Advances in laboratory medicine最新文献_第6页

Beyond mean corpuscular volume: the role of neutrophil and monocyte volume cell population data in the diagnosis of vitamin B12 deficiency in anemic patients. 超越平均红细胞体积：中性粒细胞和单核细胞体积细胞群数据在贫血患者维生素B12缺乏症诊断中的作用

IF 1.1

Advances in laboratory medicine Pub Date : 2025-08-22 eCollection Date: 2025-12-01 DOI: 10.1515/almed-2025-0097

Alba Leis-Sestayo, Álvaro Piedra-Aguilera, Laura Jiménez-Añón, Jennifer Rodríguez-Domínguez, Carme García-Martín, Alicia Martínez-Iribarren, Cristian Morales-Indiano

引用次数: 0

Biopsia líquida: Un paso adelante en la medicina de laboratorio. 液体活检：实验室医学向前迈出的一步。

IF 1.1

Advances in laboratory medicine Pub Date : 2025-08-20 eCollection Date: 2025-09-01 DOI: 10.1515/almed-2025-0117

Angel Díaz-Lagares, Wladimiro Jiménez

引用次数: 0

ADN tumoral circulante en pacientes con cáncer: perspectivas desde el laboratorio clínico. 癌症患者肿瘤DNA循环：临床实验室的展望。

IF 1.1

Advances in laboratory medicine Pub Date : 2025-08-19 eCollection Date: 2025-09-01 DOI: 10.1515/almed-2025-0093

Francisco J Illana, Esther Fernández-Galán, José Luis Muñoz-Bravo, Laura Valiña Amado, Carme García Martín, Carolina González-Fernández, Sílvia Miró-Cañís, Jaume Trapé, Antonio Martínez-Peinado, Xavier Filella, Alvaro González, Antonio Barco Sánchez, Angel Díaz-Lagares

引用次数: 0

Evaluación del análisis de la relación albúmina-creatinina mediante tira reactiva como método de cribado para la determinación de albúmina en orina en atención primaria. 在初级保健中，用反应条作为测定尿液中白蛋白的筛选方法评价白蛋白-肌酸关系分析。

IF 1.1

Advances in laboratory medicine Pub Date : 2025-08-15 eCollection Date: 2025-09-01 DOI: 10.1515/almed-2025-0102

Paula Liébanas García, Silvia Montolio Breva, Teresa Sans Mateu

引用次数: 0

BRAF V600E liquid biopsy-based detection in precision oncology. BRAF V600E液体活检在精准肿瘤学检测中的应用。

IF 1.1

Advances in laboratory medicine Pub Date : 2025-08-15 eCollection Date: 2025-09-01 DOI: 10.1515/almed-2025-0110

Gabriela R Mendeluk, Verónica A Alonso

{"title":"BRAF V600E liquid biopsy-based detection in precision oncology.","authors":"Gabriela R Mendeluk, Verónica A Alonso","doi":"10.1515/almed-2025-0110","DOIUrl":"10.1515/almed-2025-0110","url":null,"abstract":"Introduction: The BRAF V600E mutation is one of the most relevant genetic mutations in precision oncology. This variation is commonly found in several types of tumors, including melanoma, colorectal cancer, and thyroid cancer, to name a few. Liquid biopsy has emerged as a minimally-invasive screening option for this mutation.Content: This review examines the molecular biology of the BRAF V600E mutation, its role in tumor progression, and its utility in the diagnosis, prognosis and treatment of specific types of tumors. In addition, the focus is also placed on liquid biopsy-based screening options and their advantages over solid biopsy.Summary: Detection of this mutation through liquid biopsy offers a less invasive alternative to conventional tissue biopsies, with potential utility in guiding treatment adjustments and monitoring therapeutic response.Outlook: The use of liquid biopsy for the detection of BRAF V600E is expected to widespread in clinical practice, leading to the optimization of disease monitoring and personalized treatments for cancer patients.","PeriodicalId":72097,"journal":{"name":"Advances in laboratory medicine","volume":"6 3","pages":"298-305"},"PeriodicalIF":1.1,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12446921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145115321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genomic characterization of Pseudomonas aeruginosa adaptation mechanisms in bronchiectasis patients. 支气管扩张患者铜绿假单胞菌适应机制的基因组特征。

IF 1.1

Advances in laboratory medicine Pub Date : 2025-08-15 eCollection Date: 2025-12-01 DOI: 10.1515/almed-2025-0044

Alba Muñoz Santa, Xavier Gómez-Arbonés, Ricardo Pifarré Teixidó, Mercè García-González, Alba Bellés Bellés

{"title":"Genomic characterization of Pseudomonas aeruginosa adaptation mechanisms in bronchiectasis patients.","authors":"Alba Muñoz Santa, Xavier Gómez-Arbonés, Ricardo Pifarré Teixidó, Mercè García-González, Alba Bellés Bellés","doi":"10.1515/almed-2025-0044","DOIUrl":"10.1515/almed-2025-0044","url":null,"abstract":"Objectives: Pseudomonas aeruginosa is one of the main causes of chronic bronchial infection (CBI), especially in patients with chronic underlying diseases such as cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), asthma and bronchiectasis (BQ). Compared to P. aeruginosa CBI in CF, BQ infection has historically received less attention. The aim of this study was to determine the antibiotic susceptibility profile of 100 isolates recovered from 100 patients with P. aeruginosa CBI BQ and to characterize some of the adaptation mechanisms in 55 isolates by whole genome sequencing (WGS).Methods: Susceptibility testing to 10 antipseudomonal agents was done by MicroScan WalkAway broth microdilution system. WGS was performed using the Illumina DNA Prep library preparation kit. Indexed libraries were sequenced on an Illumina MiSeq benchtop sequencer (300 base pairs paired-end reads).Results: The most common loss-of-function mutations occurred in genes encoding the MexAB-OprM efflux-pump system, the pvd cluster and the fpvA receptor, and genes involved in twitching motility such as chpA and fimV.Conclusions: Our data indicates that P. aeruginosa adapts by accumulating loss-of-function mutations in several genes, resulting in changes to different phenotypes that may guide the development of new alternative treatment therapies.","PeriodicalId":72097,"journal":{"name":"Advances in laboratory medicine","volume":"6 4","pages":"477-483"},"PeriodicalIF":1.1,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12744365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145859493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The application and challenges of ChatGPT in laboratory medicine. ChatGPT在检验医学中的应用与挑战。

IF 1.1

Advances in laboratory medicine Pub Date : 2025-08-15 eCollection Date: 2025-12-01 DOI: 10.1515/almed-2025-0080

Zhili Niu, Xiandong Kuang, Juanjuan Chen, Xin Cai, Pingan Zhang

引用次数: 0

Variante no descrita previamente en el gen COL3A1: causalidad del Síndrome de Ehlers-Danlos tipo Vascular. 以前未在COL3A1基因中描述的变异：埃勒斯-丹洛斯血管型综合征的因果关系。

IF 1.1

Advances in laboratory medicine Pub Date : 2025-08-12 eCollection Date: 2025-12-01 DOI: 10.1515/almed-2025-0096

Estrella Gutiérrez Romero, Nuria Padilla Apuntate, Silvia Izquierdo Álvarez

引用次数: 0

Papel del laboratorio clínico en el estudio de nefrolitiasis y cristaluria por mesalazina. 美沙嗪在肾结石和结晶石研究中的临床实验室作用。

IF 1.1

Advances in laboratory medicine Pub Date : 2025-08-11 eCollection Date: 2025-12-01 DOI: 10.1515/almed-2025-0094

Ana Isabel Balbuena, Noelia Poveda, Araceli López, María José Ferri

引用次数: 0

Design and cost-effectiveness assessment of a model based on point-of-care testing for the improvement of the resolution of hospital emergencies. 设计和成本效益评估基于点护理测试的模型，以改善医院紧急情况的解决。

IF 1.1

Advances in laboratory medicine Pub Date : 2025-07-18 eCollection Date: 2025-12-01 DOI: 10.1515/almed-2024-0210

Marta Jimenez-Barragan, Antonio Leon-Justel, Catalina Sanchez-Mora

{"title":"Design and cost-effectiveness assessment of a model based on point-of-care testing for the improvement of the resolution of hospital emergencies.","authors":"Marta Jimenez-Barragan, Antonio Leon-Justel, Catalina Sanchez-Mora","doi":"10.1515/almed-2024-0210","DOIUrl":"10.1515/almed-2024-0210","url":null,"abstract":"Objectives: Emergency department (ED) crowding is a quality of care and financial problem. Among its causes are long length of stay in the ED (ED LoS). One of identified causes is prolonged Turnaround Time (TAT) for complementary tests, including laboratory tests. The main aim of this study is to design and validate a cost-effective model for improving resolution of hospital emergencies at the Virgen Macarena University Hospital (VMUH) based on application of point-of-care testing (POCT) on patients classified as priority 3 (P3), according to VMUH's triage system.Methods: P3 patients who met inclusion criteria were randomly assigned into: POCT group (laboratory tests in ED using POCT) or LAB group (laboratory tests in central laboratory). Previously, a correlation study of analytical parameters was done between both groups. Gender, age, reason for consultation, pre-intervention TAT, disposition-decision time (DDT) and ED LoS with or without imaging tests were analysed. A cost study and an extrapolation of strategy at national level were performed.Results: The correlation study proved favorable. POCT achieved a median reduction of DDT and ED LoS of 107.00 and 118.50 min respectively. This trend was maintained for non-pain related consultations and irrespective of imaging tests. Use of POCT resulted in a saving of €119.85/episode and a favorable incremental cost-effectiveness ratio (ICER) of €60.68 saved/ED LoS hour. Applying POCT to 50 % of national P3 EDs, potential savings of €284,206,701.19 were estimated.Conclusions: In conclusion, our strategy was shown to reduce DDT and, consequently, ED LoS in a cost-effective way.","PeriodicalId":72097,"journal":{"name":"Advances in laboratory medicine","volume":"6 4","pages":"458-466"},"PeriodicalIF":1.1,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12744367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145859458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0