Acta Clinica Belgica最新文献_第4页

Barriers and facilitators for physical activity on acute geriatric and rehabilitation wards: a survey study. 急性老年病和康复病房体育活动的障碍和促进因素：一项调查研究。

IF 1.6 4区医学

Acta Clinica Belgica Pub Date : 2023-12-01 Epub Date: 2023-07-30 DOI: 10.1080/17843286.2023.2239546

Ine Mols, Margreet van Dijk, Maaike L De Roo, Jos Tournoy, Bastiaan Van Grootven

{"title":"Barriers and facilitators for physical activity on acute geriatric and rehabilitation wards: a survey study.","authors":"Ine Mols, Margreet van Dijk, Maaike L De Roo, Jos Tournoy, Bastiaan Van Grootven","doi":"10.1080/17843286.2023.2239546","DOIUrl":"10.1080/17843286.2023.2239546","url":null,"abstract":"Objectives: During hospitalisation, physical inactivity is common among older patients and is associated with adverse outcomes, e.g. functional decline. This study identified barriers and facilitators of physical activity with geriatric patients during hospital admission.Methods: This is a cross-sectional descriptive study, on two acute geriatric units and one rehabilitation unit, using a researcher-administered survey methodology in patients 70 years or older. A new questionnaire was developed based on a literature review, and was administered bedside and face-to-face with the older patients.Results: 72 patients, mean age 83.6 years, completed the questionnaire. 88.9% of the participants found physical activity important during hospitalisation. The main patient-related determinants were fear of falling and symptoms of current illness (e.g. pain). The main environmental-related determinants were the presence of medical devices, and the availability of walking aids. Half of the patients felt motivated by the hospital staff, and one out of six participants felt discouraged. Receiving more assistance for walking and having access to other types of physical activity was expected to increase physical activity. Additionally, motivation from family would be a facilitator for 44.4% of the participants.Conclusion: Promoting physical activity on acute geriatric units will require interventions at different levels. Most importantly, focusing on interpersonal motivators and positive reinforcement by hospital staff could be beneficial strategies to increase the physical activity of older hospitalised patients.","PeriodicalId":7086,"journal":{"name":"Acta Clinica Belgica","volume":" ","pages":"452-458"},"PeriodicalIF":1.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10255612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skeletal response to teriparatide in real-life setting: effects of age, baseline bone density and prior denosumab use. 现实生活中对特立帕肽的骨骼反应：年龄、基线骨密度和既往使用狄诺沙单抗的影响。

IF 1.6 4区医学

Acta Clinica Belgica Pub Date : 2023-12-01 Epub Date: 2023-07-19 DOI: 10.1080/17843286.2023.2238375

Valerie Konings, Michaël R Laurent, Sigrid Janssens, Jolan Dupont, Evelien Gielen, Marian Dejaeger

{"title":"Skeletal response to teriparatide in real-life setting: effects of age, baseline bone density and prior denosumab use.","authors":"Valerie Konings, Michaël R Laurent, Sigrid Janssens, Jolan Dupont, Evelien Gielen, Marian Dejaeger","doi":"10.1080/17843286.2023.2238375","DOIUrl":"10.1080/17843286.2023.2238375","url":null,"abstract":"Objectives: Teriparatide (TPD) is an osteoanabolic agent used in patients with high osteoporotic fracture risk. Predictors of therapeutic response to TPD in real-life setting are not well characterised. This study investigated the influence of previous antiresorptive therapy, age and other patient characteristics on the skeletal response to TPD.Methods: Retrospective study at the metabolic bone clinic, University Hospitals Leuven, Belgium. Patients with osteoporosis and a high fracture burden received TPD for 9-18 months. Bone mineral density (BMD) was measured at baseline, 9 and 18 months at lumbar spine (LS), femoral neck (FN) and total hip (TH).Results: BMD at LS increased at 9 months (change mean (standard error) 6.8 % (0.7) p < 0.001) and at 18 months (8.0 % (0.9) p < 0.001), while BMD at FN and TH did not change significantly. Non-response in BMD change at the LS was seen with prior denosumab use (odds ratio 0.21, 95% confidence interval (CI) 0.049-0.912, p = 0.037). Changes in BMD at TH were significantly greater in younger patients and in patients with a lower baseline BMD.Conclusion: TPD-induced changes in BMD at TH might depend on age and baseline BMD and at LS on prior denosumab use. The results suggest that these factors may be relevant for clinical decision making when initiating TPD treatment, although larger studies are needed to confirm these findings.","PeriodicalId":7086,"journal":{"name":"Acta Clinica Belgica","volume":" ","pages":"446-451"},"PeriodicalIF":1.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9829413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The 2023 Belgian clinical guidance on anticoagulation management in hospitalized and ambulatory COVID-19 patients. 2023年比利时新冠肺炎住院和住院患者抗凝管理临床指南。

IF 1.6 4区医学

Acta Clinica Belgica Pub Date : 2023-12-01 Epub Date: 2023-08-07 DOI: 10.1080/17843286.2023.2241692

Thomas Vanassche, Matthias M Engelen, Christelle Orlando, Kristel Vandenbosch, Alain Gadisseur, Cedric Hermans, Kristin Jochmans, Jean-Marc Minon, Serge Motte, Harlinde Peperstraete, Pierre Péters, Muriel Sprynger, Patrizio Lancellotti, Isabelle Dehaene, Patrick Emonts, Christophe Vandenbriele, Peter Verhamme, Cecile Oury

引用次数: 0

Clinical practice of hereditary angioedema in Belgium: opportunities for optimized care. 比利时遗传性血管性水肿的临床实践：优化护理的机会。

IF 1.6 4区医学

Acta Clinica Belgica Pub Date : 2023-12-01 Epub Date: 2023-05-27 DOI: 10.1080/17843286.2023.2213491

D G Ebo, M M Van der Poorten, A L Van Gasse, R Schrijvers, C Hermans, M Bartiaux, F Haerynck, J Willekens, H Lapeere, M Moutschen, O Michel, V Sabato

{"title":"Clinical practice of hereditary angioedema in Belgium: opportunities for optimized care.","authors":"D G Ebo, M M Van der Poorten, A L Van Gasse, R Schrijvers, C Hermans, M Bartiaux, F Haerynck, J Willekens, H Lapeere, M Moutschen, O Michel, V Sabato","doi":"10.1080/17843286.2023.2213491","DOIUrl":"10.1080/17843286.2023.2213491","url":null,"abstract":"Introduction: Hereditary angioedema (HAE) is a rare disorder characterized by unpredictable painful and potentially life-threatening swelling episodes. The international WAO/EAACI guideline on the diagnosis and management of HAE was recently updated and provides up-to-date guidance for the management of. In this paper, we assessed to what extent the Belgian clinical practice was aligned with the revised guideline, and whether there were opportunities to optimise Belgian clinical practice in HAE.Methods: We compared the updated international guideline for HAE with information we acquired on Belgian clinical practice, a Belgian patient registry and expert opinion analysis. The Belgian patient registry was developed with the involvement of eight Belgian reference centers for HAE patients. Eight Belgian experts, physicians in the participating centers, included patients in the patient registry and participated in the expert opinion analysis.Results: The main action points to further optimise the Belgian clinical practice of HAE are Work towards total disease control and normalize patients' life by considering the use of new and innovative long-term prophylactic treatment options; (2) inform C1-INH-HAE patients about new long-term prophylactic therapies; (3) assure the availability of on-demand therapy for all C1-INH-HAE patients; (4) implement a more universally used assessment including multiple aspects of the disease (e.g. quality of life assessment) in daily clinical practice; and (5) continue and expand an existing patient registry to assure continued data availability on C1-INH-HAE in Belgium.Conclusions: In light of the updated WAO/EAACI guideline, five action points were identified and several other suggestions were made to optimise the Belgian clinical practice in C1-INH-HAE.","PeriodicalId":7086,"journal":{"name":"Acta Clinica Belgica","volume":" ","pages":"431-437"},"PeriodicalIF":1.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9520346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The concomitant use of paracetamol and flucloxacillin. A rare cause of high anion gap metabolic acidosis in the frail oldest old. 同时使用扑热息痛和氟氯西林。一种罕见的导致体弱老年人高阴离子间隙代谢性酸中毒的原因。

IF 1.6 4区医学

Acta Clinica Belgica Pub Date : 2023-12-01 Epub Date: 2023-08-13 DOI: 10.1080/17843286.2023.2246226

Sarah Billet, Philippe Vanbiervliet, Mark Remery, Julien Dekoninck, Wim Janssens

{"title":"The concomitant use of paracetamol and flucloxacillin. A rare cause of high anion gap metabolic acidosis in the frail oldest old.","authors":"Sarah Billet, Philippe Vanbiervliet, Mark Remery, Julien Dekoninck, Wim Janssens","doi":"10.1080/17843286.2023.2246226","DOIUrl":"10.1080/17843286.2023.2246226","url":null,"abstract":"ABSTRACT Objectives This article describes the occurrence of a high anion gap metabolic acidosis (HAGMA) in two older, female patients with a methicillin sensitive staphylococcus aureus (MSSA) infection. Both patients received flucloxacillin and paracetamol. Both of them initially improved but declined rapidly after two to three weeks of treatment. They developed a severe HAGMA resulting in their death. The objective of this article is to determine whether old age is a major risk factor for developing HAGMA when combining paracetamol with flucloxacillin. Methods A literature study was conducted using the MEDLINE database, PubMed. The used MeSH terms were ‘flucloxacillin, acetaminophen, glutathione synthetase deficiency and acidosis’. Furthermore, we used two cases to illustrate our findings. Results The origin of the high anion gap metabolic acidosis is the accumulation of 5-oxoproline which is known to occur when combining flucloxacillin with paracetamol due to their interaction with different enzymes of the gamma glutamyl cycle. This leads to the depletion of glutathione and the formation of 5-oxoproline. This phenomenon has a higher risk of occurring in frail older adults as most of them have several predisposing risk factors which result in lower baseline glutathione reserve. These risk factors include old age, malnutrition, assigned female at birth, pre-existing kidney and/or liver dysfunction, uncontrolled diabetes and sepsis. Conclusion The purpose of this article is to raise awareness of this phenomenon and its higher occurrence in frail older adults, which hopefully will lead to an earlier diagnosis with a better outcome for the patient.","PeriodicalId":7086,"journal":{"name":"Acta Clinica Belgica","volume":" ","pages":"509-515"},"PeriodicalIF":1.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10362155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inverse association between caffeine intake and albuminuria in US adults: an analysis of NHANES 2005-2016. 美国成年人咖啡因摄入与蛋白尿之间的反向关联：2005-2016年NHANES分析。

IF 1.6 4区医学

Acta Clinica Belgica Pub Date : 2023-12-01 Epub Date: 2023-06-06 DOI: 10.1080/17843286.2023.2222243

Qiqi Ma, Shuaihua Song, Gaosi Xu

{"title":"Inverse association between caffeine intake and albuminuria in US adults: an analysis of NHANES 2005-2016.","authors":"Qiqi Ma, Shuaihua Song, Gaosi Xu","doi":"10.1080/17843286.2023.2222243","DOIUrl":"10.1080/17843286.2023.2222243","url":null,"abstract":"Objectives: Albuminuria is a significant biomarker of various kidney diseases and is associated with renal outcome. Recently, caffeine intake has shown potential renoprotective effects. However, the relationship between caffeine intake and albuminuria remains profoundly elusive.Methods: We conducted a cross-sectional study aimed to explore the association between caffeine intake and albuminuria in the American adult population using the data acquired from the National Health and Nutrition Examination Survey (NHANES) 2005-2016. Caffeine intake was assessed by 24-h dietary recalls, and albuminuria was assessed by albumin-to-creatinine ratio. Multivariate logistic regression was performed to explore the independent association between caffeine intake and albuminuria. Subgroup analysis and interaction tests were also conducted.Results: Among 23,060 participants, 11.8% of the individuals exhibited albuminuria, and the prevalence of albuminuria decreased with higher caffeine intake tertiles (Tertile 1: 13%; Tertile 2: 11.9%; Tertile 3: 10.5%; P < 0.001). After adjusted potential confounders, the results of logistic regression indicated that a higher caffeine intake was associated with a decreased risk of albuminuria (OR = 0.903; 95% CI: 0.84, 0.97; P = 0.007), especially in females and the participants aged <60 years and chronic kidney disease stage II.Conclusion: The present study first indicated an inverse correlation between caffeine intake and albuminuria, which further confirmed the potentially protective effects of caffeine on the kidney.","PeriodicalId":7086,"journal":{"name":"Acta Clinica Belgica","volume":" ","pages":"438-445"},"PeriodicalIF":1.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9571181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CPAP adherence after ambulatory and in-hospital management in patients aged 65 years and older. 65岁及以上患者门诊和住院治疗后的CPAP依从性。

IF 1.6 4区医学

Acta Clinica Belgica Pub Date : 2023-12-01 Epub Date: 2023-10-16 DOI: 10.1080/17843286.2023.2260137

Charlène Collard, Maxime Regnier, Gisèle Maury

{"title":"CPAP adherence after ambulatory and in-hospital management in patients aged 65 years and older.","authors":"Charlène Collard, Maxime Regnier, Gisèle Maury","doi":"10.1080/17843286.2023.2260137","DOIUrl":"10.1080/17843286.2023.2260137","url":null,"abstract":"Objectives: The aims of this study are to evaluate the early adherence to CPAP treatment in patients aged 65 years and older and to compare ambulatory (ACPAP) and in-hospital (HCPAP) management in starting CPAP treatment.Methods: Adherence to CPAP therapy at 3 months was retrospectively studied in patients on whom CPAP therapy was initiated between 1 January 2020 and 31 December 2021. Patients in the ACPAP group were selected based on the current Belgian reimbursement criteria (OAHI ≥30/h and few comorbidities).Results: 146 patients were studied (median OAHI 43.35/h [32.02; 57.40]; median age 69 [67.0; 73.0]): 116 (79.5%) patients in the HCPAP and 30 (20.5%) in the ACPAP group. Based on an adherence threshold of average CPAP use of ≥ 4 hours per day, 120 (82%) patients were adherent to the treatment; 94 (81%) patients in the HCPAP and 26 (86.7%) in the ACPAP group. The median CPAP use for the total population was 6.4 h/day [4.89; 7.34], reaching 6.3 h/d [4.79; 7.15] for the HCPAP group and 6.8 h/d [6.21; 8.06] for the ACPAP group (p = 0.019). Insomnia was a significant risk factor for non-adherence (OR 5.16 [1.64; 16.08], p = 0.0043) but the ACPAP method was not (OR 0.66 [0.18; 1.91], p = 0.4748).Conclusion: Early CPAP adherence in patients ≥ 65 years old was good in terms of average use per day and proportion of adherent patients. ACPAP method was not a risk factor for lower CPAP adherence in patients presenting severe OSAS (OAHI ≥30/h) and few comorbidities.","PeriodicalId":7086,"journal":{"name":"Acta Clinica Belgica","volume":" ","pages":"467-477"},"PeriodicalIF":1.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10311154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abstracts presented at the 27th Annual Congress of the Belgian Society of Internal Medicine, 1-2 December 2023, Dolce La Hulpe, La Hulpe, Belgium 第27届比利时内科学会年会，2023年12月1日至2日，比利时La Hulpe, Dolce La Hulpe

IF 1.6 4区医学

Acta Clinica Belgica Pub Date : 2023-11-29 DOI: 10.1080/17843286.2023.2278952

引用次数: 0

Time to treat the climate and nature crisis as one indivisible global health emergency. 是时候将气候和自然危机视为一个不可分割的全球卫生紧急事件了。

IF 1.6 4区医学

Acta Clinica Belgica Pub Date : 2023-10-30 DOI: 10.1080/17843286.2023.2276496

Kamran Abbasi, Parveen Ali, Virginia Barbour, Thomas Benfield, Kirsten Bibbins-Domingo, Gregory E Erhabor, Stephen Hancocks, Richard Horton, Laurie Laybourn-Langton, Robert Mash, Peush Sahni, Wadeia Mohammad Sharief, Paul Yonga, Chris Zielinski

引用次数: 0

Statin-induced necrotizing autoimmune myopathy (SINAM): case report and review of the literature. 他汀类药物诱导的坏死性自身免疫性肌病(SINAM):病例报告和文献回顾

IF 1.6 4区医学

Acta Clinica Belgica Pub Date : 2023-08-01 DOI: 10.1080/17843286.2022.2156701

Leander Cornelis, Julien Duyck, Franciska Dedeurwaerdere, Gert De Schoenmakere, Thomas Malfait

引用次数: 1