Addiction neuroscience最新文献_第7页

Biased allosteric modulator of neurotensin receptor 1 reduces ethanol drinking and responses to ethanol administration in rodents 神经紧张素受体 1 的偏向异构调节剂可减少啮齿动物的乙醇饮酒量和对乙醇给药的反应

Addiction neuroscience Pub Date : 2024-12-01 Epub Date: 2024-11-02 DOI: 10.1016/j.addicn.2024.100185

Graydon B. Gereau , Diana Zhou , Kalynn Van Voorhies , Ryan E. Tyler , Jeffrey Campbell , Jackson G. Murray , Ali Alvarez-Pamir , Luke A. Wykoff , Michel A. Companion , Michael R. Jackson , Steven H. Olson , Lawrence S. Barak , Lauren M. Slosky , Ryan P. Vetreno , Joyce Besheer , Zoe A. McElligott

{"title":"Biased allosteric modulator of neurotensin receptor 1 reduces ethanol drinking and responses to ethanol administration in rodents","authors":"Graydon B. Gereau , Diana Zhou , Kalynn Van Voorhies , Ryan E. Tyler , Jeffrey Campbell , Jackson G. Murray , Ali Alvarez-Pamir , Luke A. Wykoff , Michel A. Companion , Michael R. Jackson , Steven H. Olson , Lawrence S. Barak , Lauren M. Slosky , Ryan P. Vetreno , Joyce Besheer , Zoe A. McElligott","doi":"10.1016/j.addicn.2024.100185","DOIUrl":"10.1016/j.addicn.2024.100185","url":null,"abstract":"<div><div>Alcohol use disorders (AUDs) impose an enormous societal and financial burden, and world-wide, alcohol misuse is the 7th leading cause of premature death [<span><span>1</span></span>]. Despite this, there are currently only 3 FDA approved pharmacological approaches for the treatment of AUDs in the United States. The neurotensin (Nts) system has long been implicated in modulating behaviors associated with alcohol misuse. Recently, a novel compound, SBI-553, that biases the action of Nts receptor 1 (NTSR1) activation, has shown promise in preclinical models of psychostimulant use. Here we investigate the efficacy of this compound to alter ethanol-mediated behaviors in a comprehensive battery of experiments assessing ethanol consumption, behavioral responses to ethanol, physiological sensitivity to ethanol, and ethanol metabolism. Additionally, we investigated behavior in avoidance and cognitive assays to monitor potential side effects of SBI-553. We find that SBI-553 reduces ethanol consumption in mice without altering avoidance behavior or novel object recognition. We also observe sex-dependent differences in physiological responses to sequential ethanol injections in mice. In rats, we show that SBI-553 attenuates sensitivity to the interoceptive effects of ethanol (using a Pavlovian drug discrimination task). Our data suggest that targeting NTSR1 signaling may be promising to attenuate alcohol misuse, and adds to a body of literature that suggests NTSR1 may be a common downstream target involved in the psychoactive effects of multiple reinforcing substances.</div></div>","PeriodicalId":72067,"journal":{"name":"Addiction neuroscience","volume":"13 ","pages":"Article 100185"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142653382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting the ventral pallidum in obesity 针对肥胖症的腹侧苍白球

Addiction neuroscience Pub Date : 2024-12-01 Epub Date: 2024-10-11 DOI: 10.1016/j.addicn.2024.100179

Lisa Z. Fang , Yvan M. Vachez

{"title":"Targeting the ventral pallidum in obesity","authors":"Lisa Z. Fang , Yvan M. Vachez","doi":"10.1016/j.addicn.2024.100179","DOIUrl":"10.1016/j.addicn.2024.100179","url":null,"abstract":"<div><div>Obesity remains a global health challenge with escalating prevalence and imperfect treatments, necessitating novel therapeutic interventions. Hedonic feeding has been identified as a main driver of weight gain, leading to obesity. Therefore, targeting the neural circuits that regulate hedonic intake to reverse or treat obesity may boast a promising strategy.</div><div>The ventral pallidum (VP), a crucial component of the brain's reward circuitry, plays a pivotal role in encoding reward value and reinforcing motivated behaviors, including food intake. This review highlights the work cementing the role of the VP in feeding regulation, and delves into the connectivity between the VP and other brain regions governing energy homeostasis and hedonic feeding behaviors. We also examine the evidence suggesting that dysregulation within the VP contributes to hyperphagia and the development of obesity. Lastly, we discuss the VP as a possible target for focused intervention. Deep brain stimulation for obesity has been under investigation for several years but current electrode targets yield mixed, dissatisfying results.</div><div>While considerable progress has been made in elucidating the VP's role in feeding and obesity, several challenges remain in translating these findings into clinical interventions. Dissecting the diverse neurochemical, neuroanatomical, and projection connectivity of the VP will allow us to harness the full therapeutic potential of VP-based interventions, and may open avenues for developing targeted therapies to address the multifaceted nature of obesity.</div></div>","PeriodicalId":72067,"journal":{"name":"Addiction neuroscience","volume":"13 ","pages":"Article 100179"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142434484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fentanyl demand and seeking in female rats: Role of the orexin system and estrous cycle 雌性大鼠对芬太尼的需求和寻求：奥曲肽系统和发情周期的作用

Addiction neuroscience Pub Date : 2024-12-01 Epub Date: 2024-10-09 DOI: 10.1016/j.addicn.2024.100178

David De Sa Nogueira , Chuhyon Corwin , Yogesh Rakholia , Varnitha Punnuru , Meghana Nampally , Amy S. Kohtz , Gary Aston-Jones

{"title":"Fentanyl demand and seeking in female rats: Role of the orexin system and estrous cycle","authors":"David De Sa Nogueira , Chuhyon Corwin , Yogesh Rakholia , Varnitha Punnuru , Meghana Nampally , Amy S. Kohtz , Gary Aston-Jones","doi":"10.1016/j.addicn.2024.100178","DOIUrl":"10.1016/j.addicn.2024.100178","url":null,"abstract":"<div><div>The orexin system plays a major role in drug reward. Orexin-1 receptor (OxR1) blockade reduces fentanyl demand in males. However, there are a number of sex differences in the orexin system, and it is unclear how OxR1 antagonism would decrease fentanyl demand in females. Furthermore, the relationships between the estrous cycle and fentanyl intake are yet to be delineated.</div><div>Here, we conducted a behavioral economics (BE) procedure in female rats to assess the effects of the OxR1 antagonist SB-334867 on fentanyl demand before and after short-(ShA), long- (LgA) or intermittent-access (IntA) self-administration of fentanyl; we also tested the effect of SB-334867 on cued reinstatement of fentanyl seeking. Finally, we measured the impact of the estrous cycle on fentanyl demand, intake and seeking.</div><div>Results showed that in females SB-334867 did not consistently modulate demand for fentanyl before or after chronic access periods. However, SB-334867 at 30mg/kg reduced the number of active lever presses during cued-reinstatement of fentanyl seeking. We also found that fentanyl self-administration disrupted estrous cyclicity, in particular proestrus epochs, an effect that depended on short versus chronic access. Furthermore, extended access to fentanyl shifted the role of progesterone from facilitation of fentanyl demand during short periods, to attenuation of fentanyl demand after long term exposure. These results indicate that an orexin-based therapy in women for treating opioid use disorder must consider prior drug history as well as cycle phase.</div></div>","PeriodicalId":72067,"journal":{"name":"Addiction neuroscience","volume":"13 ","pages":"Article 100178"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142527865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of amphetamine exposure on stress susceptibility in mice 接触苯丙胺对小鼠应激易感性的影响

Addiction neuroscience Pub Date : 2024-12-01 Epub Date: 2024-09-28 DOI: 10.1016/j.addicn.2024.100176

Anne K. Eby , Benjamin D. Sachs

{"title":"The effects of amphetamine exposure on stress susceptibility in mice","authors":"Anne K. Eby , Benjamin D. Sachs","doi":"10.1016/j.addicn.2024.100176","DOIUrl":"10.1016/j.addicn.2024.100176","url":null,"abstract":"<div><div>Substance use disorders (SUDs) and their many psychiatric comorbidities, including major depression and anxiety disorders, are characterized by significant sex differences. Although the causes of SUDs and their psychiatric comorbidities remain unknown, stress has been heavily implicated in their etiology. Indeed, one leading hypothesis regarding the basis of clinically observed sex differences in psychopathology argues that differences in stress susceptibility and stress exposure play key roles. Consistent with this, differences in stress susceptibility and reactivity in females compared to males have been documented across multiple species. A wide range of environmental, genetic, and epigenetic factors are also thought to impact stress susceptibility, but whether there are sex differences in the effects of specific susceptibility factors remains understudied. Preclinical work suggests that a history of cocaine exposure can increase susceptibility to stress in males, but whether similar effects occur in females following stimulant exposure has not been established. The current work examined the impact of repeated amphetamine administration on subsequent susceptibility to mild sub-chronic stress in male and female mice. In addition to examining behavior, potential sex differences in the effects of stress and amphetamine on the expression of several genes were evaluated. Our results reveal several significant sex differences in the behavioral effects of amphetamine and stress in the elevated plus maze, forced swim test, and novelty-suppressed feeding test. However, in contrast to our initial hypothesis, a history of amphetamine did not lead to an overall increase in stress susceptibility across multiple tests in males or females.</div></div>","PeriodicalId":72067,"journal":{"name":"Addiction neuroscience","volume":"13 ","pages":"Article 100176"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142425221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pavlovian cue-evoked alcohol seeking is disrupted by ventral pallidal inhibition 巴甫洛夫线索诱发的酒精寻求会受到腹侧苍白球抑制的干扰

Addiction neuroscience Pub Date : 2024-12-01 Epub Date: 2024-11-09 DOI: 10.1016/j.addicn.2024.100186

Jocelyn M. Richard , Bailey Newell , Preethi Muruganandan , Patricia H. Janak , Benjamin T. Saunders

{"title":"Pavlovian cue-evoked alcohol seeking is disrupted by ventral pallidal inhibition","authors":"Jocelyn M. Richard , Bailey Newell , Preethi Muruganandan , Patricia H. Janak , Benjamin T. Saunders","doi":"10.1016/j.addicn.2024.100186","DOIUrl":"10.1016/j.addicn.2024.100186","url":null,"abstract":"<div><div>Cues paired with alcohol can be potent drivers of craving, alcohol-seeking, consumption, and relapse. While the ventral pallidum is implicated in appetitive and consummatory responses across several reward classes and types of behaviors, its role in behavioral responses to Pavlovian alcohol cues has not previously been established. Here, we tested the impact of optogenetic inhibition of ventral pallidum on Pavlovian-conditioned alcohol-seeking in male Long Evans rats. Rats underwent Pavlovian conditioning with an auditory cue predicting alcohol delivery to a reward port and a control cue predicting no alcohol delivery, until they consistently entered the reward port more during the alcohol cue than the control cue. We then tested the within-session effects of optogenetic inhibition during 50 % of cue presentations. We found that optogenetic inhibition of ventral pallidum during the alcohol cue reduced port entry likelihood and time spent in the port, and increased port entry latency. Overall, these results suggest that normal ventral pallidum activity is necessary for Pavlovian alcohol-seeking.</div></div>","PeriodicalId":72067,"journal":{"name":"Addiction neuroscience","volume":"13 ","pages":"Article 100186"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PKMζ alters oxycodone-taking in a dose- and sex-dependent manner PKMζ 以剂量和性别依赖的方式改变服用羟考酮的行为

Addiction neuroscience Pub Date : 2024-09-01 Epub Date: 2024-07-29 DOI: 10.1016/j.addicn.2024.100169

Melissa C. Knouse , Alyssa R. Kniffin , Erin A. English , William Cuadrado , Troy M. Houser , Lisa A. Briand

{"title":"PKMζ alters oxycodone-taking in a dose- and sex-dependent manner","authors":"Melissa C. Knouse , Alyssa R. Kniffin , Erin A. English , William Cuadrado , Troy M. Houser , Lisa A. Briand","doi":"10.1016/j.addicn.2024.100169","DOIUrl":"10.1016/j.addicn.2024.100169","url":null,"abstract":"<div><p>Opioid use disorder involves disruptions to glutamate homeostasis and dendritic spine density in the reward system. PKMζ is an atypical isoform of protein kinase C that is expressed exclusively in neurons and plays a role in postsynaptic glutamate signaling and dendritic spine maturation. As opioid use leads to alterations in glutamate transmission and dendritic spine density, we hypothesized that PKMζ deletion would alter opioid-taking behaviors. The current study examined two doses of oxycodone self-administration in male and female mice with constitutive deletion of PKMζ compared to wildtype controls. At a dose of 0.25 mg/kg/infusion, PKMζ deletion significantly potentiated oxycodone self-administration in both male and female mice. However, increases in motivation for oxycodone, as indicated by increased breakpoint on a progressive ratio schedule, were only seen in male PKMζ knockout mice and not females. When we examined a lower dose of oxycodone, 0.125 mg/kg/infusion, PKMζ knockout led to increases in oxycodone self-administration only in female mice. Additionally, female PKMζ knockout mice exhibited higher breakpoints on a progressive ratio schedule at this dose compared to all other groups. In addition to the self-administration studies, we also examined locomotor sensitization in response to experimenter administered oxycodone. PKMζ KO decreased oxycodone induced locomotion in males and potentiated oxycodone sensitization in females. Together, these results suggest that PKMζ acts to dampen oxycodone taking in both sexes, but females may be more sensitive to its effects.</p></div>","PeriodicalId":72067,"journal":{"name":"Addiction neuroscience","volume":"12 ","pages":"Article 100169"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772392524000282/pdfft?md5=a2e6cd6125c7e92011a3202110676c82&pid=1-s2.0-S2772392524000282-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141961509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Voluntary adolescent alcohol exposure does not robustly increase adulthood consumption of alcohol in multiple mouse and rat models 在多种小鼠和大鼠模型中，青春期自愿接触酒精不会显著增加成年期的酒精消费量

Addiction neuroscience Pub Date : 2024-09-01 Epub Date: 2024-08-03 DOI: 10.1016/j.addicn.2024.100171

Avery R. Sicher , Andrea Liss , Valentina Vozella , Paige Marsland , Laurel R. Seemiller , Matthew Springer , William D. Starnes , Keith R. Griffith , Grace C. Smith , Amy Astefanous , Terrence Deak , Marisa Roberto , Florence P. Varodayan , Nicole A. Crowley

{"title":"Voluntary adolescent alcohol exposure does not robustly increase adulthood consumption of alcohol in multiple mouse and rat models","authors":"Avery R. Sicher , Andrea Liss , Valentina Vozella , Paige Marsland , Laurel R. Seemiller , Matthew Springer , William D. Starnes , Keith R. Griffith , Grace C. Smith , Amy Astefanous , Terrence Deak , Marisa Roberto , Florence P. Varodayan , Nicole A. Crowley","doi":"10.1016/j.addicn.2024.100171","DOIUrl":"10.1016/j.addicn.2024.100171","url":null,"abstract":"<div><p>Adolescence is a period of increased risk taking, including increased alcohol and drug use. Multiple clinical studies report a positive relationship between adolescent alcohol consumption and risk of developing an alcohol use disorder (AUD) in adulthood. However, few preclinical studies have attempted to tease apart the biological contributions of adolescent alcohol exposure, independent of other social, environmental, and stress factors, and studies that have been conducted show mixed results. Here we use several adolescent voluntary consumption of alcohol models, conducted across four labs in three institutes and with two rodent species, to investigate the ramifications of adolescent alcohol consumption on adulthood alcohol consumption in controlled, pre-clinical environments. We consistently demonstrate a lack of robust increases in adulthood alcohol consumption. This work highlights that risks seen in both human datasets and other murine drinking models may be due to unique social and environmental factors – some of which may be unique to humans.</p></div>","PeriodicalId":72067,"journal":{"name":"Addiction neuroscience","volume":"12 ","pages":"Article 100171"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772392524000300/pdfft?md5=8733c0ef79344df2b11054ad58b599eb&pid=1-s2.0-S2772392524000300-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141963117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Xylazine is an agonist at kappa opioid receptors and exhibits sex-specific responses to opioid antagonism” [Addiction Neuroscience, Volume 11, June 2024, 100155] 对 "赛拉嗪是卡巴阿片受体的激动剂，对阿片拮抗剂表现出性别特异性反应 "的更正[《成瘾神经科学》，第11卷，2024年6月，100155]

Addiction neuroscience Pub Date : 2024-09-01 Epub Date: 2024-07-12 DOI: 10.1016/j.addicn.2024.100166

Madigan L. Bedard , Xi-Ping Huang , Jackson G. Murray , Alexandra C. Nowlan , Sara Y. Conley , Sarah E. Mott , Samuel J. Loyack , Calista A. Cline , Caroline G. Clodfelter , Nabarun Dasgupta , Brian Krumm , Bryan L. Roth , Zoe A. McElligott

引用次数: 0

Protracted opioid withdrawal behaviors are reduced by nitric oxide inhibition in mice 一氧化氮抑制剂可减少小鼠的阿片类药物持久戒断行为

Addiction neuroscience Pub Date : 2024-09-01 Epub Date: 2024-07-19 DOI: 10.1016/j.addicn.2024.100167

Daniel J Kalamarides, Aditi Singh, John A Dani

{"title":"Protracted opioid withdrawal behaviors are reduced by nitric oxide inhibition in mice","authors":"Daniel J Kalamarides, Aditi Singh, John A Dani","doi":"10.1016/j.addicn.2024.100167","DOIUrl":"10.1016/j.addicn.2024.100167","url":null,"abstract":"<div><p>Following opioid cessation, patients with opioid use disorder experience physical and psychological withdrawal symptoms. Prolonged negative affect, including anxiety and heightened stress reactivity, continues after physical withdrawal symptoms subside, contributing to the high relapse rates. The nitric oxide system plays a role in synaptic plasticity downstream of the mu opioid receptor pathway, and nitric oxide synthase inhibitors attenuate physical opioid withdrawal signs. We hypothesized that N(gamma)-nitro-<span>l</span>-arginine methyl ester (L-NAME), a nitric oxide synthase inhibitor, would reduce negative affect after protracted opioid withdrawal. Therefore, we first modeled withdrawal in male and female mice using 5 days of morphine injections followed by behavioral tests after one week of forced abstinence from morphine. One week of morphine withdrawal caused altered responses to tests of affective behavior in both male and female mice. There were, however, both subtle and significant sex differences among many of the behavioral measures of negative affect. Males and females had differences in immobility during the tail suspension test during morphine withdrawal, while only females had altered grooming in the sucrose splash test. Forced <span>l</span>-NAME in the animals’ drinking water during withdrawal attenuated all physical and affective measures of withdrawal in males and females but there were subtle differences. Together, these results suggest that the nitric oxide system may be a target to ameliorate the different behavioral manifestations of negative affect in males and females.</p></div>","PeriodicalId":72067,"journal":{"name":"Addiction neuroscience","volume":"12 ","pages":"Article 100167"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772392524000269/pdfft?md5=aea024bf3bfa4ed6b55c7b161dfb806c&pid=1-s2.0-S2772392524000269-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141950531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relative invulnerability of juvenile rats to addiction: Longitudinal assessment of risk behaviors and their relationship to cocaine self-administration 幼鼠相对不易上瘾：风险行为及其与可卡因自我摄取关系的纵向评估

Addiction neuroscience Pub Date : 2024-09-01 Epub Date: 2024-06-08 DOI: 10.1016/j.addicn.2024.100161

Chloe J. Jordan , Susan L. Andersen

{"title":"The relative invulnerability of juvenile rats to addiction: Longitudinal assessment of risk behaviors and their relationship to cocaine self-administration","authors":"Chloe J. Jordan , Susan L. Andersen","doi":"10.1016/j.addicn.2024.100161","DOIUrl":"https://doi.org/10.1016/j.addicn.2024.100161","url":null,"abstract":"<div><p>Individuals who initiate drug use before 14 years of age are at increased risk of developing a lifelong addiction. Risk behaviors associated with drug use in adult animals include novel reactivity, novelty preferences, and sucrose preferences. Whether those same behaviors predict drug use in young populations is not well-studied. We determined how these risk behaviors i) change across development in Sprague-Dawley male and female rats and ii) predict adolescent cocaine self-administration when risk is assessed in juveniles. A longitudinal design characterized the behavioral trajectory of rats at the ages of 21 (juvenile), 56 (adolescent), and 96 (adult) days of age. Novel reactivity and sucrose preferences increased with maturation, with females having higher reactivity levels than males. Sucrose preferences predicted increased cocaine intake in both sexes, an effect primarily driven by males. Novelty preferences, especially in males, predicted less cocaine intake. Segregation of the data into high and low tertiles (risk and resilience) revealed that high sucrose preference predicted cocaine infusions. Low levels of novel reactivity in females significantly correlated with presses on the active lever for cocaine. The number of days to acquire stable intake was the only metric to classify a group with more overall cocaine consumption. Juvenile rats are either too immature to demonstrate predictive behavior related to novelty or, alternatively, a more extreme phenotype may be necessary to identify addiction risk.</p></div>","PeriodicalId":72067,"journal":{"name":"Addiction neuroscience","volume":"12 ","pages":"Article 100161"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772392524000208/pdfft?md5=71e2ca354b4cd906aa804e4ce07260c1&pid=1-s2.0-S2772392524000208-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141324729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0