Aging brain最新文献_第8页

Longitudinal change-change associations of cognition with cortical thickness and surface area 纵向变化-认知与皮质厚度和表面积的关联

Aging brain Pub Date : 2023-01-01 DOI: 10.1016/j.nbas.2023.100070

Lars Nyberg , Micael Andersson , Anders Lundquist

引用次数: 0

Longitudinal association between ß-amyloid accumulation and cognitive decline in cognitively healthy older adults: A systematic review 认知健康老年人中ß-淀粉样蛋白积累与认知能力下降之间的纵向关联：一项系统综述

Aging brain Pub Date : 2023-01-01 DOI: 10.1016/j.nbas.2023.100074

Camille Parent , Louis-Simon Rousseau , David Predovan , Simon Duchesne , Carol Hudon

{"title":"Longitudinal association between ß-amyloid accumulation and cognitive decline in cognitively healthy older adults: A systematic review","authors":"Camille Parent , Louis-Simon Rousseau , David Predovan , Simon Duchesne , Carol Hudon","doi":"10.1016/j.nbas.2023.100074","DOIUrl":"10.1016/j.nbas.2023.100074","url":null,"abstract":"<div><p>This systematic review examined the longitudinal association between amyloid-β (Aβ) accumulation and cognitive decline in cognitively healthy adults. It was conducted using the PubMed, Embase, PsycInfo, and Web of Science databases. The methodological quality of the selected articles was assessed. In fine, seventeen longitudinal clinical studies were included in this review. A minority (seven out of 17) of studies reported a statistically significant association or prediction of cognitive decline with Aβ change, measured by positron emission tomography (PET; n = 6) and lumbar puncture (n = 1), with a mean follow-up duration of 3.17 years for cognition and 2.99 years for Aβ. The studies reporting significant results with PET found differences in the frontal, posterior cingular, lateral parietal and global (whole brain) cortices as well as in the precuneus. Significant associations were found with episodic memory (n = 6) and global cognition (n = 1). Five of the seven studies using a composite cognitive score found significant results. A quality assessment revealed widespread methodological biases, such as failure to report or account for loss-to follow up and missing data, and failure to report <em>p</em>-values and effect sizes of non-significant results. Overall, the longitudinal association between Aβ accumulation and cognitive decline in preclinical Alzheimer’s disease remains unclear. The discrepancy in results between studies may be explained in part by the choice of neuroimaging technique used to measure Aβ change, the duration of longitudinal studies, the heterogeneity of the healthy preclinical population, and importantly, the use of a composite score to capture cognitive changes with increased sensitivity. More longitudinal studies with larger sample sizes are needed to elucidate this relationship.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"3 ","pages":"Article 100074"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/76/38/main.PMC10173297.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9839052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms underlying fragmented sleep in aging 衰老过程中零碎睡眠的潜在机制

Aging brain Pub Date : 2023-01-01 DOI: 10.1016/j.nbas.2023.100077

Sadashiva K. Pai

引用次数: 0

A gene variant protects against Alzheimer's disease 一种基因变异可以预防阿尔茨海默病

Aging brain Pub Date : 2023-01-01 DOI: 10.1016/j.nbas.2022.100063

Sadashiva K. Pai

引用次数: 0

Dopamine D1-signaling modulates maintenance of functional network segregation in aging 多巴胺D1信号调节衰老过程中功能网络分离的维持

Aging brain Pub Date : 2023-01-01 DOI: 10.1016/j.nbas.2023.100079

Robin Pedersen , Jarkko Johansson , Alireza Salami

{"title":"Dopamine D1-signaling modulates maintenance of functional network segregation in aging","authors":"Robin Pedersen , Jarkko Johansson , Alireza Salami","doi":"10.1016/j.nbas.2023.100079","DOIUrl":"10.1016/j.nbas.2023.100079","url":null,"abstract":"<div><p>Past research has shown that as individuals age, there are decreases in within-network connectivity and increases in between-network connectivity, a pattern known as functional dedifferentiation. While the mechanisms behind reduced network segregation are not fully understood, evidence suggests that age-related differences in the dopamine (DA) system may play a key role. The DA D1-receptor (D1DR) is the most abundant and age-sensitive receptor subtype in the dopaminergic system, known to modulate synaptic activity and enhance the specificity of the neuronal signals. In this study from the DyNAMiC project (N = 180, 20-79y), we set out to investigate the interplay among age, functional connectivity, and dopamine D1DR availability. Using a novel application of multivariate Partial Least squares (PLS), we found that older age, and lower D1DR availability, were simultaneously associated with a pattern of decreased within-network and increased between-network connectivity. Individuals who expressed greater distinctiveness of large-scale networks exhibited more efficient working memory. In line with the maintenance hypotheses, we found that older individuals with greater D1DR in caudate exhibited less dedifferentiation of the connectome, and greater working memory, compared to their age-matched counterparts with less D1DR. These findings suggest that dopaminergic neurotransmission plays an important role in functional dedifferentiation in aging with consequences for working memory function at older age.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"3 ","pages":"Article 100079"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10180412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Overcoming hurdles: Enhancing post-mortem capabilities for neurological investigations in Africa 克服障碍：提高非洲神经系统调查的尸检能力。

Aging brain Pub Date : 2023-01-01 DOI: 10.1016/j.nbas.2023.100099

Abdullahi Tunde Aborode , Ayah Karra-Aly , Seto Charles Ogunleye , Mercy Mayowa Olorunshola , Tayo Nafisat Folorunso , Christianah Oreoluwa Aloba , Adedayo Emmanuel Ogunware

引用次数: 0

Aging brain Pub Date : 2023-01-01 DOI: 10.1016/j.nbas.2022.100062

Robert MacLachlan , Charles E. Evans , Siew Yeen Chai , Mark A. Good , Patrick Gavin Kehoe , J. Scott Miners

{"title":"Age-related reduction in brain ACE-2 is not exacerbated by Alzheimer’s disease pathology in mouse models of Alzheimer’s disease","authors":"Robert MacLachlan , Charles E. Evans , Siew Yeen Chai , Mark A. Good , Patrick Gavin Kehoe , J. Scott Miners","doi":"10.1016/j.nbas.2022.100062","DOIUrl":"10.1016/j.nbas.2022.100062","url":null,"abstract":"<div><p>An imbalance in the circulatory and organ-specific renin-angiotensin system (RAS) pathways is associated with age-related dysfunction and disease including cardiovascular burden and more recently Alzheimer’s disease (AD). It is currently unclear whether an age-associated imbalance in components of the RAS within the brain precedes the onset of AD or whether a RAS imbalance is associated with the onset of disease pathology and cognitive decline.</p><p>Angiotensin-converting enzyme-1 (ACE-1) and -2 (ACE-2) protein (ELISA) and enzyme activity (FRET assay), markers of the classical and counter-regulatory RAS axis respectively, and Ang-II and Ang-(1–7) peptide levels (ELISA), were measured in the left cortex across four transgenic AD mouse models of amyloid pathology (5xFAD – 2, 6, and 12 months of age; Apd9 – 3-4, 12, and 18 months of age; Tg2576 – 3-4 and 24 months of age; and PDAPP – 3-4, 7, 11, 15, and 18 months of age) and littermate wild-type (WT) controls.</p><p>ACE-1 level, and enzyme activity, was unaltered in relation to age in WT mice and across all four models. In contrast, ACE-2 level and enzyme activity, was reduced and Ang-II increased with ageing in both WT animals and disease models. The changes in ACE-2 and Ang-II in AD models mirrored WT mice, except for the 5xFAD model, when the reduction in ACE-2 (and elevated Ang-II) was observed at a younger age.</p><p>These data indicate an age-related dysregulation of brain RAS is likely to be driven by a reduction in ACE-2. The reduction in ACE-2 occurs at a young age, coinciding with early pathological changes and the initial deposition of Aβ, and preceding neuronal loss and cognitive decline, in the transgenic AD models. However, the age-related loss was mirrored in WT mice suggesting that the change was independent of pathological Aβ deposition.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"3 ","pages":"Article 100062"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/40/b7/main.PMC9997187.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9455814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Rostral anterior cingulate connectivity in older adults with subthreshold depressive symptoms: A preliminary study 有阈下抑郁症状的老年人颈前扣带连接的初步研究

Aging brain Pub Date : 2023-01-01 DOI: 10.1016/j.nbas.2022.100059

Andrew M. Gradone , Gabriell Champion , Keith M. McGregor , Joe R. Nocera , Sarah J. Barber , Lisa C. Krishnamurthy , Vonetta M. Dotson

{"title":"Rostral anterior cingulate connectivity in older adults with subthreshold depressive symptoms: A preliminary study","authors":"Andrew M. Gradone , Gabriell Champion , Keith M. McGregor , Joe R. Nocera , Sarah J. Barber , Lisa C. Krishnamurthy , Vonetta M. Dotson","doi":"10.1016/j.nbas.2022.100059","DOIUrl":"10.1016/j.nbas.2022.100059","url":null,"abstract":"<div><p>Subthreshold depressive symptoms are highly prevalent among older adults and are associated with numerous health risks including cognitive decline and decreased physical health. One brain region central to neuroanatomical models of depressive disorders is the anterior cingulate cortex (ACC). The rostral portion of the ACC—comprised of the pregenual ACC and subgenual ACC—is implicated in emotion control and reward processing. The goal of the current study was to examine how functional connectivity in subregions of the rostral ACC relate to depressive symptoms, measured by the Beck Depression Inventory-Second Edition, in an ethnically diverse sample of 28 community-dwelling older adults. Based on <em>meta</em>-analyses of previous studies in primarily young adults with clinical depression, we hypothesized that greater depressive symptoms would be associated with primarily increased resting-state functional connectivity from both the subgenual ACC and pregenual ACC to default mode network regions and the dorsolateral PFC. We instead found that higher depressive symptoms were associated with lower functional connectivity of the ACC to the dorsolateral PFC and regions within the default mode network, including from the subgenual ACC to the dorsolateral PFC and anterior cingulate and from the pregenual ACC to the middle cingulate gyrus. This preliminary study highlights brain alterations at subthreshold levels of depressive symptoms in older adults, which could serve as targets for interventions.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"3 ","pages":"Article 100059"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/99/68/main.PMC9997166.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9983878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multimodal imaging of the aging brain: Baseline findings of the LoCARPoN study 脑老化的多模态成像:LoCARPoN研究的基线结果

Aging brain Pub Date : 2023-01-01 DOI: 10.1016/j.nbas.2023.100075

Pallavi Nair , Kameshwar Prasad , Parthiban Balasundaram , Deepti Vibha , Sada Nand Dwivedi , Shailesh B. Gaikwad , Achal K. Srivastava , Vivek Verma

{"title":"Multimodal imaging of the aging brain: Baseline findings of the LoCARPoN study","authors":"Pallavi Nair , Kameshwar Prasad , Parthiban Balasundaram , Deepti Vibha , Sada Nand Dwivedi , Shailesh B. Gaikwad , Achal K. Srivastava , Vivek Verma","doi":"10.1016/j.nbas.2023.100075","DOIUrl":"10.1016/j.nbas.2023.100075","url":null,"abstract":"<div><p>We quantified and investigated multimodal brain MRI measures in the LoCARPoN Study due to lack of normative data among Indians. A total of 401 participants (aged 50–88 years) without stroke or dementia completed MRI investigation. We assessed 31 brain measures in total using four brain MRI modalities, including macrostructural (global & lobar volumes, white matter hyperintensities [WMHs]), microstructural (global and tract-specific white matter fractional anisotropy [WM-FA] and mean diffusivity [MD]) and perfusion measures (global and lobar cerebral blood flow [CBF]). The absolute brain volumes of males were significantly larger than those of females, but such differences were relatively small (<1.2% of intracranial volume). With increasing age, lower macrostructural brain volumes, lower WM-FA, greater WMHs, higher WM-MD were found (<em>P</em> = 0.00018, Bonferroni threshold). Perfusion measures did not show significant differences with increasing age. Hippocampal volume showed the greatest association with age, with a reduction of approximately 0.48%/year. This preliminary study augments and provides insight into multimodal brain measures during the nascent stages of aging among the Indian population (South Asian ethnicity). Our findings establish the groundwork for future hypothetical testing studies.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"3 ","pages":"Article 100075"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8a/7f/main.PMC10173278.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9469910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Larger dlPFC and vmPFC grey matter volumes are associated with high adherence to the Mediterranean diet: A cross-sectional study in older adults 大的dlPFC和vmPFC灰质体积与地中海饮食的高依从性有关:一项针对老年人的横断面研究

Aging brain Pub Date : 2023-01-01 DOI: 10.1016/j.nbas.2023.100064

Belina Rodrigues , Carlos Portugal-Nunes , Ricardo Magalhães , Liane Schmidt , Pedro Silva Moreira , José Miguel Soares , Teresa Costa Castanho , Paulo Marques , Nuno Sousa , Nadine Correia Santos

{"title":"Larger dlPFC and vmPFC grey matter volumes are associated with high adherence to the Mediterranean diet: A cross-sectional study in older adults","authors":"Belina Rodrigues , Carlos Portugal-Nunes , Ricardo Magalhães , Liane Schmidt , Pedro Silva Moreira , José Miguel Soares , Teresa Costa Castanho , Paulo Marques , Nuno Sousa , Nadine Correia Santos","doi":"10.1016/j.nbas.2023.100064","DOIUrl":"10.1016/j.nbas.2023.100064","url":null,"abstract":"<div><p>Dietary self-control is associated with inter-individual differences in neuroanatomy. Yet, whether such inter-individual differences are also associated with healthier dietary patterns is yet to be determined. In this cross-sectional study, a total of 100 northern Portuguese older community-dwellers were assessed with regards to i) the adherence to a healthy dietary eating pattern – the Mediterranean diet (MedDiet), and ii) grey matter density (GMD) of brain regions associated with valuation and dietary self-regulation, the ventromedial (vmPFC) and dorsolateral prefrontal cortex (dlPFC), through voxel-based morphometry. Healthy food choices were ascertained through the Mediterranean Diet Adherence Screener (MEDAS) where higher scores indicated greater adherence to the MedDiet. Voxel-based morphometry showed that greater grey matter density in the dlPFC and vmPFC associated with a higher adherence to the MedDiet. These results replicate previous links between dietary decision-making measured under laboratory conditions and the neuroanatomy of the brain's valuation and self-control system. Importantly, they shed new light on the potential relevance of inter-individual differences in the neuroanatomy of these two brain regions for adhering to healthier dietary patterns in everyday life.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"3 ","pages":"Article 100064"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c8/3c/main.PMC9997170.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9471629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0