G. Basile , G. Fallara , M. Bandini , W. Cazzaniga , F. Negri , L. Dieguez , F. Montorsi , A. Salonia , A. Breda , C. Fankhauser , A. Territo
{"title":"Cáncer de pene y testículo en receptores de trasplante renal: revisión sistemática sobre la epidemiología, las opciones de tratamiento y los resultados oncológicos realizada por el grupo de trabajo de cáncer de pene y testículo de la Asociación Europea de Urología (EAU-YAU)","authors":"G. Basile , G. Fallara , M. Bandini , W. Cazzaniga , F. Negri , L. Dieguez , F. Montorsi , A. Salonia , A. Breda , C. Fankhauser , A. Territo","doi":"10.1016/j.acuro.2025.501683","DOIUrl":"10.1016/j.acuro.2025.501683","url":null,"abstract":"<div><h3>Introduction</h3><div>Kidney transplant (KT) recipients are at an elevated risk of developing de novo cancers. However, penile (PeCa) and testis cancers have received limited attention in this setting.</div></div><div><h3>Objective</h3><div>To summarize the epidemiology, treatment options, and oncological outcomes of penile and testis cancer in KT recipients.</div></div><div><h3>Evidence acquisition</h3><div>We conducted a systematic review of prospective, retrospective and national transplant registries studies published up to December 2023. Data on the incidence of penile and testis cancers among KT recipients, diagnostic protocols, screening recommendations, and therapeutic strategies tailored for KT recipients were collected. The risk of bias (RoB) of included studies was determined using the Newcastle and Ottawa scale.</div></div><div><h3>Evidence synthesis</h3><div>Overall, 21 studies involving 67924 KT male recipients were included. PeCa was diagnosed in 33 patients, yielding an incidence ranging from 0.04% to 0.3%. Additionally, 67 cases of testicular cancer were recorded, with an incidence ranging from 0.03% to 0.55%. Most tumors were localized, and histology variants were uncommon. While the surgical treatment of the primary tumor remains consistent with that of the general population, the use of radiotherapy and cytotoxic treatments are less frequently reported in this setting. These therapies should be considered on an individualized basis to minimize the risk of graft injury.</div></div><div><h3>Conclusions</h3><div>Penile and testis cancers are relatively uncommon among KT recipients. General screening protocols and deviation from current treatment guidelines are not recommended in localized diseases. Given the risk of graft damage, any non-cytotoxic option should be preferred in locally advanced cases.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 3","pages":"Article 501683"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Pyrgidis , J. Hermans , P. Keller, D. Karatas, B. Ebner, G. Schulz, C. Stief, Y. Volz
{"title":"Derivación urinaria y calidad de vida: 6 años de seguimiento después de la cirugía para el cáncer de vejiga","authors":"N. Pyrgidis , J. Hermans , P. Keller, D. Karatas, B. Ebner, G. Schulz, C. Stief, Y. Volz","doi":"10.1016/j.acuro.2025.501699","DOIUrl":"10.1016/j.acuro.2025.501699","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate health-related quality of life (HRQOL) six years post-radical cystectomy in patients with muscle-invasive bladder cancer, comparing orthotopic ileal neobladder (ONB) and ileal conduit (IC). Therefore, the study aims to analyze the under-investigated long-term impact of standard bladder cancer treatments on HRQOL and provide insights into the HRQOL differences associated with these two common urinary diversion methods.</div></div><div><h3>Patients and methods</h3><div>This prospective study included 39 patients with urothelial carcinoma treated with ONB or IC at our center between 03/2013 and 01/2023. Patients with variant histology, metastasis, neoadjuvant chemotherapy, or benign indications for cystectomy were excluded. HRQOL was assessed using the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 questionnaire preoperatively, at four and six years postoperatively. Statistical analyses included Chi-square tests, T-tests, and logistic regression models.</div></div><div><h3>Results</h3><div>Of the patients, 64% (25/39) underwent ONB, and 76.9% (30/39) were male, with an average age of 69 years. No significant differences in overall good HRQOL (GHS<!--> <!-->>70) were observed between ONB and IC at six years (IC: 60<!--> <!-->±<!--> <!-->22; ONB: 69<!--> <!-->±<!--> <!-->23, p<!--> <!-->=<!--> <!-->0.2). Patients with IC reported higher insomnia at both follow-ups (4 years: p<!--> <!-->=<!--> <!-->0.01; 6 years: p<!--> <!-->=<!--> <!-->0.03). Emotional function remained stable in ONB patients but declined in IC patients from the fourth to sixth years (p<!--> <!-->=<!--> <!-->0.04).</div></div><div><h3>Conclusions</h3><div>Long-term HRQOL did not significantly differ between ONB and IC up to six years post-radical cystectomy. Both urinary diversion methods can be offered to patients, with tailored discussions in terms of HRQOL.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 3","pages":"Article 501699"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. García-Sánchez , I. García-Obrero , C. Muñoz-Calahorro , A.J. Rodríguez-Pérez , R.A. Medina-López
{"title":"Eficacia de los ejercicios de suelo pélvico guiados pre-prostatectomía radical robótica en la incontinencia urinaria y calidad de vida","authors":"C. García-Sánchez , I. García-Obrero , C. Muñoz-Calahorro , A.J. Rodríguez-Pérez , R.A. Medina-López","doi":"10.1016/j.acuro.2025.501702","DOIUrl":"10.1016/j.acuro.2025.501702","url":null,"abstract":"<div><h3>Introduction and objective</h3><div>Radical prostatectomy has a great impact on urinary continence, although it is a multifactorial aspect. The aim of the study was to evaluate the effect of guided Pelvic Floor Exercises (PFE) versus written information prior to robotic radical prostatectomy (RRP) on the rate of urinary incontinence, and their effect on patients’ quality of life.</div></div><div><h3>Material and method</h3><div>62 patients were randomized to an experimental (physiotherapist-guided exercises) or control (written information) group. The primary outcome was incontinence rate (measured by pad test). Secondary outcomes were incontinence severity, quality of life (measured by the 36-Item Short Form Survey Instrument (SF-36) and the King's Health Questionnaire (KHQ)), voiding dynamics, correlation between incontinence and quality of life, and other incontinence-related factors.</div></div><div><h3>Results</h3><div>We found no differences in the incontinence rate between groups in the months of follow-up (82.61% vs 84.62%, month 1; 61.54% vs 75.86%, month 3; 50% vs 53.33%, month 6; 30.77% vs 40%, month 12) nor in the severity of incontinence between groups. There were significant differences in the quality of life related to “emotional problems” and “personal relationships”, in favor of the control group. We found correlations between incontinence severity and age, severity and quality of life, urgency/frequency and quality of life.</div></div><div><h3>Conclusions</h3><div>Guided exercises prior to RRP do not seem to offer benefits over written information in either the rate or severity of incontinence. Urinary incontinence correlates with age and quality of life. Quality of life correlates with urgency and voiding frequency.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 3","pages":"Article 501702"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Factores de riesgo y modelos predictivos de litiasis renal en la población estadounidense: estudio de cohortes emparejadas mediante puntuación de propensión","authors":"Y. Sun, F. Xu, Z. Xiao, Y. An, H. Zhao","doi":"10.1016/j.acuro.2025.501715","DOIUrl":"10.1016/j.acuro.2025.501715","url":null,"abstract":"<div><h3>Objective</h3><div>This study sought to identify risk factors and develop predictive models for kidney stone disease in the U.S. population using data from the National Health and Nutrition Examination Survey (NHANES).</div></div><div><h3>Methods</h3><div>In a propensity score–matched cohort study, we examined the association of serum α-Klotho, hemoglobin levels, serum creatinine, and the urinary albumin-to-creatinine ratio (uACR) with kidney stone disease.</div></div><div><h3>Results</h3><div>Initially, 216,560 participants were screened; following propensity matching, 28,370 adults aged 40 to 79 years were included in the final analysis. Serum α-Klotho levels were inversely associated with kidney stone disease, particularly among individuals with chronic kidney disease and those who consumed alcohol. Hemoglobin levels demonstrated an inverse association with kidney stone disease risk, whereas serum creatinine levels exhibited a U-shaped relationship. No significant trend was observed for uACR overall. Low hemoglobin and α-Klotho levels, as well as elevated serum creatinine and uACR, were significantly associated with increased all-cause mortality.</div></div><div><h3>Conclusion</h3><div>Our findings underscore the significance of serum α-Klotho, hemoglobin, serum creatinine, and uACR levels in assessing the risk of kidney stone disease and all-cause mortality, suggesting these markers as potential targets for prevention and management strategies. Further research is warranted to clarify the mechanisms underlying these associations.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 3","pages":"Article 501715"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L.E. Ortega Polledo , E. García Rico , A. Sánchez Pellejero , G.F.J. Bianchini Hernández , A. Sanchís Bonet , J. Gómez Rivas , I. Galante Romo , J. Moreno Sierra , B. Miñana , S. Ahyai , S. Alonso y Gregorio
{"title":"Análisis prospectivo de la curva de aprendizaje en enucleación prostática con láser de holmio: serie de 125 casos","authors":"L.E. Ortega Polledo , E. García Rico , A. Sánchez Pellejero , G.F.J. Bianchini Hernández , A. Sanchís Bonet , J. Gómez Rivas , I. Galante Romo , J. Moreno Sierra , B. Miñana , S. Ahyai , S. Alonso y Gregorio","doi":"10.1016/j.acuro.2025.501705","DOIUrl":"10.1016/j.acuro.2025.501705","url":null,"abstract":"<div><h3>Objective</h3><div>The objective is to evaluate the effectiveness and safety of a surgeon's learning curve for holmium laser enucleation of the prostate in 125 consecutive cases.</div></div><div><h3>Materials and methods</h3><div>Preoperative baseline characteristics, functional outcomes, surgical times, and complications of the first 125 patients treated by holmium laser enucleation of the prostate were recorded. The sample was divided into quintiles (25 cases/group), and statistical analysis was carried out using the ANOVA test, Kruskal-Wallis H test, Chi-squared test, and likelihood-ratio test.</div></div><div><h3>Results</h3><div>Surgical time decreased progressively: 92<!--> <!-->min (Q1), 65<!--> <!-->min (Q2), 54<!--> <!-->min (Q3), 45<!--> <!-->min (Q4) and 50<!--> <!-->min (Q5) (p<!--> <!--><<!--> <!-->0.001). Enucleation rate gradually increased: 1.08<!--> <!-->g/min (Q1), 1.65<!--> <!-->g/min (Q2), 1.82<!--> <!-->g/min (Q3), 1.96<!--> <!-->g/min (Q4) and 2.74<!--> <!-->g/min (Q5) (p<!--> <!--><<!--> <!-->0.001). There were no differences in enucleated weight (Q1: 51<!--> <!-->g, Q2: 57<!--> <!-->g, Q3: 51<!--> <!-->g, Q4: 53<!--> <!-->g, Q5: 65<!--> <!-->g) (p<!--> <!-->=<!--> <!-->0.21), length of hospital stay (median 1.12 days), bladder catheterization (mean 1.51 days), intra- and postoperative complications or urethral stricture (5.6%) (p<!--> <!-->><!--> <!-->0.05). Time to continence recovery was similar in quintiles 1 to 4 (23, 27, 21 and 20 days, respectively) and shorter in quintile 5 (3.5 days) (p<!--> <!--><<!--> <!-->0.001).</div></div><div><h3>Conclusions</h3><div>The initiation of a holmium laser enucleation of the prostate program following the completion of training demonstrates a low morbidity rate and highly favorable functional outcomes. The efficiency of the technique demonstrates a linear and consistent increase from the outset of the learning curve, with significantly reduced surgical times achieved after 25 cases.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 3","pages":"Article 501705"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"El drenaje de las venas varicosas (vein milking) durante la varicocelectomía microscópica subinguinal: efectos sobre el dolor, el resultado estético y el espermiograma","authors":"B. Kati , E. Ordek , I. Demir , E. Sabri Pelit","doi":"10.1016/j.acuro.2025.501706","DOIUrl":"10.1016/j.acuro.2025.501706","url":null,"abstract":"<div><h3>Introduction</h3><div>Varicocele, defined as abnormal convoluted enlargement of the pampiniform plexus veins, is the most common cause of correctable male infertility. This study aimed to investigate the effect of blood drainage in varicose veins on spermiogram parameters, postoperative pain, cosmetic appearance, and patient satisfaction in patients undergoing subinguinal microscopic varicocelectomy.</div></div><div><h3>Methods</h3><div>Patients diagnosed with clinical varicocele and admitted to our urology outpatient clinic between January 2020 and January 2024 were evaluated. Those with a venous vessel diameter<!--> <!-->≥<!--> <!-->2.5<!--> <!-->mm underwent subinguinal microscopic varicocelectomy. In 75 patients, a small incision was made in the thickest varicose vein, and the veins were ligated after venous blood was drained by hand patting. In another 75 patients, vessels were cut and ligated by the classical method without venous blood drainage. Exclusion criteria included patients younger than 18, those with secondary varicocelectomy history, undescended testis, testicular trauma or tumors, and prior infertility treatment. Preoperative and postoperative spermiogram values, pain scores, cosmetic appearance, and patient satisfaction were recorded and compared.</div></div><div><h3>Results</h3><div>The pain rate was significantly lower (p<!--> <!--><<!--> <!-->0.05) in the blood-milking varicocelectomy group during postoperative controls (7-10 days) compared to the classical method group. The blood-milking group also showed significantly higher (p<!--> <!--><<!--> <!-->0.05) sperm count and motility at the 3rd postoperative month. Cosmetic satisfaction was significantly higher (p<!--> <!--><<!--> <!-->0.05) in the blood-milking group.</div></div><div><h3>Conclusions</h3><div>Blood drainage during subinguinal microscopic varicocelectomy significantly reduces postoperative pain and enhances sperm values, cosmetic outcomes, and patient satisfaction. These findings reveal that vein-milking techniques during varicocelectomy can optimize postoperative outcomes.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 3","pages":"Article 501706"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M.Á. Arrabal-Polo , L. Gómez-Morón , F. Gutiérrez-Tejero , A. Zambudio-Munuera , I. Millán-Ramos , M. Arrabal-Martín
{"title":"Tratamiento adyuvante en el cáncer renal de células claras de riesgo intermedio-alto. Revisión sistemática","authors":"M.Á. Arrabal-Polo , L. Gómez-Morón , F. Gutiérrez-Tejero , A. Zambudio-Munuera , I. Millán-Ramos , M. Arrabal-Martín","doi":"10.1016/j.acuro.2025.501685","DOIUrl":"10.1016/j.acuro.2025.501685","url":null,"abstract":"<div><h3>Introduction</h3><div>Given the lack of comparative studies on adjuvant treatment for clear cell renal cell carcinoma, we present an updated systematic review, exploring the various options for adjuvant therapy. This review is conducted in accordance with the PRISMA guidelines.</div></div><div><h3>Material and method</h3><div>A systematic review was conducted, and 13 clinical trials were included after applying the pre-specified inclusion criteria. The risk of bias and the level of evidence were assessed. Subsequently, the requisite data were extracted in order to present the findings of the studies.</div></div><div><h3>Results and discussion</h3><div>The present systematic review establishes that pembrolizumab can be used as adjuvant therapy in patients with advanced renal cancer at high risk after nephrectomy. This is supported by the KEYNOTE-564 study, which concluded that it increased disease-free survival (DFS) and overall survival. The use of sunitinib is discussed, since the study published in NEJM shows a modest benefit in terms of DFS, but only in an independent and blinded central review. According to the PROTECT study, pazopanib has no overall benefit. The EVEREST study showed no significant benefit over everolimus. Further studies are needed to confirm the use of axitinib, as the ATLAS trial showed statistically significant results in DFS in higher-risk population based on investigator assessment, but not based on independent central review. Therapy with 5-FU, α-IFN and IL-2, atezolizumab, sorafenib, thalidomide, nivolumab<!--> <!-->+<!--> <!-->ipilimumab should not be used in the adjuvant setting.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 2","pages":"Article 501685"},"PeriodicalIF":1.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143518871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"¿Qué saben los varones españoles sobre el cáncer de próstata?","authors":"C. Vargas-Blasco , J. Arimany-Manso","doi":"10.1016/j.acuro.2025.501698","DOIUrl":"10.1016/j.acuro.2025.501698","url":null,"abstract":"","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 2","pages":"Article 501698"},"PeriodicalIF":1.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143518870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B.M. Ljubetic , S.L. Thorogood , E.F. Becher , I. Alvarez de Toledo , R. Carrion , A. Carvajal , E. Fernández-Pascual , J.I. Martinez-Salamanca , C. Nelson , J. Quesada , C.A. Salter , J. Torremade , M. d’Anna , R. Valenzuela , J.P. Mulhall , J.M. Flores
{"title":"Validación inicial lingüística y cultural de una encuesta de satisfacción sobre el uso de la prótesis inflable de pene en español","authors":"B.M. Ljubetic , S.L. Thorogood , E.F. Becher , I. Alvarez de Toledo , R. Carrion , A. Carvajal , E. Fernández-Pascual , J.I. Martinez-Salamanca , C. Nelson , J. Quesada , C.A. Salter , J. Torremade , M. d’Anna , R. Valenzuela , J.P. Mulhall , J.M. Flores","doi":"10.1016/j.acuro.2025.501700","DOIUrl":"10.1016/j.acuro.2025.501700","url":null,"abstract":"<div><h3>Introduction</h3><div>The Satisfaction Survey for Inflatable Penile Implant (SSIPI) is useful tool to assess patient outcomes after inflatable penile prosthesis implant (PPI) surgery. However, this survey is not validated in Spanish. This work aims to report the initial steps carried out for the linguistic validation of the SSIPI translation into Spanish.</div></div><div><h3>Method</h3><div>The linguistic validation process had the following steps: (i)<!--> <!-->SSIPI forward translation; (ii)<!--> <!-->reconciliation; (iii)<!--> <!-->back translation; (iv)<!--> <!-->harmonization, review, and correction of the translation, and (v)<!--> <!-->cognitive interviewing and testing the new translated version. Urologists from Spain, South America, and the United States participated in these steps. The last step was performed in 3 centers: Medellín, Colombia; Florida, United States; and Madrid, Spain.</div></div><div><h3>Results</h3><div>19 Spanish-speaking patients tested the initial translated version of SSIPI. Most patients found the translated SSIPI questionnaire easy to understand; however, of the 16 questions, patients most frequently commented that questions 3, 5, and 7 should be modified. The median number of observations or comments per question was 1 (1, 3). Based on these suggestions, the research group adapted the questionnaire to obtain the final version in Spanish.</div></div><div><h3>Conclusion</h3><div>This study evaluates the initial steps for the translation and linguistic validation of the SSIPI questionnaire into Spanish. The results indicate a remarkable level of readability and comprehension, while some challenges were observed in certain questions. This work demonstrates that a standardized and protocolized process is needed to translate and validate surveys into Spanish.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 2","pages":"Article 501700"},"PeriodicalIF":1.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143519474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}