Acta poloniae pharmaceutica最新文献_第7页

COMPLEX-FORMING PROPERTIES OF SYNTHETIC PYRIMIDINONE NUCLEOSIDES WITH Ag(I) IONS IN AN AQUEOUS SOLUTION 水溶液中合成嘧啶酮核苷与Ag（I）离子的络合性质

IF 0.4 4区医学

Acta poloniae pharmaceutica Pub Date : 2023-04-28 DOI: 10.32383/appdr/162766

M. Pająk, M. Woźniczka, M. Świątek, Bartłomiej Czerwiński, J. Włodarczyk, J. Fichna

{"title":"COMPLEX-FORMING PROPERTIES OF SYNTHETIC PYRIMIDINONE NUCLEOSIDES WITH Ag(I) IONS IN AN AQUEOUS SOLUTION","authors":"M. Pająk, M. Woźniczka, M. Świątek, Bartłomiej Czerwiński, J. Włodarczyk, J. Fichna","doi":"10.32383/appdr/162766","DOIUrl":"https://doi.org/10.32383/appdr/162766","url":null,"abstract":"The present work describes the complexation properties of two synthetic nucleosides (used as ligands), i.e. β-D-ribofuranoside-4-pyrimidinone (ribo) and β-D-deoxyribofuranoside-4-pyrimidinone (deoxy) with Ag(I) ions in aqueous solution. The stability constants of the studied coordination entities were calculated potentiometrically. The logarithm values of the overall stability constants of the coordination entities were found to be [Ag-deoxy]+ = 3.07, [Ag-(deoxy)2]+ = 6.90, [Ag-ribo]+ = 3.00 and [Ag-(ribo)2]+ = 6.63. Based on the species distribution curves as a function of CL/CM, the percentage of each coordination entity formed in aqueous solution was estimated (12 % [Ag-deoxy]+; 36 % [Ag-(deoxy)2]+; 16 % [Ag-ribo]+; 26 % [Ag-(ribo)2]+). It was found that the ligands form coordination entities with Ag(I) ions with stoichiometric ratios M : L = 1 : 1 and 1 : 2. Such coordination entities may show potential antiviral, antibacterial, and antitumor properties, which warrants further in vitro and in vivo studies. They may also be of great interest for their application in nanobiotechnology.","PeriodicalId":7147,"journal":{"name":"Acta poloniae pharmaceutica","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45510200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A combination of simvastatin and low-protein diet increases renal 2-oxoglutarate dehydrogenase activity in rats 辛伐他汀和低蛋白饮食联合使用可增加大鼠肾脏2-氧戊二酸脱氢酶活性

IF 0.4 4区医学

Acta poloniae pharmaceutica Pub Date : 2023-03-03 DOI: 10.32383/appdr/159789

Małgorzata Belczyk, M. Knapik-Czajka, A. Gawedzka, K. Mikołajczyk, J. Drag

{"title":"A combination of simvastatin and low-protein diet increases renal 2-oxoglutarate dehydrogenase activity in rats","authors":"Małgorzata Belczyk, M. Knapik-Czajka, A. Gawedzka, K. Mikołajczyk, J. Drag","doi":"10.32383/appdr/159789","DOIUrl":"https://doi.org/10.32383/appdr/159789","url":null,"abstract":"Mitochondrial 2-oxoglutarate dehydrogenase complex (2-OGDH) that consists of multiple copies of 3 catalytic subunits (E1, E2, E3) is a regulatory enzyme of tricarboxylic acid cycle. 2-OGDH together with branched chain α-ketoacid dehydrogenase (BCKDH) and pyruvate dehydrogenase (PDH) belongs to the 2-oxoacid dehydrogenases family. It was shown that in protein-restricted rats simvastatin stimulated liver BCKDH, whereas it exerted no effect on BCKDH in rats fed a standard diet. We hypothesized that combination of simvastatin and low-protein diet could have an impact on renal 2-OGDH. The purpose of the study was to determine the effect of combination of simvastatin and low-protein diet on renal 2-OGDH in rats. Simvastatin (80 mg/kg b.wt/day) or the vehicle (0.3% methylcellulose) were administered orally (for 14 days) to rats fed low-protein (8% protein) or standard (23% protein) diet. 2-OGDH activity, protein levels and mRNA levels for E1 and E2 subunits were determined. In addition, serum creatinine level was measured. Results: The combination of simvastatin and low-protein diet elicited the increase of renal 2-OGDH activity that corresponded to the increase of E1 protein, but not of E1 mRNA level. In contrast, simvastatin treatment did not affect 2-OGDH activity, nor protein and mRNA levels of E1 in rats fed standard diet. Serum creatinine levels were not changed upon simvastatin administration in any group. In conclusion, the results of present study indicate that combination of simvastatin and low-protein diet induces stimulation of renal 2-OGDH complex probably at post-transcriptional level.","PeriodicalId":7147,"journal":{"name":"Acta poloniae pharmaceutica","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47605321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative chirality in the binding of androgens to their receptor 雄激素与其受体结合的定量手性

IF 0.4 4区医学

Acta poloniae pharmaceutica Pub Date : 2023-03-03 DOI: 10.32383/appdr/161082

Piotr F. J. Lipiński, J. Dobrowolski, A. Baraniak

引用次数: 0

Validated HPLC-UV method for determination of venlafaxine and its metabolite - o-desmethylvenlafaxine in human plasma HPLC-UV法测定人血浆中文拉法辛及其代谢产物邻去甲基文拉法辛的含量

IF 0.4 4区医学

Acta poloniae pharmaceutica Pub Date : 2023-03-03 DOI: 10.32383/appdr/159659

T. Pawiński, I. Szlaska, Monika Kukiełka, Kinga Kośnik

引用次数: 0

Acetylcholinesterase inhibitors: structure-activity relationship and kinetic studies on selected flavonoids 乙酰胆碱酯酶抑制剂:部分黄酮类化合物的构效关系及动力学研究

IF 0.4 4区医学

Acta poloniae pharmaceutica Pub Date : 2023-03-03 DOI: 10.32383/appdr/159798

K. Jakimiuk, Diana Nazaruk, M. Tomczyk

引用次数: 1

Study of glycopyrrolate dry powder behavior in new single dose inhalers under generic product development 仿制产品开发中新型单剂量吸入器中甘罗酸干粉行为的研究

IF 0.4 4区医学

Acta poloniae pharmaceutica Pub Date : 2023-03-03 DOI: 10.32383/appdr/160204

Jakub Strzemieczny, Bogusława Musiał, Agnieszka Pawlaczyk, M. Sznitowska, D. Siluk

{"title":"Study of glycopyrrolate dry powder behavior in new single dose inhalers under generic product development","authors":"Jakub Strzemieczny, Bogusława Musiał, Agnieszka Pawlaczyk, M. Sznitowska, D. Siluk","doi":"10.32383/appdr/160204","DOIUrl":"https://doi.org/10.32383/appdr/160204","url":null,"abstract":"With increasing environmental pollution and tendency to smoking, the number of patients suffering from chronic obstructive pulmonary disease is increasing and a demand for generic products for the treatment of chronic obstructive pulmonary disease (COPD) is growing. The long process of generic formulation development can be accelerated by using an inhaler with suitable fluid dynamics features. This paper presents a study of a newly patented single-dose Memmatec Mora® inhaler in two versions: with grid openings 1.0 (A) and 0.5 mm (B), using Seebri Breezhaler® as a reference product. The studies were conducted with inhalation powders containing 44μg glycopyrronium bromide placed in a capsule. The manuscript presents studies during the selection of a generic inhaler within the course of inhalation powder development by a pharmaceutical company. The fluid dynamics features of the inhalers and the dose delivered were determined. The aerodynamic particle size distribution (APSD) and the inhalable dose were tested using a cascade impactor. The delivery dose for the Breezhaler, Mora A and Mora B inhalers for a volumetric flow of 100 L×min-1 was 38.5, 40.5 40.3μg, respectively. Fine particle fraction of the inhalers tested was 22.3, 24.6 25.5μg, respectively. Results of the study indicate that increase of the glycopyrronium bromide inhalation dose can be achieved not only by changes in the manufacturing technology of inhalation powder, hard capsule technology or addition of best quality raw materials, but also by the use of a properly selected inhaler with specific fluid dynamics features.","PeriodicalId":7147,"journal":{"name":"Acta poloniae pharmaceutica","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47378679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimization of chromatographic systems for detection and determination of carbamazepine in pharmaceutical formulations, serum, and saliva by HPLC-DAD HPLC-DAD法检测和测定制剂、血清和唾液中卡马西平的色谱系统优化

IF 0.4 4区医学

Acta poloniae pharmaceutica Pub Date : 2023-03-03 DOI: 10.32383/appdr/161081

K. Wróblewski, I. Dybała, A. Petruczynik, M. Szultka-Młyńska, Daria Janiszewska, J. Rog, H. Karakuła-Juchnowicz, D. Juchnowicz, B. Buszewski

{"title":"Optimization of chromatographic systems for detection and determination of carbamazepine in pharmaceutical formulations, serum, and saliva by HPLC-DAD","authors":"K. Wróblewski, I. Dybała, A. Petruczynik, M. Szultka-Młyńska, Daria Janiszewska, J. Rog, H. Karakuła-Juchnowicz, D. Juchnowicz, B. Buszewski","doi":"10.32383/appdr/161081","DOIUrl":"https://doi.org/10.32383/appdr/161081","url":null,"abstract":"Carbamazepine (CBZ) is an anticonvulsant drug, widely used also in various disorders like neuropathic pain, bipolar affective disorder, resistant schizophrenia, and trigeminal neuralgia. Appropriate analytical procedures are necessary to monitor, detect and quantify CBZ in pharmaceutical formulations and biological samples. The search for new methods for drug determination is one of the most important challenges of modern scientific research. It is important to study the chromatographic conditions of CBZ analysis, which is necessary for the further development of efficient drug determination methods. In this work, retention, peak symmetry, and system efficiency of CBZ on Polar RP and Phenyl-Hexyl stationary phases were investigated. Various mobile phases containing methanol (MeOH) and/or acetonitrile (ACN) as organic modifiers, acetate buffer, and the addition of diethylamine (DEA) were applied. Different chromatographic systems were compared to obtain satisfying retention, peak shape, and system efficiency. The most optimal chromatographic system with Polar RP column was applied for the determination of CBZ in pharmaceutical formulations, human serum, and saliva by the high-performance liquid chromatography with diode array detection (HPLC-DAD) method. Solid-phase extraction (SPE) method was applied for sample preparation prior to chromatographic analysis. The proposed method was validated for linearity, selectivity, precision, and accuracy. Confirmation of the presence of CBZ and its main metabolites in biological samples obtained from patients was performed using the ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method.","PeriodicalId":7147,"journal":{"name":"Acta poloniae pharmaceutica","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43426622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and characterization of fast-release oral film formulation containing ondansetron hydrochloride solid dispersion 含盐酸昂丹司琼固体分散体口服快释薄膜制剂的制备与表征

IF 0.4 4区医学

Acta poloniae pharmaceutica Pub Date : 2023-03-03 DOI: 10.32383/appdr/161039

Ting Wei, Zhongxi Zhao, Ya Zhao

{"title":"Preparation and characterization of fast-release oral film formulation containing ondansetron hydrochloride solid dispersion","authors":"Ting Wei, Zhongxi Zhao, Ya Zhao","doi":"10.32383/appdr/161039","DOIUrl":"https://doi.org/10.32383/appdr/161039","url":null,"abstract":"Ondansetron has been widely applied as an antiemetic drug in the treatment or prevention of nausea and vomiting caused by emetic cancer chemotherapy . Fast-release films have the advantages of rapid drug release and improved patients’compliance, especially for the disabled bedridden, the elderly or pediatric patients.The basic film-forming materials were studied through single factor tests and the crystal inhibitors were optimized using solid dispersion technique. The ratio of drug and polymers were optimized by X-ray diffraction (XRD) and Differential Scanning Calorimetry (DSC) which revealed there was no presence of crystal in the optimized solid dispersion. The final film was white thin films and was smooth in surface without obvious bubbles or cracks. Mean weight of each film was 40~50mg. Mean thichness was 60~70μm. Surface pH was 6.4~6.6. The films could release 85% of drug with 1.5min in 0.1mol/L HCl and within 30min in pH6.8PBS. Pharmacolinetic experiment of Ondansetron Hydrochloric solution, marketed films Zuplenz® and the preparation were carried out in rats. As a result, the films of Ondansetron Hydrochloric containing ondansetron solid dispersion had the advantages of fast drug release, improved patient compliance, higher bioavalibility compared to oral solution and the marketed films.","PeriodicalId":7147,"journal":{"name":"Acta poloniae pharmaceutica","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46425279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Food preparation methods contribution to skin aging: a systematic review 食品制备方法对皮肤衰老的影响：系统综述

IF 0.4 4区医学

Acta poloniae pharmaceutica Pub Date : 2023-03-03 DOI: 10.32383/appdr/159417

M. Filipovic, D. Pecarski, J. Djordjević, M. Ivanović, V. Ilic, M. Lukić

{"title":"Food preparation methods contribution to skin aging: a systematic review","authors":"M. Filipovic, D. Pecarski, J. Djordjević, M. Ivanović, V. Ilic, M. Lukić","doi":"10.32383/appdr/159417","DOIUrl":"https://doi.org/10.32383/appdr/159417","url":null,"abstract":"Aging of the skin is a complex and multifactorial biological process, affected by different intrinsic and extrinsic factors. Exogenous factors affecting the process of skin aging, together with nutrition, are topics which currently draw considerable attention. Although it is difficult to accurately define what presents a healthy diet for maintenance of youthful skin, considering the evident lack of clinical data and studies in humans, there are numerous evidence suggesting that the food we eat affects our skin aging and its’ appearance. Well-documented is a fact that the modern diet is a large source of advanced glycation end products and reactive oxygen species – compounds formed during certain food preparation methods which accumulation is associated with different disease and recently, skin aging as well. This review gives the current state of knowledge related to the role which advanced glycation end products and reactive oxygen species, formed during the certain food preparation methods, have in the mechanisms of the premature/extrinsic skin aging. Additionally, it summarizes available information, in the form of recommendations for both the public and nutritional professionals who have an interest in this field, regarding food preparation methods and practices which prevent formation of aforementioned compounds in food and consequently could reduce the food contribution to premature skin aging.","PeriodicalId":7147,"journal":{"name":"Acta poloniae pharmaceutica","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42628221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Temozolomide: a cytostatic drug that is still important today 替莫唑胺：一种至今仍很重要的细胞抑制药物

IF 0.4 4区医学

Acta poloniae pharmaceutica Pub Date : 2023-03-03 DOI: 10.32383/appdr/159449

Kamil Dyrka, A. Czarnywojtek, M. Borowska, Jeremi Kościński, J. Moskal, N. Sawicka-Gutaj, A. Lewandowska, S. V. Van Gool, M. Fichna, P. Gut, K. Pietrończyk, Patryk Graczyk, M. Dworacka

{"title":"Temozolomide: a cytostatic drug that is still important today","authors":"Kamil Dyrka, A. Czarnywojtek, M. Borowska, Jeremi Kościński, J. Moskal, N. Sawicka-Gutaj, A. Lewandowska, S. V. Van Gool, M. Fichna, P. Gut, K. Pietrończyk, Patryk Graczyk, M. Dworacka","doi":"10.32383/appdr/159449","DOIUrl":"https://doi.org/10.32383/appdr/159449","url":null,"abstract":"TMZ has an advantage over other traditional alkylating agents (carmustine, lomustine, procarbazine), which are highly toxic and have poor patient survival. TMZ circumvents these problems because cytochrome P450 enzymes and the kidneys are not involved in its metabolism, it has predictable side effects (nausea, vomiting, thrombocytopenia, neutropenia), which are usually reversible and only mild to moderate, have been widely described.\u0000About half of patients treated with TMZ have high drug resistance induced by activity of O6-methylguanine methyltransferase. Cancer stem cells (CSCs), which are found among the neoplastic cell population, have also been shown to be responsible for resistance to TMZ. Additionally, acquired immunity, induced by TMZ’s epigenetic and genetic alterations, may develop. Currently, there are new therapeutic strategies for GBM based on nanotechnology, which are aimed at improving TMZ treatment (e.g. the use of apolipoprotein), or other techniques (siRNA, which increases the oxygen level in the tumour).\u0000Thus, although TMZ was discovered more than three decades ago, this drug will be used to treat not only GBM, but also a large number of neoplastic pathologies. Further research focused on understanding the mechanisms of action and resistance to TMZ is required to improve its clinical application today and in the future.\u0000\u0000Keywords: alkylating agents, drug resistance, chemotherapy, nanoparticles, cancer, glioblastoma multiforme","PeriodicalId":7147,"journal":{"name":"Acta poloniae pharmaceutica","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46043449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0