Actas urologicas espanolas最新文献

{"title":"El papel de los índices de inflamación sistémica y los marcadores pronósticos en pacientes diabéticos con cáncer de vejiga no músculo invasivo tratados con BCG","authors":"A. Tunçekin ,&nbsp;Y. Aktaş","doi":"10.1016/j.acuro.2026.501925","DOIUrl":"10.1016/j.acuro.2026.501925","url":null,"abstract":"<div><h3>Introduction</h3><div>Systemic inflammatory and prognostic índices are emerging biomarkers in bladder cancer. Diabetes mellitus (DM), a chronic inflammatory disease, and Bacillus Calmette–Guérin (BCG) therapy may influence these índices in non-muscle invasive bladder cancer (NMIBC).</div></div><div><h3>Objective</h3><div>To evaluate the impact of DM and BCG therapy on inflammatory and prognostic índices in patients with NMIBC.</div></div><div><h3>Material and method</h3><div>A retrospective study of 156 NMIBC patients was conducted. Patients were stratified by DM and BCG status (DM+/DM−; BCG+/BCG−), and into 4<!--> <!-->subgroups (DM−/BCG−, DM+/BCG+, DM−/BCG+, DM+/BCG−). Laboratory and clinical parameters were compared using standard statistical tests (t-test, Chi-square, ANOVA). A p-value &lt;<!--> <!-->0.05 was considered significant.</div></div><div><h3>Results</h3><div>DM+ patients had significantly higher glucose <em>(P</em>=.001), HbA1c <em>(P</em>=.017), GKR <em>(P</em>=.014), and lower PNI <em>(P</em>=.014). Tumor recurrence was more common in DM+ <em>(P</em>=.021). In the BCG comparison, albumin (p<!--> <!-->=<!--> <!-->0.002) and PNI (p<!--> <!-->=<!--> <!-->0.009) differed. Four-group analysis showed significant differences in tumor grade, tumor recurrence, HbA1c, albumin, PNI, and MPR (all <em>P</em>&lt;.05), especially between DM+/BCG+ and DM−/BCG+.</div></div><div><h3>Conclusion</h3><div>DM and BCG therapy are associated with systemic inflammatory and prognostic índices in NMIBC. GKR and PNI may serve as practical, cost-effective markers for recurrence risk stratification.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"50 3","pages":"Article 501925"},"PeriodicalIF":1.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comentario sobre «Resultados oncológicos de pacientes con afectación ganglionar tras quimioterapia neoadyuvante y cistectomía radical para el cáncer de vejiga músculo-invasivo: Estudio observacional multicéntrico del Grupo de Trabajo de Carcinoma Urotelial de la sección de Jóvenes Urólogos Académicos de la Asociación Europea de Urología (YAU-EAU)»","authors":"V.D. Kumar Veldi ,&nbsp;R. Sah","doi":"10.1016/j.acuro.2025.501792","DOIUrl":"10.1016/j.acuro.2025.501792","url":null,"abstract":"","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"50 3","pages":"Article 501792"},"PeriodicalIF":1.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"El futuro del cribado del cáncer de próstata en la Unión Europea: programa PRAISE-U","authors":"J. Gómez Rivas ,&nbsp;P. Gómez Dávila ,&nbsp;A.M. Tarrazo Antelo ,&nbsp;M. Corujo Quinteiro ,&nbsp;Á. Gómez Amorín ,&nbsp;A. Rodríguez Alonso ,&nbsp;J.M. Vilaseca ,&nbsp;H. López ,&nbsp;J.P. Salazar ,&nbsp;Á. Borque-Fernando ,&nbsp;J. Moreno-Sierra ,&nbsp;S. Collen ,&nbsp;K. Beyer ,&nbsp;J. Helleman ,&nbsp;M.J. Roobol ,&nbsp;H. van Poppel ,&nbsp;en representación de PRAISE-U Consortium","doi":"10.1016/j.acuro.2025.501919","DOIUrl":"10.1016/j.acuro.2025.501919","url":null,"abstract":"<div><h3>Introduction</h3><div>Prostate cancer (PCa) remains one of the leading public health challenges among European men. Despite technological advances, its early detection continues to be controversial due to the risk of overdiagnosis and the limited adoption of organized screening programs.</div></div><div><h3>Materials and methods</h3><div>A review was conducted of scientific literature, institutional reports, and technical documentation from the PRAISE-U project. We describe the key components of its design, implementation and lessons learned at two pilot sites in Spain (Galicia and Manresa), with a focus on personalized strategies and operational efficiency.</div></div><div><h3>Results</h3><div>Based on the European Union recommendation of 2022, the PRAISE-U project promotes a risk-based screening program that incorporates prostate-specific antigen (PSA), magnetic resonance imaging (MRI) and risk calculators (RC). Galicia and Manresa have developed screening circuits adapted to their health systems. Galicia has managed to invite 7,000 of the 12,000 target men in less than a year, integrating digital tools and direct contact strategies. Manresa, from primary care, has developed a coordinated approach focused on accessibility and traceability. Both models prioritize equity, adherence and minimization of overtreatment.</div></div><div><h3>Conclusions</h3><div>The PRAISE-U project offers an innovative and adaptable framework for PCa screening in Europe. The Spanish experience demonstrates that it is possible to implement effective and risk-focused early detection programs, provided that there is sound planning, technological tools and a collaborative approach between levels of care.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"50 3","pages":"Article 501919"},"PeriodicalIF":1.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Análisis prospectivo de la continencia urinaria y estenosis uretral tras enucleación prostática con láser de Holmio (HoLEP): Serie consecutiva de 254 casos","authors":"L.E. Ortega Polledo ,&nbsp;A. Sánchez Pellejero ,&nbsp;G.F.J. Bianchini Hernández ,&nbsp;E. García Rico ,&nbsp;E. Redondo González ,&nbsp;J.D. Subiela Henríquez ,&nbsp;P. Mata Deniz ,&nbsp;M.J. Marugán Álvarez ,&nbsp;J. Gómez Rivas ,&nbsp;I. Galante Romo ,&nbsp;J. Moreno Sierra ,&nbsp;S. Ahyai ,&nbsp;B. Miñana ,&nbsp;S. Alonso y Gregorio","doi":"10.1016/j.acuro.2025.501912","DOIUrl":"10.1016/j.acuro.2025.501912","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the rate of stress urinary incontinence, time to continence recovery, and incidence of urethral stricture in a series of patients who underwent holmium laser enucleation of the prostate (HoLEP) from the beginning of the learning curve of a single surgeon.</div></div><div><h3>Materials and methods</h3><div>Prospective study of 254 patients consecutively operated on by one surgeon between December 2022 and December 2024. Continence was defined as the use of 0 pads. Survival analysis (Kaplan-Meier) was performed to estimate time to continence recovery. Results were stratified according to surgical technique (2- or 3-lobe vs. en bloc), prostate volume, and BMI. Overall and de novo urethral stricture rates were analyzed according to operative time, ultrasound volume, and enucleated weight.</div></div><div><h3>Results</h3><div>The median time to continence was 20 days. The continence rates at 1 month, 2 months, and 4 months were 80.7%, 91.2%, and 98.5%, respectively. Although incontinence decreased progressively, urgency was more frequent in persistent cases. No significant differences were observed in the time to continence according to surgical technique, prostate volume, or BMI. The overall rate of urethral stricture was 3.9%, with 3.65% de novo cases. No associated risk factors were identified.</div></div><div><h3>Conclusions</h3><div>HoLEP showed a low rate of transient incontinence and urethral stricture, and no correlation with surgical technique or patient clinical characteristics.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"50 3","pages":"Article 501912"},"PeriodicalIF":1.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infección e inflamación de la vía seminal: revisión de su vínculo con la fertilidad masculina","authors":"A. Vives Suñé ,&nbsp;M. Cosentino","doi":"10.1016/j.acuro.2025.501899","DOIUrl":"10.1016/j.acuro.2025.501899","url":null,"abstract":"<div><h3>Introduction</h3><div>In 1997, the WHO established the role of genital tract infections in human infertility, currently responsible for 15% of the causes of infertility in men. The WHO classifies urethritis, prostatitis, vesiculitis, orchitis, and epididymitis as infections of the male accessory gland. This paper represents the state of the art on inflammation and infection of seminal tract. Objective of the study is to revise literature and to discuss regarding association to fertility.</div></div><div><h3>Methods</h3><div>A literature search was performed on PubMed database (<span><span>http://www.pubmed.gov</span><svg><path></path></svg></span>) for peer-reviewed journal articles relating to STD, UTI, diagnosis and treatment and fertility. We carefully evaluated the most representative reports published in literature and all papers results were supported by European and American guidelines results on theme.</div></div><div><h3>Results</h3><div>Seminal tract infections may cause infertility by different mechanisms. Traditionally, the most common infectious causes of male infertility were sexually transmitted infections, especially <em>Neisseria gonorrhoeae</em>. However, the most frequent causes of infection of the seminal tract are <em>Chlamydia trachomatis</em>, <em>Mycoplasma</em> spp, especially <em>Ureaplasma urealyticum</em> and the gram-negative bacteria typical of urogenital infections. When classifying seminal tract infections, it must be considered whether or not these are sexually transmitted, and treat both partners for Sexual Transmitted Diesase if necessary (STI). There is evidence that treating STIs leads to improved semen parameters. Although antibiotics can improve sperm quality and reduce DNA fragmentation values, there is no evidence that they increase the probability of natural conception.</div></div><div><h3>Conclusions</h3><div>Taking into account the highly prevalence of infective or inflammatory affections of the male genital tract, it is clearly stablished association with infertility and that a remarkable percentage of sexual transmitted infections (STI) are asymptomatic, we believe that these infections must be ruled out during the initial andrological evaluation in couples seeking fertility.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"50 3","pages":"Article 501899"},"PeriodicalIF":1.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comentario editorial sobre el artículo «Abordaje del tratamiento antitrombótico durante el perioperatorio y el peri-procedimiento: documento de consenso 2025 de SEC, SEDAR, SEACV, SECCE, AEC, SECOM CYC, SECPRE, SEPD, SEGG, SEGO, SEHH, SETH, SEMERGEN, SEMFYC, SEMG, SEMICYUC, SEMI, SEMES, SEN, S.E.N., SENEC, SEPAR, SEO, SEORL-CCC, SEPA, SERVEI, SECOT y AEU»","authors":"L. Ibáñez Vázquez,&nbsp;J.F. Hermida Gutiérrez,&nbsp;J. Moreno Sierra","doi":"10.1016/j.acuro.2026.501931","DOIUrl":"10.1016/j.acuro.2026.501931","url":null,"abstract":"","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"50 3","pages":"Article 501931"},"PeriodicalIF":1.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adenocarcinoma de uraco: presentación de un caso, revisión bibliográfica y propuesta de algoritmo terapéutico","authors":"P. Guedes Oliva ,&nbsp;P. Jiménez Marrero ,&nbsp;R. Espino Espino ,&nbsp;R. Marrero Domínguez ,&nbsp;E. Perera Gordo","doi":"10.1016/j.acuro.2025.501916","DOIUrl":"10.1016/j.acuro.2025.501916","url":null,"abstract":"<div><div>Urachal adenocarcinoma is an extremely rare malignancy, accounting for less than 1% of all bladder tumors. Diagnosis is often delayed due to nonspecific symptoms and low clinical suspicion. We report the case of a 52-year-old male with no relevant medical history who presented with lower urinary tract symptoms. Cystoscopy revealed a cystic lesion at the bladder dome. Transurethral resection confirmed mucinous urachal adenocarcinoma. CT imaging showed no locoregional or distant spread, and tumor markers were within normal limits. The patient underwent laparoscopic partial cystectomy with en bloc excision of the urachus and umbilicus plus bilateral pelvic lymphadenectomy. Final pathology confirmed a Sheldon stage IIIA mucinous cystadenocarcinoma. At 25 months of follow-up, the patient remains free of disease recurrence. Given its low prevalence and aggressive nature, accurate diagnosis and appropriate surgical management are critical. While surgery remains the cornerstone in localized disease, the role of systemic therapy remains unclear. Immunotherapy and targeted therapies are emerging as promising options in advanced stages. This case illustrates the diagnostic challenges and emphasizes the importance of surgical planning and long-term surveillance in the absence of standardized treatment guidelines. Midline bladder lesions should prompt suspicion of urachal adenocarcinoma. Complete surgical excision is essential, with lymphadenectomy and systemic therapy considered on a case-by-case basis. Long-term follow-up is necessary due to the high risk of recurrence.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"50 3","pages":"Article 501916"},"PeriodicalIF":1.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HoLEP en los pacientes con y sin retención aguda de orina que precisa sondaje: resultados quirúrgicos y funcionales","authors":"G. Ozgur ,&nbsp;M. Cetin ,&nbsp;T. Altuntas ,&nbsp;E. Gokmen ,&nbsp;H.K. Cam ,&nbsp;T. Tarcan ,&nbsp;T.E. Sener","doi":"10.1016/j.acuro.2025.501906","DOIUrl":"10.1016/j.acuro.2025.501906","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Holmium Laser Enucleation of the Prostate (HoLEP) is an effective treatment for benign prostatic obstruction; however, data on its outcomes in patients with acute urinary retention (AUR), particularly those who remained catheter-dependent until surgery, remain limited. This study compared HoLEP outcomes in patients with and without AUR.</div></div><div><h3>Methods</h3><div>Data from 140 male patients aged 50-80 who underwent HoLEP were retrospectively and exploratorily analyzed. Patients were grouped as catheter-dependent AUR (group 1) and non-AUR (group 2). The primary comparison was Qmax at 6 months, while secondary comparisons included functional outcomes and perioperative/postoperative complications.</div></div><div><h3>Results</h3><div>Thirty-four patients (24.3%) had catheter-dependent AUR. They were older (68.9<!--> <!-->±<!--> <!-->6.9 vs. 66.2<!--> <!-->±<!--> <!-->6.5 years) and had worse baseline IPSS (25 [22-29] vs. 22 [17-25]), quality of life (QoL; 5 [4-6] vs. 4 [3-5]), Qmax (0 vs. 8 [5.6-10] ml/s), and PVR (400 [197-560] vs. 100 [60-150] ml) (<em>P</em>&lt;.05). Perioperative parameters and complication rates were not significantly different between the groups. Following HoLEP, AUR patients showed greater improvements in Qmax (Δ16 [14-20.3] vs. 10 [7-15] ml/s), IPSS (Δ16.5 [10.8-22.3] vs. 11.5 [6-17.3]), QoL (Δ4 [3-5] vs. 3 [1-3.3]), and PVR (Δ326 [128-502] vs. 62.5 [26-120] ml) (<em>P</em>&lt;.05). Although patients with catheter-dependent AUR demonstrated more pronounced improvements in functional outcomes, this was largely attributable to worse baseline parameters. No statistically significant differences were observed in postoperative outcomes between the groups. Notably, subjective measures (IPSS and QoL) improved more markedly in group 1.</div></div><div><h3>Conclusions</h3><div>HoLEP is an effective treatment option for catheter-dependent AUR patients, providing significant functional improvement. Preoperative catheterization until surgery does not negatively affect surgical efficacy or postoperative outcomes.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"50 3","pages":"Article 501906"},"PeriodicalIF":1.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Panorama actual de la formación quirúrgica y la simulación en urología: estudio multinacional de los programas de residencia de la Confederación Americana de Urología","authors":"G. Gentili ,&nbsp;N. Paesano ,&nbsp;M. Barreto ,&nbsp;G. Castillo ,&nbsp;T. Mierzwa ,&nbsp;A. Hernández Méndez ,&nbsp;M. Falcioni ,&nbsp;F. Santomil ,&nbsp;A.M. Autrán Gómez ,&nbsp;I. Tobia-González ,&nbsp;A. Rodríguez ,&nbsp;en nombre del Grupo de Trabajo del Proyecto PRYUS-CAU","doi":"10.1016/j.acuro.2025.501915","DOIUrl":"10.1016/j.acuro.2025.501915","url":null,"abstract":"<div><h3>Introduction</h3><div>Surgical training in urology has undergone significant transformation due to the increasing complexity of procedures and the integration of advanced technologies. Simulation-based education is recognized as a fundamental component of residency programs. This study aimed to evaluate the current status of surgical training and the availability of simulation resources for urology residents and early-career urologists in the countries represented by the American Confederation of Urology.</div></div><div><h3>Methods</h3><div>A descriptive, cross-sectional survey was conducted with 402 participants from 19 countries. The questionnaire included multiple-choice questions addressing demographics, access to surgical procedures, simulation tools, evaluation methods, mentorship, and the impact of the COVID-19 pandemic.</div></div><div><h3>Results</h3><div>The study revealed significant heterogeneity in surgical training. Only 17.9% had access to robotic surgery and 32.8% to prostate enucleation. Over 80% reported the absence of virtual or wet labs at their institutions. Training was based on step-by-step instruction (89.9%), in laparoscopic (45%) and endoscopic (50.7%). However, 15.7% used simulators during surgical procedures. Additionally, 50.6% reported the absence of formal assessment or mentorship. Fellowship training was considered in 84.7%. The COVID-19 pandemic negatively impacted academic (50.3%) and surgical (66.9%) training.</div></div><div><h3>Conclusions</h3><div>The findings highlight considerable variability in surgical training, limited access to simulation resources, and a general absence of standardized evaluation and mentorship systems. These results emphasize the need to implement structured and equitable training that incorporate simulation, these offer a safe and effective environment for developing surgical skills.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"50 2","pages":"Article 501915"},"PeriodicalIF":1.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147414557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nuevo biomarcador para la disfunción eréctil: inductor soluble débil de apoptosis similar al factor de necrosis tumoral","authors":"A. Iplikci ,&nbsp;O. Efiloglu ,&nbsp;A. Kado ,&nbsp;H. Erman ,&nbsp;A. Yildirim","doi":"10.1016/j.acuro.2025.501903","DOIUrl":"10.1016/j.acuro.2025.501903","url":null,"abstract":"<div><h3>Introduction</h3><div>The soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) is a cytokine that modulates inflammatory and atherogenic reactions. In our study, we aimed to determine whether sTWEAK could be a biomarker of erectile dysfunction (ED).</div></div><div><h3>Methods</h3><div>Ninety patients diagnosed with ED and 90 healthy participants were prospectively enrolled during the period of September 2021 - September 2023. Participants were divided into three groups according to International Index of Erectile Function (IIEF) Erectile Function Domain scores; severe disease (1-10), moderate-mild disease (11-21) and healthy control (22-30). All participants filled out Beck Depression Inventory (BDI). Blood samples were collected for complete blood count, biochemical analysis and hormonal assessment.</div></div><div><h3>Results</h3><div>sTWEAK levels were higher in patients and increased with the severity of the disease as well. Healthy participants had lower BDI score (p<!--> <!-->=<!--> <!-->0.001) and erythrocyte sedimentation rate (p<!--> <!-->=<!--> <!-->0.001). Analysis with ROC curve demonstrated good area under curve value for sTWEAK (0.776, p<!--> <!-->=<!--> <!-->0.001) in predicting ED. Optimal threshold level was determined as 5,41 ng/ml (71.1% sensitivity and 71.1% specificity).</div></div><div><h3>Conclusions</h3><div>We revealed that there is a significant association between sTWEAK levels and severity of disease, therefore we belive that sTWEAK pathway has a role in the pathogenesis of atherosclerosis in patients with ED.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"50 2","pages":"Article 501903"},"PeriodicalIF":1.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147414556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}