Aging brain最新文献_第7页

Sex differences in brain structures throughout the lifetime 一生中大脑结构的性别差异。

Aging brain Pub Date : 2023-01-01 DOI: 10.1016/j.nbas.2023.100098

Mohammadamin Parsaei , Hossein Sanjari Moghaddam , Mohammad Hadi Aarabi

引用次数: 0

EngAge – A metacognitive intervention to supplement working memory training: A feasibility study in older adults EngAge——补充工作记忆训练的元认知干预：一项针对老年人的可行性研究

Aging brain Pub Date : 2023-01-01 DOI: 10.1016/j.nbas.2023.100083

Susanne M. Jaeggi , Alexandria N. Weaver , Elena Carbone , Francesca E. Trane , Rachel N. Smith-Peirce , Martin Buschkuehl , Christoph Flueckiger , Madison Carlson , John Jonides , Erika Borella

{"title":"EngAge – A metacognitive intervention to supplement working memory training: A feasibility study in older adults","authors":"Susanne M. Jaeggi , Alexandria N. Weaver , Elena Carbone , Francesca E. Trane , Rachel N. Smith-Peirce , Martin Buschkuehl , Christoph Flueckiger , Madison Carlson , John Jonides , Erika Borella","doi":"10.1016/j.nbas.2023.100083","DOIUrl":"https://doi.org/10.1016/j.nbas.2023.100083","url":null,"abstract":"<div><p>Working Memory (WM) training has shown promise in supporting cognitive functioning in older adult populations, but effects that generalize beyond the trained task have been inconsistent. Targeting cognitive processes in isolation might be a limiting factor given that metacognitive and motivational factors have been shown to impact older adults’ engagement with challenging cognitive activities, such as WM training. The current feasibility study implemented a novel metacognitive intervention in conjunction with WM training in older adults and examined its potential amplifying short- and long-term effects on cognitive and self-report outcomes as compared to WM or active control training alone. One-hundred and nineteen older adults completed acognitive training over the course of 20 sessions at home. The cognitive training targeted either WM or general knowledge. In addition, one of the WM training groups completed a metacognitive program via group seminars. We tested for group differences in WM, inhibitory control, and episodic memory, andwe assessed participants’ perceived self-efficacy and everyday memory failures. At post-test, we replicated earlier work by demonstrating that participants who completed the WM intervention outperformed the active control group in non-trained WM measures, and to some extent, in inhibitory control. However, we found no evidence that the supplemental metacognitive program led to benefits over and above the WM intervention. Nonetheless, we conclude that our metacognitive program is a step in the right directiongiven the tentative long-term effects and participants’ positive feedback, but more longitudinal data with larger sample sizes are needed to confirm these early findings.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"4 ","pages":"Article 100083"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49817057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal grip strength is associated with susceptibility to the Sound Induced Flash Illusion in older adults 纵向握力与老年人对声音诱发闪光错觉的易感性有关

Aging brain Pub Date : 2023-01-01 DOI: 10.1016/j.nbas.2023.100076

A. O' Dowd , R.J. Hirst , A. Setti , R.A. Kenny , F.N. Newell

{"title":"Longitudinal grip strength is associated with susceptibility to the Sound Induced Flash Illusion in older adults","authors":"A. O' Dowd , R.J. Hirst , A. Setti , R.A. Kenny , F.N. Newell","doi":"10.1016/j.nbas.2023.100076","DOIUrl":"10.1016/j.nbas.2023.100076","url":null,"abstract":"<div><p>The precision of temporal multisensory integration is associated with specific aspects of physical functioning in ageing, including gait speed and incidents of falling. However, it is unknown if such an association exists between multisensory integration and grip strength, an important index of frailty and brain health and predictor of disease and mortality in older adults. Here, we investigated whether temporal multisensory integration is associated with longitudinal (eight-year) grip strength trajectories in a large sample of 2,061 older adults (mean age = 64.42 years, <em>SD</em> = 7.20; 52% female) drawn from The Irish Longitudinal Study on Ageing (TILDA). Grip strength (kg) for the dominant hand was assessed with a hand-held dynamometer across four testing waves. Longitudinal k-means clustering was applied to these data separately for sex (male, female) and age group (50–64, 65–74, 75+ years). At wave 3, older adults participated in the Sound Induced Flash Illusion (SIFI), a measure of the precision of temporal audio-visual integration, which included three audio-visual stimulus onset asynchronies (SOAs): 70, 150 and 230 ms. Results showed that older adults with a relatively lower (i.e., weaker) grip strength were more susceptible to the SIFI at the longer SOAs compared to those with a relatively higher (i.e., stronger) grip strength (<em>p</em> <.001). These novel findings suggest that older adults with relatively weaker grip strength exhibit an expanded temporal binding window for audio-visual events, possibly reflecting a reduction in the integrity of the central nervous system.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"3 ","pages":"Article 100076"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6f/3e/main.PMC10241972.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9971636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Longitudinal change-change associations of cognition with cortical thickness and surface area 纵向变化-认知与皮质厚度和表面积的关联

Aging brain Pub Date : 2023-01-01 DOI: 10.1016/j.nbas.2023.100070

Lars Nyberg , Micael Andersson , Anders Lundquist

引用次数: 0

Longitudinal association between ß-amyloid accumulation and cognitive decline in cognitively healthy older adults: A systematic review 认知健康老年人中ß-淀粉样蛋白积累与认知能力下降之间的纵向关联：一项系统综述

Aging brain Pub Date : 2023-01-01 DOI: 10.1016/j.nbas.2023.100074

Camille Parent , Louis-Simon Rousseau , David Predovan , Simon Duchesne , Carol Hudon

{"title":"Longitudinal association between ß-amyloid accumulation and cognitive decline in cognitively healthy older adults: A systematic review","authors":"Camille Parent , Louis-Simon Rousseau , David Predovan , Simon Duchesne , Carol Hudon","doi":"10.1016/j.nbas.2023.100074","DOIUrl":"10.1016/j.nbas.2023.100074","url":null,"abstract":"<div><p>This systematic review examined the longitudinal association between amyloid-β (Aβ) accumulation and cognitive decline in cognitively healthy adults. It was conducted using the PubMed, Embase, PsycInfo, and Web of Science databases. The methodological quality of the selected articles was assessed. In fine, seventeen longitudinal clinical studies were included in this review. A minority (seven out of 17) of studies reported a statistically significant association or prediction of cognitive decline with Aβ change, measured by positron emission tomography (PET; n = 6) and lumbar puncture (n = 1), with a mean follow-up duration of 3.17 years for cognition and 2.99 years for Aβ. The studies reporting significant results with PET found differences in the frontal, posterior cingular, lateral parietal and global (whole brain) cortices as well as in the precuneus. Significant associations were found with episodic memory (n = 6) and global cognition (n = 1). Five of the seven studies using a composite cognitive score found significant results. A quality assessment revealed widespread methodological biases, such as failure to report or account for loss-to follow up and missing data, and failure to report <em>p</em>-values and effect sizes of non-significant results. Overall, the longitudinal association between Aβ accumulation and cognitive decline in preclinical Alzheimer’s disease remains unclear. The discrepancy in results between studies may be explained in part by the choice of neuroimaging technique used to measure Aβ change, the duration of longitudinal studies, the heterogeneity of the healthy preclinical population, and importantly, the use of a composite score to capture cognitive changes with increased sensitivity. More longitudinal studies with larger sample sizes are needed to elucidate this relationship.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"3 ","pages":"Article 100074"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/76/38/main.PMC10173297.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9839052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms underlying fragmented sleep in aging 衰老过程中零碎睡眠的潜在机制

Aging brain Pub Date : 2023-01-01 DOI: 10.1016/j.nbas.2023.100077

Sadashiva K. Pai

引用次数: 0

A gene variant protects against Alzheimer's disease 一种基因变异可以预防阿尔茨海默病

Aging brain Pub Date : 2023-01-01 DOI: 10.1016/j.nbas.2022.100063

Sadashiva K. Pai

引用次数: 0

Dopamine D1-signaling modulates maintenance of functional network segregation in aging 多巴胺D1信号调节衰老过程中功能网络分离的维持

Aging brain Pub Date : 2023-01-01 DOI: 10.1016/j.nbas.2023.100079

Robin Pedersen , Jarkko Johansson , Alireza Salami

{"title":"Dopamine D1-signaling modulates maintenance of functional network segregation in aging","authors":"Robin Pedersen , Jarkko Johansson , Alireza Salami","doi":"10.1016/j.nbas.2023.100079","DOIUrl":"10.1016/j.nbas.2023.100079","url":null,"abstract":"<div><p>Past research has shown that as individuals age, there are decreases in within-network connectivity and increases in between-network connectivity, a pattern known as functional dedifferentiation. While the mechanisms behind reduced network segregation are not fully understood, evidence suggests that age-related differences in the dopamine (DA) system may play a key role. The DA D1-receptor (D1DR) is the most abundant and age-sensitive receptor subtype in the dopaminergic system, known to modulate synaptic activity and enhance the specificity of the neuronal signals. In this study from the DyNAMiC project (N = 180, 20-79y), we set out to investigate the interplay among age, functional connectivity, and dopamine D1DR availability. Using a novel application of multivariate Partial Least squares (PLS), we found that older age, and lower D1DR availability, were simultaneously associated with a pattern of decreased within-network and increased between-network connectivity. Individuals who expressed greater distinctiveness of large-scale networks exhibited more efficient working memory. In line with the maintenance hypotheses, we found that older individuals with greater D1DR in caudate exhibited less dedifferentiation of the connectome, and greater working memory, compared to their age-matched counterparts with less D1DR. These findings suggest that dopaminergic neurotransmission plays an important role in functional dedifferentiation in aging with consequences for working memory function at older age.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"3 ","pages":"Article 100079"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10180412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Overcoming hurdles: Enhancing post-mortem capabilities for neurological investigations in Africa 克服障碍：提高非洲神经系统调查的尸检能力。

Aging brain Pub Date : 2023-01-01 DOI: 10.1016/j.nbas.2023.100099

Abdullahi Tunde Aborode , Ayah Karra-Aly , Seto Charles Ogunleye , Mercy Mayowa Olorunshola , Tayo Nafisat Folorunso , Christianah Oreoluwa Aloba , Adedayo Emmanuel Ogunware

引用次数: 0

Aging brain Pub Date : 2023-01-01 DOI: 10.1016/j.nbas.2022.100062

Robert MacLachlan , Charles E. Evans , Siew Yeen Chai , Mark A. Good , Patrick Gavin Kehoe , J. Scott Miners

{"title":"Age-related reduction in brain ACE-2 is not exacerbated by Alzheimer’s disease pathology in mouse models of Alzheimer’s disease","authors":"Robert MacLachlan , Charles E. Evans , Siew Yeen Chai , Mark A. Good , Patrick Gavin Kehoe , J. Scott Miners","doi":"10.1016/j.nbas.2022.100062","DOIUrl":"10.1016/j.nbas.2022.100062","url":null,"abstract":"<div><p>An imbalance in the circulatory and organ-specific renin-angiotensin system (RAS) pathways is associated with age-related dysfunction and disease including cardiovascular burden and more recently Alzheimer’s disease (AD). It is currently unclear whether an age-associated imbalance in components of the RAS within the brain precedes the onset of AD or whether a RAS imbalance is associated with the onset of disease pathology and cognitive decline.</p><p>Angiotensin-converting enzyme-1 (ACE-1) and -2 (ACE-2) protein (ELISA) and enzyme activity (FRET assay), markers of the classical and counter-regulatory RAS axis respectively, and Ang-II and Ang-(1–7) peptide levels (ELISA), were measured in the left cortex across four transgenic AD mouse models of amyloid pathology (5xFAD – 2, 6, and 12 months of age; Apd9 – 3-4, 12, and 18 months of age; Tg2576 – 3-4 and 24 months of age; and PDAPP – 3-4, 7, 11, 15, and 18 months of age) and littermate wild-type (WT) controls.</p><p>ACE-1 level, and enzyme activity, was unaltered in relation to age in WT mice and across all four models. In contrast, ACE-2 level and enzyme activity, was reduced and Ang-II increased with ageing in both WT animals and disease models. The changes in ACE-2 and Ang-II in AD models mirrored WT mice, except for the 5xFAD model, when the reduction in ACE-2 (and elevated Ang-II) was observed at a younger age.</p><p>These data indicate an age-related dysregulation of brain RAS is likely to be driven by a reduction in ACE-2. The reduction in ACE-2 occurs at a young age, coinciding with early pathological changes and the initial deposition of Aβ, and preceding neuronal loss and cognitive decline, in the transgenic AD models. However, the age-related loss was mirrored in WT mice suggesting that the change was independent of pathological Aβ deposition.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"3 ","pages":"Article 100062"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/40/b7/main.PMC9997187.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9455814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1