Evaluation of serum oxidative stress levels and antioxidant capacity in prediabetes

Buse Balci , Buket Kin Tekce , Gulali Aktas
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Abstract

Prediabetes is a metabolic disorder marked by blood sugar levels that are elevated than usual but not yet high enough to be classified as type 2 diabetes. It is known that raised oxidative stress and insufficient antioxidant status play a role in the pathogenesis of type 1 and type 2 diabetes. In this study, we aimed to measure total oxidative stress and antioxidant status in prediabetic patients and compare them with healthy volunteers. Subjects with prediabetes according to their HbA1c and blood sugar levels in their routine tests were included in the study. The control group consisted of healthy volunteers who visited our clinics for routine health screening and had no health problems. TAS and TOS levels of the groups were compared. Mean TAS and median TOS values ​​were significantly different among study and control groups (p < 0.001 for both). Blood TOS level was a reliable risk factor of prediabetes, taking into account TAS, weight, triglycerides, and GFR. Higher oxidative stress and lower antioxidant levels were found in prediabetic patients compared to healthy ones. Diabetes development and related complications can be prevented by interventions for these markers in serum.

评估糖尿病前期的血清氧化应激水平和抗氧化能力
糖尿病前期是一种代谢紊乱,其特征是血糖水平比平时高,但还没有高到足以被归类为 2 型糖尿病的程度。众所周知,氧化应激升高和抗氧化剂不足在 1 型和 2 型糖尿病的发病机制中起着重要作用。在这项研究中,我们旨在测量糖尿病前期患者的总氧化应激和抗氧化状态,并将其与健康志愿者进行比较。研究对象包括根据 HbA1c 和血糖水平进行常规检测的糖尿病前期患者。对照组由到本诊所进行常规健康检查且无健康问题的健康志愿者组成。两组的 TAS 和 TOS 水平进行了比较。研究组和对照组的 TAS 平均值和 TOS 中位值有显著差异(P 均为 0.001)。考虑到 TAS、体重、甘油三酯和 GFR,血液 TOS 水平是糖尿病前期的可靠风险因素。与健康人相比,糖尿病前期患者的氧化应激水平更高,抗氧化剂水平更低。通过干预血清中的这些标记物,可以预防糖尿病的发展和相关并发症。
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来源期刊
CiteScore
2.60
自引率
0.00%
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审稿时长
46 days
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