Addiction neuroscience最新文献_第6页

Potential roles for vitamin D in preventing and treating impulse control disorders, behavioral addictions, and substance use disorders: A scoping review 维生素D在预防和治疗冲动控制障碍、行为成瘾和物质使用障碍中的潜在作用：范围综述

Addiction neuroscience Pub Date : 2025-03-01 Epub Date: 2024-11-26 DOI: 10.1016/j.addicn.2024.100190

Laya Jalilian-Khave , Razi Kitaneh , Binah Baht Ysrayl , Anna Borelli , Melissa C. Funaro , Marc N. Potenza , Gustavo A. Angarita

{"title":"Potential roles for vitamin D in preventing and treating impulse control disorders, behavioral addictions, and substance use disorders: A scoping review","authors":"Laya Jalilian-Khave , Razi Kitaneh , Binah Baht Ysrayl , Anna Borelli , Melissa C. Funaro , Marc N. Potenza , Gustavo A. Angarita","doi":"10.1016/j.addicn.2024.100190","DOIUrl":"10.1016/j.addicn.2024.100190","url":null,"abstract":"<div><div>Vitamin D deficiency is a problem of endemic proportions. Vitamin D is a major regulator of dopaminergic and serotonergic circuits, pathways implicated in addictive disorders. This scoping review (OSF registered as 67yhb) examines preclinical and clinical studies exploring relationships between vitamin D in impulse control disorders, behavioral addictions, and substance use disorders. We searched Ovid MEDLINE, Embase, APA PsycInfo, Cochrane Library, Web of Science, and Scopus databases. We extracted and summarized quantitative and qualitative data through a narrative synthesis and assessed the quality of studies using the Joanna Briggs Institute (JBI) and SYRCLE (Systematic Review Centre for Laboratory Animal Experimentation) criteria. Of 5,442 initial records identified, 28 preclinical and clinical studies were included. For most conditions, we found a negative relationship between vitamin D levels and symptom presence and/or severity. While data suggest a potential beneficial effect of vitamin D on preventing or treating these conditions, there were significant limitations identified by the JBI and SYRCLE assessments. Future studies should include impulse control disorders and other under-explored conditions, address heterogeneity regarding forms, doses, and duration of exposures to vitamin D, and explore vitamin D's potential therapeutic mechanisms.</div></div>","PeriodicalId":72067,"journal":{"name":"Addiction neuroscience","volume":"14 ","pages":"Article 100190"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142757671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Central amygdala neuroimmune signaling in alcohol use disorder 酒精使用障碍中的中央杏仁核神经免疫信号

Addiction neuroscience Pub Date : 2025-03-01 Epub Date: 2024-12-21 DOI: 10.1016/j.addicn.2024.100194

Mariam Melkumyan , Patrick A. Randall , Yuval Silberman

{"title":"Central amygdala neuroimmune signaling in alcohol use disorder","authors":"Mariam Melkumyan , Patrick A. Randall , Yuval Silberman","doi":"10.1016/j.addicn.2024.100194","DOIUrl":"10.1016/j.addicn.2024.100194","url":null,"abstract":"<div><div>Alcohol Use Disorder (AUD) is a prevalent and debilitating condition characterized by an inability to control alcohol consumption despite adverse consequences. Current treatments for AUD, including FDA-approved medications such as naltrexone and acamprosate, have limited efficacy and compliance, underscoring the need for novel therapeutic approaches. The central amygdala (CeA) plays a crucial role in the development and maintenance of AUD, particularly aspects associated with stress and binge behaviors. Recent research indicates neuroimmune signaling in the CeA is emerging as a key factor in this process. Chronic alcohol consumption disrupts neuroimmune signaling, leading to altered cytokine expression and activation of glial cells, including astrocytes and microglia. These changes contribute to the dysregulation of neural circuits involved in reward and stress, perpetuating alcohol-seeking behavior and relapse. This review delves into how chronic alcohol exposure affects neuroimmune signaling in the CeA, contributing to the pathophysiology of AUD. By focusing on the impact of cytokine expression and glial cell activation, this review aims to elucidate the mechanisms by which neuroinflammation in the CeA influences alcohol-related behaviors. By providing a comprehensive overview of the current state of research, this review identifies potential therapeutic targets for AUD. Understanding the complex interplay between neuroimmune signaling and alcohol-related behaviors may pave the way for more effective treatments and improved outcomes for individuals struggling with AUD.</div></div>","PeriodicalId":72067,"journal":{"name":"Addiction neuroscience","volume":"14 ","pages":"Article 100194"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143169125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proportion and distribution of neurotransmitter-defined cell types in the ventral tegmental area and substantia nigra pars compacta 腹侧被盖区和黑质紧密团中神经递质定义细胞类型的比例和分布

Addiction neuroscience Pub Date : 2024-12-01 Epub Date: 2024-10-28 DOI: 10.1016/j.addicn.2024.100183

William S. Conrad , Lucie Oriol , Grace J. Kollman , Lauren Faget , Thomas S. Hnasko

{"title":"Proportion and distribution of neurotransmitter-defined cell types in the ventral tegmental area and substantia nigra pars compacta","authors":"William S. Conrad , Lucie Oriol , Grace J. Kollman , Lauren Faget , Thomas S. Hnasko","doi":"10.1016/j.addicn.2024.100183","DOIUrl":"10.1016/j.addicn.2024.100183","url":null,"abstract":"<div><div>Most studies on the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) have focused on dopamine neurons and their role in processes such as motivation, learning, movement, and associated disorders such as addiction and Parkinson's disease. However there has been increasing attention on other VTA and SNc cell types that release GABA, glutamate, or a combination of neurotransmitters. Yet the relative distributions and proportions of neurotransmitter-defined cell types across VTA and SNc has remained unclear. Here, we used fluorescent in situ hybridization in male and female mice to label VTA and SNc neurons that expressed mRNA encoding the canonical vesicular transporters for dopamine, GABA, or glutamate: vesicular monoamine transporter (VMAT2), vesicular GABA transporter (VGAT), and vesicular glutamate transporter (VGLUT2). Within VTA, we found that no one type was particularly more abundant, instead we observed similar numbers of VMAT2+ (44 %), VGAT+ (37 %) and VGLUT2+ (41 %) neurons. In SNc we found that a slight majority of neurons expressed VMAT2 (54 %), fewer were VGAT+ (42 %), and VGLUT2+ neurons were least abundant (16 %). Moreover, 20 % of VTA neurons and 10 % of SNc neurons expressed more than one vesicular transporter, including 45 % of VGLUT2+ neurons. We also assessed within VTA and SNc subregions and found remarkable heterogeneity in cell-type composition. And by quantifying density across both anterior-posterior and medial-lateral axes we generated heatmaps to visualize the distribution of each cell type. Our data complement recent single-cell RNAseq studies and support a more diverse landscape of neurotransmitter-defined cell types in VTA and SNc than is typically appreciated.</div></div>","PeriodicalId":72067,"journal":{"name":"Addiction neuroscience","volume":"13 ","pages":"Article 100183"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral fentanyl consumption and withdrawal impairs fear extinction learning and enhances basolateral amygdala principal neuron excitatory-inhibitory balance in male and female mice 口服芬太尼和戒断芬太尼会损害雌雄小鼠的恐惧消退学习并增强杏仁核基底外侧主神经元的兴奋-抑制平衡

Addiction neuroscience Pub Date : 2024-12-01 Epub Date: 2024-10-15 DOI: 10.1016/j.addicn.2024.100182

Anthony M. Downs , Gracianne Kmiec , Zoé A. McElligott

{"title":"Oral fentanyl consumption and withdrawal impairs fear extinction learning and enhances basolateral amygdala principal neuron excitatory-inhibitory balance in male and female mice","authors":"Anthony M. Downs , Gracianne Kmiec , Zoé A. McElligott","doi":"10.1016/j.addicn.2024.100182","DOIUrl":"10.1016/j.addicn.2024.100182","url":null,"abstract":"<div><div>The number of opioid overdose deaths has increased over the past several years, mainly driven by an increase in the availability of highly potent synthetic opioids, like fentanyl, in the un-regulated drug supply. Over the last few years, changes in the drug supply, and in particular the availability of counterfeit pills containing fentanyl, have made oral use of opioids a more common route of administration. Here, we used a drinking in the dark (DiD) paradigm to model oral fentanyl self-administration using increasing fentanyl concentrations in male and female mice over 5 weeks. Fentanyl consumption peaked in both female and male mice at the 30 µg/mL dose, with female mice consuming significantly more fentanyl than male mice. Mice consumed sufficient fentanyl such that withdrawal was precipitated with naloxone, with males having increased withdrawal symptoms as compared to females, despite lower pharmacological exposure. We also performed behavioral assays to measure avoidance behavior and reward-seeking during fentanyl abstinence. Female mice displayed reduced avoidance behaviors in the open field assay, whereas male mice showed increased avoidance in the light/dark box assay. Female mice also exhibited increased reward-seeking in the sucrose preference test. Fentanyl-consuming mice of both sexes showed impaired cued fear extinction learning following fear conditioning and increased excitatory synaptic drive and increased excitability of BLA principal neurons. Our experiments demonstrate that long-term oral fentanyl consumption results in wide-ranging physiological and behavioral disruptions. This model could be useful to further study fentanyl withdrawal syndrome and behaviors and neuroplasticity associated with protracted fentanyl withdrawal.</div></div>","PeriodicalId":72067,"journal":{"name":"Addiction neuroscience","volume":"13 ","pages":"Article 100182"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impacts of endogenous opioid blockade and sex on working memory among ad-libitum and abstinent smokers and non-smokers 内源性阿片类药物阻断和性别对吸烟者和非吸烟者工作记忆的影响

Addiction neuroscience Pub Date : 2024-12-01 Epub Date: 2024-09-26 DOI: 10.1016/j.addicn.2024.100177

Ryan Johnson , Briana N. DeAngelis , Motohiro Nakajima , Sharon S. Allen , Mustafa al'Absi

{"title":"Impacts of endogenous opioid blockade and sex on working memory among ad-libitum and abstinent smokers and non-smokers","authors":"Ryan Johnson , Briana N. DeAngelis , Motohiro Nakajima , Sharon S. Allen , Mustafa al'Absi","doi":"10.1016/j.addicn.2024.100177","DOIUrl":"10.1016/j.addicn.2024.100177","url":null,"abstract":"<div><h3>Background</h3><div>Research examining the effects of opioid receptor antagonists on working memory is limited by small sample sizes that are often comprised of only male participants. Moreover, they have yielded mixed findings, and no studies have examined such effects in the context of chronic nicotine use and temporary nicotine withdrawal.</div></div><div><h3>Methods</h3><div>Male and female participants completed two lab visits at which they were administered either 50 mg naltrexone or an identical placebo (one at each lab using double-blind, counterbalanced administration). After a medication absorption period, performance on a mental arithmetic (working memory) task was assessed by number of correct responses, errors, and number of attempts. Participants were either non-smokers or regular smokers who were randomly assigned to use nicotine ad-libitum or to abstain from nicotine for 24 h prior to both lab visits.</div></div><div><h3>Results</h3><div>The results indicate a significant main effect of opioid blockade on number of correct answers and accuracy rate during the mental arithmetic task, with poorer performance after opioid blockade compared to placebo. In addition, compared to male participants, female participants made fewer answer attempts, had fewer correct answers, and a lower accuracy rate. We did not find evidence of any differences based on smoking group (non-smoker, smoking abstinence, or ad-libitum smoking), nor were there any significant interaction effects.</div></div><div><h3>Conclusions</h3><div>The findings suggest a modulating role of the endogenous opioid system in working memory function. Further investigation is needed to help identify the underlying mechanisms explaining the effects of the endogenous opioid system on working memory.</div></div>","PeriodicalId":72067,"journal":{"name":"Addiction neuroscience","volume":"13 ","pages":"Article 100177"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142425220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perirhinal cortex to the nucleus accumbens circuit in novelty salience following methamphetamine self-administration 甲基苯丙胺自我给药后新奇感显著性中的边缘皮层至脑核回路

Addiction neuroscience Pub Date : 2024-12-01 Epub Date: 2024-10-14 DOI: 10.1016/j.addicn.2024.100181

Katharine H. Nelson , Dylan L. Freels , Jordan S. Carter , Samuel K. Wood , Adam R. Denton , Jordan L. Hopkins , Sarah T. Goldsmith , Stacia I. Lewandowski , Michael D. Scofield , Carmela M. Reichel

{"title":"Perirhinal cortex to the nucleus accumbens circuit in novelty salience following methamphetamine self-administration","authors":"Katharine H. Nelson , Dylan L. Freels , Jordan S. Carter , Samuel K. Wood , Adam R. Denton , Jordan L. Hopkins , Sarah T. Goldsmith , Stacia I. Lewandowski , Michael D. Scofield , Carmela M. Reichel","doi":"10.1016/j.addicn.2024.100181","DOIUrl":"10.1016/j.addicn.2024.100181","url":null,"abstract":"<div><div>Methamphetamine (meth) use disorder is part of an overarching use disorder that encompasses continued drug seeking and an increased risk of returning to drug use following periods of abstaining. Chronic meth use results in drug-induced cortical plasticity in the perirhinal cortex (PRC) that mediates responses to novelty. PRH projection targets are numerous and include the nucleus accumbens core (NAc). Whereas the PRH-prefrontal cortex is involved in object recognition; we propose that the PRH<img>NAc is involved in novelty salience. Rats underwent short-access (ShA, 1 hr) or long-access (LgA, 6 hr) meth self-administration (SA). We then used a dual viral strategy to inhibit or activate PRH<img>NAc during a novel cue test in which rats were presented with meth‑associated and novel levers. Response patterns on these levers differ depending on the meth access protocol: ShA meth SA results in equal responding on both novel- and meth‑associated levers, whereas LgA meth results in perseverative responding on the meth‑associated lever. Inactivation of the PRH<img>NAc increased responding on the meth lever relative to the novel lever, resulting in a LgA behavioral phenotype. In contrast, activation in LgA rats was without a behavioral effect. We also report that male LgA sucrose SA animals perseverated on the novel lever rather than the meth‑associated lever, which contrast their meth SA counter parts and female specific patterns of behavior. These data open a new line of interest in the role of the PRH<img>NAc circuit in novelty salience through identification of the behavioral relevance of this circuit.</div></div>","PeriodicalId":72067,"journal":{"name":"Addiction neuroscience","volume":"13 ","pages":"Article 100181"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142527867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Opioid drug seeking after early-life adversity: a role for delta opioid receptors 早年逆境后的阿片类药物寻求：δ阿片受体的作用

Addiction neuroscience Pub Date : 2024-12-01 Epub Date: 2024-09-19 DOI: 10.1016/j.addicn.2024.100175

Sophia C. Levis , Matthew T. Birnie , Yiyan Xie , Noriko Kamei , Puja V. Kulkarni , Johanna S. Montesinos , Christina R. Perrone , Catherine M. Cahill , Tallie Z. Baram , Stephen V. Mahler

{"title":"Opioid drug seeking after early-life adversity: a role for delta opioid receptors","authors":"Sophia C. Levis , Matthew T. Birnie , Yiyan Xie , Noriko Kamei , Puja V. Kulkarni , Johanna S. Montesinos , Christina R. Perrone , Catherine M. Cahill , Tallie Z. Baram , Stephen V. Mahler","doi":"10.1016/j.addicn.2024.100175","DOIUrl":"10.1016/j.addicn.2024.100175","url":null,"abstract":"<div><div>Opioid use disorder (OUD) is associated with a history of early-life adversity (ELA), an association that is particularly strong in women. In a rodent model, we previously found that ELA enhances risk for opioid addiction selectively in females, but the mechanisms for this effect are unclear. Here, we show that ELA robustly alters cFos responses to opioid drugs in females’ nucleus accumbens (NAc) and basolateral amygdala (BLA), but not elsewhere. We further identify delta opioid receptors (DOR), which mature in the first week of life and thus later than kappa or mu opioid receptors, as a potential mediator of ELA's impacts on reward circuit functions. Accordingly, DOR mRNA in NAc was persistently reduced in adult females with ELA history. Moreover, pharmacological stimulation of NAc DORs increased opioid demand in control females (recapitulating the ELA phenotype), while blocking DORs in ELA females conversely reduced high-effort drug consumption, simulating the control rearing phenotype. These findings support a role for NAc DORs in mediating ELA-induced opioid vulnerability. In contrast, BLA neurons expressing DOR protein do not overlap heroin- responsive cells in ELA rats, arguing against a direct relationship of BLA DORs to heroin's addiction-relevant actions in the brain. Together, these results suggest a novel and selective role for NAc DORs in contributing to enduring, ELA-provoked vulnerability to OUD.</div></div>","PeriodicalId":72067,"journal":{"name":"Addiction neuroscience","volume":"13 ","pages":"Article 100175"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post-mortem human brain analysis of the ventral pallidum in alcohol use disorder 对酒精使用障碍患者腹侧苍白球的死后人脑分析

Addiction neuroscience Pub Date : 2024-12-01 Epub Date: 2024-10-11 DOI: 10.1016/j.addicn.2024.100180

Ameer Elena Rasool , Cormac Peat , Jie Liu, Greg Sutherland, Asheeta A. Prasad

{"title":"Post-mortem human brain analysis of the ventral pallidum in alcohol use disorder","authors":"Ameer Elena Rasool , Cormac Peat , Jie Liu, Greg Sutherland, Asheeta A. Prasad","doi":"10.1016/j.addicn.2024.100180","DOIUrl":"10.1016/j.addicn.2024.100180","url":null,"abstract":"<div><h3>Objective</h3><div>Alcohol use disorder (AUD) is characterised by cycles of alcohol misuse, abstinence, and relapse. The neurobiology of AUD strongly implicates the role of the ventral pallidum (VP) in a variety of drugs of abuse, including alcohol. Pre-clinical studies have demonstrated critical role of parvalbumin and calretinin neurons in the VP in modulating relapse, mood, and motivation. However, there are a limited studies examining the VP at the cellular level in AUD in humans.</div></div><div><h3>Method</h3><div>Post-mortem human brain tissue of AUD (<em>n</em> = 11), remission (<em>n</em> = 6), and control brains (<em>n</em> = 12) were processed for immunohistochemistry to examine the presence and changes in parvalbumin and calretinin neurons in the VP.</div></div><div><h3>Results</h3><div>Similar to pre-clinical rodent models, parvalbumin and calretinin neurons were present in the VP, although no significant difference was found in their number or morphology across all AUD, remission, and control brains.</div></div><div><h3>Conclusion</h3><div>The presence of parvalbumin and calretinin neurons in the VP was confirmed across all groups. This is particularly important as it supports the translatability of previous animal studies regarding the role of parvalbumin and calretinin neurons in AUD, and thus further implicates the VP in the neurobiology of AUD in humans. As there are no distinctions in the number or morphology of these neurons, their significance likely lies in their activity. The presence of both parvalbumin and calretinin in humans, particularly in both control and AUD cases supports translational capacity from preclinical findings is more feasible.</div></div>","PeriodicalId":72067,"journal":{"name":"Addiction neuroscience","volume":"13 ","pages":"Article 100180"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142527866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurokinin-1 receptors in the nucleus accumbens shell influence sensitivity to social defeat stress and stress-induced alcohol consumption in male mice 核团外壳中的神经激肽-1受体影响雄性小鼠对社会挫败应激和应激诱导的酒精消耗的敏感性

Addiction neuroscience Pub Date : 2024-12-01 Epub Date: 2024-08-27 DOI: 10.1016/j.addicn.2024.100174

Matthew G. Solomon , Sadie E. Nennig , Mallory R. Cotton, Kimberly E. Whiting, Hannah D. Fulenwider, Jesse R. Schank

{"title":"Neurokinin-1 receptors in the nucleus accumbens shell influence sensitivity to social defeat stress and stress-induced alcohol consumption in male mice","authors":"Matthew G. Solomon , Sadie E. Nennig , Mallory R. Cotton, Kimberly E. Whiting, Hannah D. Fulenwider, Jesse R. Schank","doi":"10.1016/j.addicn.2024.100174","DOIUrl":"10.1016/j.addicn.2024.100174","url":null,"abstract":"<div><p>Chronic social defeat stress (SDS) is a widely employed preclinical model of depression involving repeated exposure to physical defeats using a resident-intruder model in male mice. Exposure to SDS induces depressive-like phenotypes including anhedonia, social withdrawal, and increased drug and alcohol consumption. Previously, we found that expression of the neurokinin-1 receptor (NK1R) is increased in the nucleus accumbens (NAC) of mice that are sensitive to this stressor and increase their alcohol intake. The NK1R is the endogenous receptor for the neuropeptide substance P (SP) and plays a prominent role in stress, anxiety, and addiction. In the present study, we assessed changes in NK1R protein levels in the NAC shell and implemented viral vector strategies to demonstrate a functional role of the NK1R in sensitivity to SDS. Specifically, we found that NK1R protein levels were increased in the NAC shell following SDS exposure. Next, we found that NK1R overexpression in the NAC shell increased the sensitivity to SDS and stress-induced alcohol consumption. Together, these experiments provide evidence for a role of the NK1R in the NAC shell in the sensitivity to SDS and the subsequent escalation in alcohol intake.</p></div>","PeriodicalId":72067,"journal":{"name":"Addiction neuroscience","volume":"13 ","pages":"Article 100174"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772392524000336/pdfft?md5=d923d82125163e5185ff43b1b5cba98e&pid=1-s2.0-S2772392524000336-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142095384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subregion specific monoaminergic signaling in the female rat striatum during nicotine abstinence 尼古丁戒断期间雌性大鼠纹状体中特定亚区的单胺能信号传导

Addiction neuroscience Pub Date : 2024-12-01 Epub Date: 2024-10-24 DOI: 10.1016/j.addicn.2024.100184

Erika Lucente, Davide Cadeddu, Christian E Edvardsson, Mia Ericson, Elisabet Jerlhag, Louise Adermark

{"title":"Subregion specific monoaminergic signaling in the female rat striatum during nicotine abstinence","authors":"Erika Lucente, Davide Cadeddu, Christian E Edvardsson, Mia Ericson, Elisabet Jerlhag, Louise Adermark","doi":"10.1016/j.addicn.2024.100184","DOIUrl":"10.1016/j.addicn.2024.100184","url":null,"abstract":"<div><div>Women report more negative effect during nicotine abstinence, a state that may increase the risk of relapse. As monoamines play a key role in mood regulation the aim of this study was to outline changes in monoaminergic signaling during nicotine abstinence. To this end, tissue levels of dopamine and serotonin, as well as the impact displayed by the dopamine D2 receptor agonist quinpirole or 5-HT on excitatory neurotransmission was assessed in female rats subjected to three weeks of nicotine exposure followed by abstinence. Studies were conducted in the nucleus accumbens (nAc), a structure associated with the acute rewarding properties of nicotine, and the dorsolateral striatum (DLS), a region linked to the formation of habits. Data demonstrate that the monoaminergic profile is subregions specific, with higher levels of dopamine in the DLS, but higher levels of serotonin in the nAc. The influence displayed by quinpirole or 5-HT on excitatory neurotransmission was, however, subregion-independent. Repeated exposure to nicotine produced a robust and long-lasting behavioral sensitization to the locomotor stimulatory properties of nicotine, with no sustained changes in monoaminergic profiles when assessed in striatal tissue after five days of abstinence. However, e<em>x vivo</em> electrophysiological recordings demonstrated a subregion specific change in the responsiveness to bath perfused 5-HT, with a blunted response in the DLS, and enhanced synaptic depression in the nAc. In conclusion, while nicotine abstinence was not associated with sustained changes in tissue monoamine levels, repeated nicotine exposure produced subregion-specific neuroplasticity which might contribute to the high risk of nicotine relapse.</div></div>","PeriodicalId":72067,"journal":{"name":"Addiction neuroscience","volume":"13 ","pages":"Article 100184"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142527868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0