Actas urologicas espanolas最新文献_第5页

Estudio piloto unicéntrico, doble ciego, aleatorizado y controlado con placebo para evaluar el uso de Canoxidin® en la prevención de la incrustación de la sonda en pacientes portadores de sonda permanente 单中心、双盲、随机、安慰剂对照试验研究，评估 canoxidin® 在预防留置导管患者导管结壳方面的应用。

IF 1.2 4区医学

Actas urologicas espanolas Pub Date : 2024-11-01 DOI: 10.1016/j.acuro.2024.05.005

{"title":"Estudio piloto unicéntrico, doble ciego, aleatorizado y controlado con placebo para evaluar el uso de Canoxidin® en la prevención de la incrustación de la sonda en pacientes portadores de sonda permanente","authors":"","doi":"10.1016/j.acuro.2024.05.005","DOIUrl":"10.1016/j.acuro.2024.05.005","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Long-term use of an indwelling catheter is associated with complications such as catheter encrustation and infection. Canoxidin® is a novel oral treatment that can potentially prevent catheter encrustation, as it contains a urine acidifier and a combination of two crystallization inhibitors. This study aimed to evaluate the effects of Canoxidin® on catheter encrustation in patients with indwelling Foley catheters.</div></div><div><h3>Patients and methods</h3><div>This was a single-center, double-blind, randomized, placebo-controlled study. Neuro-urology patients aged ≥18years with an indwelling catheter (urethral or suprapubic) were randomized to treatment consisting of either Canoxidin® or placebo for one month. Foley catheters (two per patient, one before treatment and one after treatment) were removed for analysis of the presence and degree of encrustation.</div></div><div><h3>Results</h3><div>A total of 40 patients were enrolled and randomized, 28 of whom had analyzable catheters (13 assigned to Canoxidin® and 15 assigned to placebo). The patients had a mean age of 51.8years, and eight (28.6%) were female. Two patients (13.3%) in the placebo group and eight patients (61.5%) in the Canoxidin® group experienced an improvement (less encrustation). There was a significant association between Canoxidin® and improvement (odds ratio: 10.4, 95% confidence interval: 1.6 to 66.9, <em>P</em>  <!-->.016). No adverse effects attributable to the treatment were reported.</div></div><div><h3>Conclusions</h3><div>The overall rate of catheter encrustation was high among those with indwelling Foley catheters. One-month treatment with Canoxidin® reduced the formation of these encrustations, with an excellent short-term safety profile.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"48 9","pages":"Pages 658-664"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141395792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Recomendaciones de tratamiento en el cáncer de próstata hormonosensible metastásico: selección de pacientes 转移性激素敏感性前列腺癌的治疗建议：患者选择

IF 1.2 4区医学

Actas urologicas espanolas Pub Date : 2024-11-01 DOI: 10.1016/j.acuro.2024.03.002

引用次数: 0

Cornada envainada: la paradoja de un trauma contuso-penetrante. Caso clínico 鞘状疝气：钝穿性创伤的悖论。临床病例

IF 1.2 4区医学

Actas urologicas espanolas Pub Date : 2024-11-01 DOI: 10.1016/j.acuro.2024.04.003

引用次数: 0

¿Depende el éxito en nefrolitotomía percutánea solo del tamaño litiásico? Análisis de la capacidad predictiva de éxito y complicaciones de los actuales sistemas de puntuación de nefrolitometría y su relación con la superficie litiásica NLP 成功与否仅取决于碎石大小吗？分析当前肾碎石评分系统对成功率和并发症的预测能力及其与碎石面积的关系

IF 1.2 4区医学

Actas urologicas espanolas Pub Date : 2024-10-01 DOI: 10.1016/j.acuro.2024.03.005

{"title":"¿Depende el éxito en nefrolitotomía percutánea solo del tamaño litiásico? Análisis de la capacidad predictiva de éxito y complicaciones de los actuales sistemas de puntuación de nefrolitometría y su relación con la superficie litiásica","authors":"","doi":"10.1016/j.acuro.2024.03.005","DOIUrl":"10.1016/j.acuro.2024.03.005","url":null,"abstract":"<div><h3>Objective</h3><div>To analyze the predictive capacity of the nephrolithometry scoring systems (GSS, STONE, CROES and S-ReSC) and stone surface regarding success and complications following percutaneous nephrolithotomy (PCNL).</div></div><div><h3>Methods</h3><div>We studied 392 patients who had undergone PCNL in our center. Only patients with a non-contrast CT (n=240) were finally included for analysis. The predictive capacities for success and complications of the different scoring systems were evaluated using ROC curves and their area under the curve (AUC).</div></div><div><h3>Results</h3><div>Regarding success, the S-ReSC system had the highest predictive capacity with an AUC of 0.681 (95% CI 0.610 - 0.751), followed by the CROES with 0.667 (95% CI 0.595 - 0.738), the STONE with 0.654 (95% CI 0.579 - 0.728) and finally the GSS with 0.626 (95% CI 0.555 - 0.698). The stone surface as a single variable had an AUC of 0.641 (95% CI 0.565 - 0.718). As for complications, the S-ReSC had the highest AUC with 0.664 (95% CI 0.57 - 0.758), followed by STONE with 0.663 (95% CI 0.572 - 0.755), GSS with 0.626 (95% CI 0.555). - 0.698) and CROES with 0.614 (95% CI 0.518 - 0.7). The stone surface alone had an AUC of 0.616 (95% CI 0.522 - 0.715).</div></div><div><h3>Conclusion</h3><div>The nephrolithometry scales analyzed show a moderate predictive capacity for success and complications in patients undergoing PCNL in our center. Moreover, stone surface as an independent variable demonstrates moderate predictive capacity for both outcomes.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"48 8","pages":"Pages 603-610"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140791705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Prevalencia de mutaciones en genes de reparación en hombres mexicanos con cáncer de próstata 墨西哥男性前列腺癌患者中修复基因突变的发生率

IF 1.2 4区医学

Actas urologicas espanolas Pub Date : 2024-10-01 DOI: 10.1016/j.acuro.2024.03.003

{"title":"Prevalencia de mutaciones en genes de reparación en hombres mexicanos con cáncer de próstata","authors":"","doi":"10.1016/j.acuro.2024.03.003","DOIUrl":"10.1016/j.acuro.2024.03.003","url":null,"abstract":"<div><h3>Introduction and objective</h3><div>Mexico reported 26,742 new cases of prostate cancer in 2020. Different risk factors have been identified in the pathogenesis of prostate cancer. Among them, genetic factors and alterations or mutations in specific genes have been described in different ethnic groups worldwide. The aim of our study is to report the prevalence of germline DNA-repair gene mutations in Mexican patients with prostate cancer.</div></div><div><h3>Material and method</h3><div>We performed germline genetic testing in 50 patients with localized prostate cancer and 50 patients with metastatic prostate cancer. Demographic, clinical, and histopathological data were collected.</div></div><div><h3>Results</h3><div>Thirty-seven germline mutations were identified in 32 patients. The most commonly affected genes were <em>ATM</em> in 6%, followed by <em>FANCA</em> (5%), and <em>ATR</em> (4%). <em>BRCA2</em> mutations were identified in 3%. The frequency of mutations was higher in the metastatic group.</div></div><div><h3>Discussion and Conclusion</h3><div>The results of our study show different mutations from those reported in different populations or regions. The use of PARP inhibitors is indicated in patients with germline mutations, specifically BRCA2, showing improvement in overall survival and progression free survival. To our knowledge, this is the first study reporting the prevalence of mutations in DNA-repair genes in Mexican patients with prostate cancer.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"48 8","pages":"Pages 588-595"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140776661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Los últimos avances en prostatectomía robótica: ¿cómo lo hacemos en Cataluña, España? 机器人前列腺切除术的最新进展：我们如何在西班牙加泰罗尼亚地区开展这项工作？

IF 1.2 4区医学

Actas urologicas espanolas Pub Date : 2024-10-01 DOI: 10.1016/j.acuro.2024.02.006

{"title":"Los últimos avances en prostatectomía robótica: ¿cómo lo hacemos en Cataluña, España?","authors":"","doi":"10.1016/j.acuro.2024.02.006","DOIUrl":"10.1016/j.acuro.2024.02.006","url":null,"abstract":"<div><h3>Introduction and objective</h3><div>Robotic-assisted laparoscopic prostatectomy (RALP) seems to improve functional outcomes, however there is not a consensus of a standard procedure. The aim of this study was to identify the RALP “state of art” in Catalonia, Spain.</div></div><div><h3>Material and methods</h3><div>This was a cross-sectional survey-based study conducted among urologists across Catalonia. The survey was distributed through online platforms and the professional urology society. All statistical analyses were performed using Stata software, v. 20.</div></div><div><h3>Results</h3><div>Fifty-nine urologists completed the survey, revealing RALP as the most commonly used technique (79.7%). Most urologist (70%) create the pneumoperitoneum using a controlled incision with direct access and 78.3% use the AirSeal® technology. The intraperitoneal approach is performed in more than 90% of cases. Endopelvic fascia preservation is not routinely performed. A percentage of 34.5 of the survey not perform the dorsal vein complex suture. All preserves the bladder neck when oncologically safe. Nerve-vascular bundles bleeding control is performed using standard coagulation or suturing. Thirty-four percent performed posterior reconstruction. Only use hemostatic devices when evident bleeding and 70% does not routinely left a drainage. Multivariable analysis showed that center volume had a significant independent association with dorsal venous complex suturing (OR 0.073, 95% <span>C</span>I 0.07-0.826), nerve-vascular bundles suturing hemostasis (OR 11.67, 95% CI 1.07-127.60) and endopelvic fascia preservation (OR 13.64, 95% CI 1.087-201.27), but there was no correlation with time the bladder catheter or days hospitalized.</div></div><div><h3>Conclusions</h3><div>The study provides an overview of the state of RALP in Catalonia, Spain, showing significant variability and reflecting a commitment to advancing surgical technology and patient care.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"48 8","pages":"Pages 581-587"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140406751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aumento de la incidencia del cáncer testicular en España a pesar del descenso de la mortalidad: un análisis edad-periodo-cohorte 死亡率下降但西班牙睾丸癌发病率上升：年龄、时期和队列分析

IF 1.2 4区医学

Actas urologicas espanolas Pub Date : 2024-10-01 DOI: 10.1016/j.acuro.2024.03.004

{"title":"Aumento de la incidencia del cáncer testicular en España a pesar del descenso de la mortalidad: un análisis edad-periodo-cohorte","authors":"","doi":"10.1016/j.acuro.2024.03.004","DOIUrl":"10.1016/j.acuro.2024.03.004","url":null,"abstract":"<div><h3>Background</h3><div>Testicular cancer, primarily affecting young men, has seen an alarming rise globally. This study delves into incidence and mortality trends in Spain from 1990 to 2019 using the Global Burden of Disease (GBD) database and the Age-Period-Cohort (A-P-C) model.</div></div><div><h3>Methods</h3><div>We analyzed GBD data on testicular cancer cases and deaths in Spain, calculating age-standardized rates (ASIR and ASMR) and employing Joinpoint regression to identify significant shifts. The A-P-C model further dissected the effects of age, period, and birth cohort on these trends.</div></div><div><h3>Results</h3><div>A striking doubling in testicular cancer incidence was observed, from 3.09 to 5.40 per 100,000 men (1.9% annual increase), while mortality rates remained stable and even decreased in younger age groups (0.34 to 0.26 per 100,000, 0.8% annual decrease). Joinpoint analysis revealed four distinct periods of increasing incidence, with a recent slowdown. The A-P-C model highlighted a consistent rise in incidence risk with each successive generation born after 1935, contrasting with a progressive decline in mortality risk across cohorts, particularly marked for those born since the 1960s.</div></div><div><h3>Conclusion</h3><div>While mortality rates are encouraging, Spain reflects the global trend of escalating testicular cancer incidence. The A-P-C analysis suggests a generational influence, but the underlying causes remain elusive. Further research is crucial to understand these trends and implement effective prevention strategies to combat this growing health concern.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"48 8","pages":"Pages 596-602"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140765065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coinfección de viruela del mono, COVID-19 y sífilis en un HSH usuario de PrEP: informe de un caso en Barcelona 一名使用 PrEP 的男男性行为者同时感染猴痘、COVID-19 和梅毒：来自巴塞罗那的病例报告。

IF 1.2 4区医学

Actas urologicas espanolas Pub Date : 2024-10-01 DOI: 10.1016/j.acuro.2024.04.001

引用次数: 0

Tendencias de género en el Congreso Anual de la Asociación Española de Urología (AEU): revisión de los programas de la AEU en un periodo de 10 años (2012-2022) 西班牙泌尿外科协会（AEU）年会的性别趋势：对西班牙泌尿外科协会 10 年间（2012-2022 年）计划的回顾。

IF 1.2 4区医学

Actas urologicas espanolas Pub Date : 2024-10-01 DOI: 10.1016/j.acuro.2024.02.005

{"title":"Tendencias de género en el Congreso Anual de la Asociación Española de Urología (AEU): revisión de los programas de la AEU en un periodo de 10 años (2012-2022)","authors":"","doi":"10.1016/j.acuro.2024.02.005","DOIUrl":"10.1016/j.acuro.2024.02.005","url":null,"abstract":"<div><h3>Introduction</h3><div>Gender equity in urological meetings is pivotal for fostering diversity and inclusivity in the field. This study aims to evaluate the representation of Spanish urologist and regional disparities, and to assess its alignment with the demographic composition of the urological community.</div></div><div><h3>Materials and methods</h3><div>All urology meetings organized by the AEU between January 2012 and December 2022 were reviewed, including meeting information and details of the faculty. Additionally, we analysed geographic distribution of speakers across 17 different regions. Gender demographics were obtained disaggregating data by sex and year from the Organización Médica Colegial de España (OMC) and from those urologists affiliated to the AEU.</div></div><div><h3>Results</h3><div>Analysing 52 AEU congresses held from 2012 to 2022, encompassing 3,407 speakers, the study found that 95.25% of speakers were from Spain and 89.6% were male speakers. Over the years, there was a positive trend in female speaker representation, increasing by 1.1% annually, slightly lagging the 1.8% annual rise in the number of female urologists in Spain. In specific subfields like functional, transplantation, and oncology sessions, the study revealed a higher representation of women, indicating focused efforts in these areas. Geographically, Madrid, Catalonia and Andalusia exhibited the highest representation.</div></div><div><h3>Conclusions</h3><div>Although there was a positive trend towards an increased participation of female urologists in Spanish urological meetings, it fails to accurately reflect the proportional increase in the number of women entering the urology profession in recent years. This study underscores the importance of ongoing efforts to ensure diverse and balanced representation in urological forum.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"48 8","pages":"Pages 574-580"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140407819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elaboración de un modelo experimental en conejos con diferentes grados de torsión testicular 在兔子身上建立不同程度睾丸扭转的实验模型。

IF 1.2 4区医学

Actas urologicas espanolas Pub Date : 2024-10-01 DOI: 10.1016/j.acuro.2024.04.007

X. Zhu , C. Peng , Z. Wu , X. Zhang , S. Liu , Y. Luo , L. Yang

{"title":"Elaboración de un modelo experimental en conejos con diferentes grados de torsión testicular","authors":"X. Zhu , C. Peng , Z. Wu , X. Zhang , S. Liu , Y. Luo , L. Yang","doi":"10.1016/j.acuro.2024.04.007","DOIUrl":"10.1016/j.acuro.2024.04.007","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Different degrees of testicular torsion result in varying degrees of testicular damage, which influences treatment options and outcomes. Therefore, establishing a testicular torsion model with different degrees is necessary for clinical diagnosis.</div></div><div><h3>Materials and methods</h3><div>Rabbits were randomly divided into 4groups and their spermatic cords were twisted at 0°, 180°, 360°, and 720°, respectively. Color Doppler flow imaging (CDFI) were performed to evaluate the blood supply in testicles. The twisted testicles were surgically removed at 6hours post-operation and were evaluated by morphological observation and Hematoxylin and Eosin staining.</div></div><div><h3>Results</h3><div>CDFI signals were gradually decreased as the degree of testicular torsion increased, and scores of CDFI in the 360° and 720° groups were significantly decreased at postoperative 6hours compared to pre-surgery. Compared to the sham, the testicle in the 180° group exhibited slight congestion, whereas the testicles in the 360° and 720° groups were dark red in color and had severe congestion and unrecognizable vessels. Hematoxylin and Eosin staining showed mild spermatogenic cell reduction and testicular interstitial hemorrhage in the 180° group. In the 360° and 720° groups, disordered seminiferous tubules, shed spermatogenic cells in tubules, inflammatory cell infiltration, and severe hemorrhage were found. In comparison with the sham, interstitial hemorrhage scores in the 360° and 720° groups were significantly higher, and scores of germinal epithelial cell thickness in the 3testicular torsion groups were significantly decreased.</div></div><div><h3>Conclusion</h3><div>Collectively, we successfully constructed a testicular torsion model with different degrees in rabbits.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"48 8","pages":"Pages 565-573"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142419845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0