COMPLEX-FORMING PROPERTIES OF SYNTHETIC PYRIMIDINONE NUCLEOSIDES WITH Ag(I) IONS IN AN AQUEOUS SOLUTION

IF 0.4 4区医学 Q4 PHARMACOLOGY & PHARMACY

Acta poloniae pharmaceutica Pub Date : 2023-04-28 DOI:10.32383/appdr/162766

M. Pająk, M. Woźniczka, M. Świątek, Bartłomiej Czerwiński, J. Włodarczyk, J. Fichna

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引用次数: 0

Abstract

The present work describes the complexation properties of two synthetic nucleosides (used as ligands), i.e. β-D-ribofuranoside-4-pyrimidinone (ribo) and β-D-deoxyribofuranoside-4-pyrimidinone (deoxy) with Ag(I) ions in aqueous solution. The stability constants of the studied coordination entities were calculated potentiometrically. The logarithm values of the overall stability constants of the coordination entities were found to be [Ag-deoxy]+ = 3.07, [Ag-(deoxy)2]+ = 6.90, [Ag-ribo]+ = 3.00 and [Ag-(ribo)2]+ = 6.63. Based on the species distribution curves as a function of CL/CM, the percentage of each coordination entity formed in aqueous solution was estimated (12 % [Ag-deoxy]+; 36 % [Ag-(deoxy)2]+; 16 % [Ag-ribo]+; 26 % [Ag-(ribo)2]+). It was found that the ligands form coordination entities with Ag(I) ions with stoichiometric ratios M : L = 1 : 1 and 1 : 2. Such coordination entities may show potential antiviral, antibacterial, and antitumor properties, which warrants further in vitro and in vivo studies. They may also be of great interest for their application in nanobiotechnology.

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水溶液中合成嘧啶酮核苷与Ag（I）离子的络合性质

本工作描述了两种合成核苷（用作配体），即β-D-呋喃核糖-4-嘧啶酮（核糖）和β-D-脱氧呋喃核糖-4-吡啶酮（脱氧）在水溶液中与Ag（i）离子的络合性质。用电位法计算了所研究的配位体的稳定常数。发现配位实体的总稳定性常数的对数值为[Ag-脱氧]+=3.07，[Ag-（脱氧）2]+=6.90，[Ag核糖]+=3.00和[Ag-核糖2]+=6.63。基于作为CL/CM函数的物种分布曲线，估计了在水溶液中形成的每个配位实体的百分比（12%[Ag-脱氧]+；36%[Ag-（脱氧）2]+；16%[Ag-rib]+；26%[Ag-（核糖）2]+）。发现配体与化学计量比M∶L＝1∶1和1∶2的Ag（I）离子形成配位体。这种配位实体可能表现出潜在的抗病毒、抗菌和抗肿瘤特性，这需要进一步的体外和体内研究。它们在纳米生物技术中的应用也可能引起人们的极大兴趣。

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来源期刊

Acta poloniae pharmaceutica 医学-药学

CiteScore

0.80

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The international journal of the Polish Pharmaceutical Society is published in 6 issues a year. The journal offers Open Access publication of original research papers, short communications and reviews written in English, in all areas of pharmaceutical sciences. The following areas of pharmaceutical sciences are covered: Analysis, Biopharmacy, Drug Biochemistry, Drug Synthesis, Natural Drugs, Pharmaceutical Technology, Pharmacology and General. A bimonthly appearing in English since 1994, which continues “Acta Poloniae Pharmaceutica”, whose first issue appeared in December 1937. The war halted the activity of the journal’s creators. Issuance of “Acta Poloniae Pharmaceutica” was resumed in 1947. From 1947 the journal appeared irregularly, initially as a quarterly, then a bimonthly. In the years 1963 – 1973 alongside the Polish version appeared the English edition of the journal. Starting from 1974 only works in English are published in the journal. Since 1995 the journal has been appearing very regularly in two-month intervals (six books a year). The journal publishes original works from all fields of pharmacy, summaries of postdoctoral dissertations and laboratory notes.