Acta Clinica Belgica最新文献

{"title":"Evaluation of the clinical application of MALDI-TOF MS for identification of difficult-to-classify nontuberculous mycobacterial strains isolated in the laboratory.","authors":"Chan Long, Jing Gui, Feng Wang, Chunlian Wang, Li Zhang","doi":"10.1080/17843286.2026.2643452","DOIUrl":"10.1080/17843286.2026.2643452","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to evaluate the clinical application value of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) in the verification and identification of difficult-to-classify nontuberculous mycobacterial (NTM) strains.</p><p><strong>Methods: </strong>From December 2024 to June 2025, 106 suspected NTM isolates were collected from 10 districts in Shenzhen, China. Initial identification was performed using HRM and REBA commercial kits, with targeted nanopore sequencing and mNGS as the composite reference standard. MALDI-TOF MS was used to verify strains unresolved by the kits, and its diagnostic performance was evaluated.</p><p><strong>Results: </strong>The HRM kit demonstrated concordance with the reference standard in 98 of 106 samples (concordance rate: 89.1%), whereas the REBA kit concorded in 88 samples (concordance rate: 80.0%). The REBA kit exhibited a tendency toward misidentification of NTM species as <i>Mycobacterium tuberculosis</i>. When the reference results were used as a baseline with tNanopore providing parallel validation (achieving ≥95% concordance with reference results), MALDI-TOF MS demonstrated poor performance in identifying difficult-to-classify NTM strains. Specifically, MALDI-TOF MS showed poor concordance in detecting M. abscessus (Kappa = 0.244), while <i>Mycobacterium intracellulare</i>, <i>Mycobacterium kansasii</i>, and <i>Mycobacterium gordonae</i> demonstrated kappa values of 0.543, 0.477, and 0.483, respectively, indicating low concordance overall. Furthermore, 13 species exceeded the detection range of MALDI-TOF MS, resulting in false-positive identifications or detection failures, with <i>Mycobacterium abscessus</i> exhibiting the highest rate of misidentification.</p><p><strong>Conclusion: </strong>The limitations of MALDI-TOF MS in verifying difficult-to-classify NTM strains have been demonstrated. The findings emphasize that PCR-based molecular detection combined with gene sequence analysis remains the most reliable methodological approach for accurately identifying challenging NTM species in clinical practice.</p>","PeriodicalId":7086,"journal":{"name":"Acta Clinica Belgica","volume":" ","pages":"293-302"},"PeriodicalIF":0.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147388751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathologic characteristics and long-term outcomes in glomerulonephritis with crescent formation: a 20-year single-center cohort study.","authors":"Tugay Yılmaz, Hüseyin Döngelli, Mehmet Ası Oktan, Cihan Heybeli, Yelda Deligöz Bildacı, Berfu Korucu, İlker Atay, Caner Çavdar, Serpil Müge Değer","doi":"10.1080/17843286.2026.2633340","DOIUrl":"10.1080/17843286.2026.2633340","url":null,"abstract":"<p><strong>Introduction: </strong>Crescentic glomerulonephritis (GN) is among the most aggressive glomerular diseases, defined by extensive crescent formation and rapid loss of kidney function.</p><p><strong>Objective: </strong>To evaluate clinical, laboratory, and histopathologic determinants of end-stage kidney disease (ESKD) and overall survival (OS), and to identify associated factors of poor outcomes in patients with crescentic GN (cGN) and GN with crescent formation.</p><p><strong>Methods: </strong>This single-center retrospective cohort included 194 adults who underwent kidney biopsy between 2005 and 2024. The primary endpoints were progression to ESKD and OS. Cox proportional hazards and Kaplan - Meier analyses were performed.</p><p><strong>Results: </strong>Immune complex GN was the predominant subtype (59.3%), followed by pauci-immune GN (38.1%) and anti-GBM disease (2.6%). cGN accounted for 25.2% of cases. Overall, 42.8% of patients progressed to ESKD, while 35.6% died during follow-up. In multivariate Cox analysis, maintenance steroid monotherapy was a strong independent associated factor of ESKD (HR 2.349, 95% CI 1.378-4.004, <i>p</i> = 0.002), along with baseline creatinine (HR 1.180, 95% CI 1.023-1.360, <i>p</i> = 0.023), proteinuria (HR 1.067, 95% CI 1.020-1.117, <i>p</i> = 0.005), global glomerulosclerosis (HR 4.103, 95% CI 1.083-15.540, <i>p</i> = 0.038), and IgA positivity (HR 0.758, 95% CI 0.587-0.979, <i>p</i> = 0.034). For OS, steroid monotherapy remained independently associated with mortality (HR 2.427, 95% CI 1.370-4.299, <i>p</i> = 0.002), along with older age and reduced eGFR.</p><p><strong>Conclusion: </strong>Maintenance steroid monotherapy was the strongest treatment-related factor associated with both ESKD and overall survival, highlighting the potential risks of inadequate maintenance immunosuppression in high-risk patients.</p>","PeriodicalId":7086,"journal":{"name":"Acta Clinica Belgica","volume":" ","pages":"223-233"},"PeriodicalIF":0.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146218276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A structured proactive penicillin allergy delabeling intervention in adult patients in three non-university hospitals.","authors":"Jodie Langbeen, Evy Desmyttere, Evelien Delaere, Stephanie Dobbelaere, Geert Tits, Ann-Catherine Soenen, Ines Malysse, Laetitia Missiaen, Sarah Vanwynsberghe, Kristof Van Huffel, Hannelore Santens, Frederik Van Hoecke, Wim Terryn, Dirk Vogelaers","doi":"10.1080/17843286.2026.2633337","DOIUrl":"10.1080/17843286.2026.2633337","url":null,"abstract":"<p><strong>Background: </strong>Over 90% of patients with penicillin allergy do not have a true penicillin allergy. This allergy label can lead to inappropriate antibiotic prescription, a higher risk of treatment failure and toxicity, and higher rates of infections with multidrug-resistant organisms. Penicillin allergy delabeling strategies are increasingly reported and should be included in antimicrobial stewardship programs.</p><p><strong>Objectives and methods: </strong>Development and phased implementation of a structured and proactive screening tool and decision algorithm for delabeling presumed penicillin allergy in the preoperative consultations of three non-university hospitals within the same locoregional network. Risk categorization was integrated into a user-friendly screening questionnaire, and streamlined actions were developed through interdisciplinary consensus.</p><p><strong>Results: </strong>The questionnaire was implemented in two pilot phases, with adaptations through feedback from the users and other hospital networks working on penicillin allergy delabeling throughout Flanders. Among a total of 8.659 patients screened, 600 patients (6.93%) reported penicillin allergy, categorized as no risk, low, or high risk of penicillin allergy. 91 patients (15.17%) could be directly delabeled, and 33 patients (5.5%) were delabeled through patient file analysis or further testing.</p><p><strong>Conclusion: </strong>A screening tool for proactive detection of penicillin allergy was developed. This study demonstrates that a substantial proportion of patients with a presumed penicillin allergy can be delabeled non-medically by administering a structured questionnaire, offering a step up towards comprehensive allergologic questioning and patient file analysis, with eventual additional testing in selected patients. The screening tool needs to be validated in a prospective trial including definitive categorization.</p>","PeriodicalId":7086,"journal":{"name":"Acta Clinica Belgica","volume":" ","pages":"214-222"},"PeriodicalIF":0.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146211853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous coronary artery dissection in a young woman: a case report.","authors":"Floris Vandewoude, Elize Janssen, Herbert Mertens, Cornelia Genbrugge","doi":"10.1080/17843286.2026.2618120","DOIUrl":"10.1080/17843286.2026.2618120","url":null,"abstract":"<p><strong>Background: </strong>Spontaneous coronary artery dissection (SCAD) is an uncommon cause of acute coronary syndrome (ACS), particularly in young women without conventional risk factors. Recognition is essential as management differs from atherosclerotic ACS.</p><p><strong>Case presentation: </strong>A 27-year-old woman with no cardiovascular history presented to the emergency department with acute left-sided chest pain radiating to the left arm. Initial evaluation showed elevated troponin levels and an electrocardiogram with nonspecific ST-segment changes. Transthoracic echocardiography revealed mildly reduced left ventricular systolic function (≈45%) with apical hypokinesia. She was initially treated with aspirin, while dual antiplatelet therapy was deferred pending definitive diagnosis. Coronary computed tomography angiography demonstrated a short-segment, high-grade stenosis of the proximal left anterior descending (LAD) artery with features suggestive of SCAD. Subsequent invasive coronary angiography confirmed the diagnosis, showing a severe (~90%) LAD stenosis with TIMI 2 flow. Given the lesion severity and impaired coronary flow, percutaneous coronary intervention with drug-eluting stent implantation was performed, successfully restoring TIMI 3 flow.</p><p><strong>Discussion: </strong>SCAD often presents with nonspecific ECG findings, and initial troponins may be normal in a substantial proportion of patients, contributing to diagnostic delay. While coronary CT angiography may aid diagnosis in selected cases, invasive angiography remains the gold standard. Management requires careful consideration of lesion characteristics and clinical stability, as conservative treatment is often preferred but not always feasible.</p><p><strong>Conclusion: </strong>SCAD should be considered in young women presenting with ACS-like symptoms, even in the absence of cardiovascular risk factors. Timely diagnosis and individualized management are essential to optimize outcomes.</p>","PeriodicalId":7086,"journal":{"name":"Acta Clinica Belgica","volume":" ","pages":"173-180"},"PeriodicalIF":0.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145987746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the ability of SARC-F to reflect elastography-based muscle quality in older adults.","authors":"Ali Akin, Çağatay Çavuşoğlu, Recep Aydın","doi":"10.1080/17843286.2026.2639701","DOIUrl":"10.1080/17843286.2026.2639701","url":null,"abstract":"<p><strong>Background: </strong>Sarcopenia is a geriatric syndrome characterized by progressive loss of skeletal muscle mass, strength, and function associated with aging. Studies evaluating the relationship between sarcopenia screening tools and elastography-based muscle quality measurements are quite limited. The main objective of this study was to evaluate the relationship between the SARC-F score and muscle elasticity in older adults.</p><p><strong>Methods: </strong>This cross-sectional study included 140 adults aged ≥60 years attending geriatric or internal medicine outpatient clinics at a tertiary academic center. Sociodemographic characteristics, comorbidities, BMI, nutritional status (MNA-SF), frailty (Clinical Frailty Scale, FRAIL), and SARC-F scores were recorded. Rectus femoris thickness and elasticity were assessed using shear-wave elastography.</p><p><strong>Results: </strong>The median age was 65 (60-91), and 62.9% (n = 88) were female. Positive SARC-F screen (SARC-F ≥ 4) was observed in 29.3% (n = 41). Participants at risk for sarcopenia were older (70 vs. 64 years, p < 0.001), more frail (CFS 5 vs. 3, p < 0.001), more malnourished (MNA-SF 10 vs. 13, p < 0.001), and had lower RF thickness (8.4 vs. 9.8 mm, p = 0.013) and lower muscle elasticity (10.9 vs. 14.6 kPa, p = 0.002). A weak negative correlation was found between SARC-F and RF elasticity (ρ = -0.315, p < 0.001). In the age- and sex-adjusted model, this association was no longer significant (p = 0.116). In multivariable stepwise regression, RF elasticity was not independently associated with SARC-F. .</p><p><strong>Conclusions: </strong>SARC-F is a practical screening tool for sarcopenia risk but may not adequately reflect muscle quality. These findings suggest that incorporating muscle quality assessments (e.g. shear-wave elastography) into sarcopenia screening may improve diagnostic accuracy and clinical management.</p>","PeriodicalId":7086,"journal":{"name":"Acta Clinica Belgica","volume":" ","pages":"258-268"},"PeriodicalIF":0.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The global, regional, and national patterns of change in the burden of acute glomerulonephritis, 1990-2021: an analysis of the global burden of disease study 2021 and forecast to 2036.","authors":"Baoqing Liu, Chunjie Zhang, Hong Hong, Maowei Pei","doi":"10.1080/17843286.2026.2638859","DOIUrl":"10.1080/17843286.2026.2638859","url":null,"abstract":"<p><strong>Background: </strong>To understand and prevent global trends of acute glomerulonephritis (AGN), we analyzed its burden from 1990 to 2021.</p><p><strong>Methods: </strong>Using GBD 2021 data, we estimated the global burden of AGN by calculating age-standardized rates (ASR) of incidence (ASIR), prevalence (ASPR), mortality (ASMR), and DALYs (ASDR), along with corresponding counts, and assessed temporal trends using estimated annual percentage change (EAPC), decomposition analysis, frontier analysis, and ASR-based projections.</p><p><strong>Results: </strong>From 1990 to 2021, the global burden of AGN declined overall, with the largest reduction observed in DALYs (-44.96%). ASR generally decreased but showed a slight rebound after 2010. Incidence peaked at ages 10-14 and 85-89 years. Substantial disparities were observed across SDI regions: ASR was higher in middle and high-middle SDI regions; although ASIR and ASPR were lower in low SDI regions, ASMR and ASDRs were relatively higher; notably, increases in ASMR and ASDRs were observed only in high SDI regions. Correlation analyses showed that ASMR and ASDRs were significantly negatively associated with SDI. Decomposition analysis indicated that epidemiological changes were the main driver of the global decline in AGN burden. Frontier analysis suggested that countries with middle SDI have the greatest potential for improvement in disease control. Projections indicate that by 2036, global ASIR and ASPR may slightly increase, whereas ASMR and ASDRs are expected to continue declining.</p><p><strong>Conclusions: </strong>Overall, despite the marked global decline in AGN burden, substantial regional heterogeneity persists, underscoring the need for tailored public health strategies according to regional SDI levels.</p>","PeriodicalId":7086,"journal":{"name":"Acta Clinica Belgica","volume":" ","pages":"243-257"},"PeriodicalIF":0.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute promyelocytic leukemia complicated by osteofascial compartment syndrome.","authors":"Xiaojuan Li, Min Liu, Zhan Su, Xiaojun Zou","doi":"10.1080/17843286.2025.2606872","DOIUrl":"10.1080/17843286.2025.2606872","url":null,"abstract":"<p><strong>Background: </strong>Osteofascial compartment syndrome (OCS) refers to a series of clinical syndromes caused by acute ischemia and hypoxia of the tissues inside a fascial compartment. OCS secondary to acute leukemia is extremely rare. Coagulopathy is a common phenomenon in acute promyelocytic leukemia (APL), which often leads to various bleeding complications.</p><p><strong>Clinical presentation: </strong>We report the first case of APL complicated by OCS. The elderly female experienced differentiation syndrome, left forearm OCS, and rhabdomyolysis during the induction treatment. The coagulopathy ultimately resulted in a fatal cerebral hemorrhage.</p><p><strong>Conclusion: </strong>Compared to the more commonly reported OCS associated with chronic leukemias, OCS secondary to APL is particularly perilous.</p>","PeriodicalId":7086,"journal":{"name":"Acta Clinica Belgica","volume":" ","pages":"80-83"},"PeriodicalIF":0.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145802829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of point-of-care ultrasound in right upper quadrant abdominal pain in an emergency department: cost analysis.","authors":"Florence Dupriez, Delphine Druez, Apolline Ries, France Stevens, Andrea Penaloza, Bastian Rodrigues de Castro","doi":"10.1080/17843286.2026.2618115","DOIUrl":"10.1080/17843286.2026.2618115","url":null,"abstract":"<p><strong>Purpose: </strong>Point-of-care ultrasound (PoCUS) offers high diagnostic performance for the assessment of right upper quadrant (RUQ) abdominal pain. We sought to assess the economic impact on society and patients of using PoCUS for RUQ pain assessment.</p><p><strong>Methods: </strong>This study constitutes a secondary analysis based on a prospective, interventional, multicenter cohort study conducted in five Belgian emergency departments in 2023 that evaluated PoCUS's impact on the diagnostic process for patients with RUQ pain. The comparison was made between the estimated costs based on the diagnostic and therapeutic plan established before PoCUS and the actual costs after PoCUS integration.</p><p><strong>Results: </strong>Using PoCUS for RUQ pain in the emergency department saved an average of €69.1 per patient (<i>p</i> < 0.01). The Belgian National Institute for Health and Disability Insurance saved an average of €66.5 and the patient €2.6 (<i>p</i> < 0.01). This saving remained significant (<i>p</i> < 0.01) when PoCUS was charged at €25. When the PoCUS result was negative, €57.5 (<i>p</i> < 0.01) were saved and €81.5 when the result was positive (<i>p</i> < 0.01). Total savings for complementary examinations were €61.3 and €7.8 for treatments (<i>p</i> < 0.01).</p><p><strong>Conclusion: </strong>PoCUS use in abdominal RUQ pain assessment had a positive financial impact on society, even when PoCUS billing costs were taken into account. Costs associated with complementary examinations and treatments were reduced, regardless of whether PoCUS results were positive or negative.</p><p><strong>Clinical trial registration: </strong>ClinicalTrials.gov NCT05438654.</p>","PeriodicalId":7086,"journal":{"name":"Acta Clinica Belgica","volume":" ","pages":"164-172"},"PeriodicalIF":0.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146008791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of an outpatient parenteral antimicrobial therapy program at a tertiary hospital in Belgium: a monocentric retrospective observational study.","authors":"Vincent Infantino, Justine Monseur, Gilles Darcis, Catherine Orban, Frederic Frippiat, Anne-Sophie Sauvage","doi":"10.1080/17843286.2025.2601013","DOIUrl":"10.1080/17843286.2025.2601013","url":null,"abstract":"<p><strong>Objectives: </strong>Outpatient parenteral antimicrobial therapy (OPAT) offers a safe, effective, and resource-sparing alternative to inpatient treatment for various infections. Despite its widespread adoption globally, the implementation of OPAT programs in Belgium has been limited until recently. This study evaluates the safety, efficacy and healthcare impact of an OPAT program at a university hospital in Liège, Belgium.</p><p><strong>Methods: </strong>We conducted a retrospective observational study at a 1038-bed tertiary teaching hospital, including patients who received OPAT between January 2018 and December 2021. Electronic medical records were reviewed for demographics, diagnoses, treatment regimens, adverse events, and outcomes. Potential risk factors for adverse events and treatment failure were investigated.</p><p><strong>Results: </strong>A total of 352 OPAT episodes in 327 patients were analyzed. The most frequent indications were bloodstream infections (29.8%) and urinary tract infections (27.8%). Continuous antibiotic administration was used in 60.6% of cases, with a median OPAT duration of 16 days. Clinical cure was achieved in 86.4% of patients. Unplanned readmission linked to OPAT, infection-related death, drug-related adverse events, and line-related complications occurred in 8.2%, 1.1%, 5.1%, and 4.2% of episodes, respectively. Risk factors for adverse outcomes were identified, including cirrhosis, hematological malignancies, osteoarticular infections, chronic renal failure, and the use of specific antibiotics. The program avoided a mean of 1692 hospitalization days per year, underscoring its significant healthcare impact.</p><p><strong>Conclusion: </strong>This study highlights the favorable outcomes and safety profile of the OPAT program at our tertiary teaching hospital. Tailored interventions and careful antibiotic selection are warranted for specific patient groups.</p>","PeriodicalId":7086,"journal":{"name":"Acta Clinica Belgica","volume":" ","pages":"54-64"},"PeriodicalIF":0.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145761855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of anemia in patients with primary glomerulonephritis: a biopsy-based analysis.","authors":"Ayşe Öznur Urvasızoğlu, Emre Hoca, Egemen Cebeci, Sami Uzun, Serhat Karadağ, Savaş Öztürk","doi":"10.1080/17843286.2025.2605691","DOIUrl":"10.1080/17843286.2025.2605691","url":null,"abstract":"<p><strong>Background: </strong>Anemia is the second most common comorbidity among patients with chronic kidney disease. Renal tubulointerstitial lesions in patients with primary glomerular disease may result in anemia. This study aims to demonstrate the relation between interstitial fibrosis (IF) grades and anemia parameters in patients with primary glomerulonephritis (PGN).</p><p><strong>Methods: </strong>358 biopsy-proven PGN patients were included for this retrospective, cross-sectional study. We recorded the biopsy findings, demographic, clinical, and laboratory parameters of all patients on the biopsy day. The IF/cortical tissue ratio was calculated and classified into three groups; none, mild and moderate-severe IF.</p><p><strong>Results: </strong>The mean age of the patients was 43.0 ± 13.8 years, and 54.5% of patients were male. Anemia was present in 41.6% of patients. Hemoglobin and hematocrit decreased across rising IF categories (Hb: 13.1 vs 12.6 vs 12.3 g/dL; <i>p</i> = 0.026; post hoc difference driven by no IF vs moderate - severe IF, <i>p</i> = 0.046). However, in multivariable models, lower transferrin saturation, higher CRP, and lower eGFR were independently associated with anemia, whereas IF was not an independent determinant.</p><p><strong>Conclusion: </strong>In PGN, IF severity correlates with lower hemoglobin, but does not independently predict anemia after accounting for iron status, inflammation, and kidney function. Anemia appears mainly related to iron availability, inflammatory conditions, and eGFR rather than IF.</p>","PeriodicalId":7086,"journal":{"name":"Acta Clinica Belgica","volume":" ","pages":"70-79"},"PeriodicalIF":0.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145825578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}