Addiction neuroscience最新文献

{"title":"Fluoxetine potentiates methylphenidate-induced behavioral responses: Enhanced locomotion or stereotypies and facilitated acquisition of cocaine self-administration","authors":"Lorissa Lamoureux ,&nbsp;Joel A. Beverley ,&nbsp;Michela Marinelli ,&nbsp;Heinz Steiner","doi":"10.1016/j.addicn.2023.100131","DOIUrl":"https://doi.org/10.1016/j.addicn.2023.100131","url":null,"abstract":"<div><p>The medical psychostimulant methylphenidate (MP) is used to treat attention-deficit hyperactivity disorder and recreationally as a “cognitive enhancer”. MP is a dopamine reuptake inhibitor, but does not affect serotonin. Serotonin contributes to addiction-related gene regulation and behavior. Previously, we showed that enhancing serotonin action by adding a selective serotonin reuptake inhibitor, fluoxetine (FLX), to MP potentiates MP-induced gene regulation in striatum and nucleus accumbens, mimicking cocaine effects. Here, we investigated the behavioral consequences of MP+FLX treatment. Young adult male rats received MP (5 mg/kg, i.p.) or MP+FLX (5 mg/kg each) daily for 6-8 days. Behavioral effects were assessed in an open-field test during the repeated treatment. Two weeks later the motor response to a cocaine challenge (25 mg/kg) and the rate of acquisition of cocaine self-administration behavior were determined. Our results demonstrate that FLX potentiates effects of MP on open-field behavior. However, we found differential behavioral responses to MP+FLX treatment, as approximately half of the rats developed high rates of focal stereotypies (termed “MP+FLX/high reactivity” group), whereas the other half did not, and only showed increased locomotion (“MP+FLX/low reactivity” group). Two weeks later, cocaine-induced locomotion and stereotypies were positively correlated with MP+FLX-induced behavior seen at the end of the repeated MP+FLX treatment. Moreover, the MP+FLX/high reactivity group, but not the low reactivity group, showed facilitated acquisition of cocaine self-administration. These results demonstrate that repeated MP+FLX treatment can facilitate subsequent cocaine taking behavior in a subpopulation of rats. These findings suggest that MP+FLX exposure in some individuals may increase the risk for psychostimulant use later in life.</p></div>","PeriodicalId":72067,"journal":{"name":"Addiction neuroscience","volume":"9 ","pages":"Article 100131"},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49766025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spermidine prevents the reinstatement of alcohol conditioned place preference","authors":"Avner Almeida Silva ,&nbsp;Gabrielle de Morais Henriques ,&nbsp;Victor Nascimento-Rocha ,&nbsp;Behaim Correia Dias-Júnior ,&nbsp;Alexia dos Anjos Santos ,&nbsp;Alexandre Justo Oliveira Lima ,&nbsp;Eduardo Ary Villela Marinho ,&nbsp;Maribel Antonello Rubin ,&nbsp;Carlos Fernando Mello","doi":"10.1016/j.addicn.2023.100130","DOIUrl":"https://doi.org/10.1016/j.addicn.2023.100130","url":null,"abstract":"<div><p>This study investigates whether spermidine (SPD), an endogenous polyamine, alters extinction and reinstatement of alcohol-induced conditioned place preference (CPP) in adult female Swiss mice. CPP was induced by injecting alcohol (1.8 g/kg, i.p.) and placing the animals in the drug-associated compartment for 10 min in four alternate days. During extinction, animals received vehicle or SPD (3, 10 or 30 mg/kg), and were placed in the drug-associated compartment for 10 min in 4 alternate days. Alcohol re-exposure was performed in the alcohol-paired compartment. In a second experiment, after conditioning, animals received vehicle, the N-methyl-<span>d</span>-aspartate (NMDA) receptor polyamine binding site antagonist arcaine (ARC, 0.1 mg/kg), SPD (10 mg/kg) or the association of both (ARC+SDP) in the drug-associated compartment. Animals were then sequentially subjected to alcohol re-exposure and a post-reexposure test. Spermidine did not alter CPP extinction, but prevented the reinstatement of CPP induced by alcohol reexposure. Arcaine prevented the effect of spermidine on alcohol-induced CPP reinstatement. The results suggest that SPD may facilitate the reconsolidation of conditioning memory, disrupting CPP. This effect seems to involve the polyamine binding site at the NMDA receptor, because it is prevented by ARC.</p></div>","PeriodicalId":72067,"journal":{"name":"Addiction neuroscience","volume":"9 ","pages":"Article 100130"},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49759534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estradiol and Mu opioid-mediated reward: The role of estrogen receptors in opioid use","authors":"Sarah B. Ethridge,&nbsp;Mark A. Smith","doi":"10.1016/j.addicn.2023.100139","DOIUrl":"https://doi.org/10.1016/j.addicn.2023.100139","url":null,"abstract":"<div><p>Opioid use and opioid use disorder are characterized by sex and gender differences, and some of these differences may be mediated by differences in the hormonal milieu within and across individuals. This review focuses on the role of ovarian hormones, and particularly estradiol, on the endogenous mu opioid receptor system. There is an abundance of data indicating that estradiol influences the activity of endogenous mu opioid peptides, the activation of mu opioid receptors, and the internalization and desensitization of mu opioid receptors. These effects have functional consequences on behaviors mediated by endogenous mu opioid receptor activity and on sensitivity to mu opioid agonists and antagonists. Recent behavioral data suggest these consequences extend to mu opioid reward, and preclinical studies report that estradiol decreases self-administration of mu opioid receptor agonists across a range of experimental conditions. Data collected in human laboratory studies suggest that estradiol may have functionally similar effects in clinical populations, and thus estrogen receptors may be a potential target in the development of novel therapeutics. This review summarizes data from cellular assays to clinical trials to explore how estradiol influences mu opioid receptor activity, as well as potential ways in which estrogen receptors may be targeted to address the problems of opioid use.</p></div>","PeriodicalId":72067,"journal":{"name":"Addiction neuroscience","volume":"9 ","pages":"Article 100139"},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772392523000822/pdfft?md5=04aaf6d3d866968f8a8462077736975e&pid=1-s2.0-S2772392523000822-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138480492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging tools to study the brain in addiction neuroscience","authors":"Jibran Y. Khokhar ,&nbsp;Hanbing Lu","doi":"10.1016/j.addicn.2023.100136","DOIUrl":"https://doi.org/10.1016/j.addicn.2023.100136","url":null,"abstract":"","PeriodicalId":72067,"journal":{"name":"Addiction neuroscience","volume":"9 ","pages":"Article 100136"},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772392523000792/pdfft?md5=8df4dde7e6e0f2dcc44428c5bdadaac8&pid=1-s2.0-S2772392523000792-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134656392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexually dimorphic effects of a modified adolescent social isolation paradigm on behavioral risk factors of alcohol use disorder in Long Evans Rats","authors":"Olivia A. Ortelli,&nbsp;Stacy R. Pitcairn,&nbsp;Christina H. Dyson,&nbsp;Jeffrey L. Weiner","doi":"10.1016/j.addicn.2023.100134","DOIUrl":"https://doi.org/10.1016/j.addicn.2023.100134","url":null,"abstract":"<div><p>Early life stress (ELS) is a major risk factor for alcohol use disorder (AUD) and comorbid neuropsychiatric conditions. We previously demonstrated that an adolescent social isolation (aSI) model of ELS significantly increased behavioral risk factors for these disorders (e.g. anxiety-like behaviors, alcohol drinking) in male, but not female rats. Since many neurodevelopmental milestones are accelerated in females, we investigated whether an earlier/shorter isolation window (PND 21-38) would yield comparable phenotypes in both sexes. In two experiments, Long Evans rats were socially isolated (SI) or group-housed (GH) on postnatal day (PND) 21 and locomotion was assessed in the open field test (OFT; PND 30). Experiment 1 also assessed behavior on the elevated plus-maze (EPM) (PND 32). In Experiment 2, all rats were single housed on PND 38 to assess home cage alcohol drinking. Experiment 1 revealed that SI females had increased locomotor activity in the OFT but did not differ from GH subjects on the EPM. The OFT results were replicated in both sexes in Experiment 2 and both male and female SI rats had significantly greater ethanol consumption during an eight day continuous access paradigm. In contrast, during subsequent intermittent two-bottle choice drinking, only SI females displayed greater ethanol intake and preference and increased consumption of a quinine-adulterated alcohol solution. These findings demonstrate that early life social isolation can promote AUD vulnerability-related phenotypes in female rats but that there are profound sex differences in the vulnerability window to this early life stressor. Uncovering the neural mechanisms responsible for these sexually dimorphic differences in sensitivity to ELS may shed light on the biological substrates associated with vulnerability to AUD and comorbid disorders of negative emotion in men and women.</p></div>","PeriodicalId":72067,"journal":{"name":"Addiction neuroscience","volume":"9 ","pages":"Article 100134"},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772392523000779/pdfft?md5=0eb50f33f1aa7545e2452e9303c83daf&pid=1-s2.0-S2772392523000779-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134656393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Craving dynamics and related cerebral substrates predict timing of use in alcohol, tobacco, and cannabis use disorders","authors":"Valentine Chirokoff ,&nbsp;Maud Dupuy ,&nbsp;Majd Abdallah ,&nbsp;Melina Fatseas ,&nbsp;Fuschia Serre ,&nbsp;Marc Auriacombe ,&nbsp;David Misdrahi ,&nbsp;Sylvie Berthoz ,&nbsp;Joel Swendsen ,&nbsp;Edith V. Sullivan ,&nbsp;Sandra Chanraud","doi":"10.1016/j.addicn.2023.100138","DOIUrl":"https://doi.org/10.1016/j.addicn.2023.100138","url":null,"abstract":"<div><h3>Background</h3><p>Patients treated for Substance Use Disorders exhibit highly fluctuating patterns of craving that could reveal novel prognostic markers of use. Accordingly, we 1) measured fluctuations within intensively repeated measures of craving and 2) linked fluctuations of craving to connectivity indices within resting-state (rs) brain regions to assess their relation to use among patients undergoing treatment for Alcohol, Tobacco and Cannabis Use Disorders</p></div><div><h3>Method</h3><p>Participants —64 individuals with SUD for tobacco, alcohol, or cannabis and 35 healthy controls— completed a week of Ecological Momentary Assessment (EMA) during which they reported craving intensity and substance use five times daily. Before EMA, a subsample of 50 patients, and 34 healthy controls also completed resting-state (rs)-MRI acquisitions. Craving temporal dynamics within each day were characterized using Standard Deviation (SD), Auto-Correlation Factor (ACF), and Mean Successive Square Difference (MSSD). Absolute Difference (AD) in craving between assessments was a prospective prediction measure.</p></div><div><h3>Results</h3><p>Within-day, higher MSSD predicted greater substance use while controlling for mean craving. Prospectively higher AD predicted later increased substance use independently of previous use or craving level. Moreover, MSSD was linked to strength in five functional neural connections, most involving frontotemporal systems. Cerebello-thalamic and thalamo-frontal connectivity were also linked to substance use and distinguished the SUD from the controls.</p></div><div><h3>Conclusion</h3><p>To the best of our knowledge, this is the first study to indicate that instability in craving may be a trigger for use in several SUD types, beyond the known effect of craving intensity.</p></div>","PeriodicalId":72067,"journal":{"name":"Addiction neuroscience","volume":"9 ","pages":"Article 100138"},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772392523000810/pdfft?md5=d5aafecbdfaf7289bd22ef961bcf3d02&pid=1-s2.0-S2772392523000810-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138467298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HPA axis function in alcohol use disorder: A systematic review and meta-analysis","authors":"Neil Dunne,&nbsp;Jo-Hanna Ivers","doi":"10.1016/j.addicn.2023.100114","DOIUrl":"10.1016/j.addicn.2023.100114","url":null,"abstract":"<div><p>Alcohol use disorder (AUD) is a culturally pervasive and often treatment resistant disorder. Stress is a major trigger for relapse in AUD. Allostasis in response to stress is governed by the hypothalamic-pituitary-adrenal axis (HPA axis). Investigation into HPA axis functioning in response to stress in AUD may provide a novel drug target for AUD treatment. This systematic review found 46 studies concerning ongoing AUD, withdrawal from alcohol, early-abstinence (&lt;6 months), and late-abstinence (&gt;6 months). Cortisol responses were mixed in ongoing AUD and higher in withdrawal. In early abstinence, significantly lower responses to stress compared to healthy controls were found for ACTH (SMD = -1.47, <em>p</em> = &lt; .001<em>, I²:</em> 35.68%) and cortisol (SMD = −1.32, <em>p</em> = &lt; .001<em>, I²:</em> 38.97%). Baseline values did not significantly differ compared to healthy controls for ACTH (SMD = −0.39, <em>p</em> = &lt; .001, <em>I²</em>: 81.11%) and cortisol (SMD = 0.74, <em>p</em> =  .015, <em>I²</em>: 88.66%). HPA axis functionality may normalise following 6 months of abstinence, though this may be confounded by selection bias. HPA axis hypoactivity was associated with a higher risk of relapse. Future research should aim to investigate all sexes and races, increase methodological consistency and participant follow up, and use HPA-sensitising drugs during early abstinence to assess their effects on relapse rates. Overall, the HPA axis presents strong potential as a novel treatment target in AUD.</p></div>","PeriodicalId":72067,"journal":{"name":"Addiction neuroscience","volume":"8 ","pages":"Article 100114"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44671566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acquired alterations in nucleus accumbens responsiveness to a cocaine-paired discriminative stimulus preceding rats’ daily cocaine consumption","authors":"David J. Estrin ,&nbsp;Julianna M. Kulik ,&nbsp;Nicholas J. Beacher ,&nbsp;Anthony P. Pawlak ,&nbsp;Samuel D. Klein ,&nbsp;Mark O. West","doi":"10.1016/j.addicn.2023.100121","DOIUrl":"10.1016/j.addicn.2023.100121","url":null,"abstract":"<div><p>Resumption of drug taking is a primary focus for substance use disorder research and can be triggered by drug-associated environmental stimuli. The Nucleus Accumbens (NAc) is a key brain region which guides motivated behavior and is implicated in resumption. Yet, there remains a pressing need to characterize NAc neurons’ responsiveness to drug associated stimuli during withdrawal and abstinence. We recorded discriminative stimulus (DS) induced NAc activity via <em>in vivo</em> single-unit electrophysiology in rats that self-administered cocaine. Male and female rats implanted with a jugular catheter and a microwire array in NAc Core and Shell self-administered cocaine under control of a 30s auditory DS for 6 hours per session across 14 consecutive days. Rats acquired tone discrimination within 4 sessions. To exclude pharmacological effects of circulating cocaine from all neuronal analyses, we studied changes in DS-induced firing only for trials <em>preceding</em> the first infusion of cocaine in each of the 14 sessions, which were defined as “pre-drug trials.” NAc neuron responses were assessed prior to tone-evoked movement onset. Responsiveness to the DS tone was exhibited throughout all sessions by the NAc Core population, but only during Early sessions by the NAc Shell population. Both Core and Shell responded selectively to the DS, i.e., more strongly on drug taking trials, or Hits, than on Missed opportunities. These findings suggest that NAc Core and Shell play distinct roles in initiating cocaine seeking prior to daily cocaine consumption, and align with reports suggesting that as drug use becomes chronic, cue-evoked activity shifts from NAc Shell to NAc Core.</p></div>","PeriodicalId":72067,"journal":{"name":"Addiction neuroscience","volume":"8 ","pages":"Article 100121"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10525623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nucleus accumbens shell neurons’ early sensitivity to cocaine is associated with future increases in drug intake","authors":"Ashley K. Crawley ,&nbsp;Anirudh Sharma ,&nbsp;Kevin R. Coffey ,&nbsp;Mark O. West ,&nbsp;David J. Barker","doi":"10.1016/j.addicn.2023.100107","DOIUrl":"10.1016/j.addicn.2023.100107","url":null,"abstract":"<div><p>The striatum, both dorsal and ventral, is strongly implicated in substance use disorder. Chronic consumption of abused substances, such as cocaine, can cause an oversaturation of mesostriatal dopamine, which results in alterations in the firing of striatal neurons. While most preclinical studies of drug self-administration (S-A) are focused on these alterations, individual differences in a subject's early responses to drugs can also account for substantial differences in addiction susceptibility. In this study, we modeled longitudinal pharmacokinetics using data from a previous longitudinal study (Coffey et al., 2015) and aimed to determine if firing in specific dorsal and ventral striatal subregions was subject to changes across chronic cocaine S-A, and if individual animal differences in striatal firing in response to early drug exposure correlated with increases in drug intake. We observed that the firing patterns of nucleus accumbens (NAc) core and shell neurons exhibited increasing sensitivity to cocaine over the first 6 S-A sessions and maintained a strong negative correlation between drug intake and neuronal firing rates across chronic S-A. Moreover, we observed that the early sensitivity of NAc shell neurons to cocaine correlated with future increases in drug intake. Specifically, rats whose NAc shell neurons were most inhibited by increasing levels of cocaine upon first exposure exhibited the strongest increases in cocaine intake over time. If this difference can be linked to a genetic difference, or druggable targets, it may be possible to screen for similar addiction susceptibility in humans or develop novel preemptive pharmacotherapies.</p></div>","PeriodicalId":72067,"journal":{"name":"Addiction neuroscience","volume":"8 ","pages":"Article 100107"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10217245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial - Advancing Biomarkers for Treatment of Smoking and Nicotine Dependence: An Overview","authors":"Jonathan D. Pollock ,&nbsp;Kay Wanke ,&nbsp;Wilson M. Compton","doi":"10.1016/j.addicn.2023.100117","DOIUrl":"https://doi.org/10.1016/j.addicn.2023.100117","url":null,"abstract":"<div><p>The special issue on Biomarkers of Nicotine and Tobacco Dependence reviews the science for precision treatment of nicotine dependence and future opportunities for research on biomarkers for inclusion in tobacco product cessation and switching clinical trials to advance translation. This overview summarizes the articles contributed to the special issue by leading researchers in field of addiction.</p></div>","PeriodicalId":72067,"journal":{"name":"Addiction neuroscience","volume":"8 ","pages":"Article 100117"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49857786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}