急性eb病毒感染中与CD8+T细胞扩增相关的基因表达特征

IF 1.1 4区医学 Q4 VIROLOGY

Acta virologica Pub Date : 2022-01-01 DOI:10.4149/av_2022_303

Yijing Chen, Hanqing Wang, Xia Liu, Bing Luo

{"title":"急性eb病毒感染中与CD8+T细胞扩增相关的基因表达特征","authors":"Yijing Chen, Hanqing Wang, Xia Liu, Bing Luo","doi":"10.4149/av_2022_303","DOIUrl":null,"url":null,"abstract":"Acute infectious mononucleosis (AIM) is associated with Epstein-Barr virus (EBV) infection. We explored molecular mechanisms regarding the expression of CD8+T cells in convalescence stage (CONV). Differentially expressed genes (DEGs) were identified by analyzing GEO expression profiles. Subsequently, Gene Set Enrichment Analysis (GSEA), Protein-Protein Interactions (PPI) network, and gene-micro RNAs networks were used to identify hub genes and associated pathways. GSEA provided evidence that the top 3 gene sets in GSEA were all related to integrins. We identified ten hub genes in the PPI network and DGIdb was applied to predict potential targets that might reverse the expression of hub genes. Our study enhances a mechanistic understanding of the CD8+T cells expansion in acute EBV infection and provides potential treatment targets for further research. Keywords: acute infectious mononucleosis; bioinformatics; CD8+T cells; differentially expressed genes; EBV.","PeriodicalId":7205,"journal":{"name":"Acta virologica","volume":"66 3","pages":"216-227"},"PeriodicalIF":1.1000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A gene expression signature that correlates with CD8+T cell expansion in acute Epstein-Barr virus infection.\",\"authors\":\"Yijing Chen, Hanqing Wang, Xia Liu, Bing Luo\",\"doi\":\"10.4149/av_2022_303\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Acute infectious mononucleosis (AIM) is associated with Epstein-Barr virus (EBV) infection. We explored molecular mechanisms regarding the expression of CD8+T cells in convalescence stage (CONV). Differentially expressed genes (DEGs) were identified by analyzing GEO expression profiles. Subsequently, Gene Set Enrichment Analysis (GSEA), Protein-Protein Interactions (PPI) network, and gene-micro RNAs networks were used to identify hub genes and associated pathways. GSEA provided evidence that the top 3 gene sets in GSEA were all related to integrins. We identified ten hub genes in the PPI network and DGIdb was applied to predict potential targets that might reverse the expression of hub genes. Our study enhances a mechanistic understanding of the CD8+T cells expansion in acute EBV infection and provides potential treatment targets for further research. Keywords: acute infectious mononucleosis; bioinformatics; CD8+T cells; differentially expressed genes; EBV.\",\"PeriodicalId\":7205,\"journal\":{\"name\":\"Acta virologica\",\"volume\":\"66 3\",\"pages\":\"216-227\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta virologica\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.4149/av_2022_303\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"VIROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta virologica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4149/av_2022_303","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"VIROLOGY","Score":null,"Total":0}

引用次数: 0

摘要

急性传染性单核细胞增多症(AIM)与eb病毒(EBV)感染有关。我们探讨了CD8+T细胞在恢复期(CONV)表达的分子机制。通过分析GEO表达谱，鉴定出差异表达基因(DEGs)。随后，利用基因集富集分析(GSEA)、蛋白-蛋白相互作用(PPI)网络和基因-微rna网络鉴定中心基因及其相关途径。GSEA提供的证据表明，GSEA中排名前3位的基因集均与整合素相关。我们在PPI网络中鉴定了10个枢纽基因，并应用DGIdb来预测可能逆转枢纽基因表达的潜在靶点。我们的研究增强了对急性EBV感染中CD8+T细胞扩增的机制理解，并为进一步研究提供了潜在的治疗靶点。关键词:急性传染性单核细胞增多症;生物信息学;CD8 + T细胞;差异表达基因;EBV。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

A gene expression signature that correlates with CD8+T cell expansion in acute Epstein-Barr virus infection.

Acute infectious mononucleosis (AIM) is associated with Epstein-Barr virus (EBV) infection. We explored molecular mechanisms regarding the expression of CD8+T cells in convalescence stage (CONV). Differentially expressed genes (DEGs) were identified by analyzing GEO expression profiles. Subsequently, Gene Set Enrichment Analysis (GSEA), Protein-Protein Interactions (PPI) network, and gene-micro RNAs networks were used to identify hub genes and associated pathways. GSEA provided evidence that the top 3 gene sets in GSEA were all related to integrins. We identified ten hub genes in the PPI network and DGIdb was applied to predict potential targets that might reverse the expression of hub genes. Our study enhances a mechanistic understanding of the CD8+T cells expansion in acute EBV infection and provides potential treatment targets for further research. Keywords: acute infectious mononucleosis; bioinformatics; CD8+T cells; differentially expressed genes; EBV.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Acta virologica 医学-病毒学

CiteScore

3.10

自引率

11.80%

发文量

审稿时长

>12 weeks

期刊介绍： Acta virologica is an international journal of predominantly molecular and cellular virology. Acta virologica aims to publish papers reporting original results of fundamental and applied research mainly on human, animal and plant viruses at cellular and molecular level. As a matter of tradition, also rickettsiae are included. Areas of interest are virus structure and morphology, molecular biology of virus-cell interactions, molecular genetics of viruses, pathogenesis of viral diseases, viral immunology, vaccines, antiviral drugs and viral diagnostics.