>To examine the relationships of retinal structural (optical coherence tomography) and visual functional (multifocal visual evoked potentials, mfVEP) indices with neuropsychological and brain structural measurements in healthy older subjects. 95 participants (mean (SD) age 68.1 (9.0)) years were recruited in the Optic Nerve Decline and Cognitive Change (ONDCC) study in this observational clinical investigation. OCT was conducted for retinal nerve fibre layer (RNFL) and mfVEP for amplitude and latency measurements. Participants undertook neuropsychological tests for cognitive performance and MRI for volumetric evaluation of various brain regions. Generalised estimating equation models were used for association analysis (p &lt; 0.05). The brain volumetric measures including total grey matter (GM), cortex, thalamus, hippocampal and fourth ventricular volumes were significantly associated with global and sectoral RNFL. RNFL thickness correlated with delayed recalls of California verbal learning test (CVLT) and Rey complex figure test (RCFT). The mfVEP amplitudes associated with cerebral white matter (WM) and cingulate GM volumes in MRI and CVLT, RCFT and trail making test outcomes. A significant association of mfVEP latency with logical memory delayed recall and thalamus volume was also observed. Our results suggested significant association of specific RNFL and mfVEP measures with distinctive brain region volumes and cognitive tests reflecting performance in memory, visuospatial and executive functional domains. These findings indicate that the mfVEP and RNFL measurements may parallel brain structural and neuropsychological measures in the older population.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"2 ","pages":"Article 100049"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/15/94/main.PMC9997126.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9155244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring cortical proteins underlying the relation of neuroticism to cognitive resilience","authors":"Francine Grodstein ,&nbsp;Lei Yu ,&nbsp;Philip L. de Jager ,&nbsp;Allan Levey ,&nbsp;Nicholas T. Seyfried ,&nbsp;David A. Bennett","doi":"10.1016/j.nbas.2022.100031","DOIUrl":"10.1016/j.nbas.2022.100031","url":null,"abstract":"<div><p>Some individuals maintain cognitive health despite neuropathology. Targets impacting “cognitive resilience” may provide interventions for preventing dementia without decreasing neuropathology. Neuroticism represents the tendency to experience negative emotions, and is related to worse cognitive resilience. Exploring proteins associated with cognitive resilience risk factors, such as neuroticism, could yield new protein targets. We used 355 postmortem prefrontal cortex from two cohorts to measure 8356 proteins. We identified (i) proteins associated with both neuroticism and cognitive resilience, and (ii) proteins statistically mediating relations of neuroticism to cognitive resilience. We found two proteins, 40S ribosomal proteinS3 (RPS3) and branched chain keto acid dehydrogenase E1, subunit beta (BCKDHB), ranked in the top 1% of smallest p-values in parallel linear regression models of neuroticism to protein levels, and protein levels to cognitive decline resilience. In mediation models, RPS3 and BCKDHB accounted for 25% (p = 0.005) of the relation of neuroticism to cognitive resilience. Our sample size is modest, thus results may be due to chance (p-values did not meet Bonferroni significance) and will require further confirmation; however, investigating biologic mediators of associations of risk factors to cognitive resilience may help discover targets to promote cognitive resilience and reduce dementia.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"2 ","pages":"Article 100031"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2d/5c/main.PMC9979250.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9394843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}