Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe最新文献

{"title":"The complex interplay between oxinflammation, mitochondrial dysfunction and lipotoxicity: Focus on their role in the pathogenesis of skeletal muscle insulin resistance and modulation by dietary fatty acids","authors":"Angelina Passaro ,&nbsp;Juana Maria Sanz ,&nbsp;Nenad Naumovski ,&nbsp;Domenico Sergi","doi":"10.1016/j.arres.2024.100100","DOIUrl":"https://doi.org/10.1016/j.arres.2024.100100","url":null,"abstract":"<div><p>Skeletal muscle insulin resistance is pivotal in the pathogenesis of type 2 diabetes mellitus (T2DM). Oxinflammation, referred to as the coexistence of and tight relationship between inflammation and oxidative stress, along with mitochondrial dysfunction and lipotoxicity have all been implicated in the pathogenesis of skeletal muscle insulin resistance. Most importantly, these effectors of insulin resistance are able to fuel one another, thereby generating a complex vicious cycle. This review aims at providing an updated and critical overview on the intimate cross-talk between oxinflammation, mitochondrial dysfunction and lipotoxicity as key molecular mechanisms underpinning insulin resistance. Additionally, the role of dietary fatty acids in modulating the key actors of this vicious cycle and the repercussions on skeletal muscle insulin sensitivity will be discussed in detail.</p></div>","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"11 ","pages":"Article 100100"},"PeriodicalIF":0.0,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667137924000079/pdfft?md5=e90d5091265f4aac902adf1c4677b64d&pid=1-s2.0-S2667137924000079-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140559002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti- and pro-oxidant properties of polyphenols and their role in modulating glutathione synthesis, activity and cellular redox potential: Potential synergies for disease management","authors":"Courage Sedem Dzah ,&nbsp;Haihui Zhang ,&nbsp;Vera Gobe ,&nbsp;David Asante-Donyinah ,&nbsp;Yuqing Duan","doi":"10.1016/j.arres.2024.100099","DOIUrl":"https://doi.org/10.1016/j.arres.2024.100099","url":null,"abstract":"<div><p>Cellular metabolic activities are controlled by pathways catalyzed by enzymes, closely regulated by signal transduction through induction or inhibition processes. Metabolic disorders and cellular dysregulation are often linked to redox-dependent signaling in a complex relationship. Glutathione (GSH) and polyphenols which are known regulators of cellular redox homeostasis have been studied immensely. However, no study has considered their potential interactions and synergies as novel mechanisms to control cellular disorders. GSH does not only act as an antioxidant, but as a ligand that binds to inactivate enzymes and toxins. Also, depending on cellular environment, structure, pH, concentration and availability of transition metals of high charge density, polyphenols may possess either anti-oxidant or pro-oxidant properties. Owing to their remarkable influence on cellular redox potential and metabolic signaling as individual compounds, this study considered the potential interactions and synergies between GSH and polyphenols in disease management. Generally, both GSH and polyphenols reduce oxidative stress in normal cells and may under exacerbating conditions of low GSH/GSSG ratio, induce apoptotic mechanisms in abnormal cells. Investigating the effects of pH, polyphenol and GSH concentrations, availability of transition metals, caloric restriction and polyphenol structure on apoptosis and proliferation in cancer cells in the future may be a basis for the synergistic exploitation of GSH and polyphenols in disease management.</p></div>","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"11 ","pages":"Article 100099"},"PeriodicalIF":0.0,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667137924000067/pdfft?md5=6ad9a6d88ddbb84d976fa5ac5e78713d&pid=1-s2.0-S2667137924000067-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140551205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific antioxidant biomarker depletion in patients with a history of mild traumatic brain injury","authors":"Lilia A. Koza ,&nbsp;Allison N. Grossberg ,&nbsp;McKensey Bishop ,&nbsp;Chad Prusmack ,&nbsp;Daniel A. Linseman","doi":"10.1016/j.arres.2024.100097","DOIUrl":"https://doi.org/10.1016/j.arres.2024.100097","url":null,"abstract":"<div><p>Individuals with a history of mild traumatic brain injury (mTBI) are at an increased risk for neurodegenerative disease, suggesting that intrinsic neuroprotective mechanisms, such as the endogenous antioxidant reservoir, may be depleted long-term after mTBI. Here, we retrospectively analyzed symptoms and blood antioxidants in patients with a history of mTBI who presented to Resilience Code, a sports medicine clinic in Colorado. Significant decreases in alpha-tocopherol, selenium, linoleic acid, taurine, docosahexaenoic acid, and total omega-3 were measured in the total mTBI population versus controls. Male mTBI patients showed depletion of a larger array of antioxidants than females. Patients with a history of mTBI also reported significantly worsened emotional, energy, head, and cognitive symptoms, with males displaying more extensive symptomology. Multiple or chronic mTBI patients had worsened symptoms than single or acute/subchronic mTBI patients, respectively. Finally, male mTBI patients with the largest reductions in polyunsaturated fatty acids (PUFAs) displayed worse symptomology than male mTBI patients with less depletion of this antioxidant reservoir. These results demonstrate that antioxidant depletion persists in patients with a history of mTBI and these deficits are sex-specific and associated with worsened symptomology. Furthermore, supplementation with specific antioxidants, like PUFAs, may diminish symptom severity in patients suffering from chronic effects of mTBI.</p></div>","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"10 ","pages":"Article 100097"},"PeriodicalIF":0.0,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667137924000043/pdfft?md5=834b5820ad4583f3923b3af0fd1a4eee&pid=1-s2.0-S2667137924000043-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139999990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A hypothetical mechanism capable to reflect the features of the mitochondrial permeability transition pore channel","authors":"Alexander G. Dimitrov","doi":"10.1016/j.arres.2024.100096","DOIUrl":"https://doi.org/10.1016/j.arres.2024.100096","url":null,"abstract":"<div><p>Mitochondrial permeability transition pore (mPTP) channel plays a central role in cell death because it mediates the effect of a sudden large opening of the inner mitochondrial membrane. Its associations with adenine nucleotide translocase and with ATP synthase within the general framework of mPTP research were challenged by genetic knock out experiments. This paper proposes the hypothesis that the matrix ATP regulates the mPTP. That hypothesis not only succeeds in classifying and explaining the existing experimental data but it also fits quite well to a peripheral branch of mPTP research proposing that the channel is composed of a combination of polyphosphates and poly-(<em>R</em>)-3-hydroxybutyrates glued by Ca ions. ATP also has a polyphosphate part and thus could be potentially incorporated into such kind of a channel. ATP not only has the potential to decrease the effective channel cross-section when the matrix ATP pool is full, but also, having four negative charges, ATP could be driven across the membrane, together with some accompanying metal ions. Thus, an effective potassium hydrogen exchanger is constructed. Cell death and “permeability transition” happen when the matrix ATP pool is emptied and so the mPTP channel is emptied from the ATP. As a result, the effective channel cross-section would greatly increase; instead of effectively going out, potassium would go in, and the matrix would burst. Hence, the regulation of the matrix ATP level could explain the effect of cyclosporin A – the main experimental modulator of mPTP channel activity, the mechanism of hypoxic/reperfusion injury, and many other.</p></div>","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"10 ","pages":"Article 100096"},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667137924000031/pdfft?md5=b6bcea39067e15dc616ac860ea3a6333&pid=1-s2.0-S2667137924000031-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139731771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of glutamic acid-modified silica nanoparticles in promoting brain health","authors":"Essia Hamdi ,&nbsp;Slah Hidouri ,&nbsp;Ana-Belén Muniz-Gonzalez ,&nbsp;Alberto Marcos Bermejo ,&nbsp;César Venero ,&nbsp;Salem Amara ,&nbsp;Ahmed Landoulsi","doi":"10.1016/j.arres.2024.100095","DOIUrl":"https://doi.org/10.1016/j.arres.2024.100095","url":null,"abstract":"<div><p>SiO₂ nanoparticles functionalized with glutamate were investigated for their ability to alleviate oxidative stress caused by prolonged exposure to hydrogen peroxide (H₂O₂). The study involved ten different groups, each consisting of eight animals, to examine the effects of H₂O₂ <strong>-</strong>induced oxidative stress. The results demonstrated that exposure to H₂O₂ stress oxidative biomarkers were altered accompanied with a loss of spatial learning and memory in rats performing the Morris water maze task. Furthermore, SiO₂ nanoparticles functionalized with L-glutamic acid alleviated the H₂O₂-induced acceleration of necrotic and degenerative cell changes in the hippocampus, subiculum, caudate-putamen, and frontal cortex. Additionally, L-glutamic acid-functionalized SiO₂ nanoparticles reduced the redox imbalance and interfered with acetylcholinesterase (AChE) and monoamine oxidase (MAO) activities induced by H₂O₂.</p></div>","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"10 ","pages":"Article 100095"},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266713792400002X/pdfft?md5=d8351624bade960149df60700963867b&pid=1-s2.0-S266713792400002X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139714995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HOCl sensitivity associates with a reduced p53 transcriptional network and calreticulin expression in 25 human cancer cell lines","authors":"Debora Singer ,&nbsp;Anke Schmidt ,&nbsp;Sander Bekeschus","doi":"10.1016/j.arres.2024.100093","DOIUrl":"10.1016/j.arres.2024.100093","url":null,"abstract":"<div><p>Reactive oxygen species (ROS) play roles in physiological processes and pathological conditions. Higher ROS levels induce oxidative distress and cytotoxic responses, such as chronic inflammatory conditions and cancer. While the cellular responses of various cell types to cytotoxic pro-oxidative conditions have been well studied in the past decades, much less is known about the cellular gene and expression profiles that are <em>a priori</em> associated with subsequent cellular demise to oxidative stress. To this end, we used 25 human cancer cell lines of different origins and established the inhibitory concentration (IC₂₅) of hypochlorous acid (HOCl), an oxidant readily produced by neutrophils frequently present in many inflamed tissues, including cancer. The HOCl sensitivity varied throughout the 25 cell lines investigated, showing a more than 5-fold difference between the most sensitive and resistant types. In parallel, we investigated untreated cells and their basal gene expression using transcriptomic microarray and performed correlation analyses to HOCl IC₂₅ values of all cell lines. Transcriptomic analyses and functional classification of significant correlating genes revealed reduced expression of tumor protein p53 signaling network members, including <em>BAX, CDKN1A</em> (p21), and <em>BTG2,</em> as well as the p53 gene (<em>TP53)</em> itself to associate with cell line sensitivity to HOCl toxicity. Further, baseline surface membrane expression analysis of 33 inflammation- and redox-related molecules identified nitric oxide (NO) synthase 2 and the ER-stress-associated chaperone calreticulin to correlate significantly with HOCl resistance. We identified targets associated with HOCl sensitivity. Nevertheless, further studies are needed to map gene and protein expression patterns associated with oxidative stress-induced cytotoxicity.</p></div>","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"10 ","pages":"Article 100093"},"PeriodicalIF":0.0,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667137924000018/pdfft?md5=1e11f32ecde6e695c2e2ebe4249a2382&pid=1-s2.0-S2667137924000018-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139639677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect OF m-trifluoromethyl- attachment on the glutathione peroxidase mimicry and antioxidant actions of diphenyl diselenide: Essential thiols of electrogenic sodium pump as a mechanistic component","authors":"Ebenezer Morayo Ale ,&nbsp;Steve Osagie Asuelimen ,&nbsp;Victoria Ifeoluwa Ayo ,&nbsp;Mgbede Joy Timothy ,&nbsp;Isaac John Umaru ,&nbsp;Ebenezer Kayode Toluwalase","doi":"10.1016/j.arres.2023.100092","DOIUrl":"10.1016/j.arres.2023.100092","url":null,"abstract":"<div><p><em>m</em>-Ditrifluoromethyl-diphenyl diselenide [DFDD (<em>m-</em>CF₃-C₆H₄Se)₂] is a disubstituted diaryl analog of diphenyl diselenide [DPDS (C₆H₅Se)₂] in which a hydrogen atom on each aromatic ring is replaced by trifluoromethyl group (-CF₃). Herein, we investigated the effect of the -CF₃ group introduction on the GPx mimetic and antioxidant properties of DPDS. Animals were euthanized, brains were removed, and used for lipid peroxidation, cerebral sodium pump activity and thiols assays <em>in vitro</em>. Results showed that DFDD utilizes exogenous thiols [dithiol treitol (DTT), cysteine (Cys) and glutathione (GSH)] to reduce hydroperoxides. Furthermore, DFDD only protected against deoxyribose degradation in the presence of DTT. DFDD also exerted marked (<em>p</em>&lt; 0.05) inhibitory effect on Fe²⁺or H₂O₂ or fenton reaction-induced lipid peroxidation in rat cerebral tissue homogenate. In addition, DFDD simultaneously (<em>p</em>&lt; 0.05) inhibited pump activity and lipid peroxidation in cerebral tissue homogenate assaulted with prooxidants with proportionate depletion of thiol in the reaction system. This assay was repeated in the presence of DTT or Cys-or GSH and results revealed that enzyme's activity was not inhibited indicating that DFDD switched from enzymes's thiols to the oxidation of medium's thiols. It is rational to conclude that the introduction of -CF₃ group to the aromatic rings of DFDD does not abolish its GPx mimetic and antioxidant properties and these still rely on thiols of cerebral electrogenic sodium pump. DFDD could be a suitable candidate for relative pharmacological effect and weak toxicity consequent to its possession of high electron withdrawing group. However, further research is needed in this regard.</p></div>","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"10 ","pages":"Article 100092"},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667137923000322/pdfft?md5=3b9b894fe77384c92b2320c2db993ef4&pid=1-s2.0-S2667137923000322-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139190248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human hair keratin responds to oxidative stress via reactive sulfur and supersulfides","authors":"Takeru Hirai ,&nbsp;Mayumi Ikeda-Imafuku ,&nbsp;Nanami Tasaka ,&nbsp;Victor Tuan Giam Chuang ,&nbsp;Ming Xian ,&nbsp;Tatsuhiro Ishida ,&nbsp;Takaaki Akaike ,&nbsp;Yu Ishima","doi":"10.1016/j.arres.2023.100091","DOIUrl":"https://doi.org/10.1016/j.arres.2023.100091","url":null,"abstract":"<div><p>Keratin is a central component of human hair proteins, which explicitly possesses many cysteine residues (Cys-SH). For a long time, these Cys-SH residues were believed to contribute to human hair strength by forming intra- and inter-molecular disulfide bond crosslinks. However, we detected that many polysulfide bonds (R-SS_(n)H or R-SS_(n)S-R') exist in keratin. Polysulfide is one of the reactive sulfur and supersulfides, similar to cysteine persulfide (Cys-SSH), that regulates oxidative stress and redox signaling. In the present study, we elucidated the distribution of polysulfide in human hair and the reaction of polysulfide to various oxidative stress, such as heat shock and ultraviolet radiation. The decrease of the polysulfides in hair leads to the loss of antioxidant activity. Additionally, we demonstrated the effect of sulfur supplementation on human hair strength and hair cuticle structure. All types of oxidative stresses decreased the polysulfide in human hair, and hair polysulfide positively correlated with human hair strength. Intriguingly, sulfur supplementation improved human hair strength and the structure of hair cuticles. In conclusion, polysulfide in human hair keratin contributes to hair strength and antioxidant activity against oxidative stresses such as ultraviolet radiation and maintains hair homeostasis.</p></div>","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"10 ","pages":"Article 100091"},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667137923000310/pdfft?md5=839b32e3f1e00b11f49964dead5de0d0&pid=1-s2.0-S2667137923000310-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139050439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal nano-titanium dioxide inhalation exposure alters placental cyclooxygenase and oxidant balance in a sexually dimorphic manner","authors":"Julie A. Griffith ,&nbsp;Rachel D. King ,&nbsp;Allison C. Dunn ,&nbsp;Sara E. Lewis ,&nbsp;Brooke A. Maxwell ,&nbsp;Timothy R. Nurkiewicz ,&nbsp;William T. Goldsmith ,&nbsp;Eric E. Kelley ,&nbsp;Elizabeth C. Bowdridge","doi":"10.1016/j.arres.2023.100090","DOIUrl":"https://doi.org/10.1016/j.arres.2023.100090","url":null,"abstract":"<div><p>The placenta plays a critical role in nutrient-waste exchange between the maternal and fetal circulation, and thus impacts fetal growth and development. We have previously shown that nano-titanium dioxide (nano-TiO₂) inhalation exposure during gestation decreased fetal female pup and placenta mass <span>[1]</span>, which persists in the following generation <span>[2]</span>. In utero exposed females, once mated, their offspring's placentas had increased capacity for H₂O₂ production. Generation of oxidants such as hydrogen peroxide (H₂O₂), have been shown to impact cyclooxygenase activity, specifically metabolites such as prostacyclin (PGI₂) or thromboxane (TXA₂). Therefore, we hypothesized that maternal nano-TiO₂ inhalation exposure during gestation results in alterations in placental production of prostacyclin and thromboxane mediated by enhanced H₂O₂ production in a sexually dimorphic manner. Pregnant Sprague-Dawley rats were exposed to nano-TiO₂ aerosols or filtered air (sham-control) from gestational day (GD) 10–19. Dams were euthanized on GD 20, and fetal serum and placental tissue were collected based on fetal sex. Fetal placental zones (junctional zone (JZ) and labyrinth zone (LZ)) were assessed for xanthine oxidoreductase (XOR) activity, H₂O₂, and catalase activity, as well as 6-keto-PGF_1α and TXB₂ levels. Nano-TiO₂ exposed fetal female LZ demonstrated significantly greater XOR activity compared to exposed males. Exposed fetal female LZ also demonstrated significantly diminished catalase activity compared to sham-control females. Exposed fetal female LZ had significantly increased abundance of 6-keto-PGF_1α compared to sham-control females and increased TXB₂ compared to exposed males. In the aggregate these data indicate that maternal nano-TiO₂ inhalation exposure has a greater impact on redox homeostasis and PGI₂/TXA₂ balance in the fetal female LZ. Future studies need to address if treatment with an XO inhibitor during gestation can prevent diminished fetal female growth during maternal nano-TiO₂ inhalation exposure.</p></div>","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"10 ","pages":"Article 100090"},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667137923000309/pdfft?md5=9808f89b3b0e0a39afbf9868d6312269&pid=1-s2.0-S2667137923000309-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138821952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From electrons to cancer : Redox shift as a driving force of tumorigenesis","authors":"Romain Attal ,&nbsp;Ashraf Bakkar ,&nbsp;Frédéric Bouillaud ,&nbsp;Anne Devin ,&nbsp;Marc Henry ,&nbsp;Maxime Pontié ,&nbsp;Miroslav Radman ,&nbsp;Laurent Schwartz","doi":"10.1016/j.arres.2023.100087","DOIUrl":"https://doi.org/10.1016/j.arres.2023.100087","url":null,"abstract":"<div><p>Cancer cells are very diverse but mostly share a common metabolic property: they are strongly glycolytic even though oxygen is available. Herein, the metabolic abnormalities of cancer cells are interpreted as modifications of the electric currents in redox reactions. A lower current in the electron transport chain, an increase of the concentration of reduced cofactors and a partial reversal of the tricarboxylic acid cycle are physical characteristics of several forms of cancer. The existence of electric short-circuits between oxidative branches and reductive branches of the metabolic network argue in favor of an electronic approach of cancer in the nanoscopic scale. These changes of electron flows induce a pseudo-hypoxia and the Warburg effect through succinate production and divert electrons from oxygen to biosynthetic pathways. This new look at cancer may have potential therapeutic applications.</p></div>","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"10 ","pages":"Article 100087"},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667137923000279/pdfft?md5=4c1d2f8af45c7c1621b020937a9b41c9&pid=1-s2.0-S2667137923000279-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138557310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}