Aging and health research最新文献

{"title":"Interventions of cognitive impairment in older adults: A comprehensive review","authors":"Shivani Chib, Kajal Sharma, Randhir Singh","doi":"10.1016/j.ahr.2025.100223","DOIUrl":"10.1016/j.ahr.2025.100223","url":null,"abstract":"","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 1","pages":"Article 100223"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143464794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Premorbid and current intellectual performance reflects different backgrounds in patients with Parkinson's disease","authors":"Hidetomo Murakami,&nbsp;Machiko Kezuka,&nbsp;Junnosuke Ozawa,&nbsp;Kaoru Matsuoka,&nbsp;Tatsuya Nakanishi,&nbsp;Atsushi Ishida,&nbsp;Naohito Ito,&nbsp;Mizuki Kanemoto,&nbsp;Mitsuru Kawamura","doi":"10.1016/j.ahr.2025.100221","DOIUrl":"10.1016/j.ahr.2025.100221","url":null,"abstract":"<div><h3>Background</h3><div>There is growing interest in targeting Parkinson's Disease (PD) at an earlier stage, especially before emergence of motor symptoms. Cognitive dysfunction is a non-motor symptom in PD, whereas the Japanese version of the National Adult Reading Test (JART) is a validated battery to estimate the premorbid intellectual quotient (IQ). Therefore, the results of JART and current cognitive assessment after onset of PD may reflect different background factors. The goal of the study was to compare factors correlated with estimated premorbid intellectual performance using JART and current cognitive function after onset of PD.</div></div><div><h3>Methods</h3><div>Current motor symptoms (Unified Parkinson's Disease Rating Scale; UPDRS Part III) and cognitive function (Montreal Cognitive Assessment; MoCA) were assessed in 48 patients with PD. Premorbid IQs (verbal IQ: VIQ, performance IQ: PIQ, and full scale IQ: FIQ) were estimated using JART. Spearman correlation coefficients were calculated for background factors (current age, years of education, UPDRS Part III, and levodopa equivalent dose of prescribed drugs (LED)) with MoCA scores and estimated IQs.</div></div><div><h3>Results</h3><div>Estimated VIQ (<em>r</em> = 0.451, <em>p</em> = 0.001), PIQ (<em>r</em> = 0.445, <em>p</em> = 0.002) and FIQ (<em>r</em> = 0.453, <em>p</em> = 0.001) were significantly correlated with years of education that was fixed until adolescence (i.e. 20 s). MoCA was significantly correlated with current age (<em>r</em>=−0.401, <em>p</em> = 0.005) and UPDRS part III (<em>r</em>=−0.374, <em>p</em> = 0.009), both of which continue to progress gradually after onset of PD. In multiple regression analyses, these correlations were significant and independent.</div></div><div><h3>Conclusion</h3><div>Premorbid and current intellectual performance reflect different background factors in patients with PD.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 1","pages":"Article 100221"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143204997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of predictors of mortality among older residents with pneumonia in Qatar's long-term care facilities","authors":"Shafi Hashmath Ulla Khan ,&nbsp;Al Anoud Al Fehaidi ,&nbsp;Wasim Akram ,&nbsp;Irshad Badarudeen ,&nbsp;Mahmoud Ahmed Refaee ,&nbsp;Noorudeen Kunnunmal ,&nbsp;Asma Abbas ,&nbsp;Osama Idris ,&nbsp;Sheela Umakanth ,&nbsp;Hanadi Al Hamad","doi":"10.1016/j.ahr.2024.100216","DOIUrl":"10.1016/j.ahr.2024.100216","url":null,"abstract":"<div><div>It is widely recognized that older adults are at an increased risk of contracting pneumonia, which may lead to significant adverse outcomes, including increased rates of morbidity and mortality. The primary aim of this retrospective study was to identify the common factors that contribute to the mortality secondary to pneumonia in older individuals in long-term care facilities. Of the 326 admitted patients, 147 were aged over 65 years, and 51 were diagnosed with pneumonia. Of these 51 cases, only 19 met the inclusion criteria: 15 (79 %) died while 4 (21 %) survived over a 2-year follow-up period. White blood cell (WBC) count (<em>p</em> = 0.05) emerged as a significant predictor of mortality, while pneumonia was notably associated with the development of pressure ulcers (<em>p</em> = 0.08). Further research must be conducted to confirm these findings and uncover interventions designed to lower mortality rates among this population.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 1","pages":"Article 100216"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143127878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age discrimination and depression among older adults in South Korea: Moderating effects of exercise","authors":"Hyun Kang ,&nbsp;Emily S. Ihara","doi":"10.1016/j.ahr.2024.100218","DOIUrl":"10.1016/j.ahr.2024.100218","url":null,"abstract":"<div><h3>Background</h3><div>This study examines the association between perceived age discrimination and depression among South Korean older adults and whether regular exercise can moderate this association. There has been a noticeable rise in ageism in both the media and the society during and following the COVID-19 pandemic. Perceived age discrimination can lead to an internalization of ageist attitudes and stereotypes, resulting in decreased self-efficacy and increased negative emotions, which negatively impact on the health of older adults. While regular exercise has been shown to boost self-esteem and enhance positive self-perceptions of aging, its potential as an intervention against the psychological impact of age discrimination is under-explored.</div></div><div><h3>Methods</h3><div>Using data from 9,920 participants (aged 65+) in the 2020 National Survey of Older Koreans, depression was regressed on age discrimination controlling for age, gender, education, marital status, self-rated health, employment status, and activities of daily living (ADLs). A hierarchical multiple regression analysis was employed to examine the moderating effect of exercise.</div></div><div><h3>Results</h3><div>Higher levels of perceived age discrimination were directly associated with higher levels of depression. Regular exercise significantly moderated this relationship, reducing the negative impact of perceived age discrimination on depressive symptoms.</div></div><div><h3>Conclusions</h3><div>Considering the rise of ageism in South Korea, regular exercise can serve as an important mechanism for combating ageism by effectively managing stress and enhancing self-resilience. Our findings highlight the importance of promoting exercise as a potential strategy to mitigate the detrimental mental health effects of age discrimination, particularly in the post-pandemic era.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 1","pages":"Article 100218"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143127881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in TDP-43 research: Towards biomarkers and therapeutic targets for amyotrophic lateral sclerosis","authors":"Yuhan Wu ,&nbsp;Jie Wang ,&nbsp;Qianhua Zhao","doi":"10.1016/j.ahr.2024.100215","DOIUrl":"10.1016/j.ahr.2024.100215","url":null,"abstract":"<div><div>Amyotrophic lateral sclerosis (ALS) remains a devastating neurodegenerative disease characterized by progressive motor neuron degeneration, leading to paralysis and premature death. Despite advances in understanding its pathology, ALS diagnosis and treatment remain primarily symptomatic, lacking disease-specific biomarkers. TAR DNA-binding protein 43 (TDP-43) has emerged as a central player in ALS pathogenesis, undergoing pathological alterations including hyperphosphorylation, truncation, and cytoplasmic aggregation. This article reviews the physiological and pathological roles of TDP-43, its potential as a biomarker, and its candidacy as a therapeutic target. Challenges in detecting pathological forms of TDP-43 in biofluids hinder diagnostic advancements, yet recent research provides insights into its potential diagnostic and prognostic value. Moreover, ongoing efforts aim to develop targeted therapies, including genetic and proteostasis-based approaches, to mitigate TDP-43 pathology and its downstream effects. The article also discusses the need for novel animal models and antibodies to distinguish between pathological and physiological forms of TDP-43 for reliable biomarker development. Looking ahead, the article advocates for both linear and horizontal developments in TDP-43 research to advance ALS diagnosis, prognosis, and treatment paradigms.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 1","pages":"Article 100215"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142756978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assistance with oral hygiene care among family dementia caregivers in Chinese American Communities in New York City","authors":"Weiyu Mao ,&nbsp;Bei Wu ,&nbsp;Yaolin Pei","doi":"10.1016/j.ahr.2024.100210","DOIUrl":"10.1016/j.ahr.2024.100210","url":null,"abstract":"<div><h3>Background</h3><div>Oral hygiene care is instrumental to maintaining optimal oral health. As dementia progresses, individuals face challenges performing adequate oral hygiene care and become dependent on their caregivers. The role of family caregivers in assisting with oral hygiene care becomes increasingly critical. This study explored the association between caregiving circumstances, care recipient characteristics, and assistance in oral hygiene care among dementia caregivers in Chinese American communities.</div></div><div><h3>Methods</h3><div>Data came from a pilot study on Chinese dementia caregivers in New York City collected between November 2021 and June 2022. Purposive sampling was used to recruit family caregivers to participate in a survey (online or via telephone). Current caregivers (<em>n</em> = 76) were included. Caregiver assistance with oral hygiene care was measured by assistance with toothbrushing (yes or no) and assistance with flossing (yes or no). Descriptive analyses, group comparisons, and logistic regressions were conducted.</div></div><div><h3>Results</h3><div>Female caregivers tended to assist with toothbrushing. Caregivers with an average of 2.4 years in providing care tended to assist with flossing. Care recipients with tooth pain were 5.12 times more likely to receive assistance with toothbrushing. Care recipients with more natural teeth were 1.07 times more likely to receive assistance with toothbrushing. Care recipients with severe dementia were 94 % less likely to receive assistance with flossing.</div></div><div><h3>Conclusions</h3><div>The findings underscore the importance of understanding the factors that influence caregivers’ assistance with oral hygiene care. This study is a crucial first step toward developing effective, caregiver-led interventions to improve the oral hygiene of individuals with dementia.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 1","pages":"Article 100210"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142703415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of using the Step2Bed on bed transfer time, forces, balance and perceived effort in older adults","authors":"Jacqueline Erdkamp ,&nbsp;Julia Alo ,&nbsp;Hee-Jin Jun ,&nbsp;Antoinette Domingo","doi":"10.1016/j.ahr.2024.100217","DOIUrl":"10.1016/j.ahr.2024.100217","url":null,"abstract":"<div><div>The Step2Bed (S2B) is an adjustable step stool with a handrail that can improve safety during entry and exit from higher beds. The purpose of this cross-sectional study was to compare bed entry and exit time, ground reaction forces (GRF), balance and perceived effort of older adults with and without the S2B. Thirty-five participants transferred on and off a plinth while using the S2B with handrail (S2B+H), without handrail (S2B-H), and without the S2B (control). Egress time was significantly less when using the S2B+H compared to control (<em>p</em> &lt; 0.001). S2B trials resulted in smaller ground reaction forces (all <em>p</em> &lt; 0.05). Perceived effort was significantly less when using the S2B (all <em>p</em> &lt; 0.05). These results show that the Step2Bed may increase ease of bed transfers and safety, promoting aging-in-place.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 1","pages":"Article 100217"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143127879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing biological information and mood for video exercise and intervention exercise in older adults a pilot study","authors":"Yutaka Yoshida ,&nbsp;Yoshifumi Moriyama ,&nbsp;Hiroyuki Sakano ,&nbsp;Tomoki Ando ,&nbsp;Emi Yuda","doi":"10.1016/j.ahr.2024.100208","DOIUrl":"10.1016/j.ahr.2024.100208","url":null,"abstract":"<div><h3>Background</h3><div>Light exercise for older adults is effective in preventing dementia and maintaining independent living. However, difference in effectiveness between person supported intervention exercise and exercise by video watching is not clear. In this study, we compare these differences using biological information and subjective evaluation by Profile of Mood States (POMS).</div></div><div><h3>Methods</h3><div>Participants were 10 older adults in the healthy group (aged 69±5 years) and 5 in the musculoskeletal disease group (aged 72±7 years). Each participant performed 30 min of video exercise on the first day and 30 min of intervention exercise the next day. Biological information such as pulse rate, physical activity, skin temperature and conversation time were measured during the exercise using a wearable sensors. Subjective evaluation by POMS was performed before and after exercise. In addition, psychomotor vigilance test was performed and reaction time of fingertips was measured before and after exercise.</div></div><div><h3>Results</h3><div>In both groups, physical activity was significantly decreased with intervention exercise (<em>P</em> &lt; 0.01), and conversation time was significantly increased with intervention exercise (<em>P</em> &lt; 0.01). In the healthy group, skin temperature decreased significantly with both exercise therapies (<em>p</em> &lt; 0.01). Especially, video exercise decrease skin temperature more than intervention exercise. Reaction time of fingertip became significantly faster after intervention exercise in the healthy group (<em>P</em> &lt; 0.05). POMS results showed that intervention exercise resulted in significantly more positive mood.</div></div><div><h3>Conclusions</h3><div>Resistance training using elastic tubes as an intervention exercise is effective in preventing a decrease in skin temperature and improving fingertip reaction time in the healthy older adults. Intervention exercise is effective in improving mood of older adults, moreover it is suggested that intervention and conversation during the exercise may have an effect on improving mood.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"4 4","pages":"Article 100208"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142697243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promoting digital inclusion through public-private partnerships for older adults in Nigeria: A review","authors":"Judith Ifunanya ANI,&nbsp;Kezia Batisai","doi":"10.1016/j.ahr.2024.100211","DOIUrl":"10.1016/j.ahr.2024.100211","url":null,"abstract":"<div><div>In the face of global demographic shifts and rapid digitalization, ensuring digital inclusion for the aging population is imperative. Projected to reach 1.5 billion by 2050, older adults stand at the intersection of societal challenges and digital opportunities. The review emphasizes the multifaceted role of digital inclusion, aligning with the World Health Organization's Global Strategy on Ageing and Health and supporting Sustainable Development Goals 3, 4, and 10. Despite the potential benefits, the digital divide persists in developing countries like Nigeria, accentuated by limited technology access. Urgent research is needed to understand technology acceptance among older adults, highlighting the necessity for public-private partnerships to bridge these gaps. The comprehensive approach advocates for inclusive policies, technological advancements, and collaborative efforts, ensuring older adults are not left behind in the evolving digital landscape.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"4 4","pages":"Article 100211"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142664089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the common genes involved in autism spectrum disorder and Parkinson's disease: A systematic review","authors":"Kanchan Bala ,&nbsp;Khadga Raj Aran","doi":"10.1016/j.ahr.2024.100206","DOIUrl":"10.1016/j.ahr.2024.100206","url":null,"abstract":"<div><div>Autism Spectrum Disorder (ASD) and Parkinson's disease (PD) are distinct neurodevelopmental disorders associated with distinct brain areas. ASD is characterized by delayed social communication skills and restricted repetitive behaviours. Conversely, PD is a progressive neurodegenerative disorder affecting basal ganglia, causing resting tremor, rigidity, postural instability, and bradykinesia. Both diseases share similarities in affected brain areas, including motor control and social behaviour. In both diseases, PARK2, SHANK3, SLC, RIT2, DRD2, and CD157/BST1 genes are involved by regulating synaptic function and dopamine neurons. Mutations in PARK2, an E3 ubiquitin ligase, can lead to dysfunctional mitophagy, causing the accumulation of damaged mitochondria and contributing to neuronal cell death, a hallmark of PD. PARK2 pathway disruptions have also been observed in some individuals with ASD, which are involved in tagging damaged or unwanted proteins for degradation, leading to the accumulation of misfolded or dysfunctional proteins that may contribute to neurodevelopmental abnormalities. PINK1 is crucial for maintaining mitochondrial quality and eliminating dysfunctional ones that produce reactive oxygen species (ROS). Mutations in this gene lead to damaged mitochondria and increased ROS production, contributing to neurodegeneration in dopamine-producing neurons. This review highlighted the various genes involved in pathogeneses of ASD and PD with their future implications.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"4 4","pages":"Article 100206"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142531070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}