Addiction neuroscience最新文献_第4页

Using miniscopes and deep learning to compare neurobehavioral representations of psychostimulant and opioid self-administration 使用微型显微镜和深度学习比较精神兴奋剂和阿片类药物自我给药的神经行为表征

IF 2.2

Addiction neuroscience Pub Date : 2025-09-01 Epub Date: 2025-08-09 DOI: 10.1016/j.addicn.2025.100224

Matthew C. Broomer , Caroline E. Clark , Jan Shanelle J. Iringan , Michael W. Wang , Nicholas J. Beacher , Da-Ting Lin

{"title":"Using miniscopes and deep learning to compare neurobehavioral representations of psychostimulant and opioid self-administration","authors":"Matthew C. Broomer , Caroline E. Clark , Jan Shanelle J. Iringan , Michael W. Wang , Nicholas J. Beacher , Da-Ting Lin","doi":"10.1016/j.addicn.2025.100224","DOIUrl":"10.1016/j.addicn.2025.100224","url":null,"abstract":"<div><div>Concurrent abuse of psychostimulants and opioids represents a growing public health concern. However, preclinical models of substance use disorder often situate psychostimulants and opioids similarly within a unified self-administration procedure. This approach may fail to capture important differences in neurobehavioral activity related to each drug type. A large volume of <em>in vivo</em> literature suggests that, within canonical reward-related brain regions such as the nucleus accumbens (NAc), multiple reward-seeking behaviors may be represented by distinct neural populations. This comparison is often made between drug and natural rewards, however there is evidence for a similar distinction between psychostimulants and opioids. Here, we review the evidence for distinct neurobehavioral characteristics of psychostimulant versus opioid self-administration and consider the utility of two experimental approaches—miniscope calcium imaging and deep learning-assisted behavior analysis—in further exploring this topic.</div></div>","PeriodicalId":72067,"journal":{"name":"Addiction neuroscience","volume":"16 ","pages":"Article 100224"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144831445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug self-administration, drug-specific behaviors, and neurobehavioral deep learning analyses 药物自我给药，药物特异性行为和神经行为深度学习分析

IF 2.2

Addiction neuroscience Pub Date : 2025-09-01 Epub Date: 2025-08-06 DOI: 10.1016/j.addicn.2025.100222

Nicholas J. Beacher , Michael W. Wang , Jan Shanelle J. Iringan , Caroline E. Clark , D’Ottavio Ginevra , Matthew C. Broomer , Da-Ting Lin

引用次数: 0

Neurobiological convergence of pain and substance use disorders: A focus on opioidergic and mesolimbic circuitry 疼痛和物质使用障碍的神经生物学趋同：阿片能和中脑边缘回路的焦点

Addiction neuroscience Pub Date : 2025-09-01 Epub Date: 2025-07-22 DOI: 10.1016/j.addicn.2025.100220

Shamim Arif , Shekiba Madadi , Murtaza Haidary

{"title":"Neurobiological convergence of pain and substance use disorders: A focus on opioidergic and mesolimbic circuitry","authors":"Shamim Arif , Shekiba Madadi , Murtaza Haidary","doi":"10.1016/j.addicn.2025.100220","DOIUrl":"10.1016/j.addicn.2025.100220","url":null,"abstract":"<div><div>Chronic pain and substance use disorder (SUD) frequently co-occur, driven by shared and convergent neurobiological pathways that reinforce a cycle of suffering, maladaptive behavior, and resistance to treatment. This narrative review explores the bidirectional relationship between these conditions, emphasizing the overlapping dysfunctions in the opioidergic and mesolimbic systems. Central components of the brain’s neurocircuitry—including the ventral tegmental area, nucleus accumbens, amygdala, and prefrontal cortex—play pivotal roles in both nociceptive modulation and reward processing, contributing to a common pathophysiological substrate. To conceptualize the transition from acute states to chronicity, theoretical models such as the allostatic load framework, opponent process theory, and mechanisms of negative reinforcement are explored. At the molecular level, maladaptive neuroplastic changes involving CREB, ΔFosB, and BDNF are identified as key drivers of sensitization across both pain and addiction domains. Furthermore, advances in neuroimaging and genomics have begun to reveal biomarkers and genetic signatures that hold promise for stratified diagnosis and intervention. Ultimately, this review highlights the need for dual-targeted pharmacotherapies, non-addictive analgesics, and personalized treatment strategies that address the shared mechanisms underpinning chronic pain and SUD. A unified, neurobiologically informed approach may offer more effective and sustainable outcomes for individuals afflicted by this challenging comorbidity.</div></div>","PeriodicalId":72067,"journal":{"name":"Addiction neuroscience","volume":"16 ","pages":"Article 100220"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144704414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genomic and behavioral signatures of selection for ethanol preference from the heterogeneous stock collaborative cross mice – The central nucleus of the amygdala 异种种群合作杂交小鼠乙醇偏好选择的基因组和行为特征——杏仁核中央核

Addiction neuroscience Pub Date : 2025-06-01 Epub Date: 2025-05-07 DOI: 10.1016/j.addicn.2025.100209

Justin Q. Anderson , Priscila Darakjian , Robert Hitzemann , Rita Cervera-Juanes , Kip D. Zimmerman , Cheryl Reed , Denesa Lockwood , Angela R. Ozburn , Tamara J. Phillips

{"title":"Genomic and behavioral signatures of selection for ethanol preference from the heterogeneous stock collaborative cross mice – The central nucleus of the amygdala","authors":"Justin Q. Anderson , Priscila Darakjian , Robert Hitzemann , Rita Cervera-Juanes , Kip D. Zimmerman , Cheryl Reed , Denesa Lockwood , Angela R. Ozburn , Tamara J. Phillips","doi":"10.1016/j.addicn.2025.100209","DOIUrl":"10.1016/j.addicn.2025.100209","url":null,"abstract":"<div><div>Alcohol use disorder (AUD) is a complex disease with heritability of ∼0.5, indicating genetic and non-genetic factors contribute to risk. Identifying gene expression networks contributing to risk using post-mortem human brain tissue has the limitation of conflating risk for AUD with consequences of alcohol use. We leveraged mice selectively bred for differential ethanol preference from a highly genetically diverse population to overcome this limitation. Ethanol intake was highly correlated with preference, high-preferring (HP) mice consumed more sweet- but not bitter-tasting solutions compared to low-preferring (LP) mice, and the lines did not differ in rate of ethanol elimination. Adult, ethanol-naïve HP and LP mice contributed tissue from the central nucleus of the amygdala (CeA), a region critical to ethanol preference and intake. Single-nuclei and bulk RNA sequencing data were used to identify cell types and transcriptome changes related to selective breeding for differential risk for ethanol preference. Single nuclei analysis identified populations of inhibitory (∼48 % of cells) and excitatory (∼23 %) neurons, and non-neuronal (∼29 %) cells, but no differences in cell-type composition or gene expression were identified between the lines. Bulk CeA analysis identified differences between the lines for: (1) gene expression (2996 genes), (2) expression variability (426 genes), and (3) wiring (407 significant gene-gene correlations). Overall, lower variance was found in the HP line. Reduced gene-gene correlation, also found in HP mice, suggested that selection for high preference induced changes in transcriptional regulation resulting in reduced connectivity, specific to gene networks enriched in markers for inhibitory neurons expressing <em>Isl1</em> and <em>Tac1.</em></div></div>","PeriodicalId":72067,"journal":{"name":"Addiction neuroscience","volume":"15 ","pages":"Article 100209"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143937621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Proportion and distribution of neurotransmitter-defined cell types in the ventral tegmental area and substantia nigra pars compacta” [Addiction Neuroscience 13 (2024) 100183] “神经递质定义的细胞类型在腹侧被盖区和黑质致密部的比例和分布”的更正[成瘾神经科学13 (2024)100183]

Addiction neuroscience Pub Date : 2025-06-01 Epub Date: 2024-12-13 DOI: 10.1016/j.addicn.2024.100193

William S. Conrad , Lucie Oriol , Grace J. Kollman , Lauren Faget , Thomas S. Hnasko

引用次数: 0

Oxytocin attenuates demand for cocaine in female rats 催产素降低了雌性大鼠对可卡因的需求

Addiction neuroscience Pub Date : 2025-06-01 Epub Date: 2025-01-15 DOI: 10.1016/j.addicn.2025.100197

Amy S. Kohtz , Hannah Davies , Belle Lin , Gary Aston-Jones

{"title":"Oxytocin attenuates demand for cocaine in female rats","authors":"Amy S. Kohtz , Hannah Davies , Belle Lin , Gary Aston-Jones","doi":"10.1016/j.addicn.2025.100197","DOIUrl":"10.1016/j.addicn.2025.100197","url":null,"abstract":"<div><div>There are substantial sex differences in substance use disorders (SUDs), and a key feature of SUD is pathologically high economic demand for drug. The hypothalamic neuropeptide oxytocin (OXT) is heavily implicated in the modern treatment of SUDs. Using a within-session threshold behavioral economics (BE) procedure, we quantified demand elasticity (a, inverse motivation) and free consumption (Q<sub>0</sub>) in male and female rats to investigate the effect of OXT on cocaine demand. Results showed that OXT decreased motivation for cocaine; an effect greater during the high-demand phase (diestrus, low progesterone, P<sub>4</sub>) vs low demand phases (proestrus, high P<sub>4</sub>). We confirmed our prior findings that P<sub>4</sub> attenuates cocaine demand in female rats and that chronic cocaine self-administration disrupts estrus cyclicity. Following each injection, OXT at either 0.1mg/kg or 0.3mg/kg restored estrous cycling in intact females with prior cocaine experience for one week and remained effective with up to 4 weeks of injections. Fos reactivity in OXT+ neurons was greater when rats were in proestrus compared to diestrus and significantly correlated to motivation and circulating levels of P<sub>4</sub>. Finally, using ovariectomized females with P<sub>4</sub> replacement, we show that P<sub>4</sub>’s demand attenuating effects are reversed by atosiban (1.0 mg/kg, IP), an OXT antagonist. These data show an interaction between oxytocin and progesterone in female rats that may underlie differences in cocaine demand between sexes. Additionally, we show critical periods for using OXT as a treatment to reduce cocaine demand in females. Our results indicate novel therapeutic treatments for SUDs must be tailored to hormonal states.</div></div>","PeriodicalId":72067,"journal":{"name":"Addiction neuroscience","volume":"15 ","pages":"Article 100197"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143153818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Presence of distinct operant phenotypes and transient withdrawal-induced escalation of operant ethanol intake in female rats 在雌性大鼠中存在不同的操作性表型和短暂戒断诱导的操作性乙醇摄入量增加

Addiction neuroscience Pub Date : 2025-06-01 Epub Date: 2025-01-30 DOI: 10.1016/j.addicn.2025.100198

Joseph R Pitock, Shannon R Wheeler, Arleen Perez Ayala, Shikun Hou, Nathaly M Arce Soto, Elizabeth J Glover

{"title":"Presence of distinct operant phenotypes and transient withdrawal-induced escalation of operant ethanol intake in female rats","authors":"Joseph R Pitock, Shannon R Wheeler, Arleen Perez Ayala, Shikun Hou, Nathaly M Arce Soto, Elizabeth J Glover","doi":"10.1016/j.addicn.2025.100198","DOIUrl":"10.1016/j.addicn.2025.100198","url":null,"abstract":"<div><div>Operant self-administration is frequently used to investigate the neurobiological mechanisms underlying alcohol seeking and drinking and to evaluate treatments of alcohol use disorder (AUD). Although widely used by the research community, there is a paucity of operant ethanol self-administration studies that include female subjects. The current study characterizes home cage drinking and operant ethanol self-administration in female Sprague Dawley, Long Evans, and Wistar rats. Rats underwent three weeks of intermittent-access two-bottle choice home cage drinking before being trained to lever press for ethanol in standard operant chambers equipped with contact lickometers. After capturing baseline operant performance, rats were chronically exposed to control or ethanol liquid diet using the Lieber-DeCarli method followed by re-evaluation of operant performance during acute withdrawal. Our findings reveal the presence of three distinct operant phenotypes, the prevalence of which within each strain is strikingly similar to our previous observations in males. Within a given phenotype, rats of each strain performed similarly during operant testing. Ethanol intake during home cage drinking was unable to predict future operant phenotype. Relative to controls, Drinkers chronically exposed to ethanol liquid diet exhibited a significant, but transient, escalation in consummatory, but not appetitive, responding during acute withdrawal. Collectively, these data closely parallel many of our previous observations in males while also highlighting potential sex differences in drinking strategies following dependence. Our findings provide new insight into similarities and differences in operant ethanol self-administration between males and females and emphasize the importance of including females in future studies of ethanol drinking and dependence.</div></div>","PeriodicalId":72067,"journal":{"name":"Addiction neuroscience","volume":"15 ","pages":"Article 100198"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143303053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endogenous regulator of G protein signaling 14 (RGS14) blunts cocaine-induced emotionally motivated behaviors in female mice 内源性G蛋白信号14调节因子（RGS14）减弱可卡因诱导的雌性小鼠情绪动机行为

Addiction neuroscience Pub Date : 2025-06-01 Epub Date: 2025-02-15 DOI: 10.1016/j.addicn.2025.100203

Sara N. Bramlett , Stephanie L. Foster , David Weinshenker , John R. Hepler

{"title":"Endogenous regulator of G protein signaling 14 (RGS14) blunts cocaine-induced emotionally motivated behaviors in female mice","authors":"Sara N. Bramlett , Stephanie L. Foster , David Weinshenker , John R. Hepler","doi":"10.1016/j.addicn.2025.100203","DOIUrl":"10.1016/j.addicn.2025.100203","url":null,"abstract":"<div><div>Addictive drugs hijack the neuronal mechanisms of learning and memory in motivation and emotion processing circuits to reinforce their own use. Regulator of G-protein Signaling 14 (RGS14) is a natural suppressor of post-synaptic plasticity underlying learning and memory in the hippocampus. The present study used immunofluorescence and RGS14 knockout mice to assess the role of RGS14 in behavioral plasticity and reward learning induced by chronic cocaine in emotional-motivational pathways. We report that RGS14 is strongly expressed in discrete regions of the ventral striatum and extended amygdala in wild-type mice, and is co-expressed with D1 and D2 dopamine receptors in neurons of the nucleus accumbens. Of note, we found that RGS14 is upregulated in the nucleus accumbens following acute cocaine treatment in mice with chronic cocaine history. We found significantly increased cocaine-induced locomotor sensitization, as well as enhanced conditioned place preference and conditioned locomotor activity in RGS14-deficient mice compared to wild-type littermates. Together, these findings suggest that endogenous RGS14 suppresses cocaine-induced plasticity in emotional-motivational pathways, implicating RGS14 as a protective agent against the maladaptive neuroplastic changes that occur during addiction.</div></div>","PeriodicalId":72067,"journal":{"name":"Addiction neuroscience","volume":"15 ","pages":"Article 100203"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143454605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex-specific effects of predator scent stress on fear, anxiety-like behavior and methamphetamine seeking in rats 捕食者气味压力对老鼠恐惧、焦虑样行为和甲基苯丙胺寻找的性别特异性影响

Addiction neuroscience Pub Date : 2025-06-01 Epub Date: 2025-03-20 DOI: 10.1016/j.addicn.2025.100205

CG Modrak , CS Wilkinson , AD Claypool , AJ Moore , L Wu , LA Knackstedt , M Schwendt

{"title":"Sex-specific effects of predator scent stress on fear, anxiety-like behavior and methamphetamine seeking in rats","authors":"CG Modrak , CS Wilkinson , AD Claypool , AJ Moore , L Wu , LA Knackstedt , M Schwendt","doi":"10.1016/j.addicn.2025.100205","DOIUrl":"10.1016/j.addicn.2025.100205","url":null,"abstract":"<div><div>Methamphetamine use disorder (MUD) is frequently comorbid with other disorders, such as post-traumatic stress disorder (PTSD). Here, we used a rat model of PTSD+MUD to evaluate the influence of sex and stress on methamphetamine-seeking and on the activation of frontocortical regions during reinstatement of meth‑seeking. Male and female Sprague-Dawley rats were exposed to predator scent stress (PSS) or a control odor for 10 min, followed by anxiety testing one week later. Rats were re-exposed to the odor context three weeks after the exposure and then self-administered methamphetamine for 18 days. Rats underwent extinction training followed by a cue-primed reinstatement test. We found evidence for sex-specific fear and anxiety-like behaviors in PSS-exposed rats, with females exhibiting anxiety-like behavior in the elevated plus maze and males exhibiting increased acoustic startle response. There were no effects of PSS on methamphetamine intake, but males exhibited greater intake and cued reinstatement. PSS-exposed females reinstated methamphetamine-seeking, but control-exposed females did not, in parallel with higher reinstatement-induced infralimbic cortex c-Fos expression. PSS males exhibited reduced prelimbic and infralimbic c-Fos relative to control-exposed males despite similar reinstatement behavior. To identify relationships between fear and anxiety-like behavior, cortical activation, and meth‑seeking, a principal components analysis was used. The analysis revealed that discrete behaviors exhibited during PSS exposure (locomotion and digging), together with select markers of anxiety (reduced startle response), predict methamphetamine intake and seeking. Altogether, these findings suggest that a specific set of stress-reactive and anxiety-like behaviors contribute to long-term resilience to drug-taking and seeking in a sex-specific manner.</div></div>","PeriodicalId":72067,"journal":{"name":"Addiction neuroscience","volume":"15 ","pages":"Article 100205"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EcoHIV infection effects on cocaine seeking and neuroimmune responses in male mice depend on cocaine exposure pattern EcoHIV感染对雄性小鼠可卡因寻求和神经免疫反应的影响取决于可卡因暴露模式

Addiction neuroscience Pub Date : 2025-06-01 Epub Date: 2025-04-22 DOI: 10.1016/j.addicn.2025.100208

Mark D. Namba , Qiaowei Xie , Kyewon Park , Joshua G. Jackson , Jacqueline M. Barker

{"title":"EcoHIV infection effects on cocaine seeking and neuroimmune responses in male mice depend on cocaine exposure pattern","authors":"Mark D. Namba , Qiaowei Xie , Kyewon Park , Joshua G. Jackson , Jacqueline M. Barker","doi":"10.1016/j.addicn.2025.100208","DOIUrl":"10.1016/j.addicn.2025.100208","url":null,"abstract":"<div><div>Cocaine use disorders (CUDs) and human immunodeficiency virus (HIV) remain persistent public health dilemmas throughout the world. Cocaine seeking increases over a protracted period of abstinence, an effect known as the incubation of craving. Little is known about how HIV may modulate this process. Thus, we sought to examine the impact of chronic HIV infection on the incubation of cocaine craving and associated changes in the expression levels of central neuroimmune and peripheral immune substrates. Here, male mice were inoculated with EcoHIV, which is a chimeric HIV-1 construct that produces chronic HIV infection in mice. Mice were conditioned with cocaine daily or intermittently in a conditioned place preference (CPP) paradigm, followed by 1 or 21 days of forced abstinence prior to assessing preference for the cocaine-paired chamber. Mice conditioned daily exhibited potentiated incubation of cocaine CPP after 21 days of abstinence, and EcoHIV increased cocaine CPP across the test session at both abstinence timepoints. Conversely, EcoHIV-infected mice conditioned intermittently showed higher cocaine seeking after 1 day of abstinence compared to 21 days. Analysis of corticolimbic CX3CL1-CX3CR1 and glutamate receptor expression revealed a positive relationship between cocaine seeking and medial prefrontal cortex (mPFC) CX3CL1 and GluA1, as well as a nucleus accumbens (NAc) GluN2A expression. Moreover, examination of peripheral immune markers showed that the effect of abstinence and EcoHIV infection on these measures depended on the cocaine exposure regimen. Altogether, these results highlight the importance of cocaine abstinence and exposure pattern as critical variables that modulate HIV-associated neuroimmune outcomes and relapse vulnerability.</div></div>","PeriodicalId":72067,"journal":{"name":"Addiction neuroscience","volume":"15 ","pages":"Article 100208"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143881943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0