Aging brain最新文献_第7页

Longitudinal trajectories of spectral power during sleep in middle-aged and older adults 中老年人睡眠时光谱功率的纵向轨迹

Aging brain Pub Date : 2023-01-01 DOI: 10.1016/j.nbas.2022.100058

Chenlu Gao , Michael K. Scullin

{"title":"Longitudinal trajectories of spectral power during sleep in middle-aged and older adults","authors":"Chenlu Gao , Michael K. Scullin","doi":"10.1016/j.nbas.2022.100058","DOIUrl":"10.1016/j.nbas.2022.100058","url":null,"abstract":"<div><p>Age-related changes in sleep appear to contribute to cognitive aging and dementia. However, most of the current understanding of sleep across the lifespan is based on cross-sectional evidence. Using data from the Sleep Heart Health Study, we investigated longitudinal changes in sleep micro-architecture, focusing on whether such age-related changes are experienced uniformly across individuals. Participants were 2,202 adults (age<sub>Baseline</sub> = 62.40 ± 10.38, 55.36 % female, 87.92 % White) who completed home polysomnography assessment at two study visits, which were 5.23 years apart (range: 4–7 years). We analyzed NREM and REM spectral power density for each 0.5 Hz frequency bin, including slow oscillation (0.5–1 Hz), delta (1–4 Hz), theta (4–8 Hz), alpha (8–12 Hz), sigma (12–15 Hz), and beta-1 (15–20 Hz) bands. Longitudinal comparisons showed a 5-year decline in NREM delta (p <.001) and NREM sigma power density (p <.001) as well as a 5-year increase in theta power density during NREM (p =.001) and power density for all frequency bands during REM sleep (ps < 0.05). In contrast to the notion that sleep declines linearly with advancing age, longitudinal trajectories varied considerably across individuals. Within individuals, the 5-year changes in NREM and REM power density were strongly correlated (slow oscillation: r = 0.46; delta: r = 0.67; theta r = 0.78; alpha r = 0.66; sigma: r = 0.71; beta-1: r = 0.73; ps < 0.001). The convergence in the longitudinal trajectories of NREM and REM activity may reflect age-related neural de-differentiation and/or compensation processes. Future research should investigate the neurocognitive implications of longitudinal changes in sleep micro-architecture and test whether interventions for improving key sleep micro-architecture features (such as NREM delta and sigma activity) also benefit cognition over time.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"3 ","pages":"Article 100058"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9471626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The prevalence of sleep loss and sleep disorders in young and old adults 年轻人和老年人睡眠不足和睡眠障碍的患病率

Aging brain Pub Date : 2023-01-01 DOI: 10.1016/j.nbas.2022.100057

Vibha Madan Jha

引用次数: 2

Integrative Precision Medicine for Dementia and Alzheimer's Diseases in Africa 非洲痴呆症和阿尔茨海默病的综合精准医学

Aging brain Pub Date : 2023-01-01 DOI: 10.1016/j.nbas.2023.100095

Abdullahi Tunde Aborode , Nike Jesutofunmi Idowu , Samuel Tundealao , Joseph Jaiyeola , Ezemba Constance Chinyere , Seto Charles Ogunleye , Mercy Olorunshola , Ogunware Adedayo Emmanuel

引用次数: 0

Sex differences in brain structures throughout the lifetime 一生中大脑结构的性别差异。

Aging brain Pub Date : 2023-01-01 DOI: 10.1016/j.nbas.2023.100098

Mohammadamin Parsaei , Hossein Sanjari Moghaddam , Mohammad Hadi Aarabi

引用次数: 0

EngAge – A metacognitive intervention to supplement working memory training: A feasibility study in older adults EngAge——补充工作记忆训练的元认知干预：一项针对老年人的可行性研究

Aging brain Pub Date : 2023-01-01 DOI: 10.1016/j.nbas.2023.100083

Susanne M. Jaeggi , Alexandria N. Weaver , Elena Carbone , Francesca E. Trane , Rachel N. Smith-Peirce , Martin Buschkuehl , Christoph Flueckiger , Madison Carlson , John Jonides , Erika Borella

{"title":"EngAge – A metacognitive intervention to supplement working memory training: A feasibility study in older adults","authors":"Susanne M. Jaeggi , Alexandria N. Weaver , Elena Carbone , Francesca E. Trane , Rachel N. Smith-Peirce , Martin Buschkuehl , Christoph Flueckiger , Madison Carlson , John Jonides , Erika Borella","doi":"10.1016/j.nbas.2023.100083","DOIUrl":"https://doi.org/10.1016/j.nbas.2023.100083","url":null,"abstract":"<div><p>Working Memory (WM) training has shown promise in supporting cognitive functioning in older adult populations, but effects that generalize beyond the trained task have been inconsistent. Targeting cognitive processes in isolation might be a limiting factor given that metacognitive and motivational factors have been shown to impact older adults’ engagement with challenging cognitive activities, such as WM training. The current feasibility study implemented a novel metacognitive intervention in conjunction with WM training in older adults and examined its potential amplifying short- and long-term effects on cognitive and self-report outcomes as compared to WM or active control training alone. One-hundred and nineteen older adults completed acognitive training over the course of 20 sessions at home. The cognitive training targeted either WM or general knowledge. In addition, one of the WM training groups completed a metacognitive program via group seminars. We tested for group differences in WM, inhibitory control, and episodic memory, andwe assessed participants’ perceived self-efficacy and everyday memory failures. At post-test, we replicated earlier work by demonstrating that participants who completed the WM intervention outperformed the active control group in non-trained WM measures, and to some extent, in inhibitory control. However, we found no evidence that the supplemental metacognitive program led to benefits over and above the WM intervention. Nonetheless, we conclude that our metacognitive program is a step in the right directiongiven the tentative long-term effects and participants’ positive feedback, but more longitudinal data with larger sample sizes are needed to confirm these early findings.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"4 ","pages":"Article 100083"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49817057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal grip strength is associated with susceptibility to the Sound Induced Flash Illusion in older adults 纵向握力与老年人对声音诱发闪光错觉的易感性有关

Aging brain Pub Date : 2023-01-01 DOI: 10.1016/j.nbas.2023.100076

A. O' Dowd , R.J. Hirst , A. Setti , R.A. Kenny , F.N. Newell

{"title":"Longitudinal grip strength is associated with susceptibility to the Sound Induced Flash Illusion in older adults","authors":"A. O' Dowd , R.J. Hirst , A. Setti , R.A. Kenny , F.N. Newell","doi":"10.1016/j.nbas.2023.100076","DOIUrl":"10.1016/j.nbas.2023.100076","url":null,"abstract":"<div><p>The precision of temporal multisensory integration is associated with specific aspects of physical functioning in ageing, including gait speed and incidents of falling. However, it is unknown if such an association exists between multisensory integration and grip strength, an important index of frailty and brain health and predictor of disease and mortality in older adults. Here, we investigated whether temporal multisensory integration is associated with longitudinal (eight-year) grip strength trajectories in a large sample of 2,061 older adults (mean age = 64.42 years, <em>SD</em> = 7.20; 52% female) drawn from The Irish Longitudinal Study on Ageing (TILDA). Grip strength (kg) for the dominant hand was assessed with a hand-held dynamometer across four testing waves. Longitudinal k-means clustering was applied to these data separately for sex (male, female) and age group (50–64, 65–74, 75+ years). At wave 3, older adults participated in the Sound Induced Flash Illusion (SIFI), a measure of the precision of temporal audio-visual integration, which included three audio-visual stimulus onset asynchronies (SOAs): 70, 150 and 230 ms. Results showed that older adults with a relatively lower (i.e., weaker) grip strength were more susceptible to the SIFI at the longer SOAs compared to those with a relatively higher (i.e., stronger) grip strength (<em>p</em> <.001). These novel findings suggest that older adults with relatively weaker grip strength exhibit an expanded temporal binding window for audio-visual events, possibly reflecting a reduction in the integrity of the central nervous system.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"3 ","pages":"Article 100076"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6f/3e/main.PMC10241972.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9971636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Longitudinal change-change associations of cognition with cortical thickness and surface area 纵向变化-认知与皮质厚度和表面积的关联

Aging brain Pub Date : 2023-01-01 DOI: 10.1016/j.nbas.2023.100070

Lars Nyberg , Micael Andersson , Anders Lundquist

引用次数: 0

Longitudinal association between ß-amyloid accumulation and cognitive decline in cognitively healthy older adults: A systematic review 认知健康老年人中ß-淀粉样蛋白积累与认知能力下降之间的纵向关联：一项系统综述

Aging brain Pub Date : 2023-01-01 DOI: 10.1016/j.nbas.2023.100074

Camille Parent , Louis-Simon Rousseau , David Predovan , Simon Duchesne , Carol Hudon

{"title":"Longitudinal association between ß-amyloid accumulation and cognitive decline in cognitively healthy older adults: A systematic review","authors":"Camille Parent , Louis-Simon Rousseau , David Predovan , Simon Duchesne , Carol Hudon","doi":"10.1016/j.nbas.2023.100074","DOIUrl":"10.1016/j.nbas.2023.100074","url":null,"abstract":"<div><p>This systematic review examined the longitudinal association between amyloid-β (Aβ) accumulation and cognitive decline in cognitively healthy adults. It was conducted using the PubMed, Embase, PsycInfo, and Web of Science databases. The methodological quality of the selected articles was assessed. In fine, seventeen longitudinal clinical studies were included in this review. A minority (seven out of 17) of studies reported a statistically significant association or prediction of cognitive decline with Aβ change, measured by positron emission tomography (PET; n = 6) and lumbar puncture (n = 1), with a mean follow-up duration of 3.17 years for cognition and 2.99 years for Aβ. The studies reporting significant results with PET found differences in the frontal, posterior cingular, lateral parietal and global (whole brain) cortices as well as in the precuneus. Significant associations were found with episodic memory (n = 6) and global cognition (n = 1). Five of the seven studies using a composite cognitive score found significant results. A quality assessment revealed widespread methodological biases, such as failure to report or account for loss-to follow up and missing data, and failure to report <em>p</em>-values and effect sizes of non-significant results. Overall, the longitudinal association between Aβ accumulation and cognitive decline in preclinical Alzheimer’s disease remains unclear. The discrepancy in results between studies may be explained in part by the choice of neuroimaging technique used to measure Aβ change, the duration of longitudinal studies, the heterogeneity of the healthy preclinical population, and importantly, the use of a composite score to capture cognitive changes with increased sensitivity. More longitudinal studies with larger sample sizes are needed to elucidate this relationship.</p></div>","PeriodicalId":72131,"journal":{"name":"Aging brain","volume":"3 ","pages":"Article 100074"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/76/38/main.PMC10173297.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9839052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms underlying fragmented sleep in aging 衰老过程中零碎睡眠的潜在机制

Aging brain Pub Date : 2023-01-01 DOI: 10.1016/j.nbas.2023.100077

Sadashiva K. Pai

引用次数: 0

A gene variant protects against Alzheimer's disease 一种基因变异可以预防阿尔茨海默病

Aging brain Pub Date : 2023-01-01 DOI: 10.1016/j.nbas.2022.100063

Sadashiva K. Pai

引用次数: 0