Acta virologica最新文献_第6页

Insights into the factors affecting synonymous codon usage bias in the coat protein of soil-borne sugar beet-infecting viruses 土传甜菜侵染病毒外壳蛋白同义密码子使用偏向性影响因素的研究

IF 1.7 4区医学

Acta virologica Pub Date : 2022-01-01 DOI: 10.4149/av_2022_402

S. Farzadfar, R. Pourrahim

引用次数: 0

Interaction between proteins of the PPARγ and NFκB immune response pathways and rotavirus non-structural proteins. PPARγ和NFκB免疫反应通路蛋白与轮状病毒非结构蛋白的相互作用。

IF 1.7 4区医学

Acta virologica Pub Date : 2022-01-01 DOI: 10.4149/av_2022_105

Dory Gómez, C. Guerrero

引用次数: 0

A gene expression signature that correlates with CD8+T cell expansion in acute Epstein-Barr virus infection. 急性eb病毒感染中与CD8+T细胞扩增相关的基因表达特征

IF 1.7 4区医学

Acta virologica Pub Date : 2022-01-01 DOI: 10.4149/av_2022_303

Yijing Chen, Hanqing Wang, Xia Liu, Bing Luo

引用次数: 0

Genomic profiling of three progenies isolated from a swarm of eGFP-tagged canine distemper viruses undergoing 40 serial passages 从一群egfp标记的犬瘟热病毒中分离出的三个子代进行40次连续传代的基因组分析

IF 1.7 4区医学

Acta virologica Pub Date : 2022-01-01 DOI: 10.4149/av_2022_408

Shuning Zhou, Ling Wang, Jiahui Lin, Ning Wang, Yongle Yu, Youming Zhang, Fuxiao Liu

引用次数: 0

Simultaneous detection of velogenic Newcastle disease virus of genotype XIII 2.2 from spot-billed pelican and backyard chicken: implications to the viral maintenance and spread. 在斑嘴鹈鹕和家鸡中同时检测到基因型为XIII 2.2的新城疫病毒:对病毒维持和传播的意义。

IF 1.7 4区医学

Acta virologica Pub Date : 2022-01-01 DOI: 10.4149/av_2022_305

Deepthi Balam, Ratnamma Doddamane, Ramani Pushpa Rayudu, Shrikrishna Isloor, Veeregowda Belamaranahally, Himaja Maddireddy, Muralidhar Metta

{"title":"Simultaneous detection of velogenic Newcastle disease virus of genotype XIII 2.2 from spot-billed pelican and backyard chicken: implications to the viral maintenance and spread.","authors":"Deepthi Balam, Ratnamma Doddamane, Ramani Pushpa Rayudu, Shrikrishna Isloor, Veeregowda Belamaranahally, Himaja Maddireddy, Muralidhar Metta","doi":"10.4149/av_2022_305","DOIUrl":"https://doi.org/10.4149/av_2022_305","url":null,"abstract":"Despite the widespread occurence of Newcastle disease virus (NDV) in different avian species, there has been scanty reports on genetic characterization of NDV strains from wild birds in India. During 2017-18, a total of forty eight cloacal swab samples were collected from apparently healthy migratory birds (painted storks, n = 32 and spot-billed pelicans, n = 16) at the Telineelapuram bird sanctuary of Andhra Pradesh, India. NDV was isolated from a spot-billed pelican (NDV/Pelican/Telineelapuram/2018) which is genetically identical to that isolated from a naturally infected backyard chicken flock (NDV/Chicken/SKLM-1/2018). The isolates are found to be velogenic based on mean death time, intracerebral pathogenicity index and the putative fusion protein cleavage site (112R-R-R-K-R-F117). Phylogenetic analysis based on full-length fusion gene classified the isolates into genotype XIII, sub-genotype 2.2, however these isolates demonstrated multiple amino acid substitutions in the critical domains of F and HN proteins. The pelican strain (MIG-9) was tested for its pathogenic and transmission potential in three-weeks-old broiler chickens and the isolate proved to be highly virulent to chickens. To the best of our knowledge, this is the first evidence for the role of spot-billed pelicans in the maintenance of virulent NDV and its transmission to chickens in India. This study further highlights the role of wild birds in NDV transmission and the need for enhanced biosecurity in commercial poultry operations. Keywords: Newcastle disease virus; Pelecanus philippensis; chicken; transmission; pathogenicity; India.","PeriodicalId":7205,"journal":{"name":"Acta virologica","volume":"66 3","pages":"238-248"},"PeriodicalIF":1.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40447093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Molecular identification and characterization of badnaviruses infecting sugarcane in Ethiopia. 侵染埃塞俄比亚甘蔗的恶性病毒的分子鉴定和鉴定。

IF 1.7 4区医学

Acta virologica Pub Date : 2022-01-01 DOI: 10.4149/av_2022_101

Simatsidk Haregu, D. Kidanemariam, A. Abraham

{"title":"Molecular identification and characterization of badnaviruses infecting sugarcane in Ethiopia.","authors":"Simatsidk Haregu, D. Kidanemariam, A. Abraham","doi":"10.4149/av_2022_101","DOIUrl":"https://doi.org/10.4149/av_2022_101","url":null,"abstract":"Sugarcane bacilliform virus (SCBV) is an economically important virus limiting sugarcane production worldwide. Although Ethiopia is a major sugarcane producer, and virus-like symptoms are frequently observed in sugarcane fields, there is a complete lack of information as to the occurrence, distribution and molecular properties of SCBV. This study was aimed to identify and characterize SCBV isolates in Ethiopia using molecular methods. Out of 292 leaf samples collected and tested by PCR, 76 samples (26% incidence level) were found SCBV-positive. Nucleotide sequence analysis results showed that three Ethiopian isolates (SCBV-EtS3, SCBV-EtS6 and SCBV-EtC10) shared high level of nucleotide identity (99.5-100%) among themselves and with SCBV isolates from China (accession numbers MH037614 and MH037915). Another isolate, SCBV-EtC2, shared maximum identity of 78% with the other three SCBV isolates from Ethiopia and 99.8% with SCBV isolates from China (KM214357 and KM214307). Based on phylogenetic analysis, isolates from Ethiopia were segregated into two different clusters. Isolates SCBV-EtS3, SCBV-EtS6 and SCBV-EtC10 clustered with SCBV-Q group and SCBV-EtC2 with SCBV-H group. This study provides information on the occurrence of SCBV for the first time in Ethiopia and also contributes to the understanding of the genetic diversity of SCBV. Keywords: Caulimoviridae; RNase H, Saccharum spp.; Sugarcane bacilliform virus.","PeriodicalId":7205,"journal":{"name":"Acta virologica","volume":"66 1 1","pages":"3-10"},"PeriodicalIF":1.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70877031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Transcriptomic analyses reveal highly conserved plant amalgavirus genomes in different species of Allium. 转录组学分析显示葱属植物中汞齐病毒基因组高度保守。

IF 1.7 4区医学

Acta virologica Pub Date : 2022-01-01 DOI: 10.4149/av_2022_102

J. A. D. dos Santos, A. M. F. Silva, Júlio Carlos Polimeni de Mesquita, R. Blawid

引用次数: 1

Integrase deletion mutation impairs the Gag cleavage in prototype foamy virus 整合酶缺失突变影响泡沫病毒原型Gag的裂解

IF 1.7 4区医学

Acta virologica Pub Date : 2022-01-01 DOI: 10.4149/av_2022_401

Jinsun Kim, C. Shin

引用次数: 0

Molecular characterization of a ssRNA mycovirus isolated from the forest pathogenic fungus Armillaria ostoyae. 从森林致病真菌蜜环菌分离的ssRNA分枝病毒的分子特征。

IF 1.7 4区医学

Acta virologica Pub Date : 2022-01-01 DOI: 10.4149/av_2022_309

Tomáš Tonka, Lucie Walterová, Ondřej Hejna, Vladislav Čurn

引用次数: 1

The induction of virus-neutralizing antibodies in influenza A-infected mice treated with Oseltamivir phosphate: effect of dosage and scheduling. 磷酸奥司他韦在甲型流感感染小鼠体内诱导病毒中和抗体:剂量和时间安排的影响。

IF 1.7 4区医学

Acta virologica Pub Date : 2022-01-01 DOI: 10.4149/av_2022_312

Miriam Mikušová, Karolína Tomčíková, Katarína Briestenská, Eva Varečková

{"title":"The induction of virus-neutralizing antibodies in influenza A-infected mice treated with Oseltamivir phosphate: effect of dosage and scheduling.","authors":"Miriam Mikušová, Karolína Tomčíková, Katarína Briestenská, Eva Varečková","doi":"10.4149/av_2022_312","DOIUrl":"https://doi.org/10.4149/av_2022_312","url":null,"abstract":"Oseltamivir phosphate (OS) is currently the most frequently used influenza antiviral drug. It moderates the course of influenza virus type A (IAV) infection, however, its impact on the induction of virus-neutralizing antibodies (VNAbs) is not understood in details. Here, we examined the influence of low (10 mg/kg) or high (60 mg/kg) doses of OS on the viral titer in lungs of BALB/c mice infected with 0.5 LD50 of IAV and on the level of VNAbs. Prophylactic application of OS (6 h before the infection) delayed the increase of viral titer in lungs with a lower peak in comparison to non-treated control mice. After therapeutic OS application (44 h after the infection), maximum of virus titer did not significantly change. However, the induction of VNAbs strongly decreased, to 16.7%-18.1% of the control, after preventive application of high OS dose. A minimal decrease of VNAbs titers was observed in groups of mice treated with low dose of OS applied therapeutically. They lowered to 91.1% / 14 or to 94.1% / 21 days post infection (p.i.) of VNAbs titers of non-treated control mice. In all other groups, levels of VNAbs titers dropped to 26.5-53.7% of those of non-treated mice. It should be noted that VNAbs titers were in direct proportion to maximal virus titers in mouse lungs of corresponding groups. In summary, after OS application the clinical symptoms of the disease were milder or non-observable in all OS-treated groups, but the lowering of VNAbs titers was dependent on the OS dose and interval between drug app-lication and the start of infection. Keywords: influenza A virus; Oseltamivir; prophylactic treatment; therapeutic treatment; virus-neutralizing antibodies.","PeriodicalId":7205,"journal":{"name":"Acta virologica","volume":"66 3","pages":"281-286"},"PeriodicalIF":1.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40447098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0