{"title":"Development of eutectics of pioglitazone with citric acid and its effect on crystallite properties and dissolution.","authors":"Mouli Das, Shibashis Panigrahy, Rasmita Dash, Rudra Narayan Sahoo, Rakesh Swain, Souvik Nandi, Sk Habibullah, Tanisha Das, Subrata Mallick","doi":"10.17344/acsi.2024.8793","DOIUrl":"https://doi.org/10.17344/acsi.2024.8793","url":null,"abstract":"<p><p>Eutectics of pioglitazone were developed using citric acid (CA) as the co-former, and the effect on crystallite properties and dissolution has correspondingly been studied. Pioglitazone-citric acid eutectics (PC1, PC2, PC3, and PC4) in different molar ratios (3:1, 3:2, 1:1, and 3:4 respectively) were prepared by simple solvent evaporation method. Difference in dislocation density and strain value of the eutectics were observed, and the maximum strain value of PC1 might be due to the highest deformation activity compared to PC2, PC3, and PC4. Carbonyl-thiazolidine or carboxyl-pyridine weak bond formation might be the reason of producing eutectics of PGZ-CA rather than cocrystal with a docking score of - 2.2 Kcal/M. Likewise, lowest particle size was found with PC1 rather than that of pure PGZ and other eutectics. PC1 demonstrated highest dissolution of drug (68 %) rather than other eutectics (54 to 61 %) and PGZ (44 %) after 360 min.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"71 3","pages":"482-491"},"PeriodicalIF":1.2,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seyda Aydogdu, Oznur Dulger Kutlu, Ali Erdogmus, Arzu Hatipoglu
{"title":"Synthesis, characterization and DFT study of Ti(IV) phthalocyanines with quinoline groups.","authors":"Seyda Aydogdu, Oznur Dulger Kutlu, Ali Erdogmus, Arzu Hatipoglu","doi":"10.17344/acsi.2024.8813","DOIUrl":"https://doi.org/10.17344/acsi.2024.8813","url":null,"abstract":"<p><p>The synthesis, characterization, and electronic properties of 4-((7-methoxyquinolin-4-yl)oxy), 4-(quinolin-2-ylthio), and 4-((7-(trifluoromethyl)quinolin-4-yl)thio) peripherally substituted oxo-titanium phthalocyanines are described for the first time. The structures of the compounds were determined by UV-Vis, FTIR, 1H NMR, and MALDI-TOF mass spectrometry. Electronic spectra and molecular and electronic properties of compounds were calculated by Density Functional Theory (DFT) and Time-Dependent Density Functional Theory (TD-DFT) methods. Solvent effects on the electronic, geometric, and reactivity properties of the compounds were also investigated. Global and local reactivity indices and Molecular Electrostatic Potential surfaces of compounds were calculated. The reactivities and electronic structures of molecules vary depending on the solvent and substituents. It has been found that the synthesized compounds can be used for different purposes such as dye-sensitized solar cells and photodynamic therapy applications.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"71 3","pages":"437-450"},"PeriodicalIF":1.2,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exploring Teachers' Technological Pedagogical Content Knowledge as an Indicator for the Planning of In-service Teacher Training in Chemistry Education.","authors":"Mojca Orel, Cirila Peklaj, Vesna Ferk Savec","doi":"10.17344/acsi.2024.8783","DOIUrl":"https://doi.org/10.17344/acsi.2024.8783","url":null,"abstract":"<p><p>This study examined how teachers teaching chemistry at different levels of education perceive their levels of technological pedagogical content knowledge (TPACK) and examined the relationship of TPACK with age, gender, teaching at different levels of education, time spent teaching chemistry, and frequency of information and communication technology (ICT) use. The study involved 261 teachers, 246 women and 15 men, from all over Slovenia, who have been teaching chemistry for an average of 18 years at different levels of education, with an average age of 45 years. The results showed that teachers teaching chemistry content perceive a high level of TPACK. There is a statistically significant correlation between age, time spent teaching chemistry, and frequency of ICT use with the perceived level of technological pedagogical content knowledge. Younger teachers, those with less professional experience and teachers who use ICT more frequently rated their TPACK higher. Based on the results of the survey, guidelines for planning the in-service teacher training that would support the development of TPACK of teachers teaching chemistry content were developed.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"71 3","pages":"451-461"},"PeriodicalIF":1.2,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Preparation of porous imidazole-based poly(ionic liquid) adsorbents and their toluene adsorption performance.","authors":"Fangwen Luo, Xujiao Tian, Xian Dong, Longchao Liang, Zhuo Chen","doi":"10.17344/acsi.2024.8622","DOIUrl":"https://doi.org/10.17344/acsi.2024.8622","url":null,"abstract":"<p><p>Efficient, economical, and durable adsorbents are required to remove volatile organic compounds (VOCs) from air. Cross-linked polyvinylic ionic liquids (PVIC) with porous structures were synthesized by quaternizing 1-vinylimidazole (1VI) with 1-bromobutane to obtain 3-butyl-1-vinylimidazolium bromide (VIC), which was then co-polymerized with divinylbenzene (DVB) radicals. 1H NMR, 13C NMR, scanning electron microscopy, X-ray photoelectron spectroscopy, Fourier-transform infrared spectroscopy, and N2 adsorption-desorption isotherms were applied in characterizing the composites. Through modification of the polymer structure by adjustment of DVB concentration(the ratio of DVB concentration to VIC concentration was x: 1 (x=0.4, 0.6, 0.8, 1.0) and the product was named PVIC-s (s=2, 3, 4, 5)), the optimal PVIC-4 pore structure was obtained, with a specific surface area and total pore volume of 192.5 m2 g-1 and 0.192 cm3 g-1, respectively. A toluene adsorption test verified the adsorption capacity. The adsorption behavior for VOCs, based on toluene, was investigated using adsorption breakthrough curves, adsorption kinetics, and isotherms. The adsorption process is well describing by the Bangham kinetic and Langmuir isotherm models. The dynamic adsorption of toluene followed the order PVIC-4 > PVIC-5 > PVIC-3 > PVIC-2. The optimum toluene adsorption by PVIC-4 was 264.4 mg g-1 as a result of its excellent pore structure. PVIC-4 also performed well in terms of recovery and has potential for the removal of VOCs from air.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"71 3","pages":"471-481"},"PeriodicalIF":1.2,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis, crystal structures and antibacterial activity of nickel(II), cadmium(II) and zinc(II) complexes with hydrazone ligands.","authors":"Wei-Guang Zhang","doi":"10.17344/acsi.2024.8763","DOIUrl":"10.17344/acsi.2024.8763","url":null,"abstract":"<p><p>Three mononuclear nickel(II), cadmium(II) and zinc(II) complexes, [NiL2]·2CH3OH·H2O (1), [CdI2(HL)]·CH3OH (2) and [ZnL2] (3), have been synthesized from 3-hydroxy-4-methoxy-N'-[(Z)-(pyridin-2-yl)methylidene]benzohydrazide (HL) by microwave irradiation method. All complexes were characterized by CHN elemental analyses and infrared spectra. Structures of the complexes were further studied by single crystal X-ray determination, which reveals that the Ni and Zn atoms in complexes 1 and 3 are in octahedral coordination, and the Cd atom in complex 2 is in square pyramidal coordination. The biological activity of the complexes on the bacterial strains Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli was evaluated. As a result, the zinc complex has interesting antibacterial activities.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"71 3","pages":"462-470"},"PeriodicalIF":1.2,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"DRUŠTVENE VESTI IN DRUGE AKTIVNOSTI SOCIETY NEWS, ANNOUNCEMENTS, ACTIVITIES.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"71 2","pages":"S49-S74"},"PeriodicalIF":1.2,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The reusage of different wastes by using the multiple's effect technique for sustainable gasoline production.","authors":"Anita Kovač Kralj","doi":"10.17344/acsi.2024.8714","DOIUrl":"https://doi.org/10.17344/acsi.2024.8714","url":null,"abstract":"<p><p>The unused garbage which is accumulating the landfills, such as raw materials, could be reused for synthetic gasoline production. This study presents the multiple's effect technique, which is based on the reusage of different non, party and sorted municipal solid wastes (MSW), or biogas for syngas, converted into synthetic gasoline. The novelties of this technique include a basic multiple's effect parameter (MUW), which present a level of waste sorting, an effect of oxygen inhibition into different wastes, a simplified mathematical model and simulation with an Aspen Plus® simulator using the retrofitted methanol plan converted into the synthetic gasoline production. This technique includes a circular economy by using a circulated purified flue gas as raw material, co-products of hydrogen and water. This technique was tested on an existing methanol process, replacing natural gas with different alternatives of wastes or biogas for the synthetic gasoline production. The best alternative was the sorted MSW, which could generate an additional profit of 4.8 MEUR/a, including the garbage and CO2 emission reductions of 0.106·106 t/a and of 0.084 ·106 t/a.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"71 2","pages":"388-397"},"PeriodicalIF":1.2,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Preparation, Structures, Photoluminescence and Semiconductive Properties of Two Novel Lanthanide Mercury Materials with a 3-D Framework Structure.","authors":"Wen-Tong Chen, Hao-Dong Liu, Xi-Yu Shao, Yu-Yue Xu, Cheng Liu, Sheng-Ping Dai, Chang-Wang Pan","doi":"10.17344/acsi.2024.8661","DOIUrl":"https://doi.org/10.17344/acsi.2024.8661","url":null,"abstract":"<p><p>Two novel lanthanide mercury materials, [Gd(IA)3(H3O)2Hg3Br6]n·2nCl (1) and [La(IA)3(H3O)2Hg3Br6]n·2nCl (2) (IA = isonicotinic anion), have been prepared under solvothermal conditions and characterized by single-crystal X-ray diffraction techniques. They are isomorphic and characterized by a three-dimensional (3-D) framework structure. The lanthanide ions are bound by eight oxygen atoms to exhibit a square antiprismatic geometry. The solid-state photoluminescence experiment discovers that compound 1 shows a strong emission in the red region. Compound 1 possesses CIE (Commission Internationale de I'Éclairage) chromaticity coordinates of 0.7347 and 0.2653. Its CCT (correlated color temperature) is 6514 K. Compound 2 displays yellow photoluminescence and it has CIE chromaticity coordinates of 0.4411 and 0.5151. The CCT of compound 2 is 3633 K. Solid-state UV/Vis diffuse reflectance spectra revealed that their semiconductor band gaps are 2.16 eV and 2.85 eV, respectively.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"71 2","pages":"380-387"},"PeriodicalIF":1.2,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rahaman Sk Mosiur, Gouranga Dutta, Ranu Biswas, Abimanyu Sugumaran, Mohamed M Salem, Mohammed Gamal, Mohamed AbdElrahman, Mounir M Salem-Bekhit
{"title":"Succinyl curcumin conjugated chitosan polymer-prodrug Nanomicelles: A potential treatment for Type-II diabetes in Diabetic Balb/C mice.","authors":"Rahaman Sk Mosiur, Gouranga Dutta, Ranu Biswas, Abimanyu Sugumaran, Mohamed M Salem, Mohammed Gamal, Mohamed AbdElrahman, Mounir M Salem-Bekhit","doi":"10.17344/acsi.2024.8658","DOIUrl":"10.17344/acsi.2024.8658","url":null,"abstract":"<p><p>Diabetes mellitus is a chronic metabolic disorder marked by elevated blood sugar levels, leading to organ dysfunction. Curcumin, derived from turmeric, exhibits promise in managing type II diabetes. Nanomicelles were created by conjugating curcumin with chitosan through succinic anhydride. Succinyl-curcumin, the resultant compound, was esterified with chitosan to form a polymer prodrug conjugate. Nanomicelles, formed via dialysis, were spherical with a hydrodynamic size of 49.37 nm. In vitro release studies revealed 97% curcumin release at pH 5 in 7 days. A 21-day experiment on diabetic mice compared nanomicelles, standard drug, and free curcumin's impact on fasting blood glucose. The study showcased gradual, controlled curcumin release from nanomicelles, suggesting their potential in type II diabetes treatment.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"71 2","pages":"421-435"},"PeriodicalIF":1.2,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Razieh Shekari Moghadam, Babak Samiey, Jiang Ning Wu
{"title":"Graphene Oxide/Polyamidoamine G4 as a High Efficient and Eco-Friendly Adsorbent for Dichromate Ions.","authors":"Razieh Shekari Moghadam, Babak Samiey, Jiang Ning Wu","doi":"10.17344/acsi.2023.8361","DOIUrl":"https://doi.org/10.17344/acsi.2023.8361","url":null,"abstract":"<p><p>In this study, GO/PAMAM4 was used as a biocompatible nanocomposite adsorbent to adsorb dichromate (DC) ions. In alkaline solutions, DC ions changed to chromate ions which were not adsorbed on the surface of adsorbent. Thus, experiments were carried out in acidic and neutral water solution. Under these conditions, adsorption sites of adsorbent were protonated primary and ternary amine groups of adsorbent shown as -NH3+ and -NHR2+, respectively, that adsorbed DC ions through electrostatic interaction. Adsorption isotherms of DC on GO/PAMAM4 were obtained under various ionic strengths, pHs and temperatures. Isotherms were analyzed by the ARIAN model. The highest observed adsorption capacity of this process was 246.7 mg g-1 at pH=0 and 318 K. Tests at pH=2 showed that this process was endothermic. Adsorption kinetic experiments were carried out under various initial DC concentrations, pHs, temperatures, shaking rates and ionic strengths and were analyzed by the KASRA model and intraparticle diffusion, ISO and NIPPON equations. Pb2+, Cd2+, Cr3+ and tannic acid (TA) were separated by GO/PAMAM4 from DC ions and the GO/PAMAM4 was recycled by using an alkaline solution.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"71 2","pages":"363-379"},"PeriodicalIF":1.2,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}