Acta poloniae pharmaceutica最新文献_第6页

EVALUATION OF ANTIBACTERIAL ACTIVITY 5-AMINO-3-METHYLISOXAZOLE-4-CARBOHYDRAZIDE AND 5-AMINOISOXAZOLE[5,4-d]PYRIMIDIN-4-ONE DERIVATIVES 5-氨基-3-甲基异恶唑-4-羧酸和5-氨基异恶唑[5,4-d]嘧啶-4-酮衍生物的抗菌活性评价

IF 0.4 4区医学

Acta poloniae pharmaceutica Pub Date : 2023-05-04 DOI: 10.32383/appdr/162790

M. Mączyński, A. Regiec, Paulina Płoszaj, Miroslawa Kacaniova, A. Piwowar

{"title":"EVALUATION OF ANTIBACTERIAL ACTIVITY 5-AMINO-3-METHYLISOXAZOLE-4-CARBOHYDRAZIDE AND \u00005-AMINOISOXAZOLE[5,4-d]PYRIMIDIN-4-ONE DERIVATIVES","authors":"M. Mączyński, A. Regiec, Paulina Płoszaj, Miroslawa Kacaniova, A. Piwowar","doi":"10.32383/appdr/162790","DOIUrl":"https://doi.org/10.32383/appdr/162790","url":null,"abstract":"Searching for new compounds with specific biological activity in relation to various bacterial strains due to the increasing number of bacterial infections and the frequently developing antimicrobial resistance (AMR) is a significant problem in healthcare. Based on previous promising research related to the activity of isoxazole-4-carbohydrazide derivatives, we currently examined different substituted isoxazole-4-carbohydrazide derivatives in vitro against a panel of bacterial strains. In this work we evaluated antibacterial activity of 30 derivatives, previously described as mildly antimycobacterial, in 10 bacterial strains (5 Gram-negative (G-) and Gram-postive (G+) bacterias). Based on minimum inhibitory concentration (MIC), the mainly MIC50 and MIC90 values, the tested derivatives generally have shown rather weak and mild antibacterial activity. The most active compounds were 3d and 4d, both with methyl substituent in benzene ring. More detailed examination should be continued but this research increased the library of isoxazole derivatives with broad biological activity.","PeriodicalId":7147,"journal":{"name":"Acta poloniae pharmaceutica","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42472572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validated stability-indicating RP-HPLC assay method for fesoterodine fumarate in pharmaceutical products 药品中富马酸非索特罗定稳定性指示RP-HPLC测定方法验证

IF 0.4 4区医学

Acta poloniae pharmaceutica Pub Date : 2023-05-04 DOI: 10.32383/appdr/163015

O. Pınarbaşlı, Tolga Ozbay, G. Gurbetoğlu, Nagehan Sarraçoğlu, A. Doganay

{"title":"Validated stability-indicating RP-HPLC assay method for fesoterodine fumarate in pharmaceutical products","authors":"O. Pınarbaşlı, Tolga Ozbay, G. Gurbetoğlu, Nagehan Sarraçoğlu, A. Doganay","doi":"10.32383/appdr/163015","DOIUrl":"https://doi.org/10.32383/appdr/163015","url":null,"abstract":"The goal of the current study was to develop a precise, sensitive and validated reverse phase HPLC method for determination of fesoterodine fumarate (FST). The current investigation was performed for a stability indicating method in order to obtain both assay and impurity profiles of FST. All the experiment was done on HPLC Shimadzu Prominence 20A having stainless steel ACE5 C18 column with a particle size of 5µm and a dimension of 4.6 mm X 150 mm. The mobile phase was in gradient mode with mobile phase A (0.03M ammonium acetate buffer : acetonitrile : methanol (55:30:15 v/v) pH 3.8) and mobile phase B (water) . The flow rate was 1.2 mL/min and the wavelength 208 nm was selected for detection. This method was validated for linearity and range, accuracy, precision and robustness in accordance with ICH requirements. The retention time of fesoterodine was found as 11.0 min. The main degradation product 5-hydroxymethyltolterodine (5-HMT; active metabolite of FST) and the other process impurities; aldehyde, benzylated hydroxy, tolterodine ester, diester impurities were detected easily at the retention times 3.8, 13.5, 16.7, 21.5, 37.1 minutes, respectively. It was observed that the retention times of the main peak and its impurities were not affected and the selectivity of the method was proved under the applied stress conditions. With this developed method, FST and its impurities can easily be detected. It is also stable, simple, accurate, and completely validated RP-HPLC technique for the analysis of FST and related impurities that meets with ICH standards.","PeriodicalId":7147,"journal":{"name":"Acta poloniae pharmaceutica","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47432535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Propafenone-induced liver injury in an elderly patient with paroxysmal atrial fibrillation--a new case report and literature review 普罗帕酮致老年阵发性心房颤动肝损伤1例新报告并文献复习

IF 0.4 4区医学

Acta poloniae pharmaceutica Pub Date : 2023-04-28 DOI: 10.32383/appdr/162793

Katarzyna Giedzicz, Marcin Dytkowski, Justyna Rentflejsz, M. Świętek, Aleksandra Wojszel, Z. Wojszel

{"title":"Propafenone-induced liver injury in an elderly patient with paroxysmal atrial fibrillation--a new case report and literature review","authors":"Katarzyna Giedzicz, Marcin Dytkowski, Justyna Rentflejsz, M. Świętek, Aleksandra Wojszel, Z. Wojszel","doi":"10.32383/appdr/162793","DOIUrl":"https://doi.org/10.32383/appdr/162793","url":null,"abstract":"Antiarrhythmic drugs are used more and more often, which is related to the aging of the population and the growing number of arrhythmias, especially atrial fibrillation (AF). One of the drugs used in AF is propafenone, considered a relatively safe drug in people without heart disease. Nevertheless, it can cause severe damage to the liver if one ignores the subtle symptoms that indicate an incipient problem. \u0000We present the case of an 82-year-old woman diagnosed with paroxysmal AF who developed acute liver injury during treatment with propafenone. On the fifth day of her hospitalization, we observed nausea and vomiting after introducing regular treatment with propafenone. Similar symptoms occurred before hospitalization when propafenone was taken ad hoc in the event of an AF attack. They were treated as dyspeptics in a patient who underwent cholecystectomy. Laboratory tests showed high serum alanine transaminase, gamma-glutamyltranspeptidase, C-reactive protein, total bilirubin, and a slight increase in aspartate transaminase. Infection with hepatic viruses, alcohol abuse, other drugs toxicity, and intrahepatic cholangitis due to cholelithiasis were excluded as a cause of liver damage. With the discontinuation of propafenone, the patient's clinical condition and laboratory test results improved. Similar cases published in the literature are discussed in the paper. It also draws attention to the need to report adverse drug reactions to the appropriate authorities and discusses the reasons for under-reporting in Poland.","PeriodicalId":7147,"journal":{"name":"Acta poloniae pharmaceutica","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42367557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Research progress on preparation and anti-tumor application of copper sulfide nanocomposites: A review 硫化铜纳米复合材料的制备及其抗肿瘤应用研究进展

IF 0.4 4区医学

Acta poloniae pharmaceutica Pub Date : 2023-04-28 DOI: 10.32383/appdr/157410

Yuanjiao Feng, Home Miao, Xue Zeng, W. Zhong

引用次数: 0

The change of copper, zinc, iodine, and selenium contents in the scalp hair of healthy females and the efficacy of herbal extract shampoo treatment 健康女性头皮发中铜、锌、碘、硒含量的变化及草药提取物洗发效果的研究

IF 0.4 4区医学

Acta poloniae pharmaceutica Pub Date : 2023-04-28 DOI: 10.32383/appdr/161275

B. Oyuntsetseg, Khulan Uranchimeg, D. Munkhbat, Khongorzul Tumurkhuyag, Sukhbold Davaa, E. Yadamsuren, A. Natsagdorj, Uranchimeg Erdenebat

{"title":"The change of copper, zinc, iodine, and selenium contents in the scalp hair of healthy females and the efficacy of herbal extract shampoo treatment","authors":"B. Oyuntsetseg, Khulan Uranchimeg, D. Munkhbat, Khongorzul Tumurkhuyag, Sukhbold Davaa, E. Yadamsuren, A. Natsagdorj, Uranchimeg Erdenebat","doi":"10.32383/appdr/161275","DOIUrl":"https://doi.org/10.32383/appdr/161275","url":null,"abstract":"We investigated shampoo-related changes in levels of some trace elements in the scalp hair of females and their impact on scalp skin properties. Sixty healthy women divided into control and experimental group who used regular shampoo and Urtica cannabina (U.cannabina) extract shampoo, respectively. Scalp skin was examined using an electronic skin analyzer, and trichometric analysis was performed with a Folliscope. The collected scalp hair samples were digested and measured using inductively coupled plasma-mass spectrometry (ICP-MS). The average copper (p=0.05), zinc (p=0.0002), and iodine (p=0.0004) levels increased notably, whereas the selenium content decreased slightly (p=0.337) in the experimental group. We found that the average iodine content in scalp hair of Mongolian females was three times lower than the global average. The average increase in trace elements may be considered to be due to the transfer of an element into the human scalp during shampooing. These results indicate that some trace elements in human scalp hair are not only associated with nutritional status and environmental factors, but cosmetic products can also affect the trace element composition. The hair growth, diameter, and density gradually increased and were higher in the experimental group than in the control group. Scalp skin moisture, sebum, and pH values increased in the experimental group, whereas the control group showed no notable difference. Herbal extracts may potentially support scalp hair growth and increase the hair density. This ability can be explained by the trace elements in the herbal extract, which may play a key role in inducing hair growth.","PeriodicalId":7147,"journal":{"name":"Acta poloniae pharmaceutica","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47622324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enzymatic synthesis and purification of diacylglycerols from mutton tallow and hemp seed oil 酶法从羊脂和大麻籽油中合成和纯化二酰基甘油

IF 0.4 4区医学

Acta poloniae pharmaceutica Pub Date : 2023-04-28 DOI: 10.32383/appdr/157008

M. Kowalska, M. Woźniak, S. Tavernier

{"title":"Enzymatic synthesis and purification of diacylglycerols from mutton tallow and hemp seed oil","authors":"M. Kowalska, M. Woźniak, S. Tavernier","doi":"10.32383/appdr/157008","DOIUrl":"https://doi.org/10.32383/appdr/157008","url":null,"abstract":"Abstract: Production of preparations based on natural ingredients has become a priority in the cosmetic and pharmaceutical industries. The novelty of the study was to present a possible method for obtaining pure diacylglycerols (DAG) from natural raw materials like fats (hemp seed oil and mutton tallow). We have determined the optimum water content for enzymatic interesterification to shift the reaction equilibrium towards hydrolysis and obtain the highest DAG formation yield. Then, DAG were separated and purified by column chromatography. Raw fats were characterized by fatty acids composition and their positional distribution using gas chromatography. Triacylglycerols, diacylglycerols, monoacylglycerols and free fatty acid contents were determined using gel permeation chromatography. The main fatty acids found in sn-2 MAG of hemp seed oil was linoleic acid, which was followed by oleic acid. Saturated fatty acids in hemp seed oil’s TAG showed preference for the outer sn-1,3 positions. For mutton tallow, the majority of oleic acid were found at sn-2 position.\u0000The optimum water content applied during enzymatic interesterification for DAG formation was estimated to be 2.0 % w/w, using the following conditions: 5 % w/w of catalyst, 200 rpm, 60 °C, 6h. DAG yield was 27 %. Purification of the mutton tallow-based and hemp seed oil-based DAG yielded with 83 % w/w and 82 % w/w, respectively. High purity DAG could be applied as effective emulsifiers in food, cosmetic or pharmaceutical emulsions.","PeriodicalId":7147,"journal":{"name":"Acta poloniae pharmaceutica","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69582400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acetylcysteine modulates sphingolipid levels by inhibiting neutral sphingomyelinase during aging in rat tissues 在大鼠组织衰老过程中，乙酰半胱氨酸通过抑制中性鞘磷脂酶调节鞘脂水平

IF 0.4 4区医学

Acta poloniae pharmaceutica Pub Date : 2023-04-28 DOI: 10.32383/appdr/162546

L. Hassouneh, Salameh Aldajah, M. Najdawi, Z. Abudayeh, Qais Abualassal, Amajad aburmelah, Alaa Sirhan

{"title":"Acetylcysteine modulates sphingolipid levels by inhibiting neutral sphingomyelinase during aging in rat tissues","authors":"L. Hassouneh, Salameh Aldajah, M. Najdawi, Z. Abudayeh, Qais Abualassal, Amajad aburmelah, Alaa Sirhan","doi":"10.32383/appdr/162546","DOIUrl":"https://doi.org/10.32383/appdr/162546","url":null,"abstract":"Old-age-associated pathologies usually coincide with altered sphingolipid metabolism. Changes in the level of sphingomyelin (SM) and ceramide are largely determined by the activation of neutral sphingomyelinase (nSMase) during aging. nSMase is a key enzyme in sphingolipid turnover; it generates ceramide through the hydrolysis of SM. While N—acetylcysteine (NAC) is a powerful antioxidant which has anti-inflammatory properties and it is the precursor of glutathione (GSH). The aim of this study is to determine the impact of NAC on nSMase activity in the age-dependent changes of sphingolipid (SM and ceramide) levels and GSH content in blood serum, gastrocnemius muscle and kidney tissue of 24-month-old rats. It was found that the effect of NAC on the tissue of 24-month-old rats increased SM content; GSH content and decreased the ceramide content. The gastrocnemius muscle and kidney were the most sensitive to the effects of NAC. The results show that GSH inhibit the activity of nSMase. These results emphasize that nSMase. plays a key role in age-associated ceramide accumulation in rat tissues during aging. Furthermore, it was indicated that NAC is an effective modulator of nSMase and has pleiotropic effects that may alter sphingolipid metabolism. The nSMase inhibition enhances the benefits of NAC treatment.","PeriodicalId":7147,"journal":{"name":"Acta poloniae pharmaceutica","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41286302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial prospection and density functional study of some phenolic compounds 几种酚类化合物的抗菌前景及密度功能研究

IF 0.4 4区医学

Acta poloniae pharmaceutica Pub Date : 2023-04-28 DOI: 10.32383/appdr/162792

Tataringa Gabriela, Tuchilus Cristina, Zbancioc ANA MARIA

引用次数: 0

Investigation of transdermal permeation behavior of diclofenac sodium microemulsion by confocal laser scanning microscopy 共聚焦激光扫描显微镜研究双氯芬酸钠微乳液的透皮渗透行为

IF 0.4 4区医学

Acta poloniae pharmaceutica Pub Date : 2023-04-28 DOI: 10.32383/appdr/162214

Hui Yang, P. Boonme, T. Amnuaikit

{"title":"Investigation of transdermal permeation behavior of diclofenac sodium microemulsion by confocal laser scanning microscopy","authors":"Hui Yang, P. Boonme, T. Amnuaikit","doi":"10.32383/appdr/162214","DOIUrl":"https://doi.org/10.32383/appdr/162214","url":null,"abstract":"Purpose: To investigate the in vitro skin permeation and transdermal behavior of diclofenac sodium using a new system of microemulsion. \u0000Methods: Diclofenac sodium was incorporated into oil-in-water (o/w) and water-in-oil (w/o) microemulsions consisting of a 2:1 ratio of Cremophor RH 40: Span 80 as surfactant phase, ethylhexyl palmitate as oil phase, and a 2:1 ratio of water: isopropanol as aqueous phase. Franz diffusion cell was used to determine the in vitro skin permeation. Morphology of microemulsions were characterized by transmission electron microscopy (TEM). The depth of penetration distribution was visualized by fluorescently labelling, and observing using confocal laser scanning microscopy (CLSM). \u0000Results: The o/w type provided an enhanced permeation flux, with more than a 3- fold increase in permeability coefficient across skin as compared with w/o type. The morphology characterization indicated that both o/w and w/o type were nano-sized and spherical in shape. It was observed by CLSM that o/w type significantly facilitated the penetration of sulforhodamine B (SRB) to the deeper layers of the skin (220 μm) than w/o type (150 μm). \u0000Conclusion: This study demonstrates that diclofenac sodium microemulsion can be transdermal, and the skin penetration depends on the microstructure and composition of microemulsion.","PeriodicalId":7147,"journal":{"name":"Acta poloniae pharmaceutica","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47189488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effect of betulin against aluminium-induced Alzheimer-like neurodegeneration 槟榔素对铝诱导的阿尔茨海默病样神经退行性变的保护作用

IF 0.4 4区医学

Acta poloniae pharmaceutica Pub Date : 2023-04-28 DOI: 10.32383/appdr/161588

A. Zakrzeska, P. Kitlas, A. Shlyahtun, Ryszard Jabłoński, M. Tomulewicz, Natalia Szymańska

{"title":"Protective effect of betulin against aluminium-induced Alzheimer-like neurodegeneration","authors":"A. Zakrzeska, P. Kitlas, A. Shlyahtun, Ryszard Jabłoński, M. Tomulewicz, Natalia Szymańska","doi":"10.32383/appdr/161588","DOIUrl":"https://doi.org/10.32383/appdr/161588","url":null,"abstract":"The purpose of this study was to show the preventive properties of the botulin (Bet) and its combination with cyclodextrin in a model of neurodegenerative disease like Alzheimer's disease (AD) in rats. Betulin was obtained from birch bark using standard methodology. The AD model was induced by administering aluminum chloride AlCl3 (200 mg/kg/day) to animals for 120 days. All animals were divided into 4 groups: the control group (sham operation), the second - the AD model (Alz) without prevention with betulin, the third - the Alz+Bet receiving betulin (100 mg/kg/day, i.g., during the last 50% of the experimental days), and the Alz+Bet Complex receiving betulin in complex with cyclodextrin (100 mg/kg/day, i.g., during the last 50% of the experimental days). We showed that betulin in complex with cyclodextrin improve the spatial memory and lowered levels of the TNF-α, APLP2 and β-amyloid in rats with AlCl3-induced AD. We conclude that betulin has neuroprotective properties which may form the basis for the development of a new pharmaceutical that is effective in both the prevention and treatment of Alzheimer's disease.","PeriodicalId":7147,"journal":{"name":"Acta poloniae pharmaceutica","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44087892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0