Advances in nutrition (Bethesda, Md.)最新文献

{"title":"Gastrointestinal Symptoms during Cancer Therapy: The Clinician's Role.","authors":"Robert Dunn","doi":"10.1016/j.advnut.2025.100472","DOIUrl":"https://doi.org/10.1016/j.advnut.2025.100472","url":null,"abstract":"","PeriodicalId":72101,"journal":{"name":"Advances in nutrition (Bethesda, Md.)","volume":" ","pages":"100472"},"PeriodicalIF":0.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspective: Treatment of undernutrition in pregnancy requires adequate food and inflammation control.","authors":"D Taylor Hendrixson, Ashleen Lee, Eliza Kleban, Kevin B Stephenson, Aminata S Koroma, Mark J Manary","doi":"10.1016/j.advnut.2025.100479","DOIUrl":"https://doi.org/10.1016/j.advnut.2025.100479","url":null,"abstract":"<p><p>Undernutrition in pregnancy remains a substantial problem worldwide, disproportionately affecting women living in low- and middle-income countries where food insecurity and limited access to high-quality nutrition exacerbate maternal and fetal health risks. Undernutrition during this critical time in the lifecycle can have adverse effects on both the pregnant woman and on her offspring. Despite the widespread recognition of this issue, current international guidelines provide insufficient direction on optimal nutritional management strategies. Most clinical trial evidence have yielded inconclusive results. This perspective synthesizes evidence on current management strategies in addressing macronutrient and micronutrient deficiencies in pregnancy. Additionally, we examine the critical role of inflammation in moderating the effectiveness of nutritional interventions and discuss emerging strategies that integrate infection control with nutrition to optimize maternal and neonatal outcomes. Given the limitations of existing management strategies, there is an urgent need for more comprehensive, evidence-based guidelines to improve pregnancy outcomes for undernourished women worldwide. STATEMENT OF SIGNIFICANCE: The perspective provides evidence that undernutrition in pregnancy remains an important problem globally and current management strategies remain insufficient. Based on these findings, the perspective urges further research and international support to identify optimal strategies to manage this serious condition.</p>","PeriodicalId":72101,"journal":{"name":"Advances in nutrition (Bethesda, Md.)","volume":" ","pages":"100479"},"PeriodicalIF":0.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relevance of mathematical optimization as a tool for diet modelling in the development of food-based dietary recommendations in Sub-Saharan Africa: A scoping review.","authors":"Sakiko Shiratori, Mg Dilini Abeysekara","doi":"10.1016/j.advnut.2025.100480","DOIUrl":"https://doi.org/10.1016/j.advnut.2025.100480","url":null,"abstract":"<p><p>This study aims to understand the role of mathematical programming in the development of food-based dietary recommendations (FBRs) in sub-Saharan Africa (SSA), identify current limitations, and highlight opportunities for advancing evidence-based dietary interventions. Following the PRISMA Extension for Scoping Reviews (PRISMA-ScR), a systematic search from January 2000 to May 2024 identified 97 relevant studies. Among these, 30 studies spanning 12 SSA countries (out of 48 countries and territories in SSA) met the inclusion criteria. The reviewed studies leveraged linear programming (LP) or extensions of LP (i.e. linear goal programming) to formulate FBRs by optimizing current dietary patterns to meet nutritional needs and gaps (n=24), developing nutritionally and regionally optimized and cost-minimized food baskets (n=4), and describing the use of LP as a method for designing population-specific food-based dietary guidelines (n=2). The primary goal of the reviewed studies is to develop nutritionally adequate and economically affordable food patterns, rather than to address multiple chronic nutrition-related conditions simultaneously, reflecting the distinct priorities of diet modeling in low-resource settings compared to resource-rich contexts. The formulated FBRs and optimized diets are often defined for specific demographic groups, with a limited geographic scope reflecting regional priorities. Diets can be optimized both nutritionally and economically by prioritizing locally available food groups and items; however, in some cases, additional supplementation and or inclusion of rarely consumed nutrient dense foods may be necessary. Mathematical optimization, particularly LP, is a valuable tool for addressing dietary challenges and developing evidence-based, context-specific FBRs. Its use is facilitated by the availability of user-friendly software. However, its successful application requires high-quality input data, consideration of behavioral and practical aspects, and interdisciplinary collaboration. High-quality input data and incorporating sociocultural contexts are critical for leveraging mathematical optimization to inform inclusive and effective dietary recommendations in SSA.</p>","PeriodicalId":72101,"journal":{"name":"Advances in nutrition (Bethesda, Md.)","volume":" ","pages":"100480"},"PeriodicalIF":0.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of mild-to-moderate iodine deficiency with thyroid function - a systematic review and meta-analysis.","authors":"Tonje Eiane Aarsland, Inger Aakre, Tonje Holte Stea, Sigrun Henjum, Maria Wik Markhus, Tor A Strand, Lisbeth Dahl, Tim I M Korevaar, Kjersti S Bakken, Synnøve Næss Sleire","doi":"10.1016/j.advnut.2025.100471","DOIUrl":"https://doi.org/10.1016/j.advnut.2025.100471","url":null,"abstract":"<p><strong>Background: </strong>The only known function of iodine in the human body is as a component of thyroid hormones. Thus, all consequences of iodine deficiency should be mediated through altered thyroid hormone production. While it is well established that severe iodine deficiency affects thyroid hormone production, the association between mild-to-moderate iodine deficiency and thyroid function remains unclear.</p><p><strong>Objective: </strong>To review and summarize observational studies that examine the association between mild-to-moderate iodine deficiency and thyroid hormone function in the general population, including infants, children, adolescents, adults, pregnant and lactating women.</p><p><strong>Methods: </strong>Systematic searches of the literature were performed in November 2022 and repeated in February 2024 utilizing the Medline Ovid, Embase Ovid, and Cochrane Central databases. Mild-to-moderate iodine deficiency was defined as a median urinary iodine concentration (UIC) of 20-100 μg/L in children, adolescents, and general adults, and 50-150 μg/L in pregnant women. Thyroid function outcomes included TSH, (f)T3, and (f)T4, and clinical thyroid dysfunction entities.</p><p><strong>Results: </strong>A total of 72 studies were included: 59 cross-sectional, 12 repeated cross-sectional (longitudinal), and one cohort study. Populations studied included infants, children, and adolescents (n=7); women of reproductive age, including lactating women (n=5); general adults (n=20); and pregnant women (n=43). Most studies reported no clear association between iodine status and thyroid function across all groups. For all population groups, most studies found no clear association between iodine status and thyroid function. Meta-analyses for eight studies in pregnant women showed no difference in TSH, fT4, or fT3 for those with mild-to-moderate iodine deficiency vs. adequate status [mean difference (95% CI): TSH, 0.03 (-0.05, 0.12) mIU/L; fT4, -0.20 (-0.94, 0.53) pmol/L; fT3, 0.05 (-0.14, 0.03) pmol/L].</p><p><strong>Conclusion: </strong>No clear association between mild-to-moderate iodine deficiency with thyroid function in the different population groups was found.</p><p><strong>Registry number for systematic review: </strong>Registered at www.crd.york.ac.uk/PROSPERO as CRD42022360447.</p><p><strong>Statement of significance: </strong>This is the first systematic review to provide a comprehensive overview of observational studies investigating the association between mild-to-moderate iodine deficiency and thyroid function in the general population, including infants, children, adolescents, adults, pregnant and lactating women.</p>","PeriodicalId":72101,"journal":{"name":"Advances in nutrition (Bethesda, Md.)","volume":" ","pages":"100471"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspective: Growth Monitoring and Promotion as an Opportunity to Improve Early Childhood Development.","authors":"Leila M Larson, Edward A Frongillo, Fahmida Akter, Shelbie Wooten, Rebecca L Brander, Marie T Ruel, Jef L Leroy","doi":"10.1016/j.advnut.2025.100470","DOIUrl":"10.1016/j.advnut.2025.100470","url":null,"abstract":"<p><p>Growth monitoring and promotion (GMP) visits provide a frequent contact point with caregivers, which can be an opportunity for the promotion of early child development (ECD). Using a combination of quantitative analyses of longitudinal and cross-sectional data and a review of the literature, we investigated whether the GMP platform could improve ECD by identifying children at risk of poor development and delivering responsive parenting education to caregivers of young children. Cross-sectional and lagged regression analyses and area under the receiver operating characteristic curves indicated that growth indices were not accurate predictors of concurrent and later child development. Rather, validated tools, such as the Ages and Stages Questionnaire or the Survey of Well-being of Young Children, could be utilized during GMP visits to screen individual children for suboptimal development. Through a review of published literature on ECD interventions, we identified 10 light-touch ECD interventions that could feasibly be implemented during GMP visits, but only half have been evaluated for their effectiveness. Our findings demonstrate that, although growth indices cannot accurately identify children at risk of suboptimal development, the GMP platform could offer an opportunity to screen children for suboptimal development and to deliver ECD interventions. Further evidence on the implementation and effectiveness of light-touch parenting programs, however, is required.</p>","PeriodicalId":72101,"journal":{"name":"Advances in nutrition (Bethesda, Md.)","volume":" ","pages":"100470"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspective: Infant Feeding Policies among Women Living with HIV in Latin America and the Caribbean: Should They Be Updated?","authors":"Rafael Pérez-Escamilla, Sonia Hernández Cordero, Tarini Gupta","doi":"10.1016/j.advnut.2025.100469","DOIUrl":"10.1016/j.advnut.2025.100469","url":null,"abstract":"<p><p>Among women living with HIV (WLHIV), adherence to highly active antiretroviral treatment (HAART) combined with undetectable maternal viral loads and exclusive breastfeeding during the first 6 mo of life dramatically reduces the risk of mother-to-child transmission of HIV. This knowledge has led to updated World Health Organization infant feeding guidelines for WLHIV, calling for governments to support safe breastfeeding practices among WLHIV who want to breastfeed their infants by providing universal access to HAART, viral load tracking, and high-quality breastfeeding counseling and other needed support across settings. These guidelines eventually led several high-income countries, including the United States and Canada, to revise their infant feeding guidelines that previously contraindicated breastfeeding among WLHIV to incorporate safe, evidence-based breastfeeding recommendations for WLHIV. However, in the rest of the Americas, breastfeeding contraindication remains in place. We strongly recommend that all countries in Latin America and the Caribbean consider updating their breastfeeding guidance for WLHIV to allow for safe breastfeeding. Implementing the new evidence-based recommendations poses major implementation challenges as there is no room for error. Systems-driven implementation science research will be needed to understand how best to codesign, implement, scale up, and sustain intersectoral and equitable person and family-centered policies and programs to empower WLHIV to breastfeed safely if they have the choice to do so.</p>","PeriodicalId":72101,"journal":{"name":"Advances in nutrition (Bethesda, Md.)","volume":" ","pages":"100469"},"PeriodicalIF":0.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Multiomics Framework to Unlock the Relationships between Wine, Food, and Gut Health.","authors":"Antoine Abrieux, Mariana Barboza, Kristin Hirahatake, Hunter Jacobs, Harold H Schmitz, Sean H Adams, Justin B Siegel","doi":"10.1016/j.advnut.2025.100468","DOIUrl":"10.1016/j.advnut.2025.100468","url":null,"abstract":"<p><p>Wine has long been studied for its cardioprotective effects, exemplified by the French paradox-the observation of relatively lower cardiovascular disease (CVD) rates in the French population despite high dietary cholesterol and saturated fat intake, historically attributed to resveratrol and other bioactive factors from wine consumption. Recent findings suggest that the moderate consumption of wine could impact health well beyond CVD risk, including effects on intestinal physiology and gut microbial diversity and function. For example, wine contains a rich array of polyphenols, organic acids, and oligosaccharides, which may interact with the gut microbiota to alter microbial communities and to promote metabolism of wine-derived compounds into a diverse range of xenometabolites (microbe-produced metabolites) with local and systemic effects on the host. This interplay underscores the potential mechanisms by which moderate wine consumption impacts gut and systemic health. Furthermore, because wine is often consumed with meals, there is a critical need to understand how specific foods intersect with wine's chemical complexity to influence physiology in the gut and body-wide. This review explores how advancements in multiomics technologies can be leveraged to characterize wine's \"dark matter\" and to consider interactions of wine components with complex food matrices to influence gut health. This framework holds potential to enhance our understanding of how moderate consumption of wine influences health and to inform the development of functional food innovations derived from wine's molecular components.</p>","PeriodicalId":72101,"journal":{"name":"Advances in nutrition (Bethesda, Md.)","volume":" ","pages":"100468"},"PeriodicalIF":0.0,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal Intake of Animal-Source Foods: A Scoping Review to Inform a New WHO Guideline.","authors":"Magali Rios-Leyvraz, Jason Montez","doi":"10.1016/j.advnut.2025.100467","DOIUrl":"10.1016/j.advnut.2025.100467","url":null,"abstract":"<p><p>Currently, the amount and types of animal-source foods that might be part of a healthy diet remain unclear. This scoping review was commissioned by the WHO for the development of a new guideline on optimal intake of animal-source foods and aimed to collect and describe the evidence available on animal-source foods and health outcomes. A systematic search of Embase, Medline, and PubMed, complemented with a search of recent nutrition guidelines, was conducted to identify systematic, scoping, and umbrella reviews published between 2019 and 2024. Reviews of prospective observational and interventional studies with participants ≥2 y from the general population, including pregnant women, assessing the effects of animal-source foods (red meat, poultry, fish, eggs, dairy) and as comparators selected protein-rich plant-source foods on any health outcome were included. Using a mining approach, prospective observational and interventional primary studies identified in the reviews were extracted. Research availability and gaps were depicted using evidence maps. From the 7458 records identified, a total of 652 reviews were included, encompassing 1626 eligible publications from 488 unique cohorts in 65 countries and 480 eligible publications from 387 unique trials in 37 countries. Single health outcomes were grouped together into 29 groups. The most often researched outcome groups were cancer, cardiovascular diseases, diabetes, body weight and composition, and all-cause mortality. Evidence gaps were identified in older adults, children, and pregnant women, in food-insecure settings, in Sub-Saharan Africa, Central and South East Asia. This scoping review offers a comprehensive overview of existing evidence on animal-source foods and health outcomes and identifies key research gaps to support the development of new nutrition guidelines.</p>","PeriodicalId":72101,"journal":{"name":"Advances in nutrition (Bethesda, Md.)","volume":" ","pages":"100467"},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144337293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Evidence on Optimal Intake of Animal-Source Foods and Health Status.","authors":"Lukas Schwingshackl, Sabrina Schlesinger","doi":"10.1016/j.advnut.2025.100466","DOIUrl":"10.1016/j.advnut.2025.100466","url":null,"abstract":"","PeriodicalId":72101,"journal":{"name":"Advances in nutrition (Bethesda, Md.)","volume":" ","pages":"100466"},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Theory-Informed Review of Food Insecurity in Higher Education: Determinants, Gaps, and Policy Implications.","authors":"Hiwot Abebe Haileslassie","doi":"10.1016/j.advnut.2025.100462","DOIUrl":"10.1016/j.advnut.2025.100462","url":null,"abstract":"","PeriodicalId":72101,"journal":{"name":"Advances in nutrition (Bethesda, Md.)","volume":" ","pages":"100462"},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}