Advances in nutrition (Bethesda, Md.)最新文献

{"title":"A Systematic Review of Food-derived DNA Methyltransferase Modulators: Mechanistic Insights and Perspectives for Healthy Aging.","authors":"Manuela Campisi, Luana Cannella, Francesco Visioli, Sofia Pavanello","doi":"10.1016/j.advnut.2025.100521","DOIUrl":"https://doi.org/10.1016/j.advnut.2025.100521","url":null,"abstract":"<p><p>DNA methylation represents a crucial epigenetic mechanism orchestrating gene expression, cellular homeostasis, and the aging trajectory. Dysregulation of DNA methyltransferases (DNMTs)-the enzymes catalyzing this process-has been implicated in a wide spectrum of chronic conditions, including cancer, cardiovascular and metabolic disorders, and neurodegenerative diseases. Emerging evidence suggests that food-derived bioactive compounds can act as DNMT inhibitors, reshaping epigenetic landscapes. This systematic review, registered in PROSPERO (CRD42022320316), critically evaluated in vitro, in vivo animal, and ex vivo studies investigating the effects of dietary bioactives on DNMT expression and activity. A thorough search of PubMed up to May 23, 2025, yielded 103 studies, of which 76 met the inclusion criteria. Eligible publications were original, peer-reviewed, and provided evidence from in vitro, in vivo animal, or ex vivo models. Frequent candidates included epigallocatechin-3-gallate, curcumin, genistein, resveratrol, sulforaphane, and folate. Notably, nearly 90% of studies reported DNMT inhibition-often dose- and time-dependent. Approximately 21% defined minimal effective concentrations, predominantly for isolated compounds. Several studies described synergistic interactions between bioactives, and emerging data highlighted the gut microbiota's mediating role in epigenetic modulation. Despite promising outcomes, the predominance of preclinical evidence and variability in experimental protocols and dosing limit immediate translational impact. Nonetheless, current findings underscore the promise of dietary DNMT modulators as foundational elements for precision nutrition strategies aimed at promoting healthy aging and mitigating age-associated disease risk. The potential application of DNA methylation age (DNAmAge) as a biomarker of biological aging has been increasingly supported by recent literature, reinforcing its relevance in future nutritional epigenetics research. Further well-designed clinical trials are warranted to assess long-term efficacy, safety, and bioavailability of these compounds, and to validate their use in personalized epigenetic interventions, using biological aging markers. This review was funded by the European Union-Next Generation EU, PNRR Project Age-It (DM 1557 11.10.2022), and the University of Padua SID Grant (2024DCTV1SIDPROGETTI-00194).</p>","PeriodicalId":72101,"journal":{"name":"Advances in nutrition (Bethesda, Md.)","volume":" ","pages":"100521"},"PeriodicalIF":9.2,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional Challenges of Incretin-Based Obesity Management Medications: Implications for Clinical Practice A narrative review paper.","authors":"Tair Ben-Porat, Shiri Sherf-Dagan, Marilou Côté, Cherie Josephine Miner, Assaf Buch","doi":"10.1016/j.advnut.2025.100522","DOIUrl":"https://doi.org/10.1016/j.advnut.2025.100522","url":null,"abstract":"<p><p>Several novel incretin-based obesity management medications (OMMs) have been recently approved for chronic weight management in adults with obesity or overweight. These agents have demonstrated substantial weight reduction effects, alongside glucoregulatory and cardioprotective benefits. However, the use of incretin-based OMMs presents nutritional challenges that remain insufficiently addressed. These include side effects such as gastrointestinal (GI) disturbances and loss of lean body mass (LBM), which may compromise nutritional status, reduce energy expenditure, and heighten the risk of rebound weight gain, sarcopenia, and frailty. Moreover, while these medications effectively suppress energy intake and reduce food quantity, they may also have unintended effects on diet quality, potentially influencing macronutrient distribution, ultra processed food consumption, risk of vitamin and mineral deficiencies, and disordered eating behaviors, which could undermine long-term weight maintenance and the cardiometabolic benefits achieved through these pharmacotherapy agents. Emerging evidence suggests that specific dietary and behavioral strategies, such as higher protein intake, resistance training, nutrient-dense eating patterns, and fostering adaptive eating behaviors, may help mitigate nutritional challenges and physiological deterioration during significant weight reduction, while also supporting cardiometabolic health maintenance. However, the application of these strategies as adjunct treatments alongside the new OMMs remains unclear. This narrative review summarizes the current literature on these issues and proposes dietary interventions and behavioral modification strategies aimed at mitigating the adverse effects that can be associated with incretin-based OMMs. These considerations are increasingly important given the expanding use of these medications, the degree of weight reduction they induce, and the implications for specific at-risk groups, including aging populations prone to muscle and functional decline, individuals with pre-existing conditions of nutritional deficiencies, chronic diseases, and disordered eating patterns.</p>","PeriodicalId":72101,"journal":{"name":"Advances in nutrition (Bethesda, Md.)","volume":" ","pages":"100522"},"PeriodicalIF":9.2,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut Microbiota and Nutrition in Nursing Homes: Challenges and Translational Approaches for Healthy Aging.","authors":"Cristina Jiménez-Arroyo, Natalia Molinero, M Victoria Moreno-Arribas","doi":"10.1016/j.advnut.2025.100520","DOIUrl":"10.1016/j.advnut.2025.100520","url":null,"abstract":"<p><p>The growing aging population is leading to an increase in demand for long-term care. This is particularly true in nursing homes, where residents are exposed to various challenges such as immunosenescence, frailty, multimorbidity, and dietary and environmental constraints. These interrelated factors contribute to gut microbiota alterations, underscoring the need for tailored strategies to preserve health and resilience in a long-term care setting. Despite its recognized relevance in healthy aging, the gut microbiome of institutionalized older adults remains markedly understudied. This review provides a comprehensive report of the current evidence on the interplay between diet, gut microbiota, and aging among nursing-home residents. The available literature suggests that both aging and institutional living contribute to a less favorable microbiome profile, and several contributing factors, many of them dietary, have been identified. Altered gastrointestinal physiology, malnutrition, and other common conditions in residential care, such as functional or cognitive impairments, frequently lead to changes in food intake that affect the gut ecosystem. Decline in immune system, increased infection risk, sarcopenia, cognitive deterioration, and high medication burden have also been linked to microbiota disruptions in this population. Importantly, adjusting several modifiable features of institutional care, particularly those related to diet and lifestyle, may help counteract these effects by supporting gut health. We further examine how appropriate nutritional strategies can positively influence gut microbiota composition and function, offering a pathway to promote resilience and functionality even in the presence of geriatric syndromes. In addition to identifying these challenges, this review outlines feasible, microbiota-informed strategies to improve quality of life and health outcomes. These include individualized dietary adaptations, targeted supplementation, physical activity interventions, and the integration of digital and artificial intelligence tools to support personalized nutrition. Finally, we highlight the need for standardized protocols and implementation science frameworks to enhance clinical translation, thereby advancing an integrative and as yet underrepresented perspective on microbiota-based strategies to promote healthier aging trajectories in institutionalized older adults.</p>","PeriodicalId":72101,"journal":{"name":"Advances in nutrition (Bethesda, Md.)","volume":" ","pages":"100520"},"PeriodicalIF":9.2,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Folate.","authors":"Zoe Lofft, Timothy J Green, Angela M Devlin","doi":"10.1016/j.advnut.2025.100519","DOIUrl":"10.1016/j.advnut.2025.100519","url":null,"abstract":"","PeriodicalId":72101,"journal":{"name":"Advances in nutrition (Bethesda, Md.)","volume":" ","pages":"100519"},"PeriodicalIF":9.2,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Universal Subconstructs of a Healthy Diet for Children and Adolescents: A Critical Review.","authors":"Teresa R Schwendler, Edward A Frongillo, Hope C Craig, Giles T Hanley-Cook, Isabela Fleury Sattamini, Chika Hayashi, Vrinda Mehra, Alissa M Pries, Kuntal Saha, Jennifer C Coates","doi":"10.1016/j.advnut.2025.100511","DOIUrl":"10.1016/j.advnut.2025.100511","url":null,"abstract":"<p><p>To monitor diets among children and adolescents, a thorough understanding of the underlying subconstructs of a healthy diet is needed to inform what should be measured. The aim of this study was to identify universal subconstructs of a healthy diet for children and adolescents aged 2-19 y, understand alignment with subconstructs for adults, and inform recommendations for metrics that aim to monitor the healthiness of diets among children and adolescents at global and national levels. A critical narrative review was carried out in 3 phases. Phase 1: A systematic review of literature published between 2014 and 2024 was conducted. A subset of articles (n = 100) was purposefully sampled based on predefined characteristics. Then, content analysis was performed to identify subconstructs of healthy diets. Phase 2: The identified dietary subconstructs were compared with the 6 subconstructs for adults recognized by the Healthy Diets Monitoring Initiative (HDMI). Phase 3: The identified subconstructs were compared with existing healthy diet metrics concurrently identified by HDMI as suitable for global monitoring of child and adolescent diets. Eight subconstructs specific to children and adolescents were identified: nutrient, energy, and food group requirements; foods and nutrients to limit or avoid; food group diversity and variety; macronutrient and energy balance; nutrient-rich foods or food groups; food safety; eating frequency; and eating regularity. Compared with the 6 subconstructs of adult healthy diets identified by HDMI, 2 subconstructs differed in their operationalization and 2 child- and adolescent-specific subconstructs were considered to be not conceptually distinct. Diet metrics identified as suitable for global monitoring of child and adolescent diets reflect nutrient, energy, and food group requirements; foods and nutrients to limit or avoid; and food group diversity and variety but no other diet subconstructs. The findings inform the development and validation of healthy diet metrics for children and adolescents.</p>","PeriodicalId":72101,"journal":{"name":"Advances in nutrition (Bethesda, Md.)","volume":" ","pages":"100511"},"PeriodicalIF":9.2,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Methodology: the Fixed-Quality Variable-Type Dietary Intervention.","authors":"Andrew A Bremer","doi":"10.1016/j.advnut.2025.100508","DOIUrl":"10.1016/j.advnut.2025.100508","url":null,"abstract":"","PeriodicalId":72101,"journal":{"name":"Advances in nutrition (Bethesda, Md.)","volume":" ","pages":"100508"},"PeriodicalIF":9.2,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutrition Research and Programming in Multicultural Populations: The Fixed-Quality Variable-Type Dietary Intervention.","authors":"David L Katz, Christopher D Gardner","doi":"10.1016/j.advnut.2025.100505","DOIUrl":"10.1016/j.advnut.2025.100505","url":null,"abstract":"<p><p>The sine qua non of intervention studies in general, and randomized controlled trials in particular, is to define and isolate an exposure of interest that defines the intervention and distinguishes between groups. The isolation of a presumptive cause is a prerequisite to the confident attribution of given effects. In the context of dietary intervention studies, this has historically translated into a unitary intervention diet type, no matter the diversity of preferences, tastes, upbringings, ethnicities, and cultures represented in a given study cohort. To the extent such diversities have been constrained to achieve this aim, generalizability (external validity) has been diminished. To the extent such diversities have been ignored, inattention to them has likely shifted results toward the null and compromised adherence over time. These same liabilities pertain to food service projects and public health nutrition, notably the food-as-medicine movement. We propose a remedy to these issues and an update to the formula for dietary intervention research (and service) that accommodates a multicultural society: the fixed-quality, variable-type (FQVT) nutrition intervention. This method standardizes the objective measure of diet quality and incorporates fixed tolerances for nutrients of particular interest, while allowing for a range of diet types responsive to the variable preferences of study participants/population members. We describe the application of tools to facilitate this methodological innovation, enumerate the expected advantages, and characterize means of empirical testing. We submit the FQVT method as a promising, testable advance in the evolution of clinical nutrition research and food-is/as-medicine programming.</p>","PeriodicalId":72101,"journal":{"name":"Advances in nutrition (Bethesda, Md.)","volume":" ","pages":"100505"},"PeriodicalIF":9.2,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Mild-to-Moderate Iodine Deficiency With Thyroid Function-A Systematic Review and Meta-analysis.","authors":"Tonje Eiane Aarsland, Inger Aakre, Tonje Holte Stea, Sigrun Henjum, Maria Wik Markhus, Tor A Strand, Lisbeth Dahl, Tim Im Korevaar, Kjersti S Bakken, Synnøve Næss Sleire","doi":"10.1016/j.advnut.2025.100471","DOIUrl":"10.1016/j.advnut.2025.100471","url":null,"abstract":"<p><p>The only known function of iodine in the human body is as a component of thyroid hormones. Thus, all consequences of iodine deficiency should be mediated through altered thyroid hormone production. Although it is well established that severe iodine deficiency affects thyroid hormone production, the association between mild-to-moderate iodine deficiency and thyroid function remains unclear. This review aimed to review and summarize observational studies that examine the association between mild-to-moderate iodine deficiency and thyroid hormone function in the general population, including infants, children, adolescents, adults, pregnant and lactating women. Systematic searches of the literature were performed in November 2022 and repeated in February 2024 using the Medline Ovid, Embase Ovid, and Cochrane Central databases. Mild-to-moderate iodine deficiency was defined as a median urinary iodine concentration (UIC) of 20-100 μg/L in children, adolescents, and general adults, and 50-150 μg/L in pregnant women. Thyroid function outcomes included thyroid-stimulating hormone (TSH), free thyroxine (fT3), and free triiodothyronine (fT4) and clinical thyroid dysfunction entities. A total of 72 studies were included: 59 cross-sectional, 12 repeated cross-sectional (longitudinal), and 1 cohort study. Populations studied included infants, children, and adolescents (n = 7); women of reproductive age, including lactating women (n = 5); general adults (n = 20); and pregnant women (n = 43). For all population groups, most studies found no clear association between iodine status and thyroid function. Meta-analyses for 8 studies in pregnant women showed no difference in TSH, fT4, or fT3 for those with mild-to-moderate iodine deficiency compared with adequate status [mean difference (95% CI): TSH, 0.03 (-0.05, 0.12) mIU/L; fT4, -0.20 (-0.94, 0.53) pmol/L; fT3, 0.05 (-0.14, 0.03) pmol/L]. In conclusion, no clear association between mild-to-moderate iodine deficiency and thyroid function in the different population groups was found. This trial was registered at www.crd.york.ac.uk/PROSPERO as CRD42022360447.</p>","PeriodicalId":72101,"journal":{"name":"Advances in nutrition (Bethesda, Md.)","volume":" ","pages":"100471"},"PeriodicalIF":9.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reference Values for Minerals in Human Milk: the Mothers, Infants and Lactation Quality (MILQ) Study.","authors":"Lindsay H Allen, M Munirul Islam, Gilberto Kac, Kim F Michaelsen, Sophie E Moore, Maria Andersson, Janet M Peerson, Andrew M Doel, Daphna K Dror, Setareh Shahab-Ferdows, Daniela de Barros Mucci, Gabriela Torres Silva, Daniela Hampel","doi":"10.1016/j.advnut.2025.100431","DOIUrl":"https://doi.org/10.1016/j.advnut.2025.100431","url":null,"abstract":"<p><p>This fifth article in the series presenting reference values for nutrients in human milk describes minerals. The Mothers, Infants and Lactation Quality (MILQ) and Early-MILQ studies collected human milk samples throughout the first 8.5 mo of lactation in 1242 well-nourished women in Bangladesh, Brazil, Denmark, and The Gambia. All minerals were measured by inductively coupled plasma-mass spectrometry. Although pooled MILQ medians from 1 to 6 mo are within ∼10% of the concentration used by the Institute of Medicine (IOM) for magnesium, potassium, calcium, and copper, they are ∼50% of the IOM value for zinc and selenium, and ∼75% of the IOM value for sodium and iron. For zinc, sodium, and iron, the discrepancy can be explained by the IOM's use of values from early lactation (<3 mo) when the milk nutrient concentrations are higher; in contrast, for potassium the IOM benchmark concentration is consistent with later lactation (6 mo) in MILQ. Pooled median MILQ phosphorus from 1 to 6 mo is 120% of the concentration selected by the IOM. Milk iodine concentrations in MILQ varied among sites, reflecting the differing national policies for salt iodization. Total daily median mineral intakes from 1 to 6 mo were 49%-55% of IOM adequate intakes (AIs) for zinc and selenium, 74%-90% of AIs for sodium, iron, and magnesium, and 110%-125% of AIs for copper, potassium, calcium, and phosphorus. For zinc, sodium, iron, and potassium, differences can be explained by the reference time frame during lactation. The MILQ study mineral concentrations are provided as percentile curves to enable comparison and interpretation. Importantly, the MILQ data show marked changes in milk mineral concentrations during the first 6 mo of lactation, an observation often missed because of the absence of data representing a spectrum of time postpartum in previously published data.</p>","PeriodicalId":72101,"journal":{"name":"Advances in nutrition (Bethesda, Md.)","volume":" ","pages":"100431"},"PeriodicalIF":9.2,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reference Values for Fat-Soluble Vitamins in Human Milk: The Mothers, Infants and Lactation Quality (MILQ) Study.","authors":"Gilberto Kac, Kerry S Jones, Sarah R Meadows, Daniela Hampel, M Munirul Islam, Christian Mølgaard, Sophie E Moore, Daphna K Dror, Setareh Shahab-Ferdows, Daniela de Barros Mucci, Amanda C Figueiredo, Janet M Peerson, Lindsay H Allen","doi":"10.1016/j.advnut.2025.100484","DOIUrl":"https://doi.org/10.1016/j.advnut.2025.100484","url":null,"abstract":"<p><p>This fourth article in the series presenting reference values for nutrients in human milk describes the values for the fat-soluble vitamins A, E, and D. The Mothers, Infants and Lactation Quality (MILQ) and Early-MILQ studies collected human milk samples at multiple times during the first 8.5 mo of lactation, from 1242 well-nourished women in Bangladesh, Brazil, Denmark, and The Gambia. Vitamins A and E were measured using high-performance liquid chromatography, whereas vitamin D was measured by liquid chromatography-tandem mass spectrometry. Milk fat-soluble vitamin concentrations from the MILQ study were compared with those used by the Institute of Medicine (IOM) for setting recommendations for nutrient requirements of infants and with other selected data sets. MILQ median concentration was on par with the value used by the IOM for retinol activity equivalents except in early lactation, when they were higher. For α-tocopherol, MILQ median concentration was 76% of the IOM value. The estimate of 0.89 mg/L γ-tocopherol is novel, given that the IOM does not define a concentration in human milk. Although it is known that human milk does not meet infant requirements for vitamin D, results of the MILQ study suggest that actual median concentrations are 60%-80% of those estimated by the IOM. Total daily median intakes from 1 to 6 mo were 97%, 75%, and 6% of IOM adequate intakes for vitamin A, α-tocopherol, and vitamin D, respectively. The MILQ fat-soluble vitamin estimated percentile curves are provided to enable comparison and interpretation of data from other studies.</p>","PeriodicalId":72101,"journal":{"name":"Advances in nutrition (Bethesda, Md.)","volume":" ","pages":"100484"},"PeriodicalIF":9.2,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}